By Wu Tingyao

Kana kufutisa kusingagoni kudzvinyirirwa, pane nzira ipi neipi here yokuderedza uremu pasina kudzvinyirira chishuvo chokudya, kana kuti kunyange kuwedzera uremu zvine utano?Chirevo chekutsvagisa chakaburitswa nechikwata cheSouth Korea muNutrients chakaratidza izvozvoGanoderma luciduminogona kushandura AMPK, iyo enzyme inokosha musero simba remetabolism, kuderedza kuunganidza mafuta, kuvandudza kushandiswa kweglucose uye kuderedza ngozi yekufutisa, mafuta echiropa, hyperglycemia uye hyperlipidemia inokonzerwa nekudya kwemafuta akawanda (HFD).

Vatsvagiri kubva kuChungbuk National University, Kyungpook National University uye National Institute of Horticultural and Herbal Science yeSouth Korea vakabatana vakaburitsa zvavakawana mumagazini yaNovember 2020 ye "Nutrients" (Nutrients Journal):

Kune mbeva dzinodya chikafu chine mafuta akawanda, kanaGanoderma lucidumkubvisa poda (GEP) inowedzerwa kuzvokudya zvavo, mushure memavhiki e12 ekuedza, makonzo haana matambudziko akajeka ane uremu, mafuta emuviri, insulin resistance, shuga yeropa kana lipids yeropa.Uyezve, zvakanyanyaGanoderma luciduminowedzerwa inowedzerwa, iyo inoswedera pedyo izvi zviratidzo zvemakonzo anodya kudya kwemafuta akawanda zvichave kune zvemakonzo ane zvakajairwa chow kudya (ND) uye zvine hutano hutano, hunogona kutoonekwa kubva pakuonekwa.

Idya chikafu chakafanana asi uchizokora zvishoma

Zvinogona kuonekwa kubva kuMufananidzo 1 kuti mushure mekuedza kwevhiki gumi nembiri, ukuru uye huremu hwemakonzo pakudya kwemafuta akawandisa zvakapetwa kaviri zvembeva pane zvakajairwa chow chikafu, asi mbeva dzakadyiswawo.Ganoderma lucidumkuburitsa kwaive nekuchinja kwakasiyana ─ Kuwedzerwa kwe1%Ganoderma lucidumkuburitsa hakusati kuri pachena, asi kuwedzera kwe3% kuri pachena, kunyanya iyo inhibitory mhedzisiro yekuwedzera 5% kune portly inonyanya kukosha.

TheGanoderma lucidumchidimbu chakadyiwa nembeva idzi chakawanikwa nekubvisa miviri yakaomeswa yemichero yezvakagadzirwa zvekugadziraGanoderma lucidumstrains (ASI7071) ine 95% ethanol (doro) neMushroom Research department reNational Institute of Horticultural and Herbal Science yekuSouth Korea.Iwo makuru bioactive zvinoriumba zveGanoderma lucidumkutorwa kunotaurwa muTable 1: Ganoderic acids account ye53%, uye polysaccharides account ye27%.Maumbirwo echikafu akashandiswa muchidzidzo ichi anotaurwa muTebhu 2.

Sezvo Ganoderic acid ine kuravira kunorwadza, munhu haagone kubatsira asi kushamisika kana ichikanganisa kudya kwemakonzo uye inokonzera uremu.Aihwa!Zvigumisiro zvinoratidza kuti mapoka maviri emakonzo aidya inenge yakaenzana yezvokudya zuva rega rega (Mufananidzo 2 kurudyi), asi pane misiyano yakakura mukuremerwa kwemakonzo isati yatanga uye mushure mekuedza (Mufananidzo 2 kuruboshwe).Izvi zvinoratidzika kunge zvichireva kuti chikonzero neiGanoderma lucidumchinwiwa chinogona kukwikwidzana nekudya kwakawanda-mafuta kunogona kuve kwakabatana nekusimudzirwa kwesimba remetabolism.

Ganoderma luciduminhibits kuunganidzwa kwemafuta uye adipocyte hypertrophy

Kuwedzera uremu kunowanzoenderana ne "kukura kwemhasuru kana mafuta".Zvakanaka kukura mhasuru.Dambudziko riri pakukura kwemafuta, kureva kuti, white adipose tissue (WAT), iyo inokonzera kuchengetedza macalorie akawandisa mumuviri, yawedzera.Aya mamwe mafuta anogona kuungana muzvikamu zvakasiyana.Kuenzaniswa ne subcutaneous mafuta, visceral mafuta (anonziwo abdominal mafuta) akaunganidzwa pakati penhengo dzakasiyana-siyana mudumbu remudumbu uye ectopic mafuta anoonekwa munonadipose tishu (sechiropa, moyo uye tsandanyama) anowanzo hukama zvakanyanya nenjodzi dzine chekuita nekufutisa senge chirwere cheshuga. , chiropa chemafuta uye chirwere chemwoyo.

Zvinoenderana nemhedzisiro yezviyedzo zvemhuka zviri pamusoro,Ganoderma lucidumkubvisa hakugoni kuderedza kuunganidza kwe subcutaneous fat, epididymal mafuta (inomiririra visceral mafuta) uye mesenteric mafuta (inomiririra mafuta emudumbu) (Mufananidzo 3) asiwo kuderedza mafuta ari muchiropa (Mufananidzo 4);Izvo zvakanyanya kunzwisisika kuona kubva kune chikamu cheadipose tishu epididymis kuti ukuru hweadipocytes huchachinja nekuda kwekupindira kwe.Ganoderma lucidumkubvisa (Mufananidzo 5).

Ganoderma luciduminoderedza hyperlipidemia, hyperglycemia uye insulin kuramba

Adipose tissue haingori dura rekuti muviri uunganidze mafuta akawandisa asi zvakare inoburitsa akasiyana "mafuta mahormone" anokanganisa carbohydrate uye lipid metabolism.Kana huwandu hwemafuta emuviri huchikwira, kuwirirana kwemahomoni emafuta aya kunoderedza kunzwisiswa kwemasero emasero kune insulin (iyi ndiyo inonzi "insulin resistance"), zvichiita kuti zvive zvakaoma kuti masero ashandise glucose.

Mhedzisiro haingo wedzera shuga yeropa chete asi zvakare inokonzera kusagadzikana lipid metabolism, zvichikonzera matambudziko akadai se hyperlipidemia, mafuta chiropa uye atherosclerosis.Panguva imwecheteyo, pancreas inomanikidzwa kuburitsa insulin yakawanda.Nekuti insulin pachayo ine mhedzisiro yekusimudzira kuunganidzwa kwemafuta uye kuzvimba, iyo insulin yakavanzika yakawandisa haigadzirise dambudziko chete asi inoita kuti kufutisa uye matambudziko ese ari pamusoro awedzere.

Neraki, maererano neiyi South Korea yekutsvagisa chirevo,Ganoderma luciduminobvisa ine mhedzisiro yekugadzirisa pane isina kujairika secretion yemafuta mahomoni (leptin uye adiponectin), yakawedzera insulin kushomeka uye kuderera kweglucose kushandiswa kunokonzerwa nekudya kwemafuta akawanda.Mhedzisiro yacho inoratidzwa mune izvo zvataurwa pamusoro pemhuka zviedzo: Zvembeva pakudya kwemafuta akawedzerwa.Ganoderma lucidumkubvisa, dyslipidemia yavo uye shuga yakakwirira yeropa uye insulini zvaive zvishoma (Table 3 uye Figure 6).

Ganoderma luciduminoita iyo yakakosha enzyme ye cell energy metabolism - AMPK

Sei zvichigonaGanoderma lucidumkubvisa shandura dambudziko rekudya kwemafuta akawanda kuita shanduko?Vatsvakurudzi vakabudisa adipose tissue uye chiropa chemice yakataurwa pamusoro apa kuti iongorore kuti masero aya angave akasiyana sei nekuda kwekuwedzera kweGanoderma lucidumkubvisa pasi pekudya kwemafuta akawanda.

Zvakaonekwa kutiGanoderma luciduminobvisa yakasimudzira basa reiyo enzyme AMPK (5'adenosine monophosphate activated protein kinase), iyo ine basa rekugadzirisa simba muadipocytes uye masero echiropa.Iyo yakagadziriswa AMPK inogona kudzivisa kutaura kwemajini ane chokuita neadipogenesis uye kuwedzera insulin receptor uye glucose transporter (protein inotakura glucose kubva kunze kwesero kusvika mukati mesero) pamusoro pesero.

Nemamwe mashoko,Ganoderma lucidumkubvisa kurwisa kudya kwemafuta akawanda kuburikidza nenzira yataurwa pamusoro apa, nokudaro kuderedza kuunganidza mafuta, kuwedzera kushandiswa kweglucose, uye pakupedzisira kuzadzisa chinangwa chekuderedza uremu.

Kutaura zvazviri, zvine musoro chaizvo izvozvoGanoderma luciduminobvisa inogona kudzora basa re AMPK nekuti kuderedzwa kwe AMPK basa kwakabatana nekufutisa kana kuti rudzi rwe 2 chirwere cheshuga chinokonzerwa nekudya kwemafuta akawanda.Iyo inowanzo shandiswa hypoglycemic drug metformin mumakiriniki maitiro ine chikamu chakabatana nekuwedzera AMPK basa readipocytes uye masero echiropa.Parizvino, kuwedzera kwekuita kwe AMPK kunoonekwawo senzira inogoneka yekusimudzira metabolic rate mukugadzirwa kwemishonga mitsva yakawanda yekuvandudza kufutisa.

Saka tsvakurudzo pamusoroGanoderma luciduminonyatso kufambirana nekufambira mberi kwesainzi uye kumhanya kwenguva, uye tsvakiridzo yakapfava yadudzwa kubva kuSouth Korea inopa mhinduro yakapusa iwe neni avo "tinoda kudya zvakanaka asi tisingade kukanganiswa nekudya zvakanaka. ”, kureva kuti kuzadzaGanoderma luciduminobvisa iyo ine akasiyana ganoderic acids uyeGanoderma lucidumpolysaccharides.

[Data Source] Hyeon A Lee, et al.Ganoderma lucidum Extract Inoderedza Insulin Resistance neKuvandudza AMPK Activation muHigh-Fat Diet-Induced Obese Mice.Nutrients.2020 Oct 30;12(11):3338.

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Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achitaura nezvekutanga-ruokoGanoderma lucidumruzivo

kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★Chinyorwa ichi chakatsikiswa pasi pemvumo yemunyori chete ★ Mabasa ari pamusoro haagone kutsikiswa, kudonhedzwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori ★ Kutyora chirevo chiri pamusoro, munyori achaita mabasa anoenderana nemutemo ★ Iwo ekutanga. chinyorwa chechinyorwa ichi chakanyorwa neChinese naWu Tingyao uye chakashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.