(Umthombo: CNKI)

Abantu abafuna ikofu ukuze bazihlaziye yonke imihla baya kuba nexhala lokusela ikofu eninzi ngempazamo.Ukuba usela ikofu yeReishi, unokukwazi ukunqanda amaxhala anjalo kwaye ube nesivuno esingalindelekanga.

Ngokwengxelo yophando epapashwe kwiInzululwazi yoKutya kunye neTeknolojikwi-2017 yiZiko loPhando lobuNjineli beSizwe kunye neNdawo yeNdawo yokuLima kunye nokuPhathwa kweNzululwazi ye-Medicinal Fungi, ikhofi ye-Reishi inefuthe lokuphucula i-immunity.

IReishi ikofuisetyenziswe kolu phando ngumxube ofanelekileyo weI-Ganoderma lucidumisicatshulwa kunye nekofu, ebonelelwa yiGanoHerb Technology (Fujian) Corporation.Izilwanyana zovavanyo ziimpuku ze-ICR, ezisetyenziswa kakhulu kwi-pharmacology, i-toxicology, ithumba, ukutya kunye nolunye uphando lwesayensi.

Amanani amathathu ahlukeneyo (i-1.75, 3.50 kunye ne-10.5 g / kg, oko kukuthi amaxesha angama-5, amaxesha angama-10 kunye namaxesha angama-30 idosi yemihla ngemihla ecetyiswayo kumntu omdala we-60 kg, ngokulandelanayo) yekhofi ye-Reishi yayilawulwa ngomlomo kwiigundane imihla ngemihla.Emva kweentsuku ze-30 ezilandelelanayo, iziphumo zekhofi ye-Reishi kwi-immune function yegundane zahlaziywa ngeendlela ezahlukeneyo zokufumanisa.Kuye kwavela:

1. Ukunyuka kwesalathisi se-splenic (inani le-lymphocytes)

Isalathiso sesplenic ngumlinganiselo wobunzima bespleen kubunzima bomzimba.Ekubeni i-spleen ityebile kwii-lymphocytes (kubandakanywa iiseli ze-B, iiseli ze-T kunye neeseli ezibulalayo zendalo).Iqondo lokunyuka kwe-lymphocyte liya kuchaphazela ubunzima be-spleen, enokuthi ibonakaliswe kwi-index ye-splenic index.Ngoko ke, imeko eqhelekileyo yokusebenza komzimba womntu inokugwetywa ukusuka kwinqanaba lesalathisi.

Iziphumo zovavanyo zibonise ukuba xa kuthelekiswa neqela lolawulo elingazange lidleI-Ganoderma lucidumkofu, iidosi eziphantsi neziphakathi zeI-Ganoderma lucidumikofu yayingenayo impembelelo ebalulekileyo kwisalathiso se-spleen yeempuku, kodwa iidosi eziphezulu zeI-Ganoderma lucidumikofu inokunyusa isalathisi seempuku nge-16.7%, ebaluleke kakhulu ngokwezibalo.

2. Ukukwazi ukwanda kweeseli ze-T kuba namandla

I-T lymphocytes ngabaphathi be-immune system.Baya kugqiba ulwalathiso lwempendulo yomzimba ngokwemeko yotshaba oluvela kwiindawo ezingaphandle (ezifana ne-macrophages).Ezinye iiseli ze-T ziya kulwa ngokwenene notshaba okanye zikhumbule la mava ukuze zikwazi ukukhawuleza zisebenze impendulo yokuzivikela komzimba kwixesha elizayo xa zilwa notshaba.Ngoko ke, ukukwazi kwabo ukwanda ngexesha "lomkhankaso" kuhambelana nokusebenza komzimba jikelele.

Ngokweziphumo zovavanyo lwenguquko ye-ConA-induced mouse spleen lymphocyte (ekwaziwa ngokuba luvavanyo lwe-T cell proliferation), umthamo okhulayo (umahluko we-OD wokuguqulwa kwe-spleen lymphocyte) we-spleen lymphocytes yeempuku ezithatha iidosi eziphakathi kunye eziphezulu zeI-Ganoderma lucidumkofuxa ukhuthazwa yi-ConA inyuke ngaphezu kwe-30% xa kuthelekiswa neqela lolawulo.

Ekubeni i-ConA ikhetha ngokukhetha iiseli ze-T, ukwanda kwe-lymphocyte ye-spleen ye-mouse ebonwe kuvavanyo ngokwenene sisiphumo se-T cell proliferation.

3. Isakhono seeseli ze-B ukuvelisa izilwa-buhlungu zomelele kwaye nenani lezilwa-buhlungu ezizivelisayo likhulu.

Ii-lymphocyte B zikwabizwa ngokuba ziiseli ezivelisa i-antibody.Ziya kuvelisa izilwa-buhlungu ezihambelanayo ngokwemiyalelo ekhutshwe zii-T seli ukuhlasela ngokuchanekileyo abahlaseli abavalwe zii-T seli.Le "inkqubo yokuzivikela echanekileyo esebenzisa iiseli ze-B ukuvelisa amajoni omzimba ukufezekisa injongo yokukhusela" ibizwa ngokuba "i-humoral immunity", kwaye inani leeseli ze-B kunye nomthamo we-antibodies eziveliswayo ziba zizibonakaliso zokuvavanya amandla okukhusela i-humoral.

Xa iiseli ze-B zidibana neeseli zegazi ezibomvu ezivela kwimithombo eyahlukeneyo, ziya kuvelisa amajoni omzimba ukwenza iiseli ezibomvu zegazi, kwaye ii-antibodies eziveliswayo ziya kubophelela kwiiseli ezibomvu zegazi kwaye zihlangane zibe yi-clumps.Le propati yayisetyenziselwa ukuvavanya ukukwazi kweeseli ze-mouse B ukuvelisa i-antibodies (i-hemolytic plaque assay) kunye nenani le-antibodies eziveliswayo (i-serum hemolysin assay).

Kwafunyaniswa ukuba idosi ephezuluI-Ganoderma lucidumikofu inokuphucula amandla eeseli zemouse B ukuvelisa amajoni omzimba (inani lee-hemolytic plaques lenyuke nge-23%) kunye nenani le-antibodies eziveliswayo (inani le-antibodies landa ngama-26.4%), nto leyo enegalelo ekuphuculeni umsebenzi we-humoral immune immune. .

4. Umsebenzi we-macrophages kunye neeseli ze-NK zinamandla

Ukhuseleko olulungileyo alufuni kuphela umthetheli oyintloko (iiseli ze-T) kunye nenkxaso echanekileyo yolungiselelo (iiseli ze-B kunye ne-antibodies) kodwa kunye nomkhosi ohambahambayo onokunika inkxaso ekubhaqweni komgca wangaphambili weentshaba ukuya kuyo yonke inkqubo yokusabela komzimba.I-Macrophages kunye neeseli ze-NK zidlala indima enjalo.

Ngokusebenzisa "i-carbon clearance capacity" kunye ne "NK cell assay activity", kwafunyaniswa ukuba idosi ephezuluI-Ganoderma lucidumkofuinokunyusa ikhono le-phagocytic le-macrophages nge-41.7% kunye nokwandisa umsebenzi weeseli ze-NK ngama-26.4%.Lo yayingumahluko obalulekileyo ngokwezibalo xa kuthelekiswa neqela elilawulayo elingazange liseleI-Ganoderma lucidumkofu.

Indibaniselwano yeI-Ganodermalucidum kwaye ikofu yenza ikofu ngaphezu kwekofu nje.

Amajoni omzimba afuna amalungu amaninzi ukuze asebenzisane ukuze enze umnatha oxineneyo wokukhusela.Macrophages, iiseli NK, iiseli T, iiseli B kunye izilwa-buhlungu iindima eziphambili kolu thungelwano kwaye ziyimfuneko.

Izifundo ezininzi kwixesha elidlulileyo sele zikuqinisekisile okoI-Ganoderma lucidumIsicatshulwa sinokuphucula imiphumo yeeseli zomzimba ezichazwe ngasentla kunye nezithinteli-zifo, kwaye ngoku olu phononongo lubonelela ngesiseko sesayensi sokusebenza komzimba "I-Ganoderma lucidumikofu”, eyindibaniselwanoI-Ganoderma lucidumisicatshulwa kunye nekofu.

Nangona kunjalo,I-Ganoderma lucidumikofu yindibaniselwano yezithako ezimbini emva koko.I-Ganoderma lucidumisicatshulwa sikhoyo kwiimali ezilinganiselweyoI-Ganoderma lucidumkofu.Ikomityi ngosuku okanye iintsuku ezimbini okanye ezintathu zinokungasebenzi njengokongezaI-Ganoderma lucidumyodwa, kodwa inokongeza ngokuhamba kwexesha.

Kubathandi bekofu,I-Ganoderma lucidumkofungokuqinisekileyo inentsingiselo ngakumbi.Ukongeza kwi-immune significant evezwa ngovavanyo olungentla, iziphumo zeI-Ganoderma lucidumukususela kumaxesha amandulo "ukuncedisa intliziyo qi" kunye "nokwandisa ubulumko kunye nenkumbulo" kunokudlala indima ehambelanayo nekofu.

[Reference]

UJin Lingyun et al.Uphando malunga nomphumo wekofu ye-Ganoderma lucidum kwi-immune function yegundane.ISayensi yoKutya kunye neTeknoloji, i-2017, i-42 (03): 83-87.

★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali, kwaye ubunini balo bubo beGanoHerb.

★ Lo msebenzi ungasentla awunakuphinda uveliswe, ucatshulwe okanye usetyenziswe ngezinye iindlela ngaphandle kogunyaziso lweGanoHerb.

★ Ukuba umsebenzi ugunyazisiweyo ukuba usetyenziswe, kufuneka usetyenziswe ngaphakathi kwendawo yogunyaziso kwaye ubonise umthombo: GanoHerb.

★ Nakuphi na ukuphulwa kwengxelo engentla, i-GanoHerb iya kulandela uxanduva olusemthethweni olunxulumeneyo.

★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.