NguWu Tingyao
Ukuba ukutyeba akunakuthintelwa, ngaba kukho nayiphi na indlela yokucothisa ukutyeba kobunzima ngaphandle kokunciphisa umdla wokutya, okanye nokutyeba ngakumbi ngokusempilweni?Ingxelo yophando epapashwe liqela laseMzantsi Korea kwiZondlo libonise ukubaI-Ganoderma luciduminokusebenzisa i-AMPK, i-enzyme ephambili kwi-cell metabolism yamandla, ukunciphisa ukunyuswa kwamafutha, ukuphucula ukusetyenziswa kwe-glucose kunye nokunciphisa umngcipheko wokukhuluphala, isibindi esinamafutha, i-hyperglycemia kunye ne-hyperlipidemia ebangelwa kukutya okunamafutha aphezulu (HFD).
Abaphandi abavela kwiYunivesithi yeSizwe yaseChungbuk, iYunivesithi yeSizwe yaseKyungpook kunye neNational Institute of Horticultural and Herbal Science yaseMzantsi Korea ngokudibeneyo bapapashe iziphumo zabo ngoNovemba 2020 umcimbi we "Nutrients" (Nutrients Journal):
Kwiimpuku ezitya ukutya okunamafutha aphezulu, ukubaI-Ganoderma lucidumi-powder extract (GEP) yongezwa kwisondlo sabo, emva kweeveki ze-12 zokuzama, iigundane azikho iingxaki ezicacileyo ngobunzima, amanqatha omzimba, ukumelana ne-insulin, iswekile yegazi okanye i-lipids yegazi.Ngaphezu koko, ngakumbiI-Ganoderma lucidumisicatshulwa songezwa, ngokusondeleyo ezi zalathi zeempuku ezitya ukutya okunamafutha aphezulu kuya kuba kwiimpuku ezinokutya okuqhelekileyo kwe-chow (ND) kunye nesondlo esilungeleleneyo, esinokubonakala nakwimbonakalo.
Yitya umlinganiselo ofanayo wokutya kodwa utyebe kancinci
Inokubonwa kuMzobo woku-1 ukuba emva kovavanyo lweeveki ezilishumi elinambini, ubungakanani kunye nobunzima beempuku ekutyeni okunamafutha aphezulu baphantse baphinda kabini loo magundane kukutya okuqhelekileyo kwe-chow, kodwa iimpuku nazo zondliwa nazo.I-Ganoderma lucidumIsicatshulwa sibe neenguqu ezahlukeneyo ─ Udibaniso lwe-1%I-Ganoderma lucidumisicatshulwa ayikacaci, kodwa ukongezwa kwe-3% kucacile kakhulu, ngakumbi umphumo wokuthintela ukongeza i-5% kwi-portly kubaluleke kakhulu.
II-Ganoderma lucidumisicatshulwa ezithi ezimpuku zayitya yafunyanwa ngokukhupha imizimba yeziqhamo ezomisiweyo ezilinywe ngokufanelekileyoI-Ganoderma lucidumiintlobo (i-ASI7071) kunye ne-95% ye-ethanol (utywala) yiSebe loPhando lweMushroom kwiZiko leSizwe leNzululwazi yeHorticultural kunye neHerbal Science yaseMzantsi Korea.Amalungu aphambili e-bioactive weI-Ganoderma lucidumisicatshulwa sichazwe kwiThebhile 1: i-Ganoderic acids i-akhawunti ye-53%, kunye ne-polysaccharides i-akhawunti ye-27%.Iintlobo zezidlo ezisetyenziswe kolu phononongo zichazwe kwiTheyibhile yesi-2.
Njengoko i-asidi ye-Ganoderic inokunambitheka okukrakra, umntu akanakukwazi ukuzibuza ukuba ingaba ichaphazela ukutya kweegundane kwaye ibangele ukulahleka kwesisindo.Hayi!Iziphumo zibonisa ukuba omabini amaqela eempuku atya phantse umlinganiselo ofanayo wokutya yonke imihla (Umfanekiso 2 ekunene), kodwa kukho umahluko omkhulu ekufumaneni ubunzima beempuku ngaphambi nasemva kovavanyo (Umfanekiso 2 ngasekhohlo).Oku kubonakala kuthetha ukuba isizathu sokubaI-Ganoderma lucidumIsicatshulwa sinokukhuphisana nokutya okunamafutha aphezulu kunokunxulunyaniswa nokwandiswa kokusebenza kwe-metabolic.
I-Ganoderma luciduminqanda ukuqokelelwa kwamafutha kunye ne-adipocyte hypertrophy
Ukuzuza ubunzima ngokuqhelekileyo kuhambelana "nokukhula kwezihlunu okanye amanqatha".Kulungile ukukhula izihlunu.Ingxaki ikukukhula kwamafutha, oko kukuthi, izicubu ezimhlophe ze-adipose (WAT), ezinoxanduva lokugcina iicalories ezigqithiseleyo emzimbeni, ziye zanda.La mafutha ongezelelweyo asenokuqokelelana kwiindawo ezahlukeneyo.Xa kuthelekiswa namafutha angaphantsi kwe-subcutaneous, i-visceral fat (ekwabizwa ngokuba ngamafutha esisu) aqokelelwe phakathi kwamalungu ahlukeneyo kumqolo wesisu kunye namafutha e-ectopic avela kwizicubu ezingekho-nonadipose (ezifana nesibindi, intliziyo kunye nezihlunu) zihlala zisondelelene kakhulu nemingcipheko enxulumene nokutyeba kakhulu njengesifo seswekile. , isibindi esinamafutha kunye nesifo senhliziyo.
Ngokweziphumo zovavanyo lwezilwanyana olungentla,I-Ganoderma lucidumi-extract ayikwazi ukunciphisa kuphela ukuqokelela kwamafutha angaphantsi, i-epididymal fat (emele i-visceral fat) kunye ne-mesenteric fat (emele amanqatha esisu) (Umfanekiso 3) kodwa unciphisa umxholo we-fat esibindi (Umfanekiso 4);Kuyinto enembile ukubona ukusuka kwicandelo lezicubu ze-adipose ze-epididymis ukuba ubukhulu be-adipocytes buya kutshintsha ngenxa yokungenelelaI-Ganoderma lucidumisicatshulwa (umzobo 5).
I-Ganoderma luciduminciphisa i-hyperlipidemia, i-hyperglycemia kunye nokumelana ne-insulin
Izicubu ze-Adipose ayisiyiyo kuphela indawo yokugcina umzimba ukuba uqokelele amanqatha amaninzi kodwa ikwakhupha “iihomoni zamafutha” ezahlukeneyo ezichaphazela icarbohydrate kunye ne-lipid metabolism.Xa umthamo wamafutha omzimba uphezulu, ukusebenzisana kwala mahomoni anamafutha kuya kunciphisa uvakalelo lweeseli zezicubu kwi-insulin (le nto ibizwa ngokuba "yi-insulin resistance"), okwenza kube nzima ukuba iiseli zisebenzise i-glucose.
Isiphumo asiyi kwandisa kuphela iswekile yegazi kodwa ibangele i-lipid metabolism engaqhelekanga, ebangela iingxaki ezifana ne-hyperlipidemia, isibindi esinamafutha kunye ne-atherosclerosis.Ngexesha elifanayo, i-pancreas iya kunyanzeliswa ukuba ikhuphe i-insulin eninzi.Ngenxa yokuba i-insulin ngokwayo inefuthe lokukhuthaza ukuqokelelwa kwamafutha kunye nokuvuvukala, i-insulin efihliweyo ngokugqithisileyo ayixazululi kuphela ingxaki kodwa yenza ukukhuluphala kunye nazo zonke iingxaki ezingentla zibi nakakhulu.
Ngethamsanqa, ngokwengxelo yophando yaseMzantsi Korea,I-Ganoderma lucidumisicatshulwa sinempembelelo yokulungisa kwi-secretion engaqhelekanga yehomoni ezinamafutha (i-leptin kunye ne-adiponectin), ukunyuka kwe-insulin kunye nokunciphisa ukusetyenziswa kwe-glucose okubangelwa kukutya okunamafutha amaninzi.Umphumo othile uboniswa kolu vavanyo lwezilwanyana lukhankanywe apha ngasentla: Kwiimpuku ekutyeni okunamafutha aphezulu okongeziweyo.I-Ganoderma lucidumisicatshulwa, i-dyslipidemia yabo kunye neswekile yegazi ephakamileyo kunye ne-insulin yayincinci (iThebhile 3 kunye ne-Figure 6).
I-Ganoderma lucidumyenza i-enzyme ephambili ye-cell energy metabolism - i-AMPK
Kutheni unakoI-Ganoderma lucidumisicatshulwa siguqule intlekele yokutya okunamafutha aphezulu kwindawo yokuguqula?Abaphandi bakhupha izicubu ze-adipose kunye nezicubu zesibindi zeempuku zovavanyo ezikhankanywe ngasentla ukuze zihlalutywe ukuze zibone ukuba ezi seli ziya kwahluka njani ngenxa yokongezwaI-Ganoderma lucidumisicatshulwa phantsi kokutya okufanayo okunamafutha aphezulu.
Kwafunyaniswa ukuba iI-Ganoderma lucidumisicatshulwa sikhuthaze umsebenzi we-enzyme ye-AMPK (i-5'adenosine monophosphate isebenze iprotheni kinase), ejongene nokulawula amandla kwi-adipocytes kunye neeseli zesibindi.I-AMPK esebenzayo inokuthintela ukubonakaliswa kwezakhi zofuzo ezinxulumene ne-adipogenesis kunye nokwandisa i-insulin receptor kunye ne-glucose transporter (iprotheni ehambisa i-glucose ukusuka ngaphandle kweseli ukuya ngaphakathi kweseli) kwindawo yeseli.
Ngamanye amazwi,I-Ganoderma lucidumi-extract ilwa nokutya okunamafutha aphezulu ngokusebenzisa indlela ekhankanywe ngasentla, ngaloo ndlela inciphisa ukuqokelelwa kwamafutha, ukuphucula ukusetyenziswa kwe-glucose, kwaye ekugqibeleni ifezekise injongo yokunciphisa ubunzima.
Enyanisweni, inentsingiselo kakhulu loo ntoI-Ganoderma lucidumi-extract inokulawula umsebenzi we-AMPK ngenxa yokuba umsebenzi oncitshisiweyo we-AMPK uhambelana nokukhuluphala okanye uhlobo lwe-2 yesifo sikashukela esibangelwa kukutya okunamafutha aphezulu.I-metformin ye-hypoglycemic drug esetyenziswa ngokuqhelekileyo ekusebenzeni kweklinikhi inxalenye ehambelana nokwandisa umsebenzi we-AMPK we-adipocytes kunye neeseli zesibindi.Okwangoku, ukonyuka komsebenzi we-AMPK kukwajongwa njengesicwangciso esinokwenzeka sokuphucula isantya semetabolism kuphuhliso lwamachiza amaninzi amatsha ukuphucula ukutyeba.
Ngoko uphando kwiI-Ganoderma lucidumngokwenene ihambisana nenkqubela phambili yesayensi kunye nesantya samaxesha, kwaye uphando olucekethekileyo olukhankanywe ngasentla oluvela eMzantsi Korea lubonelela ngesona sisombululo silula kum nawe “abafuna ukutya kakuhle kodwa abafuni ukuchatshazelwa kukutya okulungileyo. ”, oko kukuthi, ukugcwalisaI-Ganoderma lucidumisicatshulwa equlethe ezahlukeneyo ganoderic acid kunyeI-Ganoderma lucidumiipolysaccharides.
[Umthombo weDatha] Hyeon A Lee, et al.I-Ganoderma lucidum Extract Inciphisa ukuchasana kwe-insulin ngokuPhucula i-AMPK yokuSebenza kwi-High-Fat Diet-Induced Obese Mice.Izondlo.2020 Okt 30;12(11):3338.
ISIPHELO
Malunga nombhali/ Nksz. Wu Tingyao
UWu Tingyao unike ingxelo okokuqalaI-Ganoderma lucidumulwazi
ukusukela ngo-1999. Ungumbhali weUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).
★ Eli nqaku lipapashwa phantsi kogunyaziso olukhethekileyo lombhali ★ Le misebenzi ingentla ayinakuphinda kuveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali ★ Ukwaphulwa kwale nkcazo ingasentla, umbhali uya kuqhuba uxanduva lwakhe lomthetho olunxulumeneyo ★ Eyokuqala umbhalo weli nqaku ubhalwe ngesiTshayina nguWu Tingyao kwaye waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.
Ixesha lokuposa: Jul-03-2021