La 29 Pherekhong 2020 / Sepetlele sa Batho ba Setereke sa Hunan, joalo-joalo / Oxidative Medicine le Cellular Longevity

Mongolo/Wu Tingyao

Phuputso e phatlalalitsoeng ho "Oxidative Medicine le Cellular Longevity" ke Sepetlele sa Batho sa Hunan Provincial le Hunan Provincial Key Laboratory ea Emergency le Critical Care Metabonomic e bontšitse horeGanoderma lucidumtriterpenoids(GLTs)e ka sireletsa lisele tsa methapo ea boko le ho fokotsa ho senyeha ha kelello ho bakoang ke lefu la Alzheimer (AD) ka mekhoa e kang anti-apoptosis, anti-oxidation, le anti-neurofibrillary tangles.

Ganoderma lucidumtriterpenoids lieha ho fokotseha ha kelello kabakuli ba nang leLefu la Alzheimer.

Ea pele,rbabatli ba fepaGanoderma lucidumtriterpenoids (GLTs) ho lefu la Alzheimer (AD) litoeba tse bileng le matšoao a pele. KamoraMatsatsi a 60, bonae ile ea leka bokhoni ba kelello ba litoeba ka Morris Water Maze (MWM).

Ho nka monyetla ka litšobotsi tsa litoeba tseo ka tlhaho li hloileng metsi leka mehlaleka ho fumana sebaka sa ho qoba metsi, bafuputsi ba ile ba etsa Morris Water Maze, e leng ho theha sethala sa ho phomola ka letamo le leholo le chitja ho bala sebaka seo litoeba li sesang le nako eo li e qetang ho fumanaphomolosethala e le li-index ho ahlola bokhoni ba kelelloeetsa litoeba.Haeba litoeba li sa khone ho fumana sethala sa ho phomola (ka metsotso e 'meli), bafuputsi ba tla thusa tataisoelitoeba ho ea sethaleng.

Leha sebaka sa ho qala ho kena metsing se fapane nako le nako, litoeba tse tloaelehileng li ntse li ka fumana sethala sa ho phomola kapele ka boiphihlelo ba letsatsi le letsatsi.Teko e joalo e ne e etsoa hang ka letsatsi bakeng sa kakaretso ea matsatsi a robong.Ha ba bala lintlha tsohle ka karolelano, bafuputsi ba fumane hore litoeba tsa AD (AD Group) li tlameha ho qeta nako e telele habelias kapa ho sesa kotara e telele ho feta litoeba tse tloaelehileng (sehlopha sa taolo) ho fumana sethala sa ho phomola, se bontšang hore ts'ebetso ea kelello ea boko ba litoeba tsa AD e senyeha haholo.

Leha ho le joalo, litoeba tsa AD tse feptjoang ka litekanyetso tse phahameng (1.4g/kg ka letsatsi) tsa GLTs li nkile nako e tšoanang le sebaka sa ho sesa ho fumana.thesethala sa ho phomola e le litoeba tse tloaelehileng le litoeba tsa AD (sehlopha sa taolo ea meriana ea Bophirimela) se feptjoang ka donepezil letsatsi le leng le le leng (Setšoantšo sa 1 ~ 2).

(Ha ho hlokahala nako e nyane, bokhoni ba kelello bo ntlafala)

(Ha ho hlokahala sebaka se fokolang, bokhoni ba kelello bo ntlafala)

Letsatsing le hlahlamang ka mor'a ho fela ha teko e ka holimo, bafuputsi ba ile ba tlosa sethala sa ho phomola ka letamong 'me ba kenya litoeba metsing ka metsotso e' meli.

Ka lebaka la phihlelo ea matsatsi a robong a fetileng, litoeba tse tloaelehileng li ile tsa hopola sebaka sa pele sa sethala 'me tsa qeta nako e ngata li sesa ho pota-pota sebaka sa pele ho batla "sethala se nyamelang" ha litoeba tsa Alzheimer li ntse li sesa ntle le sepheo.

Ka lehlakoreng le leng, litoeba tsa Alzheimer tse sirelelitsoeng ke GLTs li ne li itšoara joaloka litoeba tse tloaelehileng ebang ke ka tekanyo e tlaase (0.35 g/kg ka letsatsi) kapa litekanyetso tse phahameng (1.4 g/kg ka letsatsi) 'me li fumane lintlha tse batlang li tšoana le litoeba tsa MD tse feptjoang ka meriana ea Bophirimela. Lipalo 3 ho isa ho 4).

(Ha nako e telele e lula, bokhoni ba kelello bo ntlafala)

(Ha karolo e phahame, bokhoni ba kelello bo betere)

Ganoderma lucidumtriterpenoids boloka botšepehi ba lisele tsa methapo.

Ho fokotseha ha bokhoni ba ho ithuta le ho hopola ke ts'ebetso ea pele ea ts'ebetso ea kelello (bothata) ho bakuli ba nang le lefu la Alzheimer's, 'me lisele tsa methapo tse ikarabellang mosebetsing ona li sebakeng sa hippocampal gyrus.Ka hona, ka mor'a hore bafuputsi ba qete liteko tse ka holimo, ba ile ba arola boko ba mouse bakeng sa tlhahlobo e eketsehileng.

Liphello li bontšitse hore lisele tsa methapo ka har'a hippocampal gyrus ea litoeba tse tloaelehileng li hlophisitsoe ka makhethe, li lekana ka boholo, li shebahala li le teng kamehla, 'me li-membrane tsa lisele le li-nuclei li arotsoe ka ho hlaka;lisele tsa methapo ka har'a hippocampal gyrus ea litoeba tsa AD li hlophisoa ka mokhoa o sa laoleheng, li sa tšoaneng ka boholo, ponahalo e sa tloaelehang, li fokotsehile haholo ka palo, 'me ho hlakile hore sebopeho sa eona se senyehile.

Leha ho le joalo, boemo bona ha boa ka ba hlaha ho litoeba tsa AD tse jang Ganoderma lucidum triterpenoids.Lisele tsa neuronal ka har'a gyrus ea bona ea hippocampal li ne li ntse li boloka botšepehi bo phahameng, 'me ho ne ho se na cell necrosis e hlakileng, e bontšang hore.Ganoderma lucidumtriterpenoids e ne e e-na le phello e sireletsang gyrus ea hippocampal (Setšoantšo sa 5).

Ganoderma lucidumtriterpenoids ho fokotsa li-neurofibrillary tangles.

Ka nako e ts'oanang, bafuputsi ba fumane hape hore palo ea li-neurofibrillary tangles ka har'a cerebral cortex (ho boloka mohopolo oa nako e telele) le hippocampal gyrus tissue ho AD litoeba tse sirelelitsoeng keGanoderma lucidumtriterpenoids e ne e le tlase haholo ho feta ea litoeba tsa AD tse sa phekoloang (Setšoantšo sa 6).

Neurofibrillary tangles ke e 'ngoe ea matšoao a mantlha a lefu la Alzheimer's.Ho fapana le li-amyloid deposits tse hlahang ka ntle ho lisele, li-neurofibrillary tangles li hlaha liseleng tsa methapo ka lebaka la phetoho ea "tau protein".

Tlas'a maemo a tloaelehileng, protheine ea tau e tlama ho cytoskeleton (microtubules) ho thusa ho thehoa le botsitso ba cytoskeleton.Leha ho le joalo, protheine ea tau bokong ba bakuli ba nang le lefu la Alzheimer e tla fetoha 'me e ke ke ea tlama ho cytoskeleton.Ka lebaka leo, protheine ea tau e tla kopana ka lihlopha ho etsa seo ho thoeng ke "neurofibrillary tangles", e bokellang liseleng ebe e kena-kenana le mosebetsi oa lisele.Cytoskeleton e haelloang ke protheine ea tao butle-butle e tla sotheha ebe e senyeha, e lebisang lefung la sele.

Palo ea li-neurofibrillary tangles e bonts'a boemo ba ho mpefala ha lefu la Alzheimer's.Ka hona, Ganoderma lucidum triterpenoids e ka thibela ho thehoa ha li-neurofibrillary tangles, e lokelang ho ba e 'ngoe ea mekhoa ea bohlokoa bakeng sa.Ganoderma lucidumtriterpenoids ho liehisa ho fokotseha ha kelello ho lefu la Alzheimer.

Ganoderma lucidumtriterpenoids fokotsa methapo ea kutlo apoptosis.

Ebangβ-amyloid deposition kapa neurofibrillary tangles e tla qala lenaneo la ho ipolaea la sele le ho khothaletsa apoptosis ea lisele tsa methapo.Ha lisele tse ngata tsa methapo li shoa, mesebetsi e mengata ea lahleha, le cognitive deqoelae bakoang ke lefu la Alzheimer e ba matla le ho feta.

Ho latela tlhahlobo ea hippocampal gyrus ea sehlopha se seng le se seng sa litoeba tsa liteko, ho ka fumanoa hore sekhahla sa lefu la lisele tsa methapo ho litoeba tsa AD se feta makhetlo a mane ho feta litoeba tse tloaelehileng tsa lilemo tse tšoanang;leha e le tekanyo e phahamengKhanodermalucidumtriterpenoids e sitoa ka ho feletsengpthibela apoptosis e sa tloaelehang ea lisele tsa methapo,bonahavee khonne ho fokotsa tšenyo, 'me phello e tšoana le ea meriana ea bophirimela (Setšoantšo sa 7).

Bafuputsi ba ile ba tsoela pele ho sekaseka mme ba fumana hore ho AD litoeba li bolokoa keGanoderma lucidumtriterpenoids, lisele tsa methapo ea boko li na le mochine o matla oa anti-oxidant ho loantša tšenyo ea oxidative e bakoang ke protheine ea β-amyloid le mochine oa apoptosis oa sele ha o sebetse habonolo.Ka mantsoe a mang, Ganoderma lucidum triterpenes e matlafatsa khatello ea kelello ea lisele tsa methapo ea boko, e etsa hore li khone ho phela le ho sebetsa sebakeng se matla.

Ganoderma lucidumLi-polysaccharides li boetse li na le thuso.

Liphetho tsa lipatlisiso tse ka holimo li bontša seoGanoderma lucidumli-triterpenoids, ka mor'a hore li kene ka mpeng ka 'metso, li ka liehisa tsoelo-pele ea lefu la Alzheimer ka li-anti-oxidation, anti-apoptosis, le anti-neurofibrillary tangles.

Ha e le hantle, phello eaGanoderma lucidumli-polysaccharides ha li joalofokolangho feta ea Ganoderma lucidum triterpenoids.Ka 2017, phuputso e phatlalalitsoeng ka kopanelo ho "Stem Cell Reports" ke Univesithi ea Tongji le Chinese Academy of Sciences e pakile hore tlhokomelo ea nako e telele leGanoderma lucidummokelikeli oa metsi kapaGanoderma lucidumli-polysaccharides li ka fokotsa li-deposit tsa β-amyloid bokong ba litoeba tsa AD, tsa thusa ho ata ha lisele tsa methapo ea kutlo ka har'a hippocampal gyrus le ho liehisa ho theoha ha thuto le mohopolo.(Bakeng sa lintlha, bona:Ganoderma lucidum polysaccharidesfokotsa ho fokotseha ha kelello ho bakoang ke lefu la Alzheimer's)

Ganoderma lucidumtriterpenoids leGanoderma lucidumli-polysaccharides li bonahala li na le litlamorao tse fapaneng ho sireletseng boko ka lefu la Alzheimer's.Kaphello e kopantsoeng ea bobeli e liehisa tsoelo-pele ea lefu la Alzheimer?

Hang ha lefu la Alzheimer le hlaha, ho thata ho le khutlisa.Leha ho le joalo, haebawee ka boloka bokhoni bo eketsehileng ba kelello, ho kenyelletsa ho ithuta le ho hopola, hotsa ronabophelo bo fokolang,wee ka ba le monyetla oa ho fola ka lefu la Alzheimer.

Mohloli

1. Yu N, le ba bang.Ganoderma lucidumTriterpenoids (GLTs) Fokotsa Neuronal Apoptosis ka Thibelo ea ROCK Signal Pathway ho APP/PS1 Transgenic Alzheimer's Disease Litoeba.Oxid Med Cell Longev.2020;2020: 9894037.

2. Huang S, le ba bang.Li-polysaccharides tse tsoang hoGanoderma lucidumKhothaletsa Mosebetsi oa Kelello le Neural Progenitor Proliferation ho Mouse oa Moetso oa Lefu la Alzheimer.Litlaleho tsa Stem Cell.2017 Jan 10;8(1):84-94.doi: 10.1016/j.stemcr.2016.12.007.

QETA

Mabapi le mongoli/ Mme Wu Tingyao

Wu Tingyao o ntse a tlaleha ka letsoho la peleGanoderma lucidumtlhahisoleseding ho tloha ka 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).

★ Sengoliloeng sena se hatisitsoe ka tumello e khethehileng ea mongoli ★ Libuka tse ka holimo li ke ke tsa hlahisoa, tsa qotsoa kapa tsa sebelisoa ka litsela tse ling ntle le tumello ea mongoli ★ Ho tlola polelo e ka holimo, mongoli o tla phethahatsa boikarabelo ba eona ba molao ★ Ea pele. mongolo oa sengoloa sena o ngotsoe ka Sechaena ke Wu Tingyao mme oa fetoleloa ho Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.