Grifola frondosa (nanone yitwa Maitake) ikomoka mu misozi yo mu majyaruguru yUbuyapani.Nubwoko bwibihumyo biribwa-bivura bifite uburyohe bwiza ningaruka zubuvuzi.Yafatwaga cyane nk'icyubahiro umuryango w'abami b'Abayapani kuva kera.Iki gihumyo nticyigeze gihingwa neza kugeza hagati ya za 1980.Kuva icyo gihe, abahanga cyane cyane mu Buyapani bakoze ubushakashatsi bwimbitse ku gihumyo cya Maitake muri chimie, ibinyabuzima na farumasi, bagaragaza ko ibihumyo bya Maitake ari ibihumyo bifite agaciro cyane mu buvuzi n’ibiribwa.By'umwihariko Maitake D-agace, ibintu byiza cyane byakuwe mu gihumyo cya Maitake, bifite ingaruka zikomeye zo kurwanya kanseri.

Ubushakashatsi bwimbitse ku ngaruka za farumasi ya Grifola frondosa mu Buyapani, Kanada, Ubutaliyani n'Ubwongereza mu myaka yashize bwerekanye ko Grifola frondosa ifite ingaruka zo kurwanya kanseri, kongera ubudahangarwa bw'umubiri, kurwanya hypertension, kugabanya isukari mu maraso, kugabanya lipide y'amaraso na virusi irwanya hepatite.

Muri make, Grifola frondosa ifite imirimo yubuzima ikurikira:
1.Kuko ikungahaye kuri fer, umuringa na vitamine C, irashobora kwirinda amaraso make, scurvy, vitiligo, arteriosclerose na trombose yubwonko;
2.Ifite seleniyumu nyinshi na chromium, bishobora kurinda umwijima na pancreas, kwirinda umwijima cirrhose na diyabete;ibirimo seleniyumu nyinshi kandi bifite umurimo wo gukumira indwara ya Keshan, indwara ya Kashin-Beck n'indwara zimwe z'umutima;
3.Birimo calcium na vitamine D. Guhuza byombi birashobora gukumira no kuvura indwara ya rake;
4.Ibirimo byinshi bya zinc ni ingirakamaro mu guteza imbere ubwonko, kugumya kubona neza no guteza imbere gukira ibikomere;
5.Ihuriro ryinshi rya vitamine E na seleniyumu rituma rigira ingaruka zo kurwanya gusaza, kunoza kwibuka no kongera ibyiyumvo.Mugihe kimwe, ni immunomodulator nziza.
6.Nk'ubuvuzi gakondo bw'Abashinwa, Grifola frondosa ihwanye na polyporus umbellatus.Irashobora gukiza dysuria, edema, ikirenge c'umukinyi, cirrhose, asite na diyabete.
7.Bifite kandi ingaruka zo guhagarika hypertension n'umubyibuho ukabije.
8.Ibintu byinshi bya seleniyumu ya Grifola frondosa irashobora kwirinda kanseri.

Ubushakashatsi bw’inyamaswa n’ubushakashatsi bw’amavuriro bwerekana ko Maitake D-agace igira ingaruka zo kurwanya kanseri binyuze mu ngingo zikurikira:
1.Ishobora gukora selile yumubiri nka fagocytes, selile yica naturel na selile cytotoxic T, ikanatera ururenda rwa cytokine nka leukin, interferon-γ, na fonctionnement yibibyimba-α.
2.Bishobora gutera apoptose ya selile kanseri.
3. Ufatanije n’imiti gakondo ya chimiotherapie (nka mitomycine na Carmustine), ntabwo yongerera imbaraga imiti gusa ahubwo inagabanya ingaruka zuburozi ningaruka mbi mugihe cya chimiotherapie.
4.Ingaruka zingirakamaro hamwe nubuvuzi bwikingira (interferon-α2b).
5. Irashobora kugabanya ububabare bw'abarwayi ba kanseri yateye imbere, kongera ubushake bwo kurya no kuzamura imibereho y'abarwayi.