Nke Wu Tingyao

Ọ bụrụ na enweghị ike ịkwụsị oke ibu, ọ nwere ụzọ ọ bụla isi belata ibu ibu na-egbochighị agụụ, ma ọ bụ ọbụna buru ibu karịa ahụike?Otu akụkọ nyocha nke otu South Korea na-ahụ maka ihe oriri na-edozi gosiri naGanoderma lucidumnwere ike rụọ ọrụ AMPK, isi enzyme na metabolism ike cell, iji belata mkpokọta abụba, meziwanye ojiji glucose ma belata ihe ize ndụ nke oke ibu, imeju abụba abụba, hyperglycemia na hyperlipidemia kpatara site na nri nwere oke abụba (HFD).

Ndị nyocha sitere na Mahadum Mba Chungbuk, Mahadum Mba Kyungpook na National Institute of Horticultural and Herbal Science nke South Korea jikọrọ aka bipụta nchoputa ha na mbipụta November 2020 nke "Nri" (Nutrients Journal):

Maka ụmụ oke na-eri nri nwere oke abụba, ọ bụrụGanoderma lucidumwepụ ntụ ntụ (GEP) na-agbakwunyere na nri ha, mgbe 12 izu nke nnwale, ụmụ oke enweghị nsogbu doro anya na ibu, abụba anụ ahụ, nkwụsị insulin, shuga ọbara ma ọ bụ lipids ọbara.Ọzọkwa, ndị ọzọGanoderma lucidumwepụ na-agbakwunyere, nso ndị a na-egosi nke ụmụ oke na-eri nnukwu abụba nri ga-abụ nke ụmụ oke nwere a nkịtị chow diet (ND) na kwesịrị ekwesị oriri na-edozi, nke pụrụ ọbụna na-ahụ site na ọdịdị.

Rie otu nri nri mana belata abụba

Enwere ike ịhụ site na eserese 1 na mgbe nnwale izu iri na abụọ gasịrị, nha na ịdị arọ ụmụ oke na nri nwere oke abụba fọrọ nke nta ka ọ bụrụ okpukpu abụọ nke ụmụ oke na nri nri nkịtị, mana ụmụ oke ndị a na-erikwa nri.Ganoderma lucidumwepụ nwere mgbanwe dị iche iche - Mgbakwunye 1%Ganoderma lucidumwepụ ka na-apụtachaghị ìhè, mana mgbakwunye nke 3% doro anya, karịsịa mmetụta mgbochi nke ịgbakwunye 5% na portly dị ịrịba ama.

NkeGanoderma lucidumewepụtara na ụmụ oke ndị a riri site n'iwepụta ozu mkpụrụ osisi a mịrị amị nke akọpụtara n'ụdịGanoderma lucidumstrains (ASI7071) na 95% ethanol (mmanya) site na Mushroom Research Department nke National Institute of Horticultural and Herbal Science of South Korea.Isi ihe mejupụtara bioactive nkeGanoderma lucidumA na-ekwu ihe mmịpụta na Tebụl 1: Ganoderic acid na-akpata 53%, na polysaccharides na-akpata 27%.Ekwuru usoro nri ejiri mee ihe n'ọmụmụ ihe a na tebụl 2.

Dị ka Ganoderic acid nwere uto ilu, mmadụ enweghị ike ịche ma ọ na-emetụta nri ụmụ oke na-eri ma na-akpata ọnwụ.Mba!Nsonaazụ gosiri na otu ụmụ oke abụọ ahụ riri ihe fọrọ nke nta ka ọ bụrụ otu nri nri kwa ụbọchị (Njirimara 2 aka nri), mana enwere nnukwu ọdịiche dị na uru oke nke oke tupu na mgbe nnwale ahụ gasịrị (Njirimara 2 aka ekpe).Nke a yiri ka ọ pụtara na ihe kpatara yaGanoderma lucidumwepụ nwere ike mpi na a elu-abụba nri nwere ike metụtara nkwalite nke metabolic arụmọrụ.

Ganoderma lucidumna-egbochi mkpokọta abụba na hypertrophy adipocyte

Ịba arọ na-ejikọtakarị ya na "uto nke akwara ma ọ bụ abụba".Ọ dị mma ito uru ahụ.Nsogbu dị n'ịba ụbara abụba, ya bụ, anụ ahụ adipose na-acha ọcha (WAT), bụ nke na-ahụ maka ịchekwa oke calorie n'ime ahụ, abawanyela.Abụba ndị a agbakwunyere nwere ike ịgbakọta n'akụkụ dị iche iche.E jiri ya tụnyere abụba subcutaneous, abụba visceral (nke a na-akpọkwa abụba abdominal) na-agbakọba n'etiti akụkụ dị iche iche dị n'ime oghere afọ yana abụba ectopic nke na-apụta na anụ ahụ na-adịghị emerụ ahụ (dị ka imeju, obi na akwara) na-enwekarị njikọ chiri anya na ihe ize ndụ ndị metụtara oke ibu dị ka ọrịa shuga mellitus. , imeju abụba abụba na ọrịa obi.

Dịka nsonaazụ nke nnwale anụmanụ ndị dị n'elu si dị,Ganoderma lucidumwepụ nwere ike ọ bụghị nanị ibelata mkpokọta nke subcutaneous abụba, epididymal abụba (na-anọchi anya visceral abụba) na mesenteric abụba (na-anọchi anya abdominal abụba) (Onyonyo 3) ma na-ebelata abụba ọdịnaya na imeju (Figure 4);Ọ bụ ihe amamihe dị na ya ịhụ site na ngalaba nke anụ ahụ adipose nke epididymis na oke adipocytes ga-agbanwe n'ihi ntinye aka nkeGanoderma lucidumwepụ (Foto 5).

Ganoderma lucidumna-ebelata hyperlipidemia, hyperglycemia na nguzogide insulin

Ọbụlagodi anụ ahụ abụghị naanị ụlọ nkwakọba ihe maka ahụ iji chịkọta abụba karịrị akarị mana ọ na-ezobekwa “hormone abụba” dị iche iche nke na-emetụta carbohydrate na metabolism lipid.Mgbe abụba anụ ahụ dị elu, mmekọrịta nke homonụ ndị a na-abụ abụba ga-ebelata mmetụta nke mkpụrụ ndụ anụ ahụ na insulin (nke a bụ ihe a na-akpọ "nguzogide insulin"), na-eme ka o siere mkpụrụ ndụ ike iji glucose.

Ihe si na ya pụta abụghị naanị ịbawanye shuga ọbara kamakwa ọ na-ebute metabolism lipid na-adịghị mma, na-akpata nsogbu dị ka hyperlipidemia, imeju abụba na atherosclerosis.N'otu oge ahụ, a ga-amanye pancreas imepụta insulin ọzọ.N'ihi na insulin n'onwe ya nwere mmetụta nke ịkwalite mkpokọta abụba na mbufụt, insulin zoro ezo abụghị naanị na ọ naghị edozi nsogbu ahụ kamakwa ọ na-eme ka oke ibu na nsogbu niile dị n'elu ka njọ.

Ọ dabara nke ọma, dịka akụkọ nyocha South Korea a si kwuo,Ganoderma lucidumMwepụta nwere mmetụta na-edozi ahụ na nzuzo nzuzo nke homonụ abụba (leptin na adiponectin), mmụba insulin na-eguzogide yana mbelata ojiji glucose sitere na nri nwere oke abụba kpatara.E gosipụtara mmetụta a kapịrị ọnụ na nnwale anụmanụ ndị a kpọtụrụ aha n'elu: Maka ụmụ oke na nri nwere oke abụba agbakwunyere naGanoderma lucidumwepụ, dyslipidemia ha na ọbara shuga dị elu na insulin dị ntakịrị (Table 3 na Figure 6).

Ganoderma lucidumna-arụ ọrụ isi enzyme nke metabolism ike cell - AMPK

Gịnị nwere ikeGanoderma lucidumwepụ tụgharịa nsogbu nke a elu-abụba nri na-atụgharị mgbe?Ndị nyocha ahụ wepụrụ anụ ahụ adipose na anụ ahụ imeju nke ụmụ oke nnwale ndị a kpọtụrụ aha n'elu maka nyocha iji hụ ka mkpụrụ ndụ ndị a ga-esi dị iche n'ihi mgbakwunye nkeGanoderma lucidumwepụ n'okpuru otu nnukwu abụba nri.

A chọpụtara naGanoderma lucidumwepụ akwalite ọrụ nke enzyme AMPK (5′ adenosine monophosphate activated protein kinase), nke na-ahụ maka ịhazi ike na adipocytes na sel imeju.AMPK na-arụ ọrụ nwere ike igbochi okwu nke mkpụrụ ndụ ihe nketa metụtara adipogenesis ma mee ka onye na-anabata insulin na onye na-ebu glucose (protein na-ebuga glucose site na mpụga cell gaa n'ime cell) n'elu cell.

Yabụ,Ganoderma lucidummwepu na-alụ ọgụ maka nri nwere oke abụba site na usoro ahụ a kpọtụrụ aha n'elu, si otú a na-ebelata mkpokọta abụba, na-eme ka ojiji glucose dịkwuo elu, na n'ikpeazụ nweta ihe mgbaru ọsọ nke ibelata ibu ibu.

N'ezie, ọ bara uru nke ahụGanoderma lucidumMwepụta nwere ike ịhazi ọrụ AMPK n'ihi na ọrụ AMPK belatara na-ejikọta oke ibu ma ọ bụ ụdị ọrịa shuga 2 nke nri nwere nnukwu abụba kpatara.Metformin ọgwụ hypoglycemic a na-ejikarị eme ihe na omume ụlọ ọgwụ nwere akụkụ metụtara ịbawanye ọrụ AMPK nke adipocytes na sel imeju.Ka ọ dị ugbu a, a na-ahụta ịbawanye ọrụ AMPK dị ka atụmatụ enwere ike iji kwalite ọnụego metabolic na mmepe nke ọtụtụ ọgwụ ọhụrụ iji meziwanye oke ibu.

Ya mere, nnyocha naGanoderma lucidumn'ezie na-aga n'ihu na ọganihu sayensị na ọsọ nke oge, na nchọpụta siri ike nke e kwuru n'elu na South Korea na-enye m ngwọta kachasị mfe maka mụ na gị bụ onye "chọrọ iri nri nke ọma ma achọghị ka iri nri nke ọma na-emetụta ya. ”, ya bụ, imejuGanoderma lucidumwepụ nke nwere acid ganoderic dị iche iche naGanoderma lucidumpolysaccharides.

[Ebe data] Hyeon A Lee, et al.Mwepụta Ganoderma lucidum na-ebelata nguzogide insulin site na ịkwalite nkwalite AMPK n'ime oke oke ibu na-ebute nri dị oke abụba.Ihe oriri.Ọktoba 30, 12 (11): 3338.

N'ikpeazụ

Banyere onye odee/ Oriakụ Wu Tingyao

Wu Tingyao na-akọ akụkọ mbụGanoderma lucidumozi

kemgbe 1999. O bu odeeỌgwụgwọ na Ganoderma(nke e bipụtara na The People's Medical Publishing House na Eprel 2017).

★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede ★ Ọrụ ndị a dị n'elu enweghị ike imepụtaghachi, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke onye edemede ★ imebi okwu a dị n'elu, onye edemede ga-agbaso ọrụ iwu metụtara ya ★ The mbụ Wu Tingyao dere ederede akụkọ a n'asụsụ Chinese ma Alfred Liu sụgharịrị ya na Bekee.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ bụ Oriakụ Wu Tingyao.