Ianuali 29, 2020 / Hunan Provincial People's Hospital, etc. / Oxidative Medicine and Cellular Longevity

Text/Wu Tingyao

ʻO kahi haʻawina i paʻi ʻia ma "Oxidative Medicine and Cellular Longevity" e Hunan Provincial People's Hospital a me Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomic i kuhikuhi ʻia eʻO Ganoderma lucidumtriterpenoids(GLT)Hiki iā ia ke pale i nā pūnaʻi aʻalolo lolo a hoʻemi i ka pōʻino o ka naʻau i hoʻokumu ʻia e ka maʻi Alzheimer (AD) ma o nā hana e like me anti-apoptosis, anti-oxidation, a me nā anti-neurofibrillary tangles.

ʻO Ganoderma lucidumtriterpenoids lohi cognitive emi i lokonā maʻi meʻO ka maʻi o Alzheimer.

Ka mua, rua hānai ʻia nā mea noiʻiʻO Ganoderma lucidumtriterpenoids (GLTs) i nā ʻiole maʻi Alzheimer (AD) i hoʻomohala i nā hōʻailona mua. Ma hope60 lā, lakouua hoʻāʻo i ka mana cognitive o nā ʻiole me Morris Water Maze (MWM).

ʻO ka hoʻohana ʻana i nā ʻano ʻiole e inaina maoli i ka wai amauE ho'āʻo e ʻimi i kahi e pale aku ai i ka wai, ua alakaʻi nā mea noiʻi iā Morris Water Maze, ʻo ia ka hoʻonohonoho ʻana i kahi kahua hoʻomaha i loko o kahi loko pōʻai nui e helu ai i ka mamao o ka ʻauʻau ʻana o nā ʻiole a me ka manawa a lākou e hoʻolilo ai i ka loaʻa ʻana o ka wai.hoʻomahakahua ma ke ano he mau kuhikuhi no ka hookolokolo ana i ka ikeieso na iole.Inā ʻaʻole hiki i nā ʻiole ke ʻimi i ke kahua hoʻomaha (i loko o ʻelua mau minuke), e kōkua nā mea noiʻi i ke alakaʻiena iole i ka anuu.

ʻOiai ʻokoʻa ka wahi hoʻomaka no ke komo ʻana i ka wai i kēlā me kēia manawa, hiki i nā ʻiole maʻamau ke loaʻa koke i ka paepae hoʻomaha ma o ka ʻike i kēlā me kēia lā.Ua hana ʻia kēlā ʻano hoʻokolohua hoʻokahi i ka lā no ʻeiwa mau lā.I ka helu ʻana i nā helu āpau ma ka awelika, ua ʻike nā mea noiʻi he pono e hoʻolimalima ʻelua mau ʻiole AD (AD Group).as a i ʻole ʻauʻau i ʻekolu hapaha ka lōʻihi ma mua o nā ʻiole maʻamau (hui mana) e ʻimi i kahi kahua hoʻomaha, e hōʻike ana ua hoʻohaʻahaʻa nui ʻia ka hana cognitive o ka lolo o AD.

Eia nō naʻe, ʻo nā ʻiole AD i hānai ʻia me nā koina kiʻekiʻe (1.4g/kg i kēlā me kēia lā) o nā GLT i lawe kokoke i ka manawa like a me ka mamao ʻauʻau e loaʻa ai.kakahua hoʻomaha e like me nā ʻiole maʻamau a me nā mice AD ​​(Western medicine control group) i hānai ʻia me donepezil i kēlā me kēia lā (Figure 1~2).

(ʻO ka liʻiliʻi o ka manawa e pono ai, ʻoi aku ka maikaʻi o ka hiki ke noʻonoʻo)

(ʻO ka liʻiliʻi o ka mamao e pono ai, ʻoi aku ka maikaʻi o ka ʻike naʻau)

I ka lā aʻe ma hope o ka pau ʻana o ka hoʻokolohua ma luna, ua wehe nā mea noiʻi i ka paepae hoʻomaha i loko o ka loko wai a waiho i nā ʻiole i loko o ka wai no ʻelua mau minuke.

Ma muli o nā lā ʻeiwa o ka ʻike i hala, ua hoʻomanaʻo nā ʻiole maʻamau i ka wahi kumu o ka paepae a ua hoʻonui i ka manawa e ʻauʻau ai i ka wahi kumu e ʻimi ai i ka "pahu nalo" aʻo nā ʻiole o Alzheimer e ʻau ana me ka pahuhopu ʻole.

ʻO ka ʻokoʻa, ʻoi aku ka hana o nā ʻiole Alzheimer i pale ʻia e nā GLT e like me nā ʻiole maʻamau a i ʻole ma nā koina haʻahaʻa (0.35 g/kg i kēlā me kēia lā) a i ʻole kiʻekiʻe kiʻekiʻe (1.4 g/kg i kēlā me kēia lā) a ua loaʻa i nā ʻiole MD i hānai ʻia me ka lāʻau lapaʻau komohana ( Helu 3 a hiki i ka 4).

(ʻO ka lōʻihi o ka noho ʻana, ʻoi aku ka maikaʻi o ka hiki ke noʻonoʻo)

(ʻO ke kiʻekiʻe o ka māhele, ʻoi aku ka maikaʻi o ka hiki ke noʻonoʻo)

ʻO Ganoderma lucidumtriterpenoids mālama i ka pono o nā pūnaewele nerve.

ʻO ka emi ʻana o ke aʻo ʻana a me ka hoʻomanaʻo ʻana, ʻo ia ka emi ʻana o ka hana cognitive mua loa (disorder) i nā maʻi me ka maʻi Alzheimer, a aia nā pūnana aʻalolo e mālama nei i kēia hana ma ka hippocampal gyrus.No laila, ma hope o ka hoʻopau ʻana o nā mea noiʻi i nā hoʻokolohua ma luna, ua ʻoki lākou i ka lolo ʻiole no ka nānā hou ʻana.

Ua hōʻike ʻia nā hopena i ka hoʻonohonoho pono ʻana o nā pūnana aʻalolo i loko o ka hippocampal gyrus o nā ʻiole maʻamau, ʻaʻahu i ka nui, maʻamau i ka nānā ʻana, a ua hoʻokaʻawale ʻia ko lākou mau cell membranes a me nā nuclei;ʻO nā pūnana aʻalolo i loko o ka hippocampal gyrus o nā ʻiole AD ua hoʻonohonoho pono ʻole ʻia, ʻokoʻa ka nui, ʻano like ʻole ke ʻano, hoʻemi nui ʻia ka helu, a ʻike maopopo ʻia kona ʻano.

Eia naʻe, ʻaʻole i ʻike ʻia kēia kūlana i nā ʻiole AD e ʻai ana iā Ganoderma lucidum triterpenoids.ʻO nā pūnaewele neuronal i loko o kā lākou hippocampal gyrus e mālama mau ana i kahi kūlana kiʻekiʻe o ka pono, a ʻaʻohe ʻano necrosis cell maopopo, e hōʻike ana i kēlā.ʻO Ganoderma lucidumtriterpenoids he hopena pale i ka hippocampal gyrus (Figure 5).

ʻO Ganoderma lucidumtriterpenoide ho'ēmi i nā kuʻi neurofibrillary.

I ka manawa like, ua ʻike pū nā mea noiʻi i ka helu o nā neurofibrillary tangles i loko o ka cerebral cortex (mālama ʻana i ka hoʻomanaʻo lōʻihi) a me ka ʻiʻo hippocampal gyrus i nā ʻiole AD i pale ʻia eʻO Ganoderma lucidumtriterpenoids ua haʻahaʻa loa ma mua o kēlā i nā ʻiole AD i mālama ʻole ʻia (Figure 6).

ʻO Neurofibrillary tangles kekahi o nā hōʻailona nui o ka maʻi o Alzheimer.ʻAʻole like me nā waihona amyloid e puka mai ana ma waho o nā pūnaewele, hiki mai nā kuʻi neurofibrillary i loko o nā pūnana nerve ma muli o ka hoʻololi ʻana o "tau protein".

Ma lalo o nā kūlana maʻamau, hoʻopaʻa ka protein tau i ka cytoskeleton (microtubules) e kōkua i ke kūkulu ʻana a me ka paʻa o ka cytoskeleton.Eia naʻe, e hoʻololi ka protein tau i loko o ka lolo o nā maʻi me ka maʻi Alzheimer a hiki ʻole ke hoʻopaʻa i ka cytoskeleton.ʻO ka hopena, e hōʻuluʻulu ʻia ka protein tau i loko o nā pūʻulu e hana i ka mea i kapa ʻia ʻo "neurofibrillary tangles", e hōʻiliʻili i loko o nā pūnaewele a keʻakeʻa i ka hana o nā cell.ʻO ka cytoskeleton nele i ka protein tao e lilo mālie a hemo, e alakaʻi ana i ka make cell.

Hōʻike ka helu o nā neurofibrillary tangles i ke kiʻekiʻe o ka deterioration o ka maʻi o Alzheimer.No laila, hiki i ka Ganoderma lucidum triterpenoids ke kāohi i ka hoʻokumu ʻana o nā neurofibrillary tangles, ʻo ia kekahi o nā hana koʻikoʻi no kaʻO Ganoderma lucidumtriterpenoids e lohi i ka emi ʻana o ka naʻau i ka maʻi o Alzheimer.

ʻO Ganoderma lucidumtriterpenoide ho'ēmi i ka apoptosis pūnaewele nerve.

ʻO kekahiʻO ka β-amyloid deposition a i ʻole neurofibrillary tangles e hoʻomaka i ka papahana pepehi kanaka o ke kelepona a hoʻoikaika i ka apoptosis o nā pūnana nerve.I ka make ʻana o nā pūnana aʻalolo, ʻoi aku ka nui o nā hana i nalowale, a me ka cognitive declinema muli o ka maʻi o Alzheimer e lilo i mea koʻikoʻi.

Mai ka hoʻopili ʻana i ka ʻiʻo hippocampal gyrus o kēlā me kēia hui o nā ʻiole hoʻokolohua, hiki ke ʻike ʻia ka nui o ka make ʻana o nā pūnana nerve ma nā mice AD ​​ma mua o ʻehā mau manawa o nā ʻiole maʻamau o ka makahiki like;ʻoiai ka nui-doseGanodermalucidumtriterpenoids hiki ole loaphoʻihoʻi hou i ka apoptosis maʻamau o nā cell nerve,lakouhavehiki i ka hapalua o ka poino, a ua like ka hopena me ko ke komohana laau lapaau (Figure 7).

Ua ho'āʻo hou ka poʻe noiʻi a ʻike i nā ʻiole AD i mālama ʻia eʻO Ganoderma lucidumtriterpenoids, loaʻa i nā pūnaʻi aʻalolo lolo kahi hana anti-oxidant ikaika e hakakā i ka pōʻino oxidative i hoʻokumu ʻia e ka protein β-amyloid a ʻaʻole hiki ke maʻalahi ka hana apoptosis cell.I nā huaʻōlelo ʻē aʻe, hoʻoikaika ʻo Ganoderma lucidum triterpenes i ke kūpaʻa koʻikoʻi o nā pūnaʻi nerve lolo, e hiki ai iā lākou ke ola a hana i kahi ʻano koʻikoʻi.

ʻO Ganoderma lucidumHe mea pono no hoi ka polysaccharides.

Hōʻike nā hopena noiʻi ma lunaʻO Ganoderma lucidumtriterpenoids, ma hope o ke komo ʻana i ka ʻōpū o ka ʻōpū ma o ka esophagus, hiki ke hoʻolōʻihi i ka holomua o ka maʻi o Alzheimer ma o ka anti-oxidation, anti-apoptosis, a me nā anti-neurofibrillary tangles.

ʻOiaʻiʻo, ka hopena oʻO Ganoderma lucidumʻAʻole ka polysaccharidesnāwaliwalima mua o ka Ganoderma lucidum triterpenoids.Ma 2017, kahi noiʻi i paʻi pū ʻia ma "Stem Cell Reports" e Tongji University a me ka Chinese Academy of Science i hōʻoia i ka mālama lōʻihi meʻO Ganoderma lucidumka wai a i ʻoleʻO Ganoderma lucidumHiki i nā polysaccharides ke hoʻemi i nā waihona β-amyloid i loko o ka lolo o nā ʻiole AD, kōkua i ka hoʻonui ʻana o nā cell precursor nerve i ka hippocampal gyrus a hoʻolohi i ka emi ʻana o ke aʻo ʻana a me ka hoʻomanaʻo.(No nā kikoʻī, e ʻike:ʻO Ganoderma lucidum polysaccharidese hoʻemi i ka emi ʻana o ka naʻau ma muli o ka maʻi o Alzheimer)

ʻO Ganoderma lucidumtriterpenoids a meʻO Ganoderma lucidumʻOkoʻa nā hopena like ʻole o ka polysaccharides i ka pale ʻana i ka lolo me ka maʻi Alzheimer.HikiʻO ka hopena hui o nā mea ʻelua e hoʻolohi i ka holomua o ka maʻi o Alzheimer?

Ke hiki mai ka maʻi o Alzheimer, paʻakikī ke hoʻohuli.Eia naʻe, ināwehiki ke hoʻopaʻa i nā mana cognitive hou aʻe, me ke aʻo ʻana a me ka hoʻomanaʻo, makā mākouola kaupalena,weloaʻa paha kahi manawa e hoʻomaikaʻi ai me ka maʻi Alzheimer.

Puna

1. Yu N, et al.ʻO Ganoderma lucidumʻO nā Triterpenoids (GLTs) E ho'ēmi i ka Neuronal Apoptosis ma o ke Kāohi ʻana o ROCK Signal Pathway ma APP/PS1 Transgenic Alzheimer's Disease Mice.Oxid Med Cell Longev.2020;2020: 9894037.

2. Huang S, et al.Polysaccharides maiʻO Ganoderma lucidumHoʻoikaika i ka hana noʻonoʻo a me ka hoʻonui ʻana o ka neural progenitor ma ke ʻano ʻiole o ka maʻi Alzheimer.Nā Hōʻike Pūnaewele.2017 Jan 10;8(1):84-94.doi: 10.1016/j.stemcr.2016.12.007.

HOPE

No ka mea kākau/ Ms. Wu Tingyao

Ua hōʻike ʻo Wu Tingyao ma ka lima muaʻO Ganoderma lucidumʻike mai ka makahiki 1999. ʻO ia ke kumu oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).

★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau ★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻoki ʻia a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻana o ka mea kākau ★ ʻAʻole i ʻae ʻia ka ʻōlelo ma luna, e hahai ka mea kākau i kāna mau kuleana pili i ke kānāwai ★ ʻO ke kumu kumu. Ua kākau ʻia nā kikokikona o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.