E ngotsoe ke Wu Tingyao

Haeba botenya bo ke ke ba hatelloa, na ho na le tsela leha e le efe ea ho fokotsa boima ba 'mele ntle le ho thibela takatso ea lijo, kapa esita le ho nona ka tsela e phetseng hantle?Tlaleho ea lipatlisiso e hatisitsoeng ke sehlopha sa Korea Boroa ho Nutrients e bontšitse seoGanoderma lucidume ka kenya tšebetsong AMPK, e leng enzyme ea bohlokoa metabolism ea matla a lisele, ho fokotsa ho bokellana ha mafura, ho ntlafatsa tšebeliso ea tsoekere le ho fokotsa kotsi ea botenya, sebete se mafura, hyperglycemia le hyperlipidemia e bakoang ke lijo tse nang le mafura a mangata (HFD).

Bafuputsi ba Chungbuk National University, Kyungpook National University le National Institute of Horticultural and Herbal Science ea Korea Boroa ka kopanelo ba phatlalalitse seo ba se fumaneng khatisong ea November 2020 ea "Nutrients" (Nutrients Journal) :

Bakeng sa litoeba tse jang lijo tse mafura a mangata, haebaGanoderma lucidumextract powder (GEP) e kenngoa lijong tsa bona, ka mor'a libeke tsa 12 tsa liteko, litoeba ha li na mathata a totobetseng ka boima ba 'mele, mafura a' mele, ho hanyetsa insulin, tsoekere ea mali kapa lipids ea mali.Ho feta moo, le ho fetaGanoderma lucidumho eketsoa, ​​​​haufinyane matšoao ana a litoeba tse jang lijo tse nang le mafura a mangata e tla ba tsa litoeba tse nang le lijo tse tloaelehileng tsa chow (ND) le phepo e nepahetseng, e ka bonoang le ponahalong.

Ja lijo tse lekanang empa u fokotsehe mafura

E ka bonoa ho Setšoantšo sa 1 hore ka mor'a teko ea libeke tse leshome le metso e 'meli, boholo le boima ba litoeba lijong tse nang le mafura a mangata li ne li batla li le habeli tsa litoeba lijong tse tloaelehileng tsa chow, empa litoeba tse neng li feptjoa le tsona.Ganoderma lucidumtlhahiso e bile le liphetoho tse fapaneng ─ Keketso ea 1%Ganoderma lucidumtlhahiso e ntse e sa totobala, empa ho eketsoa ha 3% ho hlakile haholo, haholo-holo phello ea inhibitory ea ho eketsa 5% ho portly e bohlokoa haholo.

TheGanoderma lucidumqotsulo eo litoeba tsena li neng li e ja e ile ea fumanoa ka ho ntša 'mele o omisitsoeng oa litholoana o lenngoeng ka maiketsetsoGanoderma lucidummefuta (ASI7071) e nang le 95% ea ethanol (joala) ke Lefapha la Lipatlisiso tsa Mushroom la Setsi sa Sechaba sa Horticultural le Herbal Science sa Korea Boroa.Likarolo tse kholo tsa bioactive tsaGanoderma lucidumqotsulo e boletsoe ho Lethathamo la 1: Li-ganoderic acid li etsa 53%, 'me li-polysaccharides li etsa 27%.Liqapi tsa lijo tse sebelisitsoeng thutong ena li boletsoe ho Lethathamo la 2.

Kaha asiti ea Ganoderic e na le tatso e babang, motho ha a tsebe ho ipotsa hore na e ama lijo tse jeoang ke litoeba mme e baka tahlehelo ea boima ba 'mele.Che!Liphello li bontša hore lihlopha ka bobeli tsa litoeba li ja hoo e batlang e le lijo tse lekanang letsatsi le leng le le leng (Setšoantšo sa 2 ka ho le letona), empa ho na le phapang e kholo ea boima ba litoeba pele le ka mor'a teko (Setšoantšo sa 2 se letšehali).Sena se bonahala se bolela hore lebaka ke hobaneGanoderma lucidumqotsulo e ka qothisana lehlokoa le lijo tse nang le mafura a mangata e ka amahanngoa le ho ntlafatsa ts'ebetso ea metabolism.

Ganoderma lucidume thibela ho bokellana ha mafura le hypertrophy ea adipocyte

Boima ba 'mele hangata bo amana le "khōlo ea mesifa kapa mafura".Ho lokile ho holisa mesifa.Bothata ke ho hōla ha mafura, ke hore, lisele tse tšoeu tsa adipose (WAT), tse ikarabellang bakeng sa ho boloka lik’hilojule tse feteletseng ’meleng, li eketsehile.Mafura ana a eketsehileng a ka ’na a bokellana likarolong tse sa tšoaneng.Ha ho bapisoa le mafura a subcutaneous, mafura a visceral (a boetse a bitsoa mafura a mpeng) a bokelletsoeng pakeng tsa litho tse fapaneng tsa mpa le mafura a ectopic a hlahang liseleng tsa nonadipose (tse kang sebete, pelo le mesifa) hangata a amana haufi-ufi le likotsi tse amanang le botenya joalo ka lefu la tsoekere. , sebete se mafura le lefu la pelo.

Ho ea ka liphello tsa liteko tse ka holimo tsa liphoofolo,Ganoderma lucidumntsa e ke ke ea fokotsa feela ho bokella mafura a subcutaneous, mafura a epididymal (a emelang mafura a visceral) le mafura a mesenteric (a emelang mafura a mpeng) (Figure 3) empa hape a fokotsa mafura a mafura a sebete (Figure 4);Hoa utloahala ho bona ho tloha karolong ea lisele tsa adipose tsa epididymis hore boholo ba li-adipocyte bo tla fetoha ka lebaka la ho kenellaGanoderma lucidumntsa (setšoantšo sa 5).

Ganoderma lucidume kokobetsa hyperlipidemia, hyperglycemia le ho hanyetsa insulin

Lithane tsa Adipose ha se ntlo ea polokelo feela ea hore 'mele o bokelle mafura a feteletseng empa hape e hlahisa "lihormone tsa mafura" tse fapaneng tse amang carbohydrate le metabolism ea lipid.Ha mafura a 'mele a phahame, ho sebelisana ha lihomone tsena tsa mafura ho tla fokotsa kutloisiso ea lisele tsa lisele ho insulin (sena ke seo ho thoeng ke "insulin resistance"), ho etsa hore ho be thata haholoanyane hore lisele li sebelise tsoekere.

Phello e ke ke ea eketsa tsoekere ea mali feela empa hape e baka metabolism e sa tloaelehang ea lipid, e bakang mathata a kang hyperlipidemia, sebete se mafura le atherosclerosis.Ka nako e ts'oanang, manyeme a tla tlameha ho hlahisa insulin e ngata.Hobane insulin ka boeona e na le phello ea ho khothalletsa ho bokellana ha mafura le ho ruruha, insulin e ngata haholo ha e rarolle bothata empa e boetse e etsa hore botenya le mathata ohle a ka holimo a mpefale.

Ka lehlohonolo, ho latela tlaleho ena ea lipatlisiso tsa Korea Boroa,Ganoderma lucidume ntšitsoeng e na le phello ea ho lokisa tlhahiso e sa tloaelehang ea lihomone tsa mafura (leptin le adiponectin), ho eketseha ha insulin ho hanyetsa le ho fokotsa tšebeliso ea tsoekere e bakoang ke lijo tse nang le mafura a mangata.Phello e khethehileng e bontšoa litekong tse boletsoeng ka holimo tsa liphoofolo: Bakeng sa litoeba lijong tse nang le mafura a mangata tse tlatsitsoeng kaGanoderma lucidumntsa, dyslipidemia ea bona le tsoekere e phahameng ea mali le insulin li ne li batla li le bonolo (Letlapa la 3 le Setšoantšo sa 6).

Ganoderma lucidume kenya tšebetsong enzyme ea bohlokoa ea metabolism ea matla a lisele - AMPK

Hobaneng ho kaGanoderma lucidumextract e fetola bothata ba lijo tse mafura haholo hore e be phetoho?Bafuputsi ba ile ba ntša lisele tsa adipose le lisele tsa sebete tsa litoeba tsa liteko tse boletsoeng ka holimo bakeng sa tlhahlobo ho bona hore na lisele tsena li tla fapana joang ka lebaka la tlatsetso eaGanoderma lucidumho ntša tlas'a lijo tse nang le mafura a mangata.

Ho ile ha fumaneha horeGanoderma lucidumtlhahiso e khothalelitse ts'ebetso ea enzyme AMPK (5'adenosine monophosphate activated protein kinase), e ikarabellang bakeng sa ho laola matla a adipocyte le lisele tsa sebete.AMPK e kentsweng tshebetsong e ka thibela ponahatso ya diphatsa tsa lefutso tse amanang le adipogenesis mme ya eketsa seamohedi sa insulin le sepalangoang sa glucose (protheine e tsamaisang glucose ho tloha ka ntle ho sele ho ya ka hare ho sele) sebakeng sa sele.

Ka mantsoe a mang,Ganoderma lucidumextract e loantša lijo tse nang le mafura a mangata ka mokhoa o boletsoeng ka holimo, ka tsela eo ho fokotsa ho bokella mafura, ho matlafatsa tšebeliso ea tsoekere, 'me qetellong ho finyella sepheo sa ho fokotsa boima ba' mele.

Ha e le hantle, ho bohlokoa haholo horeGanoderma lucidumtlhahiso e ka laola ts'ebetso ea AMPK hobane ts'ebetso e fokotsehileng ea AMPK e amahanngoa le botenya kapa lefu la tsoekere la mofuta oa 2 le bakoang ke lijo tse mafura a mangata.Metformin e sebelisoang hangata ea lithethefatsi tsa hypoglycemic ts'ebetsong ea tleliniki e amana le ho eketsa ts'ebetso ea AMPK ea li-adipocyte le lisele tsa sebete.Hajoale, ts'ebetso e ntseng e eketseha ea AMPK e boetse e nkuoa e le leano le ka khonehang la ho ntlafatsa sekhahla sa metabolism ho nts'etsopele ea litlhare tse ngata tse ncha ho ntlafatsa botenya.

Kahoo lipatlisiso kaGanoderma lucidume hlile e tsamaisana le tsoelo-pele ea saense le lebelo la mehla, ’me liphuputso tse entsoeng ka hloko tse boletsoeng ka holimo tse tsoang Korea Boroa li fana ka tharollo e bonolo bakeng sa ’na le uena “ba batlang ho ja hantle empa re sa batle ho angoa ke ho ja hantle. ”, ke hore, ho tlatsaGanoderma lucidumntsa e nang le mefuta e fapaneng ea ganoderic acid leGanoderma lucidumli-polysaccharides.

[Mohloli oa Lintlha] Hyeon A Lee, et al.Ganoderma lucidum Extract E Fokotsa Khahlano ea Insulin ka ho Ntlafatsa Ts'ebetso ea AMPK ho Litoeba tse Fetang Ho Fetisisa tse Bakiloeng ke Lijo tse Fetang.Limatlafatsi.2020 Oct 30;12(11):3338.

QETA

Mabapi le mongoli/ Mme Wu Tingyao

Wu Tingyao o ntse a tlaleha ka letsoho la peleGanoderma lucidumtlhahisoleseding

ho tloha ka 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).

★ Sengoliloeng sena se hatisitsoe ka tumello e khethehileng ea mongoli ★ Libuka tse ka holimo li ke ke tsa hlahisoa, tsa qotsoa kapa tsa sebelisoa ka litsela tse ling ntle le tumello ea mongoli ★ Ho tlola polelo e ka holimo, mongoli o tla phethahatsa boikarabelo ba eona ba molao ★ Ea pele. mongolo oa sengoloa sena o ngotsoe ka Sechaena ke Wu Tingyao mme oa fetoleloa ho Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.