Grifola frondosa (yomwe imatchedwanso Maitake) imachokera kumadera amapiri kumpoto kwa Japan.Ndi mtundu wa bowa wodyera-mankhwala wokhala ndi kukoma kwabwino komanso mankhwala.Zakhala zikudziwika ngati msonkho kwa banja lachifumu la Japan kuyambira nthawi zakale.Bowa umenewu sunalimidwe bwino mpaka pakati pa zaka za m’ma 1980.Kuyambira pamenepo, asayansi makamaka ku Japan achita kafukufuku wambiri pa bowa wa Maitake mu chemistry, biochemistry ndi pharmacology, kutsimikizira kuti bowa wa Maitake ndi bowa wamtengo wapatali kwambiri pamankhwala ndi chakudya.Makamaka Maitake D-fraction, yogwira ntchito kwambiri yotengedwa ku bowa wa Maitake, imakhala ndi mphamvu yolimbana ndi khansa.

Kafukufuku wambiri wokhudzana ndi zotsatira za mankhwala a Grifola frondosa ku Japan, Canada, Italy ndi United Kingdom m'zaka zaposachedwa asonyeza kuti Grifola frondosa ali ndi zotsatira za anti-cancer, chitetezo cha mthupi, anti-hypertension, kuchepetsa shuga m'magazi, kutsitsa lipids ndi magazi. anti-hepatitis virus.

Mwachidule, Grifola frondosa ali ndi ntchito zotsatirazi:
1.Chifukwa chakuti imakhala ndi chitsulo, mkuwa ndi vitamini C, imatha kuteteza kuchepa kwa magazi, scurvy, vitiligo, arteriosclerosis ndi cerebral thrombosis;
2.Ili ndi selenium yambiri ndi chromium, yomwe imatha kuteteza chiwindi ndi kapamba, kuteteza chiwindi cha chiwindi ndi matenda a shuga;selenium yake yapamwamba imakhala ndi ntchito yoletsa matenda a Keshan, matenda a Kashin-Beck ndi matenda ena a mtima;
3.Ili ndi calcium ndi vitamini D. Kuphatikiza kwa ziwirizi kungathe kuteteza ndi kuchiza ma rickets;
4.Zambiri za zinc ndizopindulitsa kulimbikitsa kukula kwa ubongo, kusunga mawonekedwe owoneka bwino komanso kulimbikitsa machiritso a bala;
5.Kuphatikizika kwa vitamini E ndi selenium kumapangitsa kuti zikhale ndi zotsatira zotsutsana ndi ukalamba, kukumbukira kukumbukira komanso kuwonjezereka kwa chidziwitso.Nthawi yomweyo, ndi immunomodulator yabwino kwambiri.
6.Monga mankhwala achi China, Grifola frondosa ndi ofanana ndi Polyporus umbellatus.Ikhoza kuchiza dysuria, edema, phazi la wothamanga, cirrhosis, ascites ndi shuga.
7.Ilinso ndi zotsatira zolepheretsa kuthamanga kwa magazi ndi kunenepa kwambiri.
8.Kuchuluka kwa selenium mu Grifola frondosa kumatha kupewa khansa.

Zoyeserera zanyama ndi zoyeserera zamankhwala zikuwonetsa kuti gawo la Maitake D limakhala ndi zotsutsana ndi khansa kudzera m'magawo awa:
1.Ikhoza kuyambitsa maselo a chitetezo cha mthupi monga phagocytes, maselo akupha zachilengedwe ndi maselo a cytotoxic T, ndi kuyambitsa kutulutsa kwa cytokines monga leukin, interferon-γ, ndi tumor necrosis factor-α.
2.Itha kuyambitsa apoptosis yama cell a khansa.
3.Kuphatikizana ndi mankhwala osokoneza bongo (monga mitomycin ndi Carmustine), sikuti kumangowonjezera mphamvu ya mankhwalawa komanso kumachepetsa zotsatira za poizoni ndi zotsatira zake panthawi ya chemotherapy.
4.Synergistic effect ndi mankhwala a immunotherapy (interferon-α2b).
5. Ikhoza kuthetsa ululu wa odwala omwe ali ndi khansa yapamwamba, kuonjezera chilakolako cha chakudya komanso kusintha moyo wa odwala.