Janaayo 29, 2020 / Isbitaalka Dadka ee Gobolka Hunan, iwm.

Qoraal/Wu Tingyao

Daraasad lagu daabacay "Oxidative Medicine and Cellular Longevity" oo uu sameeyay Isbitaalka Dadka ee Gobolka Hunan iyo Shaybaadhka Muhiimka ah ee Gobolka Hunan ee Metabonomic ee Degdegga ah iyo Daryeelka Halis ah ayaa tilmaamayGanoderma lucidumtriterpenoids(GLTs)waxay ilaalin kartaa unugyada dareemayaasha maskaxda waxayna yareyn kartaa garashada garashada ee uu keeno cudurka Alzheimers (AD) iyada oo loo marayo hababka sida anti-apoptosis, anti-oxidation, iyo anti-neurofibrillary tangles.

Ganoderma lucidumtriterpenoids dib u dhaca garashada hoos u dhacabukaanka qabaCudurka Alzheimers.

Marka hore, rbaadhayaal quudinGanoderma lucidumtriterpenoids (GLTs) ilaa cudurka Alzheimers (AD) jiirarka kuwaas oo yeeshay calaamado hore. Kadib60 maalmood, waxayku tijaabiyay awoodaha garashada ee jiirarka Morris Water Maze (MWM).

Ka faa'iidaysiga sifooyinka jiirarka ee si dabiici ah u neceb biyaha iyohad iyo jeerisku day in aad hesho meel aad kaga fogaato biyaha, cilmi-baarayaashu waxa ay sameeyeen Morris Water Maze, kaas oo ah in la sameeyo meel lagu nasto oo ku taal barkad wareeg ah oo weyn si loo xisaabiyo masaafada ay jiirarku ku dabaalanayaan iyo wakhtiga ay ku qaataan helitaankanasashomadal sida indexes si loo xukumo awoodda garashadawaaee jiirarka.Haddii jiirarku ay awoodi waayeen inay helaan goobta lagu nasto (laba daqiiqo gudahood), cilmi-baarayaashu waxay ku caawin doonaan hagitaanejiirarka madal.

Inkasta oo meesha laga bilaabayo gelitaanka biyaha ay ka duwan tahay wakhti kasta, jiirarka caadiga ah ayaa weli si dhakhso ah u heli kara goobta lagu nasto iyada oo loo marayo waayo-aragnimo maalinle ah.Tijaabada noocan oo kale ah ayaa la sameeyay hal mar maalintii wadar ahaan sagaal maalmood.Xisaabinta dhammaan buundooyinka celcelis ahaan, cilmi-baarayaashu waxay ogaadeen in jiirarka AD (Kooxda AD) ay tahay inay ku qaataan laba jeer inta ugu badanas ama dabaasho saddex-meelood meel in ka badan jiirarka caadiga ah (kooxda xakamaynta) si aad u heshid goob lagu nasto, taas oo muujinaysa in shaqada garashada maskaxda ee jiirarka AD ay si weyn hoos ugu dhacday.

Si kastaba ha ahaatee, AD jiirarka oo lagu quudiyo qiyaaso sare (1.4g/kg maalintii) ee GLTs ayaa qaatay ku dhawaad ​​isku waqti iyo masaafada dabaasha si loo helo.ahMeesha lagu nasto sida jiirarka caadiga ah iyo jiirarka AD (kooxda kantaroolka daawada reer galbeedka) oo lagu quudiyo donpezil maalin kasta (Jaantuska 1 ~ 2).

(Waqtiga yar ee loo baahan yahay, ayaa fiicnaanta awoodda garashada)

(Masaafada yar ee loo baahan yahay, ayaa fiicnaan doonta awoodda garashada)

Maalintii xigtay ka dib markii ay dhammaatay tijaabada sare, cilmi-baarayaashu waxay ka saareen barkada nasashada ee barkada waxayna ku riday jiirarka biyaha laba daqiiqo.

Sagaalkii maalmood ee hore ee waayo-aragnimada awgeed, jiirarka caadiga ah waxay xusuustaan ​​goobta asalka ah ee madal waxayna ku lumiyeen waqti badan inay ku dabaasho agagaarka goobta asalka ah si ay u raadiyaan "goobta maqan" halka jiirarka Alzheimers ay si gool la'aan ah u dabaasheen.

Taas bedelkeeda, jiirarka Alzheimers ee ay ilaaliso GLTs waxay u dhaqmeen si ka badan sida jiirarka caadiga ah ama qiyaas yar (0.35 g/kg maalintii) ama qiyaaso sarreeya (1.4 g/kg maalintii) waxayna heleen ku dhawaad ​​​​la mid ah jiirarka MD ee lagu quudiyo daawada reer galbeedka ( Sawirada 3 ilaa 4).

(Inta sii dheeraato joogitaanka, ayaa fiicnaan doonta awoodda garashada)

(Mar kasta oo saamiga uu sarreeyo, ayaa fiicnaanta awoodda garashada)

Ganoderma lucidumtriterpenoids ilaalinta daacadnimada unugyada dareemayaasha.

Hoos u dhaca aqoonta iyo awoodda xusuusta ayaa ah hoos u dhaca shaqada garashada ee ugu horreysa ee bukaannada qaba cudurka Alzheimers, iyo unugyada dareemayaasha ee mas'uul ka ah shaqadan waxay ku yaalliin gyrus hippocampal.Sidaa darteed, ka dib markii ay cilmi-baarayaashu dhammeeyeen tijaabooyinka kor ku xusan, waxay kala gooyeen maskaxda jiirka si baaritaan dheeraad ah loo sameeyo.

Natiijadu waxay muujisay in unugyada dareemayaasha ee gyrus hippocampal ee jiirarka caadiga ah ay si fiican u habaysan yihiin, lebbiska cabbirka, muuqaalka caadiga ah, iyo xuubabka unugyada iyo xudunta ayaa si cad u xaddidan;Unugyada dareemayaasha ee gyrus hippocampal ee jiirarka AD ayaa si aan hagaagsanayn loo habeeyey, cabbirkooduna kala duwan yahay, muuqaal ahaan aan joogto ahayn, tiro ahaan aad loo dhimay, qaabdhismeedkiisuna si cad ayuu u dhaawacmay.

Si kastaba ha ahaatee, xaaladani kama soo muuqan jiirarka AD ee cunaya Ganoderma lucidum triterpenoids.Unugyada neerfaha ee gyrus hippocampal ayaa weli ilaalinaya daacadnimo sare, mana jirin necrosis unug cad, taas oo muujinaysa inGanoderma lucidumtriterpenoids ayaa saameyn difaac ah ku yeeshay gyrus hippocampal (Jaantus 5).

Ganoderma lucidumtriterpenoids waxay yareeyaan qallalka neurofibrillary.

Isla mar ahaantaana, cilmi-baarayaashu waxay sidoo kale ogaadeen in tirada neurofibrillary tangles ee kiliyaha maskaxda (keydinta xusuusta muddada dheer) iyo unugga gyrus hippocampal ee jiirarka AD ee ay ilaalinayaanGanoderma lucidumtriterpenoids aad ayuu uga hooseeyaa kan jiirarka AD ee aan la daweyn (Jaantuska 6).

Tangles Neurofibrillary waa mid ka mid ah calaamadaha ugu muhiimsan ee cudurka Alzheimers.Si ka duwan kaydka amyloid ee ka dhaca meel ka baxsan unugyada, neurofibrillary tangles waxay ku dhacaan unugyada dareemayaasha sababtoo ah isbeddelka "protein tau".

Xaaladaha caadiga ah, borotiinka tau wuxuu ku xidhan yahay cytoskeleton (microtubules) si uu u caawiyo samaynta iyo xasiloonida cytoskeleton.Si kastaba ha ahaatee, borotiinka tau ee maskaxda bukaanka qaba cudurka Alzheimers wuu isbedeli doonaa oo kuma xidhi karo cytoskeleton.Natiijo ahaan, borotiinka tau wuxuu isu geyn doonaa kooxo si ay u sameeyaan waxa loogu yeero "neurofibrillary tangles", kuwaas oo ku urura unugyada oo farageliya shaqada unugyada.Cytoskeleton ka maqan borotiinka tao wuxuu si tartiib tartiib ah u noqon doonaa qallooc iyo burbur, taasoo keenta dhimashada unugyada.

Tirada tangle neurofibrillary waxay ka tarjumaysaa heerka sii xumaanshaha cudurka Alzheimers.Sidaa darteed, Ganoderma lucidum triterpenoids waxay joojin kartaa samaynta tangles neurofibrillary, taas oo ah mid ka mid ah hababka muhiimka ahGanoderma lucidumtriterpenoids si ay u daahiyaan hoos u dhaca garashada ee cudurka Alzheimers.

Ganoderma lucidumtriterpenoids waxay yareeyaan apoptosis unugyada dareemayaasha.

Amaβ-amyloid deposition ama neurofibrillary tangles ayaa bilaabi doona barnaamijka is-dilka ee unugyada waxayna kor u qaadaan apoptosis ee unugyada dareemayaasha.Sida unugyo badan oo neerfaha u dhintaan, hawlo badan ayaa lumaya, iyo garashada deklinkauu keeno cudurka Alzheimers ayaa noqda mid aad u daran.

Laga soo bilaabo falanqaynta unugyada gyrus hippocampal ee koox kasta oo jiirarka tijaabada ah, waxaa la ogaan karaa in heerka dhimashada unugyada dareemayaasha ee jiirarka AD ay ka badan tahay afar jeer jiirarka caadiga ah ee isku da'da ah;inkasta oo qiyaasta sareGanodermalucidumtriterpenoids gabi ahaanba ma awoodopdib u soo celinta apoptosis aan caadi ahayn ee unugyada dareemayaasha,waxayhaveawooday in ay kala badh burburto, saamayntuna waxa ay la mid tahay ta daawada reer galbeedka (Jaantuska 7).

Cilmi-baarayaashu waxay sii falanqeeyeen oo ay ogaadeen in jiirarka AD lagu ilaaliyoGanoderma lucidumtriterpenoids, unugyada dareemayaasha maskaxdu waxay leeyihiin hab adag oo ka hortagga oksidant si ay ula dagaallamaan waxyeelada oksaydhka ee ay keento borotiinka β-amyloid iyo habka apoptosis-ka unugyada si fudud uma hawl galo.Si kale haddii loo dhigo, Ganoderma lucidum triterpenes waxay xoojisaa iska caabbinta walbahaarka ee unugyada dareemayaasha maskaxda, taasoo ka dhigaysa inay aad u awoodaan inay sii noolaadaan oo ay ku shaqeeyaan jawi daran.

Ganoderma lucidumpolysaccharides ayaa sidoo kale faa'iido leh.

Natiijooyinka cilmi-baarista ee kor ku xusan waxay muujinayaan inGanoderma lucidumtriterpenoids, ka dib marka ay galaan mareenka caloosha iyo mindhicirka iyada oo loo marayo hunguriga, waxay hoos u dhigi kartaa horumarka cudurka Alzheimers iyada oo loo marayo anti-oxidation, anti-apoptosis, iyo anti-neurofibrillary tangles.

Dhab ahaantii, saamayntaGanoderma lucidumpolysaccharides ma ahadaciifnimoMarka loo eego ganoderma lucidum triterpenoids.2017, daraasad si wadajir ah loogu daabacay "Stem Cell Reports" ee Jaamacadda Tongji iyo Akadeemiyada Sayniska ee Shiinaha ayaa caddeeyay in dayactirka muddada-dheerGanoderma lucidumbiyo soosaar amaGanoderma lucidumpolysaccharides waxay hoos u dhigi kartaa kaydka β-amyloid ee maskaxda jiirarka AD, waxay caawisaa faafinta unugyada horudhaca dareemayaasha ee gyrus hippocampal waxayna hoos u dhigtaa hoos u dhaca waxbarashada iyo xusuusta.(Wixii faahfaahin ah, eeg:Ganoderma lucidum polysaccharidesshoos u dhaca garashada ee uu keeno cudurka Alzheimers)

Ganoderma lucidumtriterpenoid iyoGanoderma lucidumpolysaccharides waxay u muuqdaan inay leeyihiin saameyno kala duwan si ay maskaxda uga ilaaliyaan cudurka Alzheimers.KaraaSaamaynta isku dhafan ee labadoodu waxay hoos u dhigtaa horumarka cudurka Alzheimers?

Mar alla markii cudurka Alzheimers uu dhaco, way adagtahay in dib loo celiyo.Si kastaba ha ahaatee, haddiiwewaxay hayn kartaa awoodo garasho oo dheeraad ah, oo ay ku jiraan waxbarashada iyo xusuusta, gudahaannaganolol xaddidan,wewaxaa laga yaabaa inay fursad u helaan inay ka roonaadaan cudurka Alzheimers.

Xigasho

1. Yu N, iyo al.Ganoderma lucidumTriterpenoids (GLTs) Waxay yareeyaan Apoptosis Neuronal iyada oo la joojinayo Dariiqa Calaamadaha ROCK ee APP/PS1 Jiirarka Cudurka Alzheimer ee Transgenic.Oxid Med Cell Longev.2020;2020: 9894037.

2. Huang S, iyo al.Polysaccharides kaGanoderma lucidumKor U Qaadista Shaqada Garashada iyo Kororka Horrayaasha Neural ee Qaabka Jiirka ee Cudurka Alzheimers.Warbixinnada Unugga stem.2017 Jan 10;8(1):84-94.doi: 10.1016/j.stemcr.2016.12.007.

DHAMAAD

Ku saabsan qoraaga/Ms. Wu Tingyao

Wu Tingyao ayaa si toos ah uga warbixinayayGanoderma lucidummacluumaadka tan iyo 1999. Iyadu waa qoraagaKu bogsashada Ganoderma(waxaa lagu daabacay Guriga Daabacaada Caafimaadka Dadweynaha Abriil 2017).

★ Maqaalkan waxa lagu daabacay ogolaansho gaar ah oo uu leeyahay qoraaga ★ Shaqooyinka kor ku xusan lama soo saari karo, lagana saari karo ama looma isticmaali karo siyaabo kale iyada oo aan oggolaansho laga helin qoraaga ★ ku xad-gudbida hadalka sare, qoraagu waxa uu gudan doonaa waajibaadkiisa sharci ee la xidhiidha ★ Asalka qoraalka maqaalkan waxaa ku qoray Shiinaha Wu Tingyao waxaana Ingiriis u turjumay Alfred Liu.Haddii uu jiro farqi u dhexeeya tarjumaada (Ingiriiska) iyo kan asalka ah (Shiineyska), Shiinaha asalka ah ayaa guulaysan doona.Haddii akhristayaasha ay qabaan wax su'aalo ah, fadlan la xiriir qoraaga asalka ah, Ms. Wu Tingyao.