Janairu 29, 2020 / Asibitin Jama'ar lardin Hunan, da sauransu / Magungunan Oxidative da Tsawon Rayuwa

Rubutu/Wu Tingyao

Wani bincike da aka buga a cikin "Magungunan Oxidative da Tsawon Rayuwa" na Asibitin Jama'ar lardin Hunan da Lardin Hunan Key Laboratory of Emergency and Critical Care Metabonomic ya nuna cewa.Ganoderma lucidumtriterpenoids(GLTs)na iya kare ƙwayoyin jijiyoyi na kwakwalwa da kuma rage rashin fahimta da cutar Alzheimer (AD) ke haifarwa ta hanyoyi kamar anti-apoptosis, anti-oxidation, da anti-neurofibrillary tangles.

Ganoderma lucidumtriterpenoids jinkirta fahimi raguwa a cikimarasa lafiya daCutar Alzheimer.

Na farko, rmasu binciken sun ciyarGanoderma lucidumtriterpenoids (GLTs) zuwa cutar Alzheimer (AD) berayen da suka fara bayyanar cututtuka. BayanKwanaki 60, sugwada iyawar fahimi na beraye tare da Morris Water Maze (MWM).

Yin amfani da halayen berayen da ke ƙin ruwa a zahiri dakullumkokarin nemo wurin gujewa ruwa, masu binciken sun gudanar da aikin Morris Water Maze, wanda shine kafa wurin hutawa a cikin wani katafaren tafkin madauwari don yin lissafin tazarar berayen da kuma lokacin da suke kashewa wajen gano abubuwanhutawadandamali a matsayin fihirisa don yin hukunci da iyawar fahimiina beraye.Idan berayen sun kasa samun dandalin hutawa (a cikin mintuna biyu), masu binciken zasu taimaka jagoraeberayen zuwa dandalin.

Kodayake farkon shigar ruwa ya bambanta kowane lokaci, beraye na yau da kullun na iya samun dandamalin hutu da sauri ta hanyar gogewar yau da kullun.An gudanar da irin wannan gwajin sau ɗaya a rana tsawon kwanaki tara.Ƙididdigar duk maki a matsakaici, masu binciken sun gano cewa AD beraye (AD Group) dole ne su ciyar sau biyu tsawon lokacias ko yin iyo kashi uku cikin huɗu fiye da ɓeraye na al'ada (ƙungiyar sarrafawa) don nemo dandamalin hutawa, wanda ke nuna cewa aikin fahimi na kwakwalwar berayen AD ya ragu sosai.

Koyaya, AD berayen da aka ciyar tare da manyan allurai (1.4g/kg a kowace rana) na GLTs sun ɗauki kusan lokaci guda da nisan iyo don nemo.dadandalin hutawa a matsayin mice na al'ada da kuma AD mice (Rukunin kula da magunguna na Yammacin Turai) tare da donpezil kowace rana (Hoto 1 ~ 2).

(Ƙarancin lokacin da ake buƙata, mafi kyawun ƙwarewar fahimi)

(Ƙasashen tazarar da ake buƙata, mafi kyawun ƙwarewar fahimi)

Washegari bayan ƙarshen gwajin da aka yi a sama, masu binciken sun cire dandalin hutawa a cikin tafkin kuma suka sanya berayen a cikin ruwa na mintuna biyu.

Saboda gogewar kwanaki tara da suka gabata, beraye na yau da kullun sun tuna asalin wurin dandali kuma sun ƙara yin iyo a kusa da ainihin wurin don neman "dandalin da ba ya ɓacewa" yayin da berayen Alzheimer na iyo ba tare da cin nasara ba.

Sabanin haka, berayen Alzheimer da GLTs ke karewa sun yi kama da berayen na yau da kullun ko dai a ƙananan allurai (0.35 g/kg a kowace rana) ko manyan allurai (1.4 g/kg a kowace rana) kuma sun zira kusan iri ɗaya da waɗanda berayen MD da aka ciyar da magungunan yamma. Hoto na 3 zuwa 4).

(Yawancin tsayin daka, mafi kyawun iyawar fahimta)

(Mafi girman girman, mafi kyawun iyawar fahimta)

Ganoderma lucidumtriterpenoids kula da mutuncin jijiyoyi.

Ragewar ilmantarwa da ƙwaƙwalwar ajiya shine raguwar aikin fahimi na farko (rashin lafiya) a cikin marasa lafiya da cutar Alzheimer, kuma ƙwayoyin jijiya da ke kula da wannan aikin suna cikin gyrus hippocampal.Don haka, bayan da masu binciken suka kammala gwaje-gwajen da suka gabata, sun rarraba kwakwalwar linzamin kwamfuta don ƙarin bincike.

Sakamakon ya nuna cewa ƙwayoyin jijiya a cikin gyrus hippocampal na berayen al'ada an tsara su da kyau, daidaitattun girman girman su, na yau da kullum a bayyanar, kuma ƙwayoyin jikinsu da ƙananan ƙwayoyin su an tsara su a fili;Kwayoyin jijiyoyi a cikin gyrus hippocampal na AD beraye suna da tsari mara kyau, daban-daban masu girma dabam, ba a saba da su ba, kamanni suna raguwa sosai, kuma tsarinsa ya lalace.

Koyaya, wannan yanayin bai bayyana a cikin berayen AD suna cinye Ganoderma lucidum triterpen baoids.Kwayoyin neuronal a cikin gyrus na hippocampal har yanzu suna da babban matsayi na mutunci, kuma babu wani fili necrosis cell, yana nuna cewa.Ganoderma lucidumtriterpenoids yana da tasirin kariya akan gyrus hippocampal (Hoto 5).

Ganoderma lucidumtriterpenoids rage neurofibrillary tangles.

A lokaci guda, masu binciken sun kuma gano cewa adadin neurofibrillary tangles a cikin kwakwalwar kwakwalwa (ajiya na dogon lokaci memory) da gyrus na hippocampal a cikin AD berayen da aka kiyaye su.Ganoderma lucidumtriterpenoids ya ragu sosai fiye da wancan a cikin berayen AD da ba a kula da su ba (Hoto na 6).

Neurofibrillary tangles ɗaya ne daga cikin manyan alamun cutar Alzheimer.Ba kamar amyloid adibas da ke faruwa a waje da sel, neurofibrillary tangles faruwa a cikin jijiya Kwayoyin saboda maye gurbin "tau protein".

A ƙarƙashin yanayi na al'ada, furotin tau yana ɗaure zuwa cytoskeleton (microtubules) don taimakawa samuwar cytoskeleton da kwanciyar hankali.Duk da haka, furotin tau a cikin kwakwalwar marasa lafiya masu cutar Alzheimer za su rikide kuma ba zai iya ɗaure ga cytoskeleton ba.A sakamakon haka, furotin tau zai tara cikin gungu don samar da abin da ake kira "neurofibrillary tangles", wanda ke taruwa a cikin sel kuma yana tsoma baki tare da aikin sel.Cytoskeleton da ba shi da furotin tao zai zama sannu a hankali ya zama gurɓatacce kuma ya tarwatse, yana haifar da mutuwar tantanin halitta.

Yawan tangles na neurofibrillary yana nuna girman lalacewar cutar Alzheimer.Saboda haka, Ganoderma lucidum triterpenoids zai iya hana samuwar neurofibrillary tangles, wanda ya kamata ya zama daya daga cikin mahimman hanyoyin don magance cututtuka.Ganoderma lucidumtriterpenoids don jinkirta raguwar fahimi a cikin cutar Alzheimer.

Ganoderma lucidumtriterpenoids rage jijiya cell apoptosis.

Ko daiβ-amyloid deposition ko neurofibrillary tangles zai fara shirin kashe kansa na tantanin halitta kuma ya inganta apoptosis na ƙwayoyin jijiya.Yayin da ƙwayoyin jijiya suka mutu, ƙarin ayyuka suna ɓacewa, da fahimi delayicutar Alzheimer ke haifarwa yana ƙara tsanani.

Daga nazarin ƙwayar gyrus hippocampal na kowane rukuni na berayen gwaji, ana iya gano cewa adadin mutuwar ƙwayoyin jijiya a cikin berayen AD ya ninka fiye da sau huɗu na al'ada na al'ada na zamani;ko da yake yawan kashiGanodermalucidumtriterpenoids ba zai iya gaba dayapsake dawo da apoptosis mara kyau na ƙwayoyin jijiya,suhaveya iya rage rabin lalacewa, kuma tasirin yana kwatankwacin na magungunan yamma (Hoto 7).

Masu binciken sun kara yin nazari kuma sun gano cewa a cikin berayen AD suna kiyaye taGanoderma lucidumtriterpenoids, sel jijiya na kwakwalwa suna da tsarin anti-oxidant mai ƙarfi don magance lalacewar oxidative da furotin β-amyloid ke haifar da kuma tsarin apoptosis tantanin halitta ba a iya kunna shi cikin sauƙi.A wasu kalmomi, Ganoderma lucidum triterpenes yana ƙarfafa juriya na ƙwayoyin jijiyoyi na kwakwalwa, yana sa su iya rayuwa da kuma aiki a cikin yanayi mai tsanani.

Ganoderma lucidumpolysaccharides kuma suna da amfani.

Sakamakon binciken da ke sama ya nuna cewaGanoderma lucidumtriterpenoids, bayan shigar da gastrointestinal tract ta cikin esophagus, zai iya rage ci gaban cutar Alzheimer ta hanyar anti-oxidation, anti-apoptosis, da anti-neurofibrillary tangles.

A gaskiya ma, tasirinGanoderma lucidumpolysaccharides bamai raunifiye da na Ganoderma lucidum triterpenoids.A cikin 2017, wani binciken da aka buga tare a cikin "Stem Cell Reports" na Jami'ar Tongji da Cibiyar Kimiyya ta kasar Sin ta tabbatar da cewa kulawa na dogon lokaci tare daGanoderma lucidumcire ruwa koGanoderma lucidumpolysaccharides na iya rage β-amyloid adibas a cikin kwakwalwar AD berayen, taimaka yaduwa na jijiya precursor sel a cikin hippocampal gyrus da kuma rage gudu na koyo da memory.(Don ƙarin bayani, duba:Ganoderma lucidum polysaccharidessrage fahimi da cutar Alzheimer ke haifarwa)

Ganoderma lucidumtriterpenoidGanoderma lucidumpolysaccharides da alama suna da tasiri daban-daban wajen kare kwakwalwa tare da cutar Alzheimer.CanHaɗin gwiwar tasirin biyu yana rage jinkirin ci gaban cutar Alzheimer?

Da zarar cutar Alzheimer ta faru, yana da wuya a iya juyar da shi.Duk da haka, idanwezai iya riƙe ƙarin ƙwarewar fahimi, gami da koyo da ƙwaƙwalwa, a cikinamuiyakantaccen rayuwa,wena iya samun damar samun lafiya tare da cutar Alzheimer.

Source

1. Yu N, et al.Ganoderma lucidumTriterpenoids (GLTs) Rage Apoptosis na Neuronal ta hanyar Hana Hanyar Siginar ROCK a cikin APP/PS1 Cutar Cutar Cutar Alzheimer ta Transgenic.Oxid Med Cell Longev.2020;2020: 9894037.

2. Huang S, et al.Polysaccharides dagaGanoderma lucidumHaɓaka Ayyukan Fahimi da Yaɗuwar Ƙwararrun Jijiya a Model Mouse na Cutar Alzheimer.Rahoton Kwayoyin Stem.2017 Jan 10; 8 (1): 84-94.doi: 10.1016/j.stemcr.2016.12.007.

KARSHE

Game da marubucin / Ms. Wu Tingyao

Wu Tingyao ya kasance yana bayar da rahoto da farkoGanoderma lucidumbayanai tun 1999. Ita ce marubucinWaraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).

★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubuci ★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cirewa ko amfani da su ta wasu hanyoyi ba tare da izini daga marubucin ba. Wu Tingyao ne ya rubuta wannan labarin da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.