Wolemba Wu Tingyao

Ngati kunenepa sikungathe kuponderezedwa, kodi pali njira iliyonse yochepetsera kunenepa popanda kupondereza chikhumbo, kapena ngakhale kunenepa mwaumoyo?Lipoti la kafukufuku lofalitsidwa ndi gulu la South Korea mu Nutrients linasonyeza zimenezoGanoderma lucidumimatha kuyambitsa AMPK, enzyme yofunika kwambiri mu metabolism yamagetsi, kuchepetsa kuchuluka kwa mafuta, kupititsa patsogolo kugwiritsa ntchito shuga komanso kuchepetsa chiopsezo cha kunenepa kwambiri, chiwindi chamafuta, hyperglycemia ndi hyperlipidemia yoyambitsidwa ndi zakudya zamafuta ambiri (HFD).

Ofufuza ochokera ku Chungbuk National University, Kyungpook National University ndi National Institute of Horticultural and Herbal Science of South Korea pamodzi adafalitsa zomwe apeza mu Novembala 2020 nkhani ya "Nutrients" (Nutrients Journal):

Kwa mbewa zomwe zimadya chakudya chamafuta ambiri, ngatiGanoderma lucidumufa wothira (GEP) umawonjezeredwa ku chakudya chawo, pambuyo pa masabata a 12 akuyesera, mbewa zilibe vuto lodziwikiratu ndi kulemera, mafuta a thupi, kukana insulini, shuga wa magazi kapena lipids.Komanso, kwambiriGanoderma lucidumKuchotsa kumawonjezera, zizindikiro za mbewa zomwe zimadya zakudya zamafuta kwambiri zidzakhala za mbewa zokhala ndi zakudya zamtundu wa chow (ND) komanso zakudya zopatsa thanzi, zomwe zimatha kuwonedwa ndi mawonekedwe.

Idyani chakudya chofanana koma muchepetse mafuta

Zitha kuwoneka kuchokera ku Chithunzi 1 kuti pambuyo pa kuyesa kwa masabata khumi ndi awiri, kukula ndi kulemera kwa mbewa pa zakudya zamafuta kwambiri zinali pafupifupi kuwirikiza kawiri kwa mbewa pazakudya zodziwika bwino za chow, koma mbewa zomwe zidadyetsedwanso nazo.Ganoderma lucidumKutulutsa kunali ndi zosintha zosiyanasiyana ─ Kuwonjezera 1%Ganoderma lucidumKutulutsa sikukuwonekerabe, koma kuwonjezera kwa 3% ndikoonekeratu, makamaka cholepheretsa chowonjezera 5% ku portly ndichofunika kwambiri.

TheGanoderma lucidumTingafinye kuti mbewa anadya anapezedwa ndi yopezera zouma matupi a fruiting a yokumba nakulitsa mwachindunjiGanoderma lucidummitundu (ASI7071) yokhala ndi 95% ethanol (mowa) ndi Dipatimenti Yofufuza za Bowa ya National Institute of Horticultural and Herbal Science ya South Korea.Zinthu zazikulu za bioactive zaGanoderma lucidumTingafinye tafotokozedwa mu Table 1: Maganoderic acid amawerengera 53%, ndipo ma polysaccharides amakhala 27%.Zolemba zazakudya zomwe zagwiritsidwa ntchito mu kafukufukuyu zafotokozedwa mu Gulu 2.

Monga asidi a Ganoderic ali ndi kukoma kowawa, munthu sangachitire mwina koma kudabwa ngati zimakhudza kudya kwa mbewa ndikuchepetsa thupi.Ayi!Zotsatira zikuwonetsa kuti magulu onse awiri a mbewa amadya pafupifupi chakudya chofanana tsiku lililonse (Chithunzi 2 kumanja), koma pali kusiyana kwakukulu pa kulemera kwa mbewa zisanayambe komanso pambuyo poyesera (Chithunzi 2 kumanzere).Izi zikuwoneka kuti ndi chifukwa chakeGanoderma lucidumKuchotsa kumatha kupikisana ndi zakudya zamafuta ambiri kumatha kukhala kokhudzana ndi kupititsa patsogolo kagayidwe kachakudya.

Ganoderma lucidumAmalepheretsa kuchuluka kwa mafuta m'thupi komanso adipocyte hypertrophy

Kulemera kwa thupi nthawi zambiri kumakhudzana ndi "kukula kwa minofu kapena mafuta".Ndi bwino kukula minofu.Vuto liri pakukula kwa mafuta, ndiko kuti, minofu yoyera ya adipose (WAT), yomwe imasunga ma calories ochulukirapo m'thupi, yawonjezeka.Mafuta owonjezerawa amatha kuwunjikana m'malo osiyanasiyana.Poyerekeza ndi mafuta a subcutaneous, mafuta a visceral (omwe amatchedwanso mafuta a m'mimba) omwe amaunjikana pakati pa ziwalo zosiyanasiyana za m'mimba ndi mafuta a ectopic omwe amawoneka m'matenda a nonadipose (monga chiwindi, mtima ndi minofu) nthawi zambiri amakhala ogwirizana kwambiri ndi zoopsa zokhudzana ndi kunenepa kwambiri monga matenda a shuga. , chiwindi chamafuta ndi matenda a mtima.

Malinga ndi zotsatira za zoyeserera za nyama zomwe zili pamwambapa,Ganoderma lucidumTingafinye osati kuchepetsa kudzikundikira subcutaneous mafuta, epididymal mafuta (oimira visceral mafuta) ndi mesenteric mafuta (woimira m`mimba mafuta) (Chithunzi 3) komanso kuchepetsa mafuta zili mu chiwindi (Chithunzi 4);Ndizomveka kuwona kuchokera ku gawo la minofu ya adipose ya epididymis kuti kukula kwa adipocytes kudzasintha chifukwa cha kulowetsedwa kwaGanoderma lucidumkuchotsa (Chithunzi 5).

Ganoderma lucidumamachepetsa hyperlipidemia, hyperglycemia ndi insulin kukana

Minofu ya Adipose sikuti ndi nkhokwe yokha kuti thupi liunjike mafuta ochulukirapo komanso limatulutsa "mahomoni amafuta" osiyanasiyana omwe amakhudza kagayidwe kachakudya ndi lipid metabolism.Mafuta a m'thupi akachuluka, kuyanjana kwa mahomoni amafutawa kumachepetsa kukhudzidwa kwa maselo am'minyewa kupita ku insulin (ichi ndi chomwe chimatchedwa "insulin resistance"), zomwe zimapangitsa kuti maselo azikhala ovuta kugwiritsa ntchito shuga.

Zotsatira zake sizimangowonjezera shuga wamagazi komanso zimayambitsa matenda a lipid metabolism, zomwe zimayambitsa mavuto monga hyperlipidemia, chiwindi chamafuta ndi atherosulinosis.Nthawi yomweyo, kapamba amakakamizika kutulutsa insulin yambiri.Chifukwa insulini yokha imakhala ndi zotsatira zolimbikitsa kudzikundikira kwamafuta ndi kutupa, insulin yobisika kwambiri sikuti imangothetsa vutoli komanso imapangitsa kunenepa kwambiri komanso mavuto onse omwe ali pamwambapa.

Mwamwayi, malinga ndi lipoti ili la kafukufuku waku South Korea,Ganoderma lucidumKutulutsa kumakhudzanso kutulutsa kwachilendo kwa mahomoni amafuta (leptin ndi adiponectin), kuchuluka kwa insulin kukana ndikuchepetsa kugwiritsa ntchito shuga chifukwa cha zakudya zamafuta ambiri.Zotsatira zenizeni zikuwonetsedwa muzoyeserera zanyama zomwe tazitchulazi: Kwa mbewa pazakudya zokhala ndi mafuta ambiriGanoderma lucidumkuchotsa, dyslipidemia yawo ndi shuga wokwera wamagazi ndi insulini zinali zochepa (Table 3 ndi Chithunzi 6).

Ganoderma lucidumimayendetsa enzyme yofunika kwambiri ya cell energy metabolism - AMPK

Chifukwa chiyani?Ganoderma lucidumchotsani kutembenuza vuto lazakudya zonenepa kwambiri kukhala posinthira?Ofufuzawo adatulutsa minofu ya adipose ndi chiwindi cha mbewa zoyesera zomwe tazitchula pamwambapa kuti awunike kuti awone momwe ma cellwa angasiyanire chifukwa chowonjezera.Ganoderma lucidumTingafinye pansi pa zakudya zomwezo zamafuta ambiri.

Zinapezeka kutiGanoderma lucidumKuchotsa kumalimbikitsa ntchito ya enzyme AMPK (5'adenosine monophosphate activated protein kinase), yomwe imayang'anira mphamvu mu adipocytes ndi maselo a chiwindi.AMPK yotsegulidwa imatha kulepheretsa kufotokozera kwa majini okhudzana ndi adipogenesis ndikuwonjezera cholandilira cha insulin ndi glucose transporter (mapuloteni omwe amanyamula shuga kuchokera kunja kwa selo kupita mkati mwa selo) pamwamba pa selo.

Mwanjira ina,Ganoderma lucidumKuchotsa kumalimbana ndi zakudya zokhala ndi mafuta ambiri kudzera m'makina omwe tatchulawa, potero amachepetsa kuchuluka kwa mafuta, kupititsa patsogolo kagwiritsidwe ntchito ka shuga, ndipo pamapeto pake amakwaniritsa cholinga chochepetsera kunenepa.

Ndipotu, ndi tanthauzo kwambiriGanoderma lucidumKuchotsa kumatha kuwongolera zochita za AMPK chifukwa kuchepa kwa ntchito ya AMPK kumalumikizidwa ndi kunenepa kwambiri kapena mtundu wa 2 shuga wopangidwa ndi zakudya zamafuta ambiri.Metformin yomwe imagwiritsidwa ntchito kwambiri muzachipatala imakhudzana ndi kuchuluka kwa ntchito ya AMPK ya adipocytes ndi maselo a chiwindi.Pakalipano, kuwonjezeka kwa ntchito za AMPK kumaganiziridwanso ngati njira yotheka yopititsira patsogolo kagayidwe kachakudya pakupanga mankhwala ambiri atsopano kuti athetse kunenepa kwambiri.

Choncho kufufuza paGanoderma lucidumimagwirizana kwambiri ndi kupita patsogolo kwa sayansi komanso kuthamanga kwa nthawi, ndipo kafukufuku wosakhwima womwe watchulidwa pamwambapa wochokera ku South Korea umapereka yankho losavuta kwa inu ndi ine omwe “tikufuna kudya bwino koma osafuna kukhudzidwa ndi kudya bwino. ”, ndiye kuti, kudzazaGanoderma lucidumTingafinye amene ali zosiyanasiyana ganoderic zidulo ndiGanoderma lucidumma polysaccharides.

[Gwero la Data] Hyeon A Lee, et al.Kutulutsa kwa Ganoderma lucidum Kumachepetsa Kukaniza kwa Insulin mwa Kupititsa patsogolo Kuyambitsa kwa AMPK mu Mbewa Zonenepa Kwambiri Zomwe Zimayambitsa Zakudya Zopatsa Mafuta.Zopatsa thanzi.2020 Oct 30; 12(11):3338.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao

Wu Tingyao wakhala akunena za zomwe zikuchitikaGanoderma lucidumzambiri

kuyambira 1999. Iye ndi mlembi waKuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa ndi chilolezo cha mlembi ★ Ntchito zomwe zili pamwambazi sizingabwerezedwe, kutsanulidwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba ★ Kuphwanya mawu omwe ali pamwambawa, wolemba adzakwaniritsa udindo wake wazamalamulo ★ Zoyambirira Nkhaniyi idalembedwa m'Chitchaina ndi Wu Tingyao ndikumasuliridwa m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.