Jenụwarị 29, 2020 / Hospitallọ ọgwụ ndị mmadụ na mpaghara Hunan, wdg / Ọgwụ Oxidative na Ogologo ndụ Cellular

Ederede/Wu Tingyao

Nnyocha e bipụtara na "Oxidative Medicine and Cellular Longevity" nke Hunan Provincial People's Hospital na Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomic rụtụrụ aka naGanoderma lucidumtriterpenmmas(GLTs)nwere ike ichekwa mkpụrụ ndụ akwara ụbụrụ ma belata nhụsianya nke ọrịa Alzheimer (AD) kpatara site na usoro dị ka mgbochi apoptosis, mgbochi oxidation, na mgbochi neurofibrillary tangles.

Ganoderma lucidumtriterpenmmas igbu oge nghọta mbelata nandị ọrịa nwereỌrịa Alzheimer.

Mbụ, rndị nyocha nriGanoderma lucidumtriterpenoids (GLTs) ruo ọrịa Alzheimer (AD) ụmụ oke ndị mepụtara mgbaàmà mbụ. MgbeỤbọchị 60, hajiri Morris Water Maze (MWM) nwale ikike ọgụgụ isi nke ụmụ oke.

N'iji njirimara nke ụmụ oke na-akpọ mmiri asị namgbe niilegbalịa ịchọta ebe ị ga-esi gbanarị mmiri, ndị nchọpụta ahụ mere Morris Water Maze, nke bụ ịtọ ebe izu ike n'ime nnukwu ọdọ mmiri okirikiri iji gbakọọ ebe ụmụ oke na-egwu mmiri na oge ha na-etinye n'ịchọta mmiri ozuzo.izu ikeikpo okwu dị ka indexes na-ekpe ikpe na cognitive ikikeeenke oke.Ọ bụrụ na ụmụ oke enweghị ike ịchọta ikpo okwu izu ike (na nkeji abụọ), ndị nchọpụta ga-enyere aka na-eduzieumu oke na ikpo okwu.

Ọ bụ ezie na mmalite maka ịbanye mmiri dị iche n'oge ọ bụla, ụmụ oke nkịtị ka nwere ike ịchọta ikpo okwu izu ike ngwa ngwa site na ahụmahụ kwa ụbọchị.A na-eme nnwale dị otú ahụ otu ugboro n'ụbọchị maka ngụkọta nke ụbọchị itoolu.N'ịgbakọ akara niile na nkezi, ndị nyocha ahụ chọpụtara na ụmụ oke AD (AD Group) ga-anọrịrị ugboro abụọas ma ọ bụ igwu mmiri ụzọ atọ n'ụzọ anọ karịa ụmụ oke nkịtị (òtù njikwa) iji chọta ebe izu ike, nke na-egosi na ọrụ ọgụgụ isi nke ụbụrụ AD ụmụ oke na-emebi emebi nke ukwuu.

Agbanyeghị, ụmụ oke AD ejiri nnukwu doses (1.4g/kg kwa ụbọchị) nke GLT nri were ihe fọrọ nke nta ka ọ bụrụ otu oge na ebe igwu mmiri iji chọta.nkeikpo okwu izu ike dị ka ụmụ oke nkịtị na ụmụ oke AD (òtù ndị na-ahụ maka ọgwụ na Western) na-eri nri na donpezil kwa ụbọchị (Figure 1 ~ 2).

(Obere oge achọrọ, ikike ọgụgụ isi ka mma)

(Obere anya achọrọ, ka ikike nghọta dịkwuo mma)

N'echi ya mgbe njedebe nke nnwale ahụ dị n'elu, ndị nchọpụta wepụrụ ikpo okwu izu ike na ọdọ mmiri ma tinye ụmụ oke n'ime mmiri maka nkeji abụọ.

N'ihi ahụmahụ ụbọchị itoolu gara aga, ụmụ oke nkịtị chetara ebe mbụ nke ikpo okwu ma tinyekwuo oge igwu mmiri na ebe mbụ iji chọọ "ikpo okwu na-apụ apụ" ebe ụmụ oke Alzheimer na-egwu mmiri na-enweghị goolu.

N'ụzọ dị iche, ụmụ oke Alzheimer nke GLTs chebere na-akpa àgwà dị ka ụmụ oke nkịtị ma ọ bụ na obere doses (0.35 g / kg kwa ụbọchị) ma ọ bụ nnukwu doses (1.4 g / kg kwa ụbọchị) wee gbarie ihe fọrọ nke nta ka ọ bụrụ ụmụ oke MD ndị ahụ na-eri nri na ọgwụ ọdịda anyanwụ. Ọgụgụ 3 ruo 4).

(Ka ogologo oge ahụ, ka ikike ọgụgụ isi dịkwuo mma)

(Ka ọnụ ọgụgụ ahụ dị elu, ikike ọgụgụ isi ka mma)

Ganoderma lucidumtriterpenmmas na-edobe iguzosi ike n'ezi ihe nke mkpụrụ ndụ akwara.

Mbelata mmụta na ikike ncheta bụ mbelata ọrụ ọgụgụ isi mbụ (ọgbaghara) na ndị ọrịa nwere ọrịa Alzheimer, na mkpụrụ ndụ akwara na-ahụ maka ọrụ a dị na gyrus hippocampal.Ya mere, mgbe ndị nyocha ahụ mechara nyocha ndị a dị n'elu, ha chụpụrụ ụbụrụ òké maka nyocha ọzọ.

Nsonaazụ gosiri na mkpụrụ ndụ akwara dị na gyrus hippocampal nke ụmụ oke nkịtị na-ahazi nke ọma, edo edo na nha, ọdịdị ha na-adị mgbe niile, na akpụkpọ ahụ ha na akwara ha na-edobe nke ọma;A na-ahazi mkpụrụ ndụ akwara dị na gyrus hippocampal nke ụmụ oke AD n'ụzọ na-adịghị mma, dị iche iche na nha, ọdịdị na-adịghị ahụkebe, na-ebelata nke ukwuu na ọnụ ọgụgụ, na ihe owuwu ya na-emebi emebi.

Agbanyeghị, ọnọdụ a apụtaghị na ụmụ oke AD na-eri Ganoderma lucidum triterpenmmas.Mkpụrụ ndụ neuronal dị na gyrus hippocampal ha ka nọgidere na-eguzosi ike n'ezi ihe dị elu, ọ nweghịkwa necrosis cell doro anya, na-egosi naGanoderma lucidumtriterpenmmas nwere mmetụta nchebe na gyrus hippocampal (Fig 5).

Ganoderma lucidumtriterpenmmas belata neurofibrillary tangles.

N'otu oge ahụ, ndị nchọpụta ahụ chọpụtakwara na ọnụ ọgụgụ nke neurofibrillary tangles na cerebral cortex (na-echekwa ebe nchekwa ogologo oge) na anụ ahụ gyrus hippocampal na AD ụmụ oke na-echebe site na.Ganoderma lucidumtriterpenmmas dị obere ala karịa nke ahụ n'ime ụmụ oke AD a na-agwọghị (Foto 6).

Neurofibrillary tangles bụ otu n'ime isi ihe mgbaàmà nke ọrịa Alzheimer.N'adịghị ka nkwụnye ego amyloid nke na-eme n'èzí sel, neurofibrillary tangles na-eme na mkpụrụ ndụ akwara n'ihi ngbanwe nke "protein tau".

N'ọnọdụ nkịtị, protein tau na-ejikọta na cytoskeleton (microtubules) iji nyere aka guzobe na nkwụsi ike nke cytoskeleton.Agbanyeghị, protein tau dị n'ụbụrụ nke ndị ọrịa nwere ọrịa Alzheimer ga-agbanwe ma ọ nweghị ike ijikọ na cytoskeleton.N'ihi ya, protein tau ga-agbakọta n'ime ụyọkọ iji mepụta ihe a na-akpọ "neurofibrillary tangles", nke na-agbakọta na sel ma na-egbochi ọrụ nke mkpụrụ ndụ.Cytoskeleton na-enweghị protein tao ga-eji nwayọọ nwayọọ na-agbagọ ma gbarie, na-eduga na ọnwụ cell.

Ọnụ ọgụgụ nke neurofibrillary tangles na-egosipụta ogo nke njọ nke ọrịa Alzheimer.Ya mere, Ganoderma lucidum triterpenoids nwere ike igbochi nguzobe nke neurofibrillary tangles, nke kwesịrị ịbụ otu n'ime usoro dị mkpa maka.Ganoderma lucidumtriterpenoids na-egbu oge mbelata ọgụgụ isi na ọrịa Alzheimer.

Ganoderma lucidumtriterpenmmas belata akwara cell apoptosis.

Nke ọ bụlaβ-amyloid deposition ma ọ bụ neurofibrillary tangles ga-amalite usoro igbu onwe nke cell ma kwalite apoptosis nke mkpụrụ ndụ akwara.Ka ọtụtụ mkpụrụ ndụ akwara na-anwụ, ọtụtụ ọrụ na-efunahụ, na cognitive deklineọrịa Alzheimer kpatara na-akawanye njọ.

Site na nyocha nke anụ ahụ hippocampal gyrus nke otu ọ bụla nke ụmụ oke nnwale, enwere ike ịchọpụta na ọnụọgụ ọnwụ nke mkpụrụ ndụ akwara na ụmụ oke AD karịrị okpukpu anọ karịa ụmụ oke nkịtị nke otu afọ;ọ bụ ezie na oke doseGanodermalucidumtriterpenmmas enweghị ike kpamkpampiweghachi apoptosis na-adịghị mma nke mkpụrụ ndụ akwara,hahaveenweela ike ibelata mmebi ahụ ọkara, mmetụta ya dịkwa ka nke ọgwụ ọdịda anyanwụ (Njirimara 7).

Ndị nchọpụta gara n'ihu nyochaa wee chọpụta na na AD ụmụ oke nọgidere na-enwe siteGanoderma lucidumtriterpenoids, mkpụrụ ndụ akwara ụbụrụ nwere usoro mgbochi antioxidant siri ike iji luso mmebi oxidative nke protein β-amyloid kpatara na usoro apoptosis cell anaghị arụ ọrụ ngwa ngwa.N'ikwu ya n'ụzọ ọzọ, Ganoderma lucidum triterpenes na-ewusi nrụgide nrụgide nke ụbụrụ ụbụrụ ụbụrụ ike, na-eme ka ha nwekwuo ike ịlanarị ma rụọ ọrụ na gburugburu ebe obibi siri ike.

Ganoderma lucidumpolysaccharides dịkwa uru.

Nsonaazụ nyocha dị n'elu na-egosi nke ahụGanoderma lucidumtriterpenoids, mgbe ịbanye na eriri afọ eriri afọ site na esophagus, nwere ike belata ọganihu nke ọrịa Alzheimer site na mgbochi oxidation, mgbochi apoptosis, na mgbochi neurofibrillary tangles.

N'ezie, mmetụta nkeGanoderma lucidumpolysaccharides adịghịesighi ikekarịa nke Ganoderma lucidum triterpenmmas.Na 2017, nnyocha e jikọtara ọnụ na "Stem Cell Reports" nke Mahadum Tongji na Chinese Academy of Sciences gosipụtara na nlekọta ogologo oge naGanoderma lucidummmiri wepụ ma ọ bụGanoderma lucidumpolysaccharides nwere ike ibelata β-amyloid nkwụnye ego n'ime ụbụrụ nke ụmụ oke AD, na-enyere aka n'ịbawanye mkpụrụ ndụ akwara na hippocampal gyrus ma na-ebelata ọdịda mmụta na ebe nchekwa.(Maka nkọwapụta, lee:Ganoderma lucidum polysaccharidessbelata mbelata ọgụgụ isi nke ọrịa Alzheimer kpatara)

Ganoderma lucidumtriterpenoids na ndị ọzọGanoderma lucidumpolysaccharides yiri ka ọ nwere mmetụta dị iche iche n'ichekwa ụbụrụ na ọrịa Alzheimer.Nwere ikemmetụta jikọtara ọnụ nke abụọ na-ebelata ọganihu nke ọrịa Alzheimer?

Ozugbo ọrịa Alzheimer pụtara, ọ na-esiri ike ịgbanwe ya.Agbanyeghị, ọ bụrụwenwere ike idowe ikike nghọta karịa, gụnyere mmụta na ebe nchekwa, n'imeanyindụ nwere oke,wenwere ike nwee ohere ịkawanye ọrịa Alzheimer.

Isi mmalite

1. Yu N, et al.Ganoderma lucidumTriterpenoids (GLTs) na-ebelata Apoptosis Neuronal site na Mgbochi nke ROCK Signal Pathway na APP/PS1 Transgenic Alzheimer's Disease Disease.Oxid Med Cell Longev.2020;2020: 9894037.

2. Huang S, et al.Polysaccharides sitere naGanoderma lucidumKwalite ọrụ ọgụgụ isi na mmụba nke Neural Progenitor na Mouse Model nke Ọrịa Alzheimer.Akụkọ Stem Cell.2017 Jan 10;8 (1):84-94 .doi: 10.1016/j.stemcr.2016.12.007.

N'ikpeazụ

Banyere onye odee/ Oriakụ Wu Tingyao

Wu Tingyao na-akọ akụkọ mbụGanoderma lucidumozi kemgbe 1999. O bu odeeỌgwụgwọ na Ganoderma(nke e bipụtara na The People's Medical Publishing House na Eprel 2017).

★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede ★ Ọrụ ndị a dị n'elu enweghị ike ịmegharị, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke onye edemede ★ imebi okwu a dị n'elu, onye edemede ga-agbaso ọrụ iwu metụtara ya ★ The mbụ Wu Tingyao dere ederede akụkọ a n'asụsụ Chinese ma Alfred Liu sụgharịrị ya na Bekee.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ, Nwada Wu Tingyao.