8 Ugushyingo 2020 / Ishuri Rikuru ry'Ubuvuzi, Kaminuza ya Tibet / Ibinyabuzima bya farumasi

Inyandiko / Wu Tingyao

Ese abarwayi ba kanseri bashobora gufataGanoderma lucidummugihe wakiriye imiti igamije?Twizere ko raporo yubushakashatsi ikurikira ishobora gutanga ibisubizo bimwe.

Gefitinib (GEF) ni umwe mu miti y'ingenzi igamije kuvura kanseri y'ibihaha yateye imbere kandi metastatike itari ntoya (harimo ibihaha adenocarcinoma, kanseri y'ibihaha ya kanseri y'ibihaha, na kanseri y'ibihaha nini), bizana urumuri rw'icyizere ku barwayi bafite barokoka mu mwijima.Ariko urumuri rwo gusohoka muri tunnel ntirushobora guhora rwaka, kuko kurwanya ibiyobyabwenge bikunda gukura nyuma y'amezi icumi kugeza kuri cumi n'itandatu yo kwivuza.

Kubwibyo, niba dushobora gufata umwanya wo kunoza ingaruka zo kuvura GEF, gerageza kuvura kanseri yibihaha kugirango igenzurwe kandi ibungabunzwe neza cyangwa ndetse bigabanye ingaruka zibiyobyabwenge kugirango abarwayi bashobore kugira ubuzima bwiza kumubiri. kanseri, birashoboka ko hari amahirwe yo gutuma urumuri rwubuzima rukayangana.

Abashakashatsi bo mu ishami rya Oncology ry’ibitaro bya Yantai by’ubuvuzi gakondo bw’Abashinwa n’Ishuri Rikuru ry’Ubuvuzi rya kaminuza ya Tibet bafatanije gusohora raporo y’ubushakashatsi muri “Pharmaceutical Biology” mu mpera za 2020 byagaragaje binyuze mu bushakashatsi bw’inyamaswa ko kuri adenocarcinoma y'ibihaha ikunze kugaragara mu bitari bito kanseri y'ibihaha selile, ikoreshwa hamweGanodermalucidumtriterpenoide (GLTs) na GEF birashobora guhagarika neza imikurire yikibyimba no kugabanya ingaruka zibiyobyabwenge, bigatanga gahunda nshya ikwiye gutekereza kubikorwa bijyanye no kuvura.

Abashakashatsi babanje gushyira imirongo ya selile ya alveolar adenocarcinoma (imirongo ya selile A549) munsi yuruhu rwimbeba hamwe na sisitemu zo kwirinda indwara.Nyuma ya diametre yibibyimba byo munsi yuburebure bwa mm 6-8, batangiye kugaburiraGanoderma lucidumtriterpenoide (GLT, 1 g / kg / kumunsi), gefitinib (GEF, 15 mg / kg / kumunsi) cyangwa guhuza byombi muminsi 14, kandi ubushakashatsi bwarangiye kumunsi wa 15.Byaragaragaye ko:

(1) Kunoza igipimo cyo gukumira ikibyimba

GLTs na GEF birashobora kubuza gukura kw'ibibyimba adenocarcinoma y'ibihaha, ariko guhuza byombi bigira ingaruka nziza (Ishusho 1 ~ 3).

Igicapo 1 Ibibyimba byakuwe mu mbeba adenocarcinoma y'ibihaha birangiye

Igicapo 2 Imihindagurikire yikura ryikibyimba cyimbeba adenocarcinoma mugihe cyibigeragezo

Igicapo 3 Ikura ryikura ryikibyimba cyimbeba adenocarcinoma yimbeba hakoreshejwe uburyo butandukanye bwo kuvura

2) Shimangira kubuza ikibyimba angiogenez no guteza imbere kanseri ya apoptose

Ibibyimba bigomba gukora imiyoboro mishya kugirango ikomeze gukura.Kubwibyo, ubucucike bwa microvessels mubice byibyimba byabaye urufunguzo rwingenzi rwo gukura neza kwibibyimba.Igicapo 4 (A) cerekana ikwirakwizwa rya microvessels mu bice by'ibibyimba bya buri tsinda.Igishushanyo 4 (B) cyerekana ko guhuza GLTs na GEF bifite ingaruka nziza zo kubuza kuruta ebyiri zonyine.

Igicapo ca 4 Ibibyimba bya Tumor hamwe na microvessel ubwinshi bwimbeba ya adenocarcinoma yimbeba

Muyandi magambo, guhuza GLTs na GEF birashobora guhagarika ingirabuzimafatizo nyinshi kubona intungamubiri kandi bigatuma ibibyimba bigora gukura.Ubu buryo bwibikorwa buturuka kumabwiriza ashimangiwe yerekana imiterere ya gene hamwe no gusohora poroteyine mu ngingo zifata ibibyimba, harimo no kubuza “imiyoboro y'amaraso ikura ya reseptor 2 (VEGFR2)” no guteza imbere umusaruro wa “Angiostatin” na “endostatine”.

Byongeye kandi, abashakashatsi banabonye mu gice cy’ibibyimba bya buri tsinda ry’imbeba ko hakurikijwe ibikorwa bya GLTs na GEF, isohoka rya poroteyine (Bax) itera kanseri ya apoptose ya kanseri iziyongera cyane mu gihe isohoka rya poroteyine (Bcl- 2) ibuza apoptose ya selile kanseri izagabanuka.Ibihaha adenocarcinoma bihuta mugutezimbere kugana icyerekezo cya apoptose muribi byongeweho imbaraga.

(3) Kugabanya ingaruka mbi zibiyobyabwenge

Imbeba y'ibihaha adenocarcinoma yavuwe na GEF gusa yatakaje ibiro byinshi;kurundi ruhande, guhuza GLTs na GEF birashobora gukomeza neza uburemere bwimibiri yimbeba adenocarcinoma yimbeba ── yegereye iyimbeba zisanzwe (itsinda rishinzwe kugenzura bisanzwe) (Ishusho 5).

Byongeye kandi, imbeba y'ibihaha adenocarcinoma ivurwa na GEF gusa yerekanaga guhangayika, umunaniro, gusinzira, kugabanuka k'ibikorwa, kugabanya ubushake bwo kurya no kuruhu rwijimye.Ariko, ibi bintu byari byoroshye cyane cyangwa ntibigaragara mumatsinda yavuwe hamwe na GLTs na GEF.Biragaragara, GLTs irashobora gukosora ingaruka mbi zatewe na GEF.

Igicapo 5 Imirongo yerekana uburemere hamwe nimpinduka zimbeba adenocarcinoma yimbeba mugihe cyubushakashatsi

(4) Umutekano wa GLTs

Mu rwego rwo gusuzuma umutekano wa GLTs, abashakashatsi bateje imbere imirongo isanzwe ya alveolar epithelial selile selile BEAS-2B hamwe numurongo wa selile ya alveolar adenocarcinoma A549 yakoreshejwe mubushakashatsi bwinyamaswa hamwe na GLT muri vitro mumasaha 48.

Ibisubizo byerekanwe ku gishushanyo cya 6. Iyo GLTs (intumbero ya 2,5 na 5 mg / L) yabujije igipimo cyo kubaho kwa selile adenocarcinoma y'ibihaha kugera kuri 80-60%, selile zisanzwe zari zikiri muzima;ndetse no mubitekerezo byinshi, GLTs iracyafata neza kanseri ya kanseri ningirabuzimafatizo zisanzwe, kandi iri tandukaniro rirakomeye kuruta GEF (Ishusho 7).

Igicapo 6 Ingaruka zibuza GLTs kumikurire ya selile

Igicapo 7 Ingaruka zibuza gefitinib kumikurire ya selile

Nk’uko isesengura ry’abashakashatsi ribigaragaza, indangagaciro za IC50 za GLTs kuri 48 h zo kuvura imirongo ya selire A549 zari 14.38 ± 0.29 mg / L mu gihe GLTs yerekanye ingaruka nke za cytotoxic nkeya ku murongo w’akagari ka BEAS-2B ufite IC50 ifite agaciro ka 78.62 ± 2.53 mg / L, bivuze ko iyo GLT zica kanseri ya kanseri, zirashobora gukomeza umutekano muke kuri selile zisanzwe.

GLTs hamwe nubuvuzi bugamije bijyana, bigatuma ubuvuzi burushaho gutanga icyizere.

Iyi raporo y'ubushakashatsi yatweretse:

Mubihe bimwe byubushakashatsi, ubuyobozi bwo munwa bwa GLTs ntibushobora kugira ingaruka nkizibuza ibihaha byabantu adenocarcinoma yibibyimba nka GEF, ariko GLTs nta ngaruka mbi za GEF.

Iyo GLTs na GEF bikoranye, ntibishobora kongera gusa ingaruka zo kubuza ikibyimba gusa ahubwo binagabanya ingaruka za gefitinib kuburemere, umwuka, imbaraga, ubushake nuruhu.Ibi nibyo bita "kongera imikorere no kugabanya uburozi".

Impamvu GLTs ishobora kunoza GEF kubuza ibibyimba adenocarcinoma ibihaha bifitanye isano no "kubuza ikibyimba angiogenezi" no "guteza imbere kanseri ya apoptose".

Mu rwego rwo gusuzuma kanseri y’abantu mu nyamaswa, abashakashatsi bakoresheje imbeba zifite sisitemu zo kwirinda indwara (kugira ngo kanseri y’abantu ikure ku moko atandukanye).Kubwibyo, ibisubizo ahanini byari ingaruka za GLTs na GEF ubwayo kuri selile kanseri.

Ariko, mubikorwa nyabyo byo kurwanya kanseri, imikorere yubudahangarwa igomba kubigiramo uruhare.Kubwibyo, usibye GLTs na GEF, niba "ubudahangarwa bwiza" bwongeyeho, ibisubizo bizaba byiza cyane?

Abashakashatsi ntibatanze ibisobanuro byinshi kuri GLTs yakoreshejwe mu bushakashatsi, ariko ukurikije ibisobanuro by'uru rupapuro, igomba kuba ikuramo rito rya GLT zitandukanye.Ariko igipimo cyiza cya garama imwe kuri kilo yuburemere bwumubiri mu mbeba mubyukuri ni byinshi.Ibi biratubwira ko ibikorwa bifatika bishobora gusaba igipimo kinini kugirango gikore neza.Kurundi ruhande, biraduha kandi ibyiringiro ko mugihe kizaza bishoboka ko dushobora kubona ibintu byingenzi bishobora gukora neza cyangwa byiza kurwego rwo hasi.

Ibyo ari byo byose, byibuze ubu bushakashatsi bwerekanye ko triterpenoide ikomoka kuri Ganoderma lucidum itabuza gusa kuvura imiti ikoreshwa cyane mu mavuriro ahubwo inagira ingaruka nziza zo "kongera imikorere no kugabanya uburozi" bushingiye ku mutekano uhagije.
Kwikubita mu mwobo wijimye bisaba urumuri rwinshi rwo kuyobora inzira no kumurika.Ugereranije n '"ibyiringiro" bitagerwaho cyangwa bigoye kubyara umusaruro, cyangwa "resept y'ibanga" hamwe n'inkomoko itazwi n'ibigize,Ganoderma lucidumtriterpenoide, ishobora kuboneka mugihe ubishaka kandi ukaba ufite uburambe bwigihe kirekire cyo gukoresha, bigomba kuba byiza kugerageza.

[Inkomoko] Wei Liu, n'abandi.Ganoderma triterpenoids yerekana ikibyimba angiogenezi muri kanseri y'ibihaha ibibyimba byambaye ubusa.Pharm Biol.2020: 58 (1): 1061-1068.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao
Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma kuva mu 1999. Ni umwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).
 
★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi.Works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira n'umwanditsi.★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakurikirana inshingano zemewe n'amategeko.Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.