I-Grifola frondosa (ebuye ibizwe ngokuthi i-Maitake) idabuka ezindaweni ezisezintabeni ezisenyakatho ye-Japan.Iwuhlobo lwekhowe elidliwayo-lemithi elinokunambitheka okuhle kanye nemiphumela yokwelapha.Bekubhekwa kakhulu njengenkokhiso emndenini wasebukhosini baseJapan kusukela ezikhathini zasendulo.Lelikhowe alizange lilinywe ngempumelelo kwaze kwaba maphakathi nawo-1980.Kusukela ngaleso sikhathi, ososayensi ikakhulukazi eJapane baye benza ucwaningo olunzulu nge-Maitake mushroom ku-chemistry, biochemistry kanye ne-pharmacology, okufakazela ukuthi i-Maitake mushroom iyikhowe eliyigugu kakhulu lemithi nokudla.Ikakhulukazi i-Maitake D-fraction, isithako esisebenza ngempumelelo kakhulu esikhishwe ku-Maitake mushroom, sinomthelela oqinile wokulwa nomdlavuza.

Ucwaningo olunzulu ngemiphumela yemithi ye-Grifola frondosa eJapane, eCanada, e-Italy nase-United Kingdom eminyakeni yamuva lubonise ukuthi i-Grifola frondosa inemiphumela yokulwa nomdlavuza, ukuqinisa amasosha omzimba, ukulwa nomfutho wegazi ophezulu, ukwehlisa ushukela egazini, ukwehlisa i-lipids egazini kanye anti-hepatitis virus.

Kafushane, i-Grifola frondosa inemisebenzi yokunakekelwa kwezempilo elandelayo:
1.Ngenxa yokuthi inothile ngensimbi, ithusi kanye ne-vitamin C, ingavimbela i-anemia, i-scurvy, i-vitiligo, i-arteriosclerosis kanye ne-cerebral thrombosis;
I-2.Inokuqukethwe okuphezulu kwe-selenium ne-chromium, engavikela isibindi nama-pancreas, ivimbele i-cirrhosis yesibindi nesifo sikashukela;okuqukethwe kwayo okuphezulu kwe-selenium nakho kunomsebenzi wokuvimbela isifo sikaKeshan, isifo sikaKashin-Beck kanye nezifo ezithile zenhliziyo;
3.Iqukethe kokubili i-calcium ne-vitamin D. Inhlanganisela yakho kokubili ingavimbela ngempumelelo futhi yelaphe ama-rickets;
I-4.Okuqukethwe kwayo kwe-zinc ephakeme kunenzuzo ukukhuthaza ukukhula kobuchopho, ukugcina ukungaboni kahle nokugqugquzela ukuphulukiswa kwesilonda;
5.Inhlanganisela yokuqukethwe okuphezulu kwevithamini E kanye ne-selenium iyenza ibe nemiphumela yokulwa nokuguga, ukuthuthukiswa kwenkumbulo kanye nokuthuthukisa ukuzwela.Ngesikhathi esifanayo, i-immunomodulator enhle kakhulu.
6.Njengomuthi wendabuko waseShayina, i-Grifola frondosa ilingana ne-Polyporus umbellatus.Ingakwazi ukwelapha i-dysuria, i-edema, unyawo lomsubathi, i-cirrhosis, i-ascites nesifo sikashukela.
7.Iphinde ibe nomthelela wokuvimbela umfutho wegazi ophezulu kanye nokukhuluphala ngokweqile.
8.Okuqukethwe okuphezulu kwe-selenium ku-Grifola frondosa kunganqanda umdlavuza.

Ukuhlolwa kwezilwane nokuhlolwa komtholampilo kubonisa ukuthi ingxenye ye-Maitake D inemiphumela elwa nomdlavuza ngalezi zici ezilandelayo:
I-1.Ingakwazi ukusebenzisa amangqamuzana omzimba afana ne-phagocyte, amangqamuzana abulalayo wemvelo kanye namaseli e-cytotoxic T, futhi enze ukukhishwa kwama-cytokines afana ne-leukin, i-interferon-γ, ne-tumor necrosis factor-α.
2.Ingadala i-apoptosis yamaseli omdlavuza.
I-3.Ihlanganiswe nemithi yendabuko ye-chemotherapy (njenge-mitomycin ne-Carmustine), ayikhulisi nje kuphela ukusebenza komuthi kodwa futhi inciphisa imiphumela enobuthi kanye nemiphumela emibi ngesikhathi sokwelashwa ngamakhemikhali.
I-4.Umphumela we-Synergistic ngezidakamizwa ze-immunotherapy (interferon-α2b).
5. Kungadambisa izinhlungu zeziguli ezinomdlavuza osekhulile, kwandise isifiso sokudla futhi kuthuthukise izinga lempilo yeziguli.