Lub Ib Hlis 29, 2020 / Hunan Provincial Tsev Kho Mob, thiab lwm yam. / Oxidative Medicine thiab Cellular Longevity

Text/Wu Tingyao

Ib txoj kev tshawb fawb luam tawm hauv "Oxidative Medicine thiab Cellular Longevity" los ntawm Hunan Provincial People's Hospital thiab Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomic taw qhia tiasGanoderma lucidumtriterpenua oids(GLTs)tuaj yeem tiv thaiv lub hlwb paj hlwb thiab txo qis kev paub tsis zoo los ntawm Alzheimer's disease (AD) los ntawm cov txheej txheem xws li kev tiv thaiv apoptosis, tiv thaiv oxidation, thiab anti-neurofibrillary tangles.

Ganoderma lucidumtriterpenua oids ncua kev txawj ntse poob rau hauvcov neeg mob nrogAlzheimer tus kab mob.

Ua ntej, rtshawb nrhiav nojGanoderma lucidumtriterpenoids (GLTs) rau Alzheimer's disease (AD) nas uas tau tsim cov tsos mob ntxov. Tom qab60 hnub, lawvkuaj lub peev xwm ntawm cov nas nrog Morris Water Maze (MWM).

Noj kom zoo dua cov yam ntxwv ntawm nas uas ib txwm ntxub dej thiabib txwmsim nrhiav qhov chaw kom tsis txhob muaj dej, cov kws tshawb fawb tau ua Morris Water Maze, uas yog los teeb tsa lub chaw so hauv lub pas dej loj loj los xam qhov deb ntawm cov nas ua luam dej thiab lub sijhawm lawv siv los nrhiav covsoplatform raws li indexes los txiav txim qhov kev txawj ntse abilityogntawm nas.Yog tias cov nas tsis tuaj yeem nrhiav tau lub platform so (hauv ob feeb), cov kws tshawb fawb yuav pab qhiaecov nas mus rau lub platform.

Txawm hais tias qhov pib ntawm kev nkag mus rau hauv dej sib txawv txhua lub sijhawm, cov nas ib txwm tseem tuaj yeem nrhiav qhov chaw so sai sai los ntawm kev paub niaj hnub.Qhov kev sim no tau ua ib zaug ib hnub rau tag nrho cuaj hnub.Xam tag nrho cov qhab nia nruab nrab, cov kws tshawb fawb pom tias AD nas (AD Group) yuav tsum siv sijhawm ntev li ob zaug.as los yog ua luam dej peb lub hlis twg ntev tshaj li cov nas ib txwm (tswj pab pawg) kom nrhiav tau lub platform so, uas qhia tau hais tias kev paub txog kev ua haujlwm ntawm lub hlwb ntawm AD nas yog qhov tsis zoo.

Txawm li cas los xij, AD nas noj nrog cov koob tshuaj siab (1.4g / kg ib hnub) ntawm GLTs yuav luag tib lub sijhawm thiab ua luam dej nyob deb.tusso platform raws li cov nas ib txwm muaj thiab cov nas AD (Pab pawg tswj hwm sab hnub poob) tau noj nrog cov tshuaj tas li txhua hnub (Daim duab 1 ~ 2).

(Lub sijhawm tsawg dua, qhov zoo dua qhov kev txawj ntse)

(Qhov kev ncua deb tsawg dua, qhov zoo dua qhov kev txawj ntse)

Hnub tom qab tom qab qhov kawg ntawm qhov kev sim saum toj no, cov kws tshawb fawb tau tshem tawm qhov chaw so hauv lub pas dej thiab muab cov nas tso rau hauv dej rau ob feeb.

Vim muaj cuaj hnub dhau los ntawm kev paub dhau los, cov nas ib txwm nco qab qhov chaw qub ntawm lub platform thiab siv sijhawm ntau dua ua luam dej nyob ib puag ncig qhov chaw qub los nrhiav "plab ploj ploj" thaum Alzheimer's nas swam lub hom phiaj.

Hauv qhov sib piv, Alzheimer's nas tiv thaiv los ntawm GLTs coj zoo li cov nas ib txwm noj tsawg (0.35 g / kg hauv ib hnub) lossis cov koob tshuaj siab (1.4 g / kg ib hnub) thiab tau qhab nia zoo ib yam li cov nas MD noj nrog cov tshuaj sab hnub poob ( Daim duab 3 txog 4).

(Lub sijhawm nyob ntev, qhov zoo dua qhov kev txawj ntse)

(Qhov ntau dua qhov sib piv, qhov zoo dua qhov kev txawj ntse)

Ganoderma lucidumtriterpenua oids tswj kev ncaj ncees ntawm paj hlwb.

Kev poob qis thiab kev muaj peev xwm nco tau yog qhov kev paub ntxov tshaj plaws ntawm kev poob qis (kev tsis sib haum xeeb) hauv cov neeg mob Alzheimer's disease, thiab cov paj hlwb ua haujlwm ntawm cov haujlwm no nyob hauv hippocampal gyrus.Yog li ntawd, tom qab cov kws tshawb fawb tau ua tiav cov kev sim saum toj no, lawv tau txiav cov nas hlwb rau kev kuaj ntxiv.

Cov txiaj ntsig tau pom tias cov paj hlwb hauv hippocampal gyrus ntawm cov nas ib txwm yog cov txheej txheem zoo, sib xws hauv qhov loj me, tsis tu ncua ntawm cov tsos, thiab lawv cov cell membranes thiab nuclei tau meej meej demarcated;Cov paj hlwb hauv hippocampal gyrus ntawm AD nas yog cov txheej txheem tsis sib xws, qhov sib txawv ntawm qhov ntau thiab tsawg, qhov tsis zoo ntawm cov tsos, txo qis hauv tus lej, thiab nws cov qauv yog pom tseeb puas.

Txawm li cas los xij, qhov xwm txheej no tsis tshwm sim hauv AD nas noj Ganoderma lucidum triterpenua oids.Cov hlwb neuronal nyob rau hauv lawv cov hippocampal gyrus tseem tswj tau qhov siab ntawm kev ncaj ncees, thiab tsis muaj qhov pom tseeb ntawm tes necrosis, qhia tias.Ganoderma lucidumtriterpenua oids muaj kev tiv thaiv ntawm hippocampal gyrus (Daim duab 5).

Ganoderma lucidumtriterpenua oids txo neurofibrillary tangles.

Nyob rau tib lub sijhawm, cov kws tshawb fawb kuj pom tias muaj pes tsawg tus neurofibrillary tangles nyob rau hauv cerebral cortex ( khaws cia ntev ntev) thiab hippocampal gyrus cov ntaub so ntswg hauv AD nas tiv thaiv los ntawmGanoderma lucidumtriterpenua oids tau qis dua qhov uas tsis kho AD nas (Daim duab 6).

Neurofibrillary tangles yog ib qho ntawm cov tsos mob tseem ceeb ntawm Alzheimer's kab mob.Tsis zoo li amyloid deposits uas tshwm sim sab nraum lub hlwb, neurofibrillary tangles tshwm sim nyob rau hauv paj hlwb vim kev hloov ntawm "tau protein".

Raws li ib txwm muaj, tau protein khi rau cytoskeleton (microtubules) los pab tsim thiab ruaj khov ntawm cytoskeleton.Txawm li cas los xij, tau protein ntau hauv lub hlwb ntawm cov neeg mob Alzheimer's tus kab mob yuav hloov pauv thiab tsis tuaj yeem khi rau cytoskeleton.Raws li qhov tshwm sim, tau cov protein ntau yuav sib sau ua ke los ua cov hu ua "neurofibrillary tangles", uas suav nrog hauv cov hlwb thiab cuam tshuam nrog kev ua haujlwm ntawm cov hlwb.Lub cytoskeleton uas tsis muaj tao protein yuav maj mam hloov zuj zus thiab tawg, ua rau kev tuag ntawm tes.

Tus naj npawb ntawm neurofibrillary tangles qhia txog qib ntawm kev tsis zoo ntawm Alzheimer's disease.Yog li ntawd, Ganoderma lucidum triterpenoids tuaj yeem inhibit qhov tsim ntawm neurofibrillary tangles, uas yuav tsum yog ib qho ntawm cov txheej txheem tseem ceeb rauGanoderma lucidumtriterpenoids kom ncua kev paub txog kev poob qis hauv Alzheimer's kab mob.

Ganoderma lucidumtriterpenua oids txo cov paj hlwb apoptosis.

Los yogβ-amyloid deposition los yog neurofibrillary tangles yuav pib qhov kev pab cuam tua tus kheej ntawm tes thiab txhawb lub apoptosis ntawm paj hlwb.Raws li ntau cov paj hlwb tuag, ntau lub zog poob, thiab kev paub txog dekho mobtshwm sim los ntawm Alzheimer's kab mob yuav hnyav dua.

Los ntawm kev tshuaj xyuas ntawm hippocampal gyrus cov ntaub so ntswg ntawm txhua pawg ntawm cov nas sim, nws tuaj yeem pom tias qhov kev tuag ntawm cov hlab ntsha hauv cov nas AD yog ntau tshaj plaub npaug ntawm cov nas ib txwm muaj hnub nyoog tib yam;txawm tias high-doseGanodermalucidumtriterpenua oids ua tsis tau kiag lipkho qhov txawv txav apoptosis ntawm paj hlwb,lawvhavetau muaj peev xwm txo tau qhov kev puas tsuaj ib nrab, thiab cov txiaj ntsig zoo piv rau cov tshuaj sab hnub poob (Daim duab 7).

Cov kws tshawb fawb tau soj ntsuam ntxiv thiab pom tias hauv AD nas tswj los ntawmGanoderma lucidumtriterpenoids, lub paj hlwb hlwb muaj zog tiv thaiv oxidant mechanism los tawm tsam oxidative puas los ntawm β-amyloid protein thiab cell apoptosis mechanism tsis yooj yim qhib.Hauv lwm lo lus, Ganoderma lucidum triterpenes ntxiv dag zog rau kev ntxhov siab ntawm lub hlwb cov paj hlwb, ua rau lawv muaj peev xwm muaj sia nyob thiab ua haujlwm hauv ib puag ncig hnyav.

Ganoderma lucidumpolysaccharides kuj tseem siv tau.

Cov kev tshawb fawb saum toj no qhia tau tiasGanoderma lucidumtriterpenoids, tom qab nkag mus rau hauv lub plab zom mov los ntawm txoj hlab pas, tuaj yeem ua rau qeeb ntawm Alzheimer's kab mob los ntawm kev tiv thaiv oxidation, anti-apoptosis, thiab anti-neurofibrillary tangles.

Qhov tseeb, cov nyhuv ntawmGanoderma lucidumpolysaccharides tsis yogtsis muaj zogtshaj li ntawm Ganoderma lucidum triterpenua oids.Hauv xyoo 2017, ib txoj kev tshawb fawb tau luam tawm hauv "Stem Cell Reports" los ntawm Tongji University thiab Suav Academy ntawm Kev Tshawb Fawb tau ua pov thawj tias kev saib xyuas mus ntev nrog.Ganoderma lucidumdej extract los yogGanoderma lucidumpolysaccharides tuaj yeem txo β-amyloid deposits nyob rau hauv lub hlwb ntawm AD nas, pab lub proliferation ntawm paj hlwb precursor hlwb nyob rau hauv lub hippocampal gyrus thiab slows down poob ntawm kev kawm thiab nco.(Yog xav paub ntxiv, saib:Ganoderma lucidum polysaccharidestxo kev txawj ntse poob los ntawm Alzheimer's kab mob)

Ganoderma lucidumtriterpenoids thiabGanoderma lucidumpolysaccharides zoo li muaj qhov sib txawv hauv kev tiv thaiv lub hlwb nrog Alzheimer's kab mob.Ua taukev sib xyaw ua ke ntawm ob qho tib si ua rau kev loj hlob ntawm Alzheimer's disease?

Thaum Alzheimer's tus kab mob tshwm sim, nws nyuaj rau thim rov qab.Txawm li cas los xij, yog tiaswetuaj yeem khaws ntau lub peev xwm kev txawj ntse, suav nrog kev kawm thiab kev nco, hauvpebtxwv lub neej,wetej zaum yuav muaj txoj hauv kev zoo dua nrog Alzheimer's disease.

Qhov chaw

1. Yu N, et al.Ganoderma lucidumTriterpenoids (GLTs) Txo Neuronal Apoptosis ntawm Inhibition of ROCK Signal Pathway hauv APP/PS1 Transgenic Alzheimer's Disease nas.Oxid Med Cell Longev.2020;Xyoo 2020: 9894037.

2. Huang S, et al.Polysaccharides los ntawmGanoderma lucidumTxhawb kev paub txog kev ua haujlwm thiab Neural Progenitor Proliferation hauv nas qauv ntawm Alzheimer's Disease.Stem Cell Reports.2017 Jan 10; 8(1:84-94.doi: 10.1016/j.stemcr.2016.12.007.

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Hais txog tus sau/ Ms. Wu Tingyao

Wu Tingyao tau tshaj tawm thawj zaugGanoderma lucidumcov ntaub ntawv txij thaum 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).

★ Kab lus no yog luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau ★ Cov hauj lwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis tau txais kev tso cai los ntawm tus sau ★ Kev ua txhaum ntawm cov lus saum toj no, tus sau yuav ua raws li nws cov luag haujlwm raws cai ★ Thawj Cov ntawv ntawm tsab xov xwm no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.