Los ntawm Wu Tingyao

Yog tias kev rog tsis tuaj yeem txwv tsis pub, puas muaj ib txoj hauv kev los txo qhov hnyav dua yam tsis muaj kev tshaib plab, lossis tseem nce qhov hnyav dua?Ib daim ntawv tshaj tawm kev tshawb fawb luam tawm los ntawm South Kauslim pab pawg hauv Nutrients qhia tiasGanoderma lucidumtuaj yeem qhib AMPK, ib qho tseem ceeb ntawm cov enzymes hauv cell zog metabolism, txo cov rog rog, txhim kho kev siv cov piam thaj thiab txo qhov kev pheej hmoo ntawm kev rog rog, rog rog, hyperglycemia thiab hyperlipidemia tshwm sim los ntawm kev noj zaub mov muaj roj ntau (HFD).

Cov kws tshawb fawb los ntawm Chungbuk National University, Kyungpook National University thiab National Institute of Horticultural thiab Herbal Science ntawm South Kauslim tau koom ua ke luam tawm lawv cov kev tshawb pom nyob rau lub Kaum Ib Hlis 2020 qhov teeb meem ntawm "Nutrients" (Nutrients Journal):

Rau cov nas uas noj cov rog rog, yog tiasGanoderma lucidumextract hmoov (GEP) yog ntxiv rau lawv cov pub, tom qab 12 lub lis piam ntawm kev sim, cov nas tsis muaj teeb meem pom tseeb txog qhov hnyav, lub cev rog, insulin tsis kam, ntshav qab zib lossis ntshav lipids.Ntxiv mus, qhov ntauGanoderma lucidumextract yog ntxiv, qhov ze dua cov ntsuas no ntawm cov nas uas noj cov rog rog yuav yog rau cov nas uas muaj cov zaub mov zoo li qub (ND) thiab cov khoom noj khoom haus sib npaug, uas tuaj yeem pom los ntawm cov tsos.

Noj tib yam khoom noj tab sis ua rog tsawg

Nws tuaj yeem pom los ntawm daim duab 1 tias tom qab kev sim kaum ob lub lis piam, qhov loj thiab qhov hnyav ntawm cov nas ntawm cov zaub mov muaj roj ntau yuav luag ob npaug ntawm cov nas ntawm cov zaub mov noj ib txwm, tab sis cov nas uas tau noj nrog.Ganoderma lucidumextract muaj txawv kev hloov ─ Qhov sib ntxiv ntawm 1%Ganoderma lucidumextract tseem tsis pom tseeb, tab sis qhov sib ntxiv ntawm 3% yog qhov pom tseeb heev, tshwj xeeb tshaj yog cov nyhuv inhibitory ntawm kev ntxiv 5% rau lub portly yog qhov tseem ceeb dua.

CovGanoderma lucidumextract uas cov nas noj tau los ntawm extracting txiv hmab txiv ntoo qhuav lub cev ntawm artificially cultivated tshwj xeebGanoderma lucidumHom (ASI7071) nrog 95% ethanol (cawv) los ntawm Mushroom Research Department ntawm National Institute of Horticultural thiab Herbal Science ntawm South Kauslim.Qhov tseem ceeb bioactive cov ntsiab lus ntawm covGanoderma lucidumextract tau teev nyob rau hauv Table 1: Ganoderic acids account rau 53%, thiab polysaccharides account rau 27%.Cov khoom noj khoom haus uas siv hauv txoj kev tshawb fawb no tau teev tseg hauv Table 2.

Raws li Ganoderic acid muaj iab saj, ib tug tsis tuaj yeem pab tab sis xav paub seb nws puas cuam tshuam rau cov khoom noj ntawm cov nas thiab ua rau poob phaus.Tsis muaj!Cov txiaj ntsig tau pom tias ob pawg nas tau noj yuav luag tib yam khoom noj txhua hnub (Daim duab 2 sab xis), tab sis muaj qhov sib txawv ntawm qhov hnyav nce ntawm cov nas ua ntej thiab tom qab kev sim (Daim duab 2 sab laug).Qhov no zoo nkaus li qhia tias yog vim li casGanoderma lucidumExtract tuaj yeem sib tw nrog kev noj zaub mov muaj roj ntau tuaj yeem cuam tshuam nrog kev txhim kho cov metabolism hauv kev ua haujlwm.

Ganoderma luciduminhibits rog tsub zuj zuj thiab adipocytes hypertrophy

Qhov hnyav nce feem ntau cuam tshuam nrog "kev loj hlob ntawm cov leeg nqaij lossis rog".Nws yog ua tau kom loj hlob cov leeg.Qhov teeb meem nyob rau hauv loj hlob rog, uas yog, dawb adipose ntaub so ntswg (WAT), uas yog lub luag hauj lwm rau khaws cia cov calorie ntau ntau nyob rau hauv lub cev, tau nce.Cov rog ntxiv no tuaj yeem sib sau ua ke hauv ntau qhov chaw.Piv nrog rau cov roj subcutaneous, cov roj visceral (tseem hu ua cov rog hauv plab) sib sau ua ke ntawm ntau yam kabmob hauv plab kab noj hniav thiab cov roj ectopic uas tshwm sim hauv cov ntaub so ntswg nonadipose (xws li daim siab, lub plawv thiab cov leeg) feem ntau muaj feem cuam tshuam txog kev rog rog xws li ntshav qab zib. , fatty siab thiab kab mob plawv.

Raws li cov txiaj ntsig ntawm cov tsiaj sim saum toj no,Ganoderma lucidumextract tsis tau tsuas yog txo cov tsub zuj zuj ntawm subcutaneous rog, epididymal rog ( sawv cev rau visceral rog) thiab mesenteric rog ( sawv cev rau plab rog) (Daim duab 3) tab sis kuj txo cov roj cov ntsiab lus nyob rau hauv daim siab (Daim duab 4);Nws yog qhov yooj yim dua kom pom los ntawm ntu ntawm cov ntaub so ntswg adipose ntawm epididymis tias qhov loj ntawm cov adipocytes yuav hloov vim muaj kev cuam tshuam ntawmGanoderma lucidumextract (Daim duab 5).

Ganoderma lucidumalleviates hyperlipidemia, hyperglycemia thiab insulin tsis kam

Cov ntaub so ntswg adipose tsis yog tsuas yog lub tsev khaws khoom rau lub cev kom khaws cov roj ntau dhau, tab sis tseem zais ntau yam "cov tshuaj hormones rog" uas cuam tshuam rau carbohydrate thiab lipid metabolism.Thaum lub cev rog cov ntsiab lus siab dua, kev sib cuam tshuam ntawm cov rog cov tshuaj hormones no yuav txo qis kev nkag siab ntawm cov ntaub so ntswg mus rau insulin (qhov no yog qhov hu ua "insulin resistance"), ua rau nws nyuaj rau cov hlwb siv cov piam thaj.

Qhov tshwm sim yuav tsis tsuas yog nce ntshav qab zib xwb tab sis kuj ua rau cov metabolism hauv lipid tsis zoo, ua rau muaj teeb meem xws li hyperlipidemia, fatty siab thiab atherosclerosis.Nyob rau tib lub sijhawm, txiav txiav yuav raug yuam kom tso cov tshuaj insulin ntau dua.Vim tias insulin nws tus kheej muaj cov txiaj ntsig ntawm kev txhawb nqa cov rog thiab ua rau mob, cov tshuaj insulin ntau dhau tsis tsuas yog daws qhov teeb meem xwb tab sis kuj ua rau rog rog thiab tag nrho cov teeb meem saum toj no.

Hmoov zoo, raws li cov ntaub ntawv tshawb fawb South Kauslim,Ganoderma lucidumExtract muaj qhov kho cov nyhuv ntawm qhov txawv txav ntawm cov tshuaj hormones roj (leptin thiab adiponectin), nce insulin tsis kam thiab txo qis kev siv cov piam thaj los ntawm kev noj zaub mov muaj roj ntau.Cov txiaj ntsig tshwj xeeb tau qhia hauv cov kev sim tsiaj saum toj no: Rau cov nas ntawm cov zaub mov muaj roj ntau ntxiv nrogGanoderma lucidumextract, lawv cov dyslipidemia thiab nce ntshav qab zib thiab insulin kuj yog me me (Table 3 thiab daim duab 6).

Ganoderma lucidumactivates lub enzyme tseem ceeb ntawm cell zog metabolism - AMPK

Vim li cas thiaj ua tauGanoderma lucidumextract tig qhov kev kub ntxhov ntawm kev noj zaub mov muaj roj ntau rau hauv qhov hloov pauv?Cov kws tshawb fawb tau coj tawm cov ntaub so ntswg adipose thiab daim siab daim siab ntawm cov nas uas tau hais los saum toj no rau kev tshuaj xyuas kom pom tias cov cell yuav txawv li cas vim qhov ntxiv ntawmGanoderma lucidumextract nyob rau hauv tib yam khoom noj muaj roj.

Nws tau pom tias lubGanoderma lucidumextract txhawb kev ua haujlwm ntawm enzyme AMPK (5′ adenosine monophosphate activated protein kinase), uas yog lub luag haujlwm rau tswj lub zog hauv adipocytes thiab daim siab hlwb.Lub tshuab ua kom AMPK tuaj yeem cuam tshuam qhov kev qhia ntawm cov noob ntsig txog adipogenesis thiab nce cov tshuaj insulin receptor thiab glucose transporter (cov protein uas thauj cov piam thaj los ntawm sab nraud ntawm lub cell mus rau sab hauv ntawm tes) ntawm lub cell.

Hauv lwm lo lus,Ganoderma lucidumextract fights high-rog noj cov zaub mov los ntawm cov saum toj no-hais mechanism, yog li txo cov rog tsub zuj zuj, txhim kho kev siv cov piam thaj, thiab thaum kawg ua tiav lub hom phiaj ntawm kev txo qhov hnyav nce.

Qhov tseeb, nws tseem ceeb heev uasGanoderma lucidumExtract tuaj yeem tswj hwm AMPK kev ua haujlwm vim tias txo cov haujlwm AMPK yog cuam tshuam nrog kev rog lossis hom 2 mob ntshav qab zib vim los ntawm kev noj zaub mov ntau.Feem ntau siv cov tshuaj hypoglycemic tshuaj metformin hauv kev kho mob yog ib feem cuam tshuam nrog kev nce AMPK kev ua ntawm adipocytes thiab lub siab hlwb.Tam sim no, nce AMPK kev ua haujlwm tseem suav tias yog lub tswv yim ua tau los txhim kho cov metabolism hauv kev txhim kho ntau yam tshuaj tshiab los txhim kho kev rog.

Yog li kev tshawb nrhiav ntawmGanoderma lucidumyeej ua raws li kev kawm txuj ci thiab kev nrawm ntawm lub sijhawm, thiab cov kev tshawb fawb uas tau hais los saum toj no los ntawm South Kauslim muab cov kev daws teeb meem yooj yim tshaj plaws rau koj thiab kuv uas "xav noj zoo tab sis tsis xav kom muaj kev cuam tshuam los ntawm kev noj zaub mov zoo. ”, uas yog, kom ntxivGanoderma lucidumextract uas muaj ntau yam ganoderic acids thiabGanoderma lucidumpolysaccharides.

[Data Source] Hyeon A Lee, et al.Ganoderma lucidum Extract txo qis Insulin Resistance los ntawm Kev Txhim Kho AMPK Ua kom muaj rog hauv cov rog rog-Induced Obese nas.Khoom noj khoom haus.2020 Peb Hlis 30, 12:33.

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Hais txog tus sau/ Ms. Wu Tingyao

Wu Tingyao tau tshaj tawm thawj zaugGanoderma lucidumcov ntaub ntawv

txij li xyoo 1999. Nws yog tus sauKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).

★ Kab lus no yog luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau ★ Cov hauj lwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis tau txais kev tso cai los ntawm tus sau ★ Kev ua txhaum ntawm cov lus saum toj no, tus sau yuav ua raws li nws cov luag haujlwm raws cai ★ Thawj Cov ntawv ntawm tsab xov xwm no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.