Ngisho ne-Alzheimer's Disease ihlotshaniswa nokungalali kahle.

Ubuwazi ukuthi “ukulala kahle” akusizi nje kuphela amandla, ukungatheleleki komzimba kanye nemizwa kodwa kuvimbela i-Alzheimer's?

USolwazi Maiken Nedergaard, isazi sezinzwa zaseDenmark, washicilela isihloko ku-Scientific American ngo-2016, eveza ukuthi isikhathi sokulala yisikhathi esisebenza kakhulu nesisebenza kahle kakhulu "sokukhipha ubuthi ebuchosheni".Uma inqubo yokukhipha ubuthi ithikamezwa, imikhiqizo yemfucuza enobuthi efana ne-amyloid ekhiqizwa ngesikhathi sokusebenza kobuchopho inganqwabelana phakathi noma eduze kwamangqamuzana ezinzwa, okungaholela ezifweni ze-neurodegenerative ezifana nesifo i-Alzheimer's.

Isenzakalo sokuthintana phakathi kokulala nokugonywa komzimba, okwatholwa ekuqaleni kwekhulu leminyaka elidlule, siye saqondwa kabanzi kuleli khulu leminyaka.

Isazi sezinzwa esihamba phambili saseJalimane uDkt. Jan Born nethimba lakhe bafakazele ngocwaningo ukuthi amasosha omzimba anemisebenzi emibili ehlukene phakathi nokulala ebusuku (kusuka ngo-11:00 ebusuku kuya ku-7:00 ekuseni ngosuku olulandelayo) nangesikhathi sokuphaphama: Ukujula kwe-Slow Wave. Ukulala (SWS), lapho kusebenza kakhulu ukusabela komzimba ku-anti-tumor kanye ne-anti-infection (ukugxila okukhulayo kwe-IL-6, TNF-α, IL-12, kanye nemisebenzi eyandisiwe yamaseli T, amaseli e-dendritic nama-macrophages) ngenkathi amasosha omzimba. impendulo ngesikhathi sokuphaphama yayicindezelwe ngokuqhathaniswa.

Ikhwalithi yokulala kwakho ayikho ngaphansi kokulawula kwakho.

Ukubaluleka kokulala akubuzwa, kodwa inkinga ukuthi ukulala, okubonakala kulula kakhulu, kunzima nakakhulu kubantu abaningi.Lokhu kungenxa yokuthi ukulala, njengokushaya kwenhliziyo nomfutho wegazi, kulawulwa isimiso sezinzwa ezizimele futhi angeke kulawulwe intando yomuntu ngamunye (ukwazi).

Uhlelo lwezinzwa oluzimele luqukethe uhlelo lwezinzwa olunozwela kanye nesistimu yezinzwa ye-parasympathetic.Owokuqala unesibopho “sokuthokozela (ukushuba)”, ohlanganisa izinsiza zomzimba ukuze ubhekane nengcindezi endaweni ezungezile;Lesi sakamuva sinesibopho "sokucindezelwa kwenjabulo (ukuphumula)", lapho umzimba ungaphumula, ulungise futhi uvuselele.Ubudlelwano phakathi kwabo bufana nesaha, olunye uhlangothi luphakeme (luqinile) kanti olunye luphansi (lubuthakathaka).

Ngaphansi kwezimo ezijwayelekile, izinzwa ezinozwela kanye ne-parasympathetic zingashintsha ngokukhululekile.Kodwa-ke, lapho ezinye izizathu (njengokugula, izidakamizwa, umsebenzi nokuphumula, indawo ezungezile, ukucindezeleka kanye nezici ezingokwengqondo) zibhubhisa indlela yokulungisa phakathi kokubili, okusho ukuthi, kubangela ukungalingani lapho izinzwa ezinozwela zihlala ziqinile (kulula). ukushuba) kanye nezinzwa ze-parasympathetic zihlala zibuthakathaka (kunzima ukuphumula).Lokhu kuphazamiseka kokulawula phakathi kwezinzwa (ikhono elingalungile lokushintsha) yilokho okubizwa ngokuthi "i-neurasthenia".

Umthelela we-neurasthenia emzimbeni ubanzi, futhi uphawu oluphawuleka kakhulu "ukuqwasha".Ubunzima bokulala, ukungalali ngokwanele, ukuphupha njalo nokuvuka kalula (ukungalali kahle), isikhathi esinganele sokulala, nokuphazamiseka kokulala kalula (ubunzima bokubuyela ebuthongweni ngemva kokuvuka).Kuwukubonakaliswa kokuqwasha, futhi ukuqwasha kumane nje kuyisiqephu seqhwa lapho i-neurasthenia iholela ekungasebenzini kahle kwezitho ezihlukahlukene.

Isistimu yezinzwa enozwela (bomvu) &

I-Parasympathetic nervous system (blue)

(Umthombo wesithombe: Wikimedia Commons)

Ngawo-1970, kwafakazelwa lokhoI-Ganoderma luciduminomphumela okhuthaza ukulala emzimbeni womuntu.

I-Ganoderma lucidumingathuthukisa izimpawu ezihlobene nokuqwasha kanye ne-neurasthenia, eyafakazelwa ekuqaleni ngokusetshenziswa komtholampilo eminyakeni engu-50 edlule (imininingwane kuthebula elingezansi).

Funda kokuhlangenwe nakho komtholampilo kweI-Ganoderma lucidumukusiza ukulala

Ezinsukwini zokuqala, ngenxa yezinsiza ezilinganiselwe zokuhlolwa kwezilwane, kwakunamathuba amaningi okuqinisekisa ukusebenza kahle kwezilwane.I-Ganoderma lucidumngokuhlolwa kwabantu.Ngokuvamile, nomaI-Ganoderma lucidumisetshenziswa iyodwa noma ihlanganiswe nemithi yaseNtshonalanga, ukusebenza kwayo ekulungiseni ukuphazamiseka kokulala okubangelwa yi-neurasthenia nokuxazulula izinkinga ezihlobene nokulala ezifana nesifiso sokudla, amandla engqondo namandla omzimba kuphezulu kakhulu.Ngisho neziguli ezine-neurasthenia ezinenkani zinamathuba amahle.

Nokho, umphumela weI-Ganoderma lucidumayisheshi, futhi ngokuvamile kuthatha amasonto angu-1-2, noma ngisho nenyanga engu-1, ukubona umphumela, kodwa njengoba inkambo yokwelashwa ikhula, umphumela wokuthuthukisa uzoba sobala kakhulu.Izinkinga ezikhona zezinye zezifundo ezinjengezinkomba zesifo sokusha kwesibindi kohlobo olungajwayelekile, i-cholesterol ephezulu, ukucinana kwemigudu yokuphefumula, i-angina pectoris, nokuphazamiseka kokuya esikhathini nakho kungathuthukiswa noma kubuyiselwe kokujwayelekile phakathi nenkambo yokwelashwa.

I-Ganodermaamalungiselelo enziwe ahlukeneI-Ganoderma lucidumizinto ezingavuthiwe nezindlela zokucubungula zibonakala zinemiphumela yazo, futhi umthamo osebenzayo awunalo ibanga elithile.Ngokuyisisekelo, umthamo odingekayoI-Ganodermaamalungiselelo ewodwa kufanele abe ngaphezu kwalokho okulindelekile, okungase futhi kudlale indima ehambisanayo lapho esetshenziswa ngokuhambisana namaphilisi okulala alalisayo noma izidakamizwa zokwelashwa kwe-neurasthenia.

Abantu abambalwa bangase babe nezimpawu ezinjengomlomo owomile nomphimbo, izindebe eziqhaqhazelayo, ukungakhululeki emathunjini, ukuqunjelwa noma isifo sohudo ekuqaleni kokuthatha.I-Ganoderma lucidumamalungiselelo, kodwa lezi zimpawu ngokuvamile zinyamalale ngokwazo ngesikhathi ukusetshenziswa okuqhubekayo kwesiguliI-Ganoderma lucidum(ngokushesha njengosuku olulodwa noma ezimbili, kancane njengeviki elilodwa noma amabili).Abantu abanesicanucanu nabo bangagwema ukungakhululeki ngokushintsha ubude besikhathi sokuthathaI-Ganoderma lucidum(kungaba phakathi noma ngemva kokudla).Kucatshangelwa ukuthi lokhu kusabela cishe kuyinqubo yemithethosisekelo yomuntu ngamunye evumelana nayoI-Ganoderma lucidum, futhi uma umzimba usuzivumelanisa nezimo, lokhu kusabela kuzoqedwa ngokwemvelo.

Kusukela ekutheni ezinye izifundo ziqhubekile nokuthathaI-Ganoderma lucidumamalungiselelo izinyanga ezingu-6 noma 8 ngaphandle kwemiphumela emibi, kungaphethwa ngokuthiI-Ganoderma luciduminezinga eliphezulu lokuphepha kokudla futhi ukusetshenziswa kwesikhathi eside akunangozi.Ezinye izifundo nazo zibonile ezifundweni ebezithathaI-Ganoderma lucidumizinyanga ezingu-2 izimpawu esezivele zithuthukile noma zanyamalala kancane kancane phakathi nenyanga engu-1 ngemva kokuyeka ukusebenzisaI-Ganoderma lucidum.

Lokhu kukhombisa ukuthi akulula ukwenza uhlelo lwezinzwa oluphazamisekile lwe-autonomic lusebenze ngokujwayelekile nangokuzinza isikhathi eside ngemuva kokulungiswa kokuphazamiseka.Ngakho-ke, ukugcinwa okuqhubekayo kungase kudingeke ngaphansi kwesisekelo sakho kokubili ukuphepha nokusebenza.

Okuhlangenwe nakho kusitshela ukuthi ukuthathaI-Ganoderma lucidumukuthuthukisa ukulala kudinga isineke esengeziwe, ukuzethemba okwengeziwe, futhi ngezinye izikhathi umthamo owengeziwe.Futhi ukuhlolwa kwezilwane kubonisa ukuthi yikuphiGi-anodermalucidumamalungiselelo angase aphumelele futhi kungani.Ngokuphathelene nalokhu kwakamuva, sizokuchaza ngokuningiliziwe esihlokweni esilandelayo.

Izithenjwa

1. Uhlelo Lokulahla Udoti Lobuchopho Lungase Lubhaliselwe Ukwelapha I-Alzheimer kanye Nezinye Ukugula Kobuchopho.Ku: Scientific American, 2016. Kutholwe kusukela: https://www.scientificamerican.com/article/the-brain-s-waste-disposal -system-may-be-enlisted-to-treat-alzheimer-s-and- ezinye izifo zobuchopho/

2. I-T cell ne-antigen yethula umsebenzi weseli ngesikhathi sokulala.Ku: BrainImmune, 2011. Kutholwe kusukela: https://brainimmune.com/t-cell-antigen-presenting-cell-sleep/

3. I-Wikipedia.Isistimu yezinzwa ye-Autonomic.Ku: Wikipedia, 2021. Kutholwe kusukela ku-https://en.wikipedia.org/zh-tw/autonomic nervous system

4. Izinkomba ezifanele zeI-Ganoderma lucidumzichazwe kabanzi kumanothi ethebula alesi sihloko

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