Ndira 29, 2020 / Hunan Provincial People's Hospital, nezvimwewo / Oxidative Medicine uye Cellular Hurefu

Chinyorwa/Wu Tingyao

Chidzidzo chakabudiswa mu "Oxidative Medicine uye Cellular Longevity" neHunan Provincial People's Hospital uye Hunan Provincial Key Laboratory yeEmergency uye Critical Care Metabonomic yakaratidza kuti.Ganoderma lucidumtriterpenoids(GLTs)inogona kudzivirira masero etsinga dzehuropi uye kuderedza kukanganiswa kwekuziva kunokonzerwa nechirwere cheAlzheimer (AD) kuburikidza nenzira dzakadai se anti-apoptosis, anti-oxidation, uye anti-neurofibrillary tangles.

Ganoderma lucidumtriterpenoids kunonoka kwekuziva kuderera mukativarwere vaneChirwere cheAlzheimer.

Chekutanga, rvatsvaki vakadyiswaGanoderma lucidumtriterpenoids (GLTs) kuchirwere cheAlzheimer (AD) mbeva dzakanga dzatanga zviratidzo. Mushure60 mazuva, ivoyakaedza kugona kugona kwemakonzo neMorris Water Maze (MWM).

Kutora mukana wehunhu hwembeva dzinongovenga mvura uyenguva dzoseedza kutsvaga nzvimbo yekunzvenga mvura, vaongorori vakaita Morris Water Maze, inova yekumisikidza chikuva chekuzorora mune hombe denderedzwa dziva kuverenga kureba kwemakonzo kushambira uye nguva yavanopedza mukutsvaga.kuzororachikuva sema indexes ekutonga kugona kwekuzivaieszvembeva.Kana mbeva dzisingakwanisi kuwana nzvimbo yekuzorora (mumaminitsi maviri), vatsvakurudzi vachabatsira kutungamiraembeva kupuratifomu.

Kunyangwe pekutangira kupinda mumvura kwakasiyana nguva yega yega, mbeva dzakajairwa dzinogona kukurumidza kuwana chikuva chekuzorora kuburikidza neruzivo rwezuva nezuva.Kuedza kwakadaro kwakaitwa kamwe chete pazuva kwemazuva mapfumbamwe.Kuverenga zvibodzwa zvese paavhareji, vaongorori vakawana kuti AD mbeva (AD Group) inofanira kupedza zvakapetwa kavirias kana kushambira katatu-kureba kupfuura mbeva dzakajairwa (boka rekutonga) kuti uwane nzvimbo yekuzorora, iyo inoratidza kuti basa rekuziva kwehuropi hweAD mbeva dzakanyanya kuderedzwa.

Nekudaro, mbeva dzeAD dzakadyiswa nedosi yakakura (1.4g/kg pazuva) yeGLTs yakatora inenge nguva imwe chete uye kureba kwekushambira kuti uwane.thechikuva chekuzorora seyakajairika mbeva uye AD mbeva (Western mishonga inodzora boka) inodyiswa nedonepezil mazuva ese (Mufananidzo 1 ~ 2).

(Iyo nguva shoma inodiwa, zviri nani kugona kwekuziva)

(Iyo nhambwe shoma inodiwa, zviri nani kugona kwekuziva)

Zuva rakatevera mushure mekupera kwekuedza kwepamusoro, vatsvakurudzi vakabvisa nzvimbo yekuzorora mudziva ndokuisa mbeva mumvura kwemaminitsi maviri.

Nekuda kwemazuva mapfumbamwe apfuura echiitiko, mbeva dzakajairwa dzakarangarira nzvimbo yekutanga yepuratifomu uye dzakapedza nguva yakawanda dzichituhwina dzakatenderedza nzvimbo yepakutanga kutsvaga "chikuva chainyangarika" uku mbeva dzeAlzheimer dzaituhwina zvisina chinangwa.

Kusiyana neizvi, mbeva dzeAlzheimer dzakadzivirirwa neGLTs dzakaita senge mbeva dzakajairwa pamwe padiki dosi (0.35 g/kg pazuva) kana madosi akakwira (1.4 g/kg pazuva) uye akawana zvakada kufanana neaya MD mbeva dzakadyiswa nemishonga yekumadokero. Zvifananidzo 3 kusvika 4).

(Iyo nguva yakareba yekugara, zviri nani kugona kwekuziva)

(Iyo yakakwirira chikamu, zviri nani kugona kwekuziva)

Ganoderma lucidumtriterpenoids kuchengetedza kuvimbika kwemasero etsinga.

Kuderera kwekudzidza uye kugona kuyeuka ndiko kutanga kwekuziva kwekuita kuderera (kusagadzikana) muvarwere vane chirwere cheAlzheimer, uye masero etsinga anotarisira basa iri anowanikwa muhippocampal gyrus.Nokudaro, mushure mokunge vatsvakurudzi vapedza zvidzidzo zviri pamusoro, vakaparadzanisa uropi hwegonzo kuti vawedzere kuongororwa.

Mhedzisiro yacho yakaratidza kuti masero etsinga ari muhippocampal gyrus yemakonzo akajairwa akarongwa zvakanaka, yunifomu muhukuru, anogara achitaridzika, uye maseru adzo uye nuclei zvakaganhurwa zvakajeka;masero etsinga ari muhippocampal gyrus yeAD mbeva akarongwa zvisina kurongeka, akasiyana muhukuru, asina kuenzana pakuonekwa, akaderedzwa zvakanyanya muhuwandu, uye chimiro chayo chiri pachena chakakuvadzwa.

Zvakadaro, mamiriro aya haana kuoneka muAD mbeva dzinodya Ganoderma lucidum triterpenoids.Masero neuronal muhippocampal gyrus yavo ichiri kuchengetedza chiyero chepamusoro chekuvimbika, uye pakanga pasina pachena cell necrosis, zvichiratidza kutiGanoderma lucidumtriterpenoids yakanga ine simba rekudzivirira pane hippocampal gyrus (Mufananidzo 5).

Ganoderma lucidumtriterpenoids kuderedza neurofibrillary tangles.

Panguva imwecheteyo, vatsvakurudzi vakawanawo kuti nhamba yeurofibrillary tangles mu cerebral cortex (kuchengeta ndangariro yenguva refu) uye hippocampal gyrus tissue mu AD mice inodzivirirwa na.Ganoderma lucidumtriterpenoids yaive yakaderera zvakanyanya pane iyo isina kurapwa AD mice (Mufananidzo 6).

Neurofibrillary tangles chimwe chezviratidzo zvikuru zvechirwere cheAlzheimer.Kusiyana neamyloid deposits inoitika kunze kwemasero, neurofibrillary tangles inoitika mumasero etsinga nekuda kwekuchinja kwe "tau protein".

Mumamiriro ezvinhu akajairika, tau protein inosunga kune cytoskeleton (microtubules) kubatsira kuumbwa uye kugadzikana kwe cytoskeleton.Nekudaro, iyo protein yetau muuropi yevarwere vane chirwere cheAlzheimer inoshanduka uye haigone kusunga kune cytoskeleton.Somugumisiro, puroteni yetau ichaungana mumapoka kuti iite iyo inonzi "neurofibrillary tangles", iyo inounganidza mumasero uye inovhiringidza basa remasero.Iyo cytoskeleton inoshaya tao protein inozokanganiswa zvishoma nezvishoma uye iparare, zvichitungamira kurufu rwesero.

Huwandu hwema neurofibrillary tangles hunoratidza huwandu hwekuderera kwechirwere cheAlzheimer.Nokudaro, Ganoderma lucidum triterpenoids inogona kudzivisa kuumbwa kweurofibrillary tangles, iyo inofanira kuva imwe yenzira dzakakosha dzekuita.Ganoderma lucidumtriterpenoids kunonoka kuziva kuderera kwechirwere cheAlzheimer.

Ganoderma lucidumtriterpenoids kuderedza nerve cell apoptosis.

Zvimweβ-amyloid deposition kana neurofibrillary tangles ichatanga chirongwa chekuzviuraya chesero uye kukurudzira apoptosis yemasero etsinga.Sezvo mamwe masero etsinga achifa, mamwe mabasa anorasika, uye cognitive declinezvinokonzerwa nehosha yeAlzheimer inowedzera.

Kubva pakuongororwa kweiyo hippocampal gyrus tissue yeboka rimwe nerimwe rekuedza mbeva, zvinogona kuwanikwa kuti kufa kwemasero etsinga muAD mice kunopfuura kanopfuura kana kune emakonzo akajairwa ezera rimwe chete;kunyange high-doseGanodermalucidumtriterpenoids haigone zvachosepkudzoreredza apoptosis yemasero etsinga,ivohaveyakakwanisa kuderedza kukuvadzwa nehafu, uye mhedzisiro yacho inofananidzwa neyemushonga wekumadokero (Mufananidzo 7).

Vatsvakurudzi vakaongororazve uye vakaona kuti muAD mbeva dzinochengetwa neGanoderma lucidumtriterpenoids, masero etsinga europi ane simba rinopesana ne-oxidant nzira yekurwisa kukuvadzwa kweoxidative kunokonzerwa ne-β-amyloid protein uye cell apoptosis mechanism haisi nyore kushandiswa.Mune mamwe mazwi, Ganoderma lucidum triterpenes inosimbisa kusagadzikana kwemasero etsinga dzeuropi, zvichiita kuti vakwanise kurarama uye kushanda munzvimbo yakaoma.

Ganoderma lucidumpolysaccharides inobatsira zvakare.

Migumisiro yetsvakurudzo iri pamusoro inoratidza izvozvoGanoderma lucidumtriterpenoids, mushure mekupinda mudumbu remukati kuburikidza nesophagus, inogona kunonoka kufambira mberi kwechirwere cheAlzheimer kuburikidza ne-anti-oxidation, anti-apoptosis, uye anti-neurofibrillary tangles.

Muchokwadi, mhedzisiro yeGanoderma lucidumpolysaccharides haisiweakerkupfuura iyo yeGanoderma lucidum triterpenoids.Muna 2017, chidzidzo chakadhindwa pamwe chete mu "Stem Cell Reports" neTongji University uye Chinese Academy of Sciences yakaratidza kuti kuchengetedza kwenguva refu neGanoderma lucidummvura inotorwa kanaGanoderma lucidumpolysaccharides inogona kuderedza β-amyloid deposits muuropi hweAD mbeva, kubatsira kuwanda kwemasero etsinga anotangira muhippocampal gyrus uye kunonotsa kuderera kwekudzidza nekuyeuka.(Kuti uwane rumwe ruzivo, ona:Ganoderma lucidum polysaccharideskuderedza kuderera kwekuziva kunokonzerwa nechirwere cheAlzheimer)

Ganoderma lucidumtriterpenoids uyeGanoderma lucidummapolysaccharides anoita seane mhedzisiro dzakasiyana mukudzivirira huropi nechirwere cheAlzheimer.Inogonamubatanidzwa wezviviri izvi zvinononoka kufambira mberi kwechirwere cheAlzheimer?

Kana hosha yeAlzheimer yangoitika, zvakaoma kuidzosera.Zvisinei, kanaweinogona kuchengetedza mamwe masimba ekuziva, kusanganisira kudzidza uye ndangariro, mukatizveduhupenyu hushoma,weinogona kuve nemukana wekupora nechirwere cheAlzheimer.

Source

1. Yu N, nevamwe.Ganoderma lucidumTriterpenoids (GLTs) Deredza Neuronal Apoptosis kuburikidza neInhibition yeROCK Signal Pathway muAPP/PS1 Transgenic Alzheimer's Disease Mice.Oxid Med Cell Longev.2020;2020: 9894037.

2. Huang S, nevamwe.Polysaccharides kubvaGanoderma lucidumKurudzira Basa reCognitive uye Neural Progenitor Proliferation muMouse Model yeAlzheimer's Disease.Stem Cell Reports.2017 Jan 10;8(1):84-94.doi: 10.1016/j.stemcr.2016.12.007.

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Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achitaura nezvekutanga-ruokoGanoderma lucidumruzivo kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★Chinyorwa ichi chakatsikiswa pasi pemvumo yemunyori chete ★ Mabasa ari pamusoro haagone kutsikiswa, kudonhedzwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori ★ Kutyora chirevo chiri pamusoro, munyori achaita mabasa anoenderana nemutemo ★ Iwo ekutanga. chinyorwa chechinyorwa ichi chakanyorwa neChinese naWu Tingyao uye chakashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.