(Kwakabva: CNKI)

Vanhu vanoda kofi kuti vazvizorodze vamene zuva rega rega vanozonetsekana nezvekunwa kofi yakawandisa netsaona.Kana iwe ukanwa Reishi kofi, unogona kudzivirira kushushikana kwakadaro uye kunyange kuva negoho risingatarisirwi.

Sekureva kwetsvakiridzo yakabudiswa munaSayenzi Yezvokudya uye Tekinorojimuna 2017 neNational and Local Joint Engineering Research Center yeKurima uye Kudzika Kugadziriswa kweMedicinal Fungi, Reishi kofi ine mhedzisiro yekuwedzera kusadzivirirwa.

TheReishi kofirinoshandiswa mutsvakurudzo iyi musanganiswa unonzwisisika weGanoderma luciduminobvisa uye kofi, yakapihwa neGanoHerb Technology (Fujian) Corporation.Mhuka dzekuyedza iICR mbeva, dzinoshandiswa zvakanyanya mupharmacology, toxicology, bundu, chikafu uye kumwe kutsvagisa kwesainzi.

Mishonga mitatu yakasiyana (1.75, 3.50 uye 10.5 g / kg, kureva nguva 5, 10 nguva uye 30 nguva yakakurudzirwa zuva rega rega ye60 kg mukuru, maererano) yeReishi kofi yaipiwa nemuromo kumakonzo zuva nezuva.Mushure memazuva makumi matatu akateedzana, mhedzisiro yeReishi kofi pamushonga wekudzivirira wembeva yakaongororwa nenzira dzakasiyana dzekuona.Zvakaitika:

1. Kuwedzera splenic index (nhamba ye lymphocytes)

The splenic index ireshiyo yehuremu hwespleen kune huremu hwemuviri.Sezvo spleen yakapfuma mu-lymphocytes (kusanganisira B masero, T masero uye masero emuurayi chaiwo).Chiyero chekuwedzera kwe lymphocyte chichakanganisa huremu hwepundu, iyo inobva yaratidzwa mu splenic index.Nokudaro, mamiriro ezvinhu ehutano hwemunhu anogona kutongwa kubva pachiyero che index.

Migumisiro yekuedza yakaratidza kuti ichienzaniswa neboka rekutonga risina kudyaGanoderma lucidumkofi, yakaderera uye yepakati madosi eGanoderma lucidumkofi yakanga isina mhedzisiro yakakosha pane spleen index yemakonzo, asi yakakwira dosesGanoderma lucidumkofi inogona kuwedzera spleen index yemakonzo ne16.7%, iyo inonyanya kukosha.

2. Kukwanisa kweT masero kuwedzera kunowedzera kusimba

T lymphocytes ndivo vatungamiri vezvirwere zvemuviri.Ivo vanozosarudza kutungamira kwemhinduro yekudzivirira kwemuviri zvinoenderana nemamiriro emuvengi kubva kunzvimbo dzekunze (senge macrophages).Mamwe masero eT anotonyatso kurwisa muvengi kana kurangarira chiitiko ichi kuitira kuti vagone kukurumidza kuita kuti immune system iite nguva inotevera pavanorwisa muvengi.Nokudaro, kukwanisa kwavo kuwedzera panguva ye "mushandirapamwe" kune chokuita nehutachiona hwese.

Zvinoenderana nemhedzisiro yeConA-induced mouse spleen lymphocyte shanduko bvunzo (inozivikanwawo seT cell proliferation test), iyo proliferative kugona (iyo OD mutsauko wespleen lymphocyte shanduko) yespleen lymphocytes yemakonzo inotora epakati nepamusoro madosi.Ganoderma lucidumkofipainokurudzirwa neConA yakawedzera neinopfuura 30% ichienzaniswa neboka rekutonga.

Sezvo ConA inosarudza inokurudzira masero eT, kuwanda kwembeva spleen lymphocytes inoonekwa mukuyedza ndiyo mhedzisiro yeT cell kuwanda.

3. Kugona kweB masero kugadzira masoja ekudzivirira chirwere akasimba uye huwandu hwemasoja ekudzivirira huzhinji hwaanogadzira hwakakura.

Ma-lymphocyte eB anozivikanwawo semasero anogadzira antibody.Vanozogadzira masoja ekudzivirira chirwere anoenderana nemirairo yakapihwa nemaT cell kuti anyatso kurwisa vapambi vakakiiwa nemaT cell.Iyi "specific immune immune system inoshandisa B masero kugadzira masoja ekudzivirira chirwere kuti azadzise chinangwa chekudzivirira" inonzi "humoral immunity", uye nhamba yemasero eB uye huwandu hwemasoja ekudzivirira anogadzirwa anova zviratidzo zvekuongorora kusimba kwehumoral immunity.

Kana B masero asangana nemasero matsvuku eropa kubva kwakasiyana masosi, anoburitsa masoja ekudzivirira eropa kuti aite lyse masero matsvuku eropa, uye masoja ekudzivirira chirwere anogadzirwa anosunga kumasero matsvuku eropa uye oungana kuita clumps.Ichi chivakwa chakashandiswa kuongorora kugona kwembeva B masero kugadzira masoja ekudzivirira chirwere (hemolytic plaque assay) uye huwandu hwemasoja ekudzivirira anogadzirwa (serum hemolysin assay).

Zvakaonekwa kuti high-doseGanoderma lucidumkofi inogona kuvandudza kugona kwembeva B masero kugadzira masoja ekudzivirira chirwere (nhamba yehemolytic plaques yakawedzera ne23%) uye huwandu hwemasoja anogadzirwa (nhamba yemasoja ekudzivirira yakawedzera ne26.4%), ayo ese anobatsira mukuvandudzwa kwehumoral immune function. .

4. Basa re macrophages uye NK masero rakasimba

Kusadzivirirwa kwakanaka kunoda kwete chete mutungamiriri akanaka-mukuru (T masero) uye nerutsigiro chairwo rwezvinhu (B masero nemasoja ekudzivirira chirwere) asiwo nenharembozha inogona kupa rutsigiro kubva mukuonekwa kwemutsetse wepamberi wemuvengi kusvika kune yese nzira yekupindura immune system.Macrophages uye NK masero ari kutamba akadaro.

Kuburikidza ne "carbon clearance capacity" uye "NK cell activity assay", yakawanikwa kuti yakakwirira-doseGanoderma lucidumkofiinogona kuwedzera kugona kwephagocytic ye macrophages ne 41.7% uye kuwedzera basa reNK masero ne26.4%.Uyu waiva mutsauko wakakosha uchienzaniswa neboka rekutonga risina kunwaGanoderma lucidumkofi.

Kusanganiswa kweGanodermalucidum uye kofi inoita kofi kupfuura kofi chete.

Masoja ekudzivirira emuviri anoda mativi mazhinji kuti ashande pamwe chete kuti aumbe mambure akasimba ekudzivirira.Macrophages, NK masero, T masero, B masero uye masoja ekudzivirira chirwere ndiwo akakosha mabasa mumambure aya uye akakosha.

Zvidzidzo zvakawanda munguva yakapfuura zvakatosimbisa izvozvoGanoderma luciduminobvisa inogona kukwidziridza mhedzisiro yeaya ataurwa pamusoro ekudzivirira immune masero uye masoja ekudzivirira chirwere, uye ikozvino chidzidzo ichi chinopa hwaro hwesainzi hwekushanda kwe immune kwe "Ganoderma lucidumkofi", inova musanganiswa weGanoderma lucidumkubvisa uye kofi.

Zvisinei,Ganoderma lucidumkofi isanganiswa yezviviri zviviri mushure mezvose.Ganoderma lucidumextract iripo mune shoma shoma muGanoderma lucidumkofi.Kapu pazuva kana maviri kana matatu mazuva inogona kusashanda sekuwedzera nayoGanoderma lucidumchete, asi inogona kuwedzera nekufamba kwenguva.

Kune vanoda kofi,Ganoderma lucidumkofizvirokwazvo inotova nerevo.Pamusoro pekukosha kwekudzivirira kunoratidzwa nemiedzo iri pamusoro, mhedzisiro yeGanoderma lucidumkubva panguva dzekare ku "kuwedzera mwoyo qi" uye "kuwedzera huchenjeri uye ndangariro" inogonawo kuita basa rinobatsirana nekofi.

[Reference]

Jin Lingyun et al.Tsvagiridzo pamusoro pemhedzisiro yeGanoderma lucidum kofi pane immune mashandiro emakonzo.Chikafu Sayenzi uye Technology, 2017, 42 (03): 83-87.

★ Chinyorwa ichi chakaburitswa pasi pemvumo yakasarudzika yemunyori, uye muridzi wacho ndeweGanoHerb.

★ Basa riri pamusoro harigone kudhindwa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yeGanoHerb.

★ Kana basa racho rakabvumirwa kushandiswa, rinofanira kushandiswa mukati mechikamu chemvumo uye kuratidza kwakabva: GanoHerb.

★ Pakutyorwa kwechirevo chiri pamusoro, GanoHerb ichatevera mabasa anoenderana nemutemo.

★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.