29 Mutarama 2020 / Ibitaro byabaturage byintara ya Hunan, nibindi / Ubuvuzi bwa Oxidative hamwe no kuramba kwa selile

Inyandiko / Wu Tingyao

Ubushakashatsi bwasohotse muri “Oxidative Medicine and Cellular Longevity” bwakozwe n’ibitaro by’abaturage bo mu Ntara ya Hunan na Laboratoire y’Intara ya Hunan y’ubuvuzi bwihutirwa n’ubuvuzi bukomeye Metabonomic yerekanye koGanoderma lucidumtriterpenoids(GLTs)Irashobora kurinda ingirabuzimafatizo zo mu bwonko no kugabanya ubumuga bwo mu mutwe buterwa n'indwara ya Alzheimer (AD) hakoreshejwe uburyo nka anti-apoptose, anti-okiside, na anti-neurofibrillary tangles.

Ganoderma lucidumtriterpenoids gutinda kugabanuka kwubwenge muriabarwayi hamweIndwara ya Alzheimer.

Ubwa mbere, rabashakashatsi baragaburiweGanoderma lucidumtriterpenoids (GLTs) ku mbeba za Alzheimer (AD) zagize ibimenyetso hakiri kare. NyumaIminsi 60, boyagerageje ubushobozi bwo kumenya imbeba hamwe na Morris Water Maze (MWM).

Kwifashisha ibiranga imbeba zisanzwe zanga amazi kandiburigihegerageza ushake aho wirinda amazi, abashakashatsi bakoze Morris Water Maze, aribwo gushyiraho urubuga rwo kuruhukira muri pisine nini izenguruka kugirango babaze intera imbeba zoga nigihe bamara mugushakishakuruhukaurubuga nkibipimo byo guca imanza abilitiesy'imbeba.Niba imbeba zarashoboye kubona ikibanza cyo kuruhukiramo (muminota ibiri), abashakashatsi bazafasha kuyoboraeimbeba kuri platifomu.

Nubwo aho gutangirira kwinjira mumazi bitandukanye buri gihe, imbeba zisanzwe zirashobora kubona byihuse urubuga rwo kuruhuka binyuze muburambe bwa buri munsi.Ubushakashatsi nkubu bwakozwe rimwe kumunsi iminsi icyenda yose.Kubara amanota yose ugereranije, abashakashatsi basanze imbeba za AD (Itsinda rya AD) zigomba kumara kabirias cyangwa koga bitatu bya kane kurenza imbeba zisanzwe (itsinda rishinzwe kugenzura) kugirango ubone urubuga rwo kuruhukira, byerekana ko imikorere yubwenge bwubwonko bwimbeba za AD yangiritse cyane.

Ariko, imbeba za AD zagaburiwe na dosiye nyinshi (1,4g / kg kumunsi) za GLTs zafashe igihe kimwe nintera yo koga kugirango ziboneiikiruhuko cyo kuruhuka nkimbeba zisanzwe nimbeba za AD (itsinda rishinzwe kugenzura imiti yuburengerazuba) zigaburirwa na donepezil burimunsi (Ishusho 1 ~ 2).

(Igihe gito gisabwa, nubushobozi bwo kumenya)

(Intera nkeya isabwa, nubushobozi bwo kumenya)

Bukeye bwaho nyuma yubushakashatsi bwavuzwe haruguru, abashakashatsi bakuyeho ikiruhuko cyo kuruhukira muri pisine bashyira imbeba mumazi muminota ibiri.

Bitewe niminsi icyenda y'uburambe, imbeba zisanzwe zibukaga ahahoze hambere kandi zimara umwanya munini wo koga hafi yumwanya wambere kugirango zishakishe "urubuga ruzimira" mugihe imbeba za Alzheimer zoga nta ntego.

Ibinyuranye, imbeba za Alzheimer zirinzwe na GLTs yitwaye cyane nkimbeba zisanzwe haba kuri dosiye nkeya (0,35 g / kg kumunsi) cyangwa dosiye nyinshi (1,4 g / kg kumunsi) kandi zatsindiye hafi kimwe nizo mbeba MD zagaburiwe nubuvuzi bwiburengerazuba ( Igishushanyo cya 3 kugeza 4).

(Umwanya muremure, niko ubushobozi bwo kumenya)

(Iyo igipimo kiri hejuru, nubushobozi bwo kumenya)

Ganoderma lucidumtriterpenoids kugumana ubusugire bwimikorere ya selile.

Kugabanuka kwimyigire nubushobozi bwo kwibuka nubushobozi bwambere bwubwenge bwo kugabanuka (disorder) kubarwayi barwaye Alzheimer, kandi selile nervice zishinzwe iki gikorwa ziri muri girus ya hippocampal.Kubwibyo, abashakashatsi bamaze kurangiza ubushakashatsi bwavuzwe haruguru, batandukanije ubwonko bwimbeba kugirango basuzume.

Ibisubizo byerekanaga ko ingirabuzimafatizo zo mu bwoko bwa hippocampal girus yimbeba zisanzwe zitunganijwe neza, zingana mubunini, zisanzwe zigaragara, kandi uturemangingo twa selile na nuclei bitandukanijwe neza;selile nervice muri hippocampal girus yimbeba ya AD itunganijwe neza, itandukanye mubunini, idasanzwe muburyo bugaragara, yagabanutse cyane mumibare, kandi biragaragara ko imiterere yayo yangiritse.

Ariko, ibi bintu ntibyagaragaye mu mbeba za AD zirya Ganoderma lucidum triterpenoids.Ingirabuzimafatizo zo mu bwoko bwa hippocampal girus zarakomeje kuba inyangamugayo zo mu rwego rwo hejuru, kandi nta na nérosose yagaragaye, byerekana koGanoderma lucidumtriterpenoids yagize ingaruka zo gukingira girus ya hippocampal (Ishusho 5).

Ganoderma lucidumtriterpenoids kugabanya neurofibrillary tangles.

Muri icyo gihe, abashakashatsi basanze kandi umubare w’imitsi ya neurofibrillary muri cortex yubwonko (kubika ububiko bwigihe kirekire) hamwe nuduce twa hippocampal girus mu mbeba za AD zirinzwe naGanoderma lucidumtriterpenoids yari hasi cyane ugereranije nimbeba za AD zitavuwe (Ishusho 6).

Indwara ya Neurofibrillary ni kimwe mu bimenyetso nyamukuru byindwara ya Alzheimer.Bitandukanye na amyloide yabitswe hanze ya selile, tangles ya neurofibrillary iba mu ngirabuzimafatizo bitewe na mutation ya “tau protein”.

Mubihe bisanzwe, tau protein ihuza cytoskeleton (microtubules) kugirango ifashe gushiraho no gutuza kwa cytoskeleton.Nyamara, tau proteine ​​mu bwonko bw'abarwayi barwaye Alzheimer izahinduka kandi ntishobora guhuza na cytoskeleton.Kubera iyo mpamvu, poroteyine ya tau izegeranya mu matsinda kugira ngo ikore icyo bita "neurofibrillary tangles", yegeranya mu ngirabuzimafatizo kandi ikabangamira imikorere ya selile.Cytoskeleton idafite proteine ​​ya tao izagenda igoreka buhoro buhoro kandi isenyuke, biganisha ku rupfu.

Umubare wa tangles ya neurofibrillary yerekana urugero rwo kwangirika kwindwara ya Alzheimer.Kubwibyo, Ganoderma lucidum triterpenoide irashobora kubuza ishingwa rya neurofibrillary tangles, igomba kuba imwe muburyo bwingenzi kuriGanoderma lucidumtriterpenoids kugirango itinde kugabanuka kwubwenge bwindwara ya Alzheimer.

Ganoderma lucidumtriterpenoids kugabanya selile selile apoptose.

Cyangwaβ-amyloide deposition cyangwa neurofibrillary tangles bizatangiza gahunda yo kwiyahura kwakagari kandi biteze apoptose yingirabuzimafatizo.Nkuko ingirabuzimafatizo nyinshi zipfa, imirimo myinshi iratakara, hamwe na cognitive declinebiterwa n'indwara ya Alzheimer iba ikomeye cyane.

Duhereye ku isesengura rya hippocampal girus tissue ya buri tsinda ryimbeba zigeragezwa, urashobora gusanga igipimo cyurupfu rwingirabuzimafatizo mu mbeba za AD cyikubye inshuro zirenga enye imbeba zisanzwe zingana;nubwo ari byinshiGanodermalucidumtriterpenoids ntishobora rwoseprevent apoptose idasanzwe ya selile nervice,bohavebashoboye kugabanya ibyangiritse, kandi ingaruka ziragereranywa nubuvuzi bwiburengerazuba (Ishusho 7).

Abashakashatsi bakomeje gusesengura basanga muri AD imbeba zabungabunzwe naGanoderma lucidumtriterpenoide, ingirabuzimafatizo zo mu bwonko zifite uburyo bukomeye bwo kurwanya anti-okiside mu kurwanya ibyangiza okiside iterwa na protein-amyloide proteine ​​kandi uburyo bwa apoptose selile ntibukora byoroshye.Mu yandi magambo, Ganoderma lucidum triterpène ikomeza imbaraga zo guhangana ningirabuzimafatizo zubwonko bwubwonko, bigatuma barushaho kubaho no gukorera ahantu habi.

Ganoderma lucidumpolysaccharide nayo ifite akamaro.

Ibisubizo byubushakashatsi byavuzwe haruguru byerekana koGanoderma lucidumtriterpenoide, nyuma yo kwinjira mu nzira ya gastrointestinal binyuze muri esofagusi, irashobora kudindiza iterambere ryindwara ya Alzheimer ikoresheje anti-okiside, anti-apoptose, hamwe na tangles anti-neurofibrillary.

Mubyukuri, ingaruka zaGanoderma lucidumpolysaccharide ntabwointege nkekurenza iya Ganoderma lucidum triterpenoids.Muri 2017, ubushakashatsi bwatangajwe hamwe muri “Stem Cell Reports” bwakozwe na kaminuza ya Tongji na Academy ya siyanse y'Ubushinwa bwerekanye ko kubungabunga igihe kirekire hamweGanoderma lucidumkuvoma amazi cyangwaGanoderma lucidumpolysaccharide irashobora kugabanya β-amyloide yabitswe mubwonko bwimbeba za AD, ifasha ikwirakwizwa ryingirabuzimafatizo ya nervurs muri girus ya hippocampal kandi igabanya umuvuduko wo kwiga no kwibuka.(Ushaka ibisobanuro birambuye, reba:Ganoderma lucidum polysaccharideskugabanya kugabanuka kwubwenge guterwa n'indwara ya Alzheimer)

Ganoderma lucidumtriterpenoids naGanoderma lucidumpolysaccharide isa nkaho igira ingaruka zitandukanye mukurinda ubwonko n'indwara ya Alzheimer.Birashobokaingaruka zifatika zombi zitinda iterambere ryindwara ya Alzheimer?

Indwara ya Alzheimer imaze kubaho, biragoye kuyihindura.Ariko, nibaweirashobora kugumana ubushobozi bwubwenge bwinshi, harimo kwiga no kwibuka, muriyacuubuzima bugarukira,weirashobora kugira amahirwe yo gukira nindwara ya Alzheimer.

Inkomoko

1. Yu N, n'abandi.Ganoderma lucidumTriterpenoids (GLTs) Kugabanya Apoptose ya Neuronal ukoresheje Kubuza inzira ya signal ya ROKK muri APP / PS1 Imbeba zindwara ya Alzheimer ya Transgenic.Oxid Med Cell Longev.2020;2020: 9894037.

2. Huang S, n'abandi.Polysaccharide kuvaGanoderma lucidumDutezimbere Imikorere Yubwenge no Gukwirakwiza Neural Progenitor Ikwirakwizwa ryimbeba Model yindwara ya Alzheimer.Raporo y'akagari.2017 Mutarama 10; 8 (1): 84-94.doi: 10.1016 / j.stemcr.2016.12.007.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao

Wu Tingyao yagiye atanga raporo imbonankuboneGanoderma lucidumamakuru kuva 1999. Niwe mwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).

★ Iyi ngingo yasohowe ku ruhushya rwihariye rw’umwanditsi works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mu bundi buryo utabiherewe uburenganzira n’umwanditsi ★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakomeza inshingano zijyanye n’amategeko ★ Umwimerere inyandiko yiyi ngingo yanditswe mu gishinwa na Wu Tingyao ihindurwa mu Cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.