(Chitsime: CNKI)

Anthu omwe amafunikira khofi kuti adzitsitsimutse tsiku ndi tsiku amadandaula kuti mwangozi kumwa khofi wochuluka.Ngati mumamwa khofi wa Reishi, mutha kupewa nkhawa zotere komanso kukhala ndi zokolola zosayembekezereka.

Malinga ndi lipoti la kafukufuku lomwe linasindikizidwa muSayansi Yazakudya ndi Zamakonomu 2017 ndi National and Local Joint Engineering Research Center for Cultivation and Deep Processing of Medicinal Fungi, Reishi khofi ali ndi zotsatira zolimbikitsa chitetezo chamthupi.

TheReishi khofintchito mu kafukufuku ndi wololera osakaniza waGanoderma lucidumkhofi ndi khofi, zoperekedwa ndi GanoHerb Technology (Fujian) Corporation.Nyama zoyesera ndi mbewa za ICR, zomwe zimagwiritsidwa ntchito kwambiri mu pharmacology, toxicology, chotupa, chakudya ndi kafukufuku wina wasayansi.

Milingo itatu yosiyana (1.75, 3.50 ndi 10.5 g/kg, mwachitsanzo, nthawi 5, nthawi 10 ndi nthawi 30 mlingo wovomerezeka wa tsiku ndi tsiku wa 60 kg wamkulu, motsatira) wa Reishi khofi ankaperekedwa pamlomo kwa mbewa tsiku ndi tsiku.Pambuyo pa masiku otsatizana a 30, zotsatira za khofi ya Reishi pa chitetezo cha chitetezo cha mbewa zinawunikidwa ndi njira zosiyanasiyana zodziwira.Zinapezeka kuti:

1. Kuchuluka kwa splenic index (chiwerengero cha ma lymphocyte)

Mlozera wa splenic ndi chiŵerengero cha kulemera kwa ndulu ndi kulemera kwa thupi.Popeza ndulu imakhala ndi ma lymphocyte (kuphatikiza ma B cell, T cell ndi ma cell akupha achilengedwe).Mlingo wa kuchuluka kwa ma lymphocyte kumakhudza kulemera kwa ndulu, komwe kumawonetsedwa mu index ya splenic.Chifukwa chake, momwe chitetezo cha mthupi cha munthu chimakhalira chikhoza kuwerengedwa kuchokera pamlingo wa index.

Zotsatira zoyesera zinasonyeza kuti poyerekeza ndi gulu lolamulira lomwe silinadyeGanoderma lucidumkhofi, mlingo wochepa ndi wapakatikati waGanoderma lucidumkhofi analibe kwambiri zotsatira ndulu ya mbewa, koma mlingo waukulu waGanoderma lucidumkhofi ikhoza kuonjezera ndulu ya mbewa ndi 16.7%, zomwe ndizofunika kwambiri.

2. Kuthekera kwa ma T cell kuchulukirachulukira kumakhala kolimba

T lymphocytes ndi akuluakulu a chitetezo cha mthupi.Adzasankha momwe chitetezo cha mthupi chimayendera malinga ndi momwe adani alili kuchokera kumalo akunja (monga macrophages).Ma cell ena a T amatha kulimbana ndi mdani kapena kukumbukira izi kuti athe kuyambitsa chitetezo chamthupi nthawi ina akadzamenyana ndi mdani.Choncho, kuthekera kwawo kuchulukirachulukira panthawi ya "kampeni" kumakhudzana ndi chitetezo cha mthupi lonse.

Malinga ndi zotsatira za ConA-induced mouse spleen lymphocyte transformation test (yomwe imadziwikanso kuti T cell proliferation test), kuchuluka kwa mphamvu (kusiyana kwa OD kwa spleen lymphocyte transformation) kwa spleen lymphocytes mbewa zomwe zimatenga mlingo wapakati komanso waukulu waGanoderma lucidumkhofipamene kusonkhezeredwa ndi ConA kunawonjezeka ndi oposa 30% poyerekeza ndi gulu lolamulira.

Popeza ConA imayambitsa ma cell a T, kuchuluka kwa ma lymphocyte a mbewa omwe amawonedwa pakuyesako ndi chifukwa cha kuchuluka kwa T cell.

3. Kuthekera kwa ma B cell kupanga ma antibodies ndi amphamvu ndipo kuchuluka kwa ma antibodies omwe amapanga kumakhala kokulirapo.

Ma lymphocyte a B amadziwikanso kuti maselo opanga ma antibodies.Apanga ma antibodies olingana ndi malangizo operekedwa ndi ma T cell kuti aukire ndendende omwe atsekeredwa ndi ma T cell."Njira yeniyeni ya chitetezo cha mthupi yomwe imagwiritsa ntchito maselo a B kupanga ma antibodies kuti akwaniritse cholinga cha chitetezo" amatchedwa "humoral chitetezo", ndipo chiwerengero cha maselo a B ndi kuchuluka kwa ma antibodies opangidwa kukhala zizindikiro zowunikira mphamvu ya chitetezo cha humoral.

Maselo a B akakumana ndi maselo ofiira a m'magazi kuchokera kumagwero osiyanasiyana, amapanga ma antibodies kuti apange maselo ofiira a magazi, ndipo ma antibodies opangidwa amamanga ku maselo ofiira amagazi ndikuphatikizana kukhala magulu.Katunduyu adagwiritsidwa ntchito poyesa kuthekera kwa ma cell a mbewa B kupanga ma antibodies (hemolytic plaque assay) ndi kuchuluka kwa ma antibodies opangidwa (serum hemolysin assay).

Zinapezeka kuti mlingo waukuluGanoderma lucidumkhofi imatha kupititsa patsogolo mphamvu ya ma cell a mbewa B kupanga ma antibodies (chiwerengero cha zolembera za hemolytic chinawonjezeka ndi 23%) ndi kuchuluka kwa ma antibodies opangidwa (chiwerengero cha ma antibodies chikuwonjezeka ndi 26.4%), zomwe zonse zimathandizira kupititsa patsogolo chitetezo chamthupi. .

4. Ntchito ya macrophages ndi NK maselo ndi amphamvu

Chitetezo chabwino chimafuna osati wolamulira wamkulu (maselo a T) ndi chithandizo cholondola chothandizira (maselo a B ndi ma antibodies) komanso mphamvu yam'manja yomwe imatha kupereka chithandizo kuchokera pakuzindikira mzere wakutsogolo wa mdani kupita ku njira yonse yoyankhira chitetezo chamthupi.Macrophages ndi NK maselo akugwira ntchito yotere.

Kupyolera mu "carbon clearance capacity" ndi "NK cell activity assay", zinapezeka kuti mlingo waukuluGanoderma lucidumkhofiakhoza kuonjezera phagocytic mphamvu ya macrophages ndi 41,7% ndi kuonjezera ntchito ya NK maselo ndi 26,4%.Uku kunali kusiyana kwakukulu kowerengera poyerekeza ndi gulu lolamulira lomwe silinamweGanoderma lucidumkhofi.

Kuphatikiza kwaGanodermalucidum ndipo khofi imapanga khofi kuposa khofi.

Chitetezo cha mthupi chimafunika mbali zambiri kuti zigwirizane kuti zipange ukonde woteteza.Macrophages, NK cell, T cell, B cell ndi ma antibodies ndizofunikira kwambiri pamanetiwu ndipo ndizofunikira kwambiri.

Maphunziro ambiri m'mbuyomu adatsimikizira kale iziGanoderma lucidumKuchotsa kumatha kukulitsa zotsatira za maselo oteteza thupi omwe tawatchulawa komanso ma antibodies, ndipo tsopano kafukufukuyu amapereka maziko asayansi achitetezo cha chitetezo chamthupi "Ganoderma lucidumkhofi", womwe ndi wophatikizaGanoderma lucidumkuchotsa ndi khofi.

Komabe,Ganoderma lucidumkhofi ndi osakaniza awiri zosakaniza pambuyo zonse.Ganoderma lucidumkuchotsa alipo mu ndalama zochepaGanoderma lucidumkhofi.Kapu patsiku kapena masiku awiri kapena atatu sangakhale othandiza monga kuonjezeraGanoderma lucidumokha, koma akhoza kuwonjezera pakapita nthawi.

Kwa okonda khofi,Ganoderma lucidumkhofiNdithu, ili ndi tanthauzo kwambiri.Kuphatikiza pa kufunikira kwa chitetezo chamthupi komwe kumaperekedwa ndi zoyeserera pamwambapa, zotsatira zaGanoderma lucidumkuyambira nthawi zakale kuti "kuwonjezera mtima qi" ndi "kuwonjezera nzeru ndi kukumbukira" kungakhalenso ndi gawo lothandizira ndi khofi.

[Nkhani]

Jin Lingyun et al.Kafukufuku wokhudza khofi ya Ganoderma lucidum pachitetezo cha chitetezo cha mbewa.Sayansi Yazakudya ndi Zamakono, 2017, 42 (03): 83-87.

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba, ndipo umwini wake ndi wa GanoHerb.

★ Ntchito zomwe zili pamwambazi sizingapangidwenso, kuchotsedwa kapena kugwiritsidwa ntchito m'njira zina popanda chilolezo cha GanoHerb.

★ Ngati ntchitoyo yaloledwa kugwiritsidwa ntchito, iyenera kugwiritsidwa ntchito mkati mwa chilolezo ndikuwonetsa gwero: GanoHerb.

★ Pakuphwanya kulikonse kwa mawu omwe ali pamwambapa, GanoHerb idzatsata maudindo okhudzana ndi zamalamulo.

★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.