Ibhalwe nguWu Tingyao

Uma ukukhuluphala kungenakucindezelwa, ingabe ikhona indlela yokunciphisa ukukhuluphala ngaphandle kokucindezela ukudla, noma ngisho nokukhuluphala ngendlela enempilo?Umbiko wocwaningo oshicilelwe ithimba laseNingizimu Korea eNutrients ubonise lokhoI-Ganoderma lucidumingenza kusebenze i-AMPK, i-enzyme eyinhloko kumetabolism yamandla engqamuzana, ukunciphisa ukunqwabelana kwamafutha, ukuthuthukisa ukusetshenziswa kwe-glucose kanye nokunciphisa ingozi yokukhuluphala, isibindi esinamafutha, i-hyperglycemia kanye ne-hyperlipidemia ebangelwa ukudla okunamafutha amaningi (HFD).

Abacwaningi abavela eChungbuk National University, Kyungpook National University kanye neNational Institute of Horticultural and Herbal Science yaseNingizimu Korea ngokuhlanganyela bashicilele abakutholile kumagazini kaNovemba 2020 we “Nutrients” (Nutrients Journal) :

Kumagundane adla ukudla okunamafutha amaningi, umaI-Ganoderma lucidumi-powder ekhishwe (GEP) yengezwa ekudleni kwabo, ngemva kwamasonto e-12 okuhlolwa, amagundane awanazo izinkinga ezicacile ngesisindo, amafutha omzimba, ukumelana ne-insulin, ushukela wegazi noma i-lipids yegazi.Ngaphezu kwalokho, kuningiI-Ganoderma lucidumi-extract ingeziwe, lezi zinkomba zamagundane ezidla ukudla okunamafutha aphezulu zizosondelana nalezo zamagundane anokudla okujwayelekile kwe-chow (ND) nokudla okunomsoco, okungabonakala ngisho nokubukeka.

Yidla inani elifanayo lokudla kodwa ube namafutha amancane

Kungabonakala kuMfanekiso 1 ukuthi ngemva kokuhlolwa kwamasonto ayishumi nambili, usayizi nesisindo samagundane ekudleni okunamafutha amaningi kwakucishe kuphindwe kabili kunamagundane ekudleni okujwayelekile kwe-chow, kodwa amagundane nawo aphiwa ukudla.I-Ganoderma lucidumukukhishwa kube nezinguquko ezihlukene ─ Ukwengezwa kwe-1%I-Ganoderma lucidumukukhishwa akukacaci, kodwa ukungezwa kwe-3% kusobala kakhulu, ikakhulukazi umphumela ovimbelayo wokwengeza u-5% ku-portly ubaluleke kakhulu.

II-Ganoderma lucidumukukhishwa okwadliwa yila magundane kutholwe ngokukhipha imizimba yezithelo ezomisiwe ezitshalwe ngokwenziwaI-Ganoderma lucidumizinhlobo (i-ASI7071) ezino-95% we-ethanol (utshwala) nguMnyango Wokucwaninga Amakhowe we-National Institute of Horticultural and Herbal Science of South Korea.Izingxenye eziyinhloko ze-bioactive ze-I-Ganoderma lucidumukukhishwa kushiwo kuThebula 1: I-Ganoderic acid i-akhawunti engu-53%, futhi i-polysaccharides i-27%.Izinhlobo zokudla ezisetshenziswe kulolu cwaningo zishiwo kuThebula lesi-2.

Njengoba i-Ganoderic acid inokunambitheka okubabayo, umuntu akakwazi ukuzibamba kodwa uyazibuza ukuthi ithinta ukudla kwamagundane futhi ibangele ukuncipha kwesisindo.Cha!Imiphumela ibonisa ukuthi womabili amaqembu amagundane adla cishe inani elifanayo lokuphakelayo nsuku zonke (Umfanekiso 2 kwesokudla), kodwa kukhona umehluko omkhulu ekuzuzeni isisindo samagundane ngaphambi nangemuva kokuhlolwa (Umfanekiso 2 kwesokunxele).Lokhu kubonakala kusikisela ukuthi kunganiI-Ganoderma lucidumukukhishwa kungaqhudelana nokudla okunamafutha amaningi kungase kuhlobane nokuthuthukiswa kokusebenza kahle kwe-metabolic.

I-Ganoderma lucidumkuvimbela ukunqwabelana kwamafutha kanye ne-adipocyte hypertrophy

Ukuzuza kwesisindo ngokuvamile kuhlobene "nokukhula kwemisipha noma amafutha".Kulungile ukukhulisa imisipha.Inkinga isekukhuleni kwamafutha, okungukuthi, izicubu ezimhlophe ze-adipose (WAT), ezinesibopho sokugcina ama-calories eqile emzimbeni, ande.Lawa mafutha engeziwe angase anqwabelane ezingxenyeni ezihlukahlukene.Uma kuqhathaniswa namafutha angaphansi kwesikhumba, amafutha e-visceral (abuye abizwe ngokuthi amafutha esisu) anqwabelana phakathi kwezitho ezihlukahlukene zesisu kanye namafutha e-ectopic avela ezicutshini ezingezona ze-nonadipose (njengesibindi, inhliziyo kanye nemisipha) ngokuvamile ahlobene kakhulu nezingozi ezihlobene nokukhuluphala njengesifo sikashukela. , isibindi esinamafutha kanye nesifo senhliziyo nemithambo yegazi.

Ngokwemiphumela yocwaningo lwezilwane olungenhla,I-Ganoderma lucidumukukhishwa akukwazi ukunciphisa kuphela ukuqoqwa kwamafutha angaphansi kwesikhumba, amafutha e-epididymal (amele amafutha e-visceral) namafutha e-mesenteric (amele amafutha esiswini) (Umfanekiso 3) kodwa futhi anciphise okuqukethwe kwamafutha esibindi (Umfanekiso 4);Kuyinto enembile ukubona kusukela esigabeni sezicubu ze-adipose ze-epididymis ukuthi ubukhulu be-adipocytes buzoshintsha ngenxa yokungenelelaI-Ganoderma lucidumkhipha (Umfanekiso 5).

I-Ganoderma lucidumyehlisa i-hyperlipidemia, i-hyperglycemia kanye nokumelana ne-insulin

Izicubu ze-adipose aziyona nje inqolobane yokuthi umzimba uqongelele amafutha amaningi kodwa futhi ukhiqiza “amahomoni amafutha” ahlukahlukene athinta i-carbohydrate kanye ne-lipid metabolism.Lapho inani lamafutha omzimba liphezulu, ukusebenzisana kwalawa mahomoni amafutha kuzonciphisa ukuzwela kwamangqamuzana ezicubu ku-insulin (lokhu okubizwa ngokuthi “ukumelana ne-insulin”), okwenza kube nzima kakhulu kumaseli ukusebenzisa i-glucose.

Umphumela ngeke nje ukhulise ushukela wegazi kodwa futhi ubangele ukungahambi kahle kwe-lipid metabolism, okubangela izinkinga ezifana ne-hyperlipidemia, isibindi esinamafutha kanye ne-atherosclerosis.Ngasikhathi sinye, ama-pancreas azophoqeleka ukuthi akhiphe i-insulin eyengeziwe.Ngenxa yokuthi i-insulin ngokwayo inomphumela wokukhuthaza ukunqwabelana kwamafutha kanye nokuvuvukala, i-insulin efihlwe ngokweqile ayigcini nje ngokuxazulula inkinga kodwa yenza ukukhuluphala nazo zonke izinkinga ezingenhla zibe zimbi nakakhulu.

Ngenhlanhla, ngokwalo mbiko wocwaningo waseNingizimu Korea,I-Ganoderma lucidumukukhishwa kunomthelela wokulungisa ekukhiqizweni okungavamile kwamahomoni amafutha (i-leptin ne-adiponectin), ukwanda kokumelana ne-insulin nokuncipha kokusetshenziswa kwe-glucose okubangelwa ukudla okunamafutha amaningi.Umthelela othize uboniswa ekuhlolweni kwezilwane okukhulunywe ngenhla: Kumagundane ekudleni okunamafutha amaningi okunezelwaI-Ganoderma lucidumukukhishwa, i-dyslipidemia yabo kanye noshukela wegazi ophakeme kanye ne-insulin kwakuthambile (Ithebula 3 kanye noMdwebo 6).

I-Ganoderma lucidumivuselela i-enzyme eyinhloko ye-cell energy metabolism - AMPK

Kungani kungenzekaI-Ganoderma lucidumukukhipha kuphendule inkinga yokudla okunamafutha amaningi kube yinguquko?Abacwaningi bakhiphe izicubu ze-adipose nezicubu zesibindi zamagundane okuhlola ashiwo ngenhla ukuze kuhlaziywe ukuze kubonakale ukuthi la maseli azohluka kanjani ngenxa yokwengezwa kweI-Ganoderma lucidumkhipha ngaphansi kokudla okufanayo okunamafutha aphezulu.

Kwatholakala ukuthi iI-Ganoderma lucidumi-extract ikhuthaze umsebenzi we-enzyme ye-AMPK (i-5'adenosine monophosphate activated protein kinase), enesibopho sokulawula amandla kuma-adipocytes namaseli esibindi.I-AMPK ecushiwe inganqanda ukuvezwa kofuzo okuhlobene ne-adipogenesis futhi ikhulise i-insulin receptor kanye ne-glucose transporter (iphrotheni ehambisa i-glucose isuka ngaphandle kweseli iye ngaphakathi kweseli) endaweni yeseli.

Ngamanye amazwi,I-Ganoderma lucidumi-extract ilwa nokudla okunamafutha amaningi ngokusebenzisa indlela eshiwo ngenhla, ngaleyo ndlela inciphise ukunqwabelana kwamafutha, ithuthukise ukusetshenziswa kwe-glucose, futhi ekugcineni ifinyelele umgomo wokunciphisa ukukhuluphala.

Eqinisweni, kunengqondo kakhulu lokhoI-Ganoderma lucidumukukhishwa kungalawula umsebenzi we-AMPK ngoba umsebenzi we-AMPK owehlisiwe uhlotshaniswa nokukhuluphala noma uhlobo lwesifo sikashukela sohlobo 2 olubangelwa ukudla okunamafutha amaningi.Umuthi osetshenziswa kakhulu we-hypoglycemic metformin ekusebenzeni komtholampilo ngokwengxenye uhlobene nokwandisa umsebenzi we-AMPK wama-adipocyte namaseli esibindi.Njengamanje, ukwanda komsebenzi we-AMPK nakho kuthathwa njengesu elingenzeka lokuthuthukisa izinga lokugayeka kokudla emzimbeni ekuthuthukisweni kwemithi eminingi emisha yokuthuthukisa ukukhuluphala.

Ngakho ucwaningo onI-Ganoderma lucidumihambisana ngempela nenqubekelaphambili yesayensi kanye nesivinini sezikhathi, futhi ucwaningo olubucayi olushiwo ngenhla oluvela eNingizimu Korea lunikeza isisombululo esilula kuwe nami “esifuna ukudla kahle kodwa esingafuni ukuthinteka ngokudla kahle. ”, okungukuthi, ukugcwalisaI-Ganoderma lucidumukukhipha okuqukethe ama-anoderic acid ahlukahlukene kanyeI-Ganoderma lucidumama-polysaccharides.

[Umthombo Wedatha] Hyeon A Lee, et al.I-Ganoderma lucidum Extract Yehlisa Ukuphikiswa Kwe-insulin Ngokuthuthukisa Ukwenziwa Kusebenze kwe-AMPK Kumagundane Akhuluphale Abangelwa Ukudla Okunamafutha Aphezulu.Izakhamzimba.2020 Okthoba 30;12(11):3338.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao

U-Wu Tingyao ubelokhu ebika mathuphaI-Ganoderma lucidumulwazi

kusukela ngo-1999. Ungumbhali weUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).

★ Lesi sihloko sishicilelwe ngaphansi kwegunya elikhethekile lombhali ★ Le misebenzi engenhla ayikwazi ukuphinda ikhiqizwe, icashunwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali ★ Ukwephulwa kwesitatimende esingenhla, umbhali uzoqhuba izibopho zayo zomthetho ezihlobene ★ Eyokuqala umbhalo walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.