(Umthombo: CNKI)

Abantu abadinga ikhofi ukuze bazivuselele nsuku zonke bazokhathazeka nakanjani ngokuphuza ikhofi eliningi ngephutha.Uma uphuza ikhofi ye-Reishi, ungakwazi ukugwema ukukhathazeka okunjalo futhi ube nesivuno esingalindelekile.

Ngokombiko wocwaningo oshicilelwe kuIsayensi Yokudla Nobuchwepheshengo-2017 yi-National and Local Joint Engineering Research Center for Cultivation and Deep Processing of Medicinal Fungi, ikhofi ye-Reishi inomphumela wokuthuthukisa ukungatheleleki.

IIkhofi ye-Reishiesetshenziswe kulolu cwaningo ingxube enengqondo yeI-Ganoderma lucidumukukhishwa nekhofi, kuhlinzekwe yi-GanoHerb Technology (Fujian) Corporation.Izilwane zokuhlola amagundane e-ICR, asetshenziswa kakhulu ku-pharmacology, i-toxicology, isimila, ukudla kanye nolunye ucwaningo lwesayensi.

Imithamo emithathu ehlukene (1.75, 3.50 kanye ne-10.5 g/kg, okungukuthi izikhathi ezingu-5, izikhathi ezingu-10 kanye nezikhathi ezingu-30 umthamo wansuku zonke onconywayo womuntu omdala ongu-60 kg, ngokulandelana) wekhofi le-Reishi wawunikezwa ngomlomo kumagundane nsuku zonke.Ngemuva kwezinsuku ze-30 ezilandelanayo, imiphumela yekhofi ye-Reishi ekusebenzeni komzimba kwamagundane yahlaziywa ngezindlela ezihlukahlukene zokuthola.Kwavela:

1. Ukwenyuka kwe-splenic index (inani lama-lymphocyte)

Inkomba ye-splenic isilinganiso sesisindo se-spleen nesisindo somzimba.Njengoba i-spleen inothile ngama-lymphocyte (kuhlanganise namaseli B, T cell kanye namaseli ababulali bemvelo).Izinga lokwanda kwe-lymphocyte lizothinta isisindo se-spleen, esizobonakala ku-splenic index.Ngakho-ke, isimo esijwayelekile somzimba womuntu singahlulelwa kusukela ezingeni lenkomba.

Imiphumela yokuhlola ibonise lokho uma kuqhathaniswa neqembu lokulawula elingazange lidleI-Ganoderma lucidumikhofi, imithamo ephansi nemaphakathi yeI-Ganoderma lucidumikhofi lalingenawo umthelela omkhulu ku-spleen index of amagundane, kodwa imithamo ephezulu yeI-Ganoderma lucidumikhofi lingakhuphula inkomba ye-spleen yamagundane ngo-16.7%, okubalulekile ngokwezibalo.

2. Amandla ama-T cell okwanda ayaqina

Ama-T lymphocyte angabaphathi bamasosha omzimba.Bazonquma isiqondiso sokusabela komzimba ngokuvumelana nesimo sesitha esivela ezindaweni ezingaphandle (njengama-macrophages).Amanye amaseli e-T azolwa nesitha ngempela noma akhumbule lokhu okuhlangenwe nakho ukuze akwazi ukwenza kusebenze impendulo yokuzivikela komzimba ngesikhathi esizayo lapho elwa nesitha.Ngakho-ke, ikhono labo lokwanda ngesikhathi "somkhankaso" lihlobene nokusebenza komzimba wonke.

Ngokusho kwemiphumela yokuhlolwa kwe-ConA-induced mouse spleen lymphocyte transformation test (eyaziwa nangokuthi i-T cell proliferation test), umthamo okhulayo (umehluko we-OD we-spleen lymphocyte transformation) wama-spleen lymphocyte wamagundane athatha imithamo ephakathi nephezuluI-Ganoderma lucidumikhofilapho ikhuthazwa i-ConA ikhuphuke ngaphezu kuka-30% uma iqhathaniswa neqembu lokulawula.

Njengoba i-ConA ikhetha ngokukhetha amaseli e-T, ukwanda kwama-lymphocyte we-spleen yegundane okubonwe ekuhloleni empeleni kuwumphumela wokwanda kwe-T cell.

3. Ikhono lamaseli B okukhiqiza amasosha omzimba linamandla futhi inani lamasosha omzimba awakhiqizayo likhulu.

Ama-lymphocyte B ayaziwa nangokuthi amaseli akhiqiza amasosha omzimba.Azokhiqiza amasosha omzimba ahambisanayo ngokwemiyalelo ekhishwe ama-T cell ukuze ahlasele ngokunembile abahlaseli abavalelwe ama-T cell.Le "imishini yokuzivikela eqondile esebenzisa ama-B cell ukukhiqiza amasosha omzimba ukuze afeze injongo yokuvikela" ibizwa ngokuthi "i-humoral immunity", futhi inani lama-B cell kanye nenani lamasosha omzimba akhiqizwayo liba izinkomba zokuhlola amandla okugonywa kwe-humoral.

Lapho ama-B cell ehlangana namaseli abomvu egazi avela emithonjeni ehlukene, azokhiqiza amasosha omzimba ukuze akhiphe amangqamuzana abomvu egazi, futhi amasosha omzimba akhiqizwayo azobopha amangqamuzana egazi abomvu futhi ahlangane abe yizigaxa.Lesi sakhiwo sasetshenziselwa ukuhlola amandla egundane B amaseli ukukhiqiza amasosha omzimba (i-hemolytic plaque assay) kanye nenani lamasosha omzimba akhiqizwayo (i-serum hemolysin assay).

Kwatholakala ukuthi umthamo omkhuluI-Ganoderma lucidumikhofi lingathuthukisa ikhono legundane B amaseli ukukhiqiza amasosha omzimba (inani le-hemolytic plaque lenyuke ngo-23%) kanye nenani lamasosha omzimba akhiqizwayo (inani lamasosha omzimba lenyuke ngo-26.4%), wonke afaka isandla ekuthuthukiseni ukusebenza kwe-humoral immune immune. .

4. Umsebenzi wama-macrophages kanye namaseli e-NK unamandla

Ukuvikeleka okuhle akudingi kuphela umkhuzi omkhulu oyinhloko (ama-T cell) kanye nokwesekwa okunembile (ama-B cells namasosha omzimba) kodwa futhi namandla ahambayo anganikeza ukwesekwa kusukela ekutholeni umugqa ongaphambili wesitha kuya kuyo yonke inqubo yokusabela komzimba.Ama-Macrophage namaseli e-NK adlala indima enjalo.

Ngokusebenzisa "umthamo we-carbon clearance" kanye "nokuhlolwa komsebenzi we-NK cell", kwatholakala ukuthi umthamo ophezuluI-Ganoderma lucidumikhofiingakhuphula ikhono le-phagocytic lama-macrophages ngo-41.7% futhi ikhulise umsebenzi wamaseli e-NK ngo-26.4%.Lona bekuwumehluko obalulekile ngokwezibalo uma kuqhathaniswa neqembu elilawulayo elingazange liphuzeI-Ganoderma lucidumikhofi.

Inhlanganisela yeI-Ganodermalucidum futhi ikhofi lenza ikhofi ngaphezu kwekhofi nje.

Amasosha omzimba adinga izingxenye eziningi ukuze asebenzisane ukuze akhe inetha eliqinile elivikelayo.Ama-Macrophage, amaseli e-NK, ama-T cell, ama-B cell kanye namasosha omzimba ayizindima ezibalulekile kule nethiwekhi futhi abalulekile.

Izifundo eziningi esikhathini esidlule sezivele zikuqinisekisile lokhoI-Ganoderma lucidumukukhishwa kungathuthukisa imiphumela yamangqamuzana okuzivikela omzimba ashiwo ngenhla kanye namasosha omzimba, futhi manje lolu cwaningo lunikeza isisekelo sesayensi somsebenzi wokuzivikela komzimba "I-Ganoderma lucidumikhofi”, okuyinhlanganisela yeI-Ganoderma lucidumikhiphe nekhofi.

Nokho,I-Ganoderma lucidumikhofi inhlanganisela izithako ezimbili phela.I-Ganoderma lucidumi-extract ikhona ngamanani akhawulelwe kuI-Ganoderma lucidumikhofi.Inkomishi ngosuku noma izinsuku ezimbili noma ezintathu ingase ingasebenzi njengokwengezaI-Ganoderma lucidumiyodwa, kodwa ingase yengeze ngokuhamba kwesikhathi.

Kubathandi bekhofi,I-Ganoderma lucidumikhofingokuqinisekile inenjongo nakakhulu.Ngaphezu kokubaluleka kokuzivikela komzimba okwethulwa yilolu cwaningo olungenhla, imiphumela yeI-Ganoderma lucidumkusukela ezikhathini zasendulo "ukwengeza inhliziyo qi" kanye "nokwandisa ukuhlakanipha nenkumbulo" kungase futhi kudlale indima ehambisanayo nekhofi.

[Inkomba]

UJin Lingyun et al.Ucwaningo ngomphumela wekhofi ye-Ganoderma lucidum ekusebenzeni komzimba kwamagundane.Isayensi Yokudla Nobuchwepheshe, 2017, 42(03): 83-87.

★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali, futhi ubunikazi baso bungobe-GanoHerb.

★ Umsebenzi ongenhla awukwazi ukuphinda ukhiqizwe, ucashunwe noma usetshenziswe ngezinye izindlela ngaphandle kwemvume ye-GanoHerb.

★ Uma umsebenzi ugunyazwe ukusetshenziswa, kufanele usetshenziswe ngaphakathi kobubanzi bokugunyazwa futhi ubonise umthombo: GanoHerb.

★ Kunoma yikuphi ukwephulwa kwesitatimende esingenhla, i-GanoHerb izolandela izibopho ezingokomthetho ezihlobene.

★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.