Agusta 26, 2015 / Jami'ar Kyushu / Rahoton Kimiyya

Rubutu/Wu Tingyao

Tawagar binciken Kuniyoshi Shimizu, farfesa a Cibiyar Kimiyyar Aikin Noma ta Jami'ar Kyushu a Japan, ta tabbatar da cewa triterpenoid 31 da aka ware daga jikin 'ya'yan itace na Ganoderma suna hana neuraminidase na ƙwayoyin cuta guda biyar na mura A zuwa digiri daban-daban, daga cikinsu akwai guda biyu. triterpenoids har ma dace da haɓakawa azaman magungunan rigakafin mura.An buga sakamakon binciken a cikin "Rahotanni na Kimiyya" a ƙarƙashin ƙungiyar wallafe-wallafen "Nature" a ƙarshen Agusta 2015.

Neuraminidase yana daya daga cikin sunadaran sunadarai guda biyu da ke fitowa a saman kwayar cutar mura A.Kowace kwayar cutar mura tana da kusan ɗari ɗaya na waɗannan ƙwayoyin cuta.Lokacin da kwayar cutar ta mamaye tantanin halitta kuma ta yi amfani da kayan da ke cikin tantanin halitta don yin sabon ƙwayoyin ƙwayoyin cuta, ana buƙatar neuraminidase don sabbin ƙwayoyin ƙwayoyin cuta su rabu da tantanin halitta kuma su ƙara harba sauran ƙwayoyin cuta.Saboda haka, lokacin da neuraminidase ya rasa aikinsa, sabon kwayar cutar za a kulle a cikin tantanin halitta kuma ba zai iya tserewa ba, za a rage barazanar mai gida, kuma za a iya magance cutar.Oseltamivir (Tamiflu) da aka saba amfani dashi a aikin asibiti shine yin amfani da wannan ka'ida don hana yaduwa da yaduwar kwayar cutar.

Bisa ga binciken da Kuniyoshi Shimizu ya gudanar, a cikin taro na 200 μM, waɗannan Ganoderma triterpenoids sun hana ayyukan H1N1, H5N1, H7N9 da nau'i-nau'i masu tsayayya guda biyu NA (H1N1, N295S) da NA (H3N2, E119V) zuwa digiri daban-daban.Gabaɗaya, tasirin hanawa akan neuraminidase na nau'in N1 (musamman H5N1) shine mafi kyawun, kuma tasirin hanawa akan neuraminidase na H7N9 shine mafi muni.Daga cikin waɗannan triterpenoids, ganoderic acid TQ da ganoderic acid TR sun nuna matakan hanawa mafi girma, kuma tasirin waɗannan mahadi guda biyu sun kasance daga 55.4% zuwa 96.5% hanawa don nau'o'in NA daban-daban.

Ƙarin bincike game da dangantaka-aiki na waɗannan triterpenoids ya nuna cewa triterpenoids, waɗanda ke da tasiri mai mahimmanci akan N1 neuraminidase, suna da babban tsari na "tetracyclic triterpenoids tare da biyu shaidu biyu, reshe a matsayin ƙungiyar carboxylic, da kuma oxygen- mai dauke da rukuni a rukunin R5” (Kashin baya A a cikin hoton da ke ƙasa).Idan babban tsarin shine sauran biyun (Backbone B da C a cikin hoton da ke ƙasa), tasirin zai zama mara kyau.

(Madogararsa/Sci Rep. 2015 Agusta 26; 5:13194.)

A cikin docking na silico ana amfani dashi don daidaita hulɗar ganoderic acid (TQ da TR) da neuraminidases (H1N1 da H5N1).A sakamakon haka, an gano cewa duka ganoderic acid da Tamiflu sun sami damar ɗaure kai tsaye zuwa yanki mai aiki na neuraminidase.Wannan yanki mai aiki ya ƙunshi ragowar amino acid da yawa.Ganoderma acid TQ da TR za su ɗaure ga ragowar amino acid guda biyu Arg292 da Glu119.Tamiflu yana da wani zaɓi amma kuma yana iya sa neuraminidase yayi rashin tasiri.

Idan aka kwatanta da hana sauran sunadaran akan kwayar cutar mura (kamar sunadaran M2, wanda ke buɗe harsashin ƙwayoyin cuta a lokacin da kwayar cutar ta ɗaure zuwa kwayar halitta kuma ta aika da kwayar cutar kwayar cutar zuwa tantanin halitta), a halin yanzu an gane masu hana neuraminidase a matsayin masu tasiri da ƙasa. magungunan maganin mura masu juriya.Saboda haka, masu bincike sun yi imanin cewa ganoderic acid TQ da TR, waɗanda suke kama da amma ba iri ɗaya ba a cikin tsarin Tamiflu, suna da damar da za a yi amfani da su azaman sabon ƙarni na magungunan rigakafin mura ko ƙira.

Duk da haka, akwai sharuɗɗan da ake buƙata don amfani da maganin a matsayin maganin mura, wato, dole ne maganin ya hana haifuwar kwayar cutar yadda ya kamata ba tare da cutar da kwayoyin da kwayar cutar ta kama ba.Duk da haka, a cikin gwaje-gwajen da aka yi a kan sel masu kamuwa da ƙwayoyin cuta masu rai da layin ƙwayar nono (MCF-7), an gano cewa lokacin da masu binciken suka yi amfani da waɗannan nau'in ganoderic acid guda biyu kawai, suna da shakku game da babban cytotoxicity, amma kuma sun sami wani nau'i. na Ganoderma triterpenoid, ganoderol B, yana da tasirin hanawa akan H5N1 (amma tasirin hanawa mara kyau), amma ba cytotoxic ba.Sabili da haka, masu bincike sunyi imanin cewa yadda za a inganta lafiyar ganoderic acid TQ da TR ta hanyar gyare-gyaren tsarin sinadarai yayin da suke riƙe da hana ayyukan neuraminidase dole ne a yi la'akari da su a hankali.

[Madogararsa] Zhu Q, et al.Hanawa neuraminidase ta Ganoderma triterpenoids da abubuwan da ke haifar da ƙirar neuraminidase inhibitor.Sci Rep. 2015 ga Agusta 26;5:13194.doi: 10.1038/srep13194.

KARSHE

Game da marubucin / Ms. Wu Tingyao
Wu Tingyao ta kasance tana ba da rahoto game da bayanan Ganoderma na farko tun 1999. Ita ce marubucin labarun Ganoderma.Waraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).
 
★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubucin.★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin marubuci ba.★ Don keta bayanin da ke sama, marubucin zai bi alhakin da ya dace na shari'a.★ Asalin rubutun wannan labarin Wu Tingyao ne ya rubuta shi da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.