I-Grifola frondosa (ekwabizwa ngokuba yi-Maitake) izalelwa kwimimandla yeentaba kumantla eJapan.Luhlobo lwe-mushroom oludliwayo-lweyeza kunye nencasa elungileyo kunye neziphumo zonyango.Ijongwa kakhulu njengembeko kusapho lwasebukhosini baseJapan ukusukela kumaxesha amandulo.Eli khowa alizange lilinywe ngempumelelo de kwaphakathi kwiminyaka yoo-1980.Ukususela ngoko, izazinzulu ikakhulu eJapan ziye zenza uphando olubanzi malunga ne-Maitake mushroom kwi-chemistry, i-biochemistry kunye ne-pharmacology, ebonisa ukuba i-mushroom ye-Maitake yi-mushroom ebaluleke kakhulu kwiyeza kunye nokutya.Ngokukodwa i-Maitake D-fraction, eyona nto isebenzayo esebenzayo ekhutshwe kwi-Maitake mushroom, inomphumela onamandla wokuchasana nomhlaza.

Uphononongo olubanzi malunga neempembelelo ze-pharmacological ze-Grifola frondosa eJapan, eKhanada, eItali nase-United Kingdom kwiminyaka yamuva nje zibonise ukuba i-Grifola frondosa ineempembelelo ze-anti-cancer, ukuphuculwa kwe-immune, ukulwa noxinzelelo lwegazi, ukunciphisa iswekile yegazi, ukunciphisa i-lipids egazini iintsholongwane ezichasene ne-hepatitis.

Isishwankathelo, iGrifola frondosa inemisebenzi elandelayo yokhathalelo lwempilo:
1.Ngenxa yokuba isityebi kwisinyithi, ithusi kunye ne-vitamin C, inokuthintela i-anemia, i-scurvy, i-vitiligo, i-arteriosclerosis kunye ne-cerebral thrombosis;
I-2.Inomxholo ophezulu we-selenium kunye ne-chromium, enokukhusela isibindi kunye ne-pancreas, ukukhusela i-cirrhosis yesibindi kunye nesifo sikashukela;umxholo wayo ophezulu we-selenium nawo unomsebenzi wokuthintela isifo seKeshan, isifo sikaKashin-Beck kunye nezifo ezithile zentliziyo;
I-3.Iqulethe zombini i-calcium kunye ne-vitamin D. Ukudibaniswa kwezi zibini kunokuthintela ngokufanelekileyo kunye nokunyanga i-rickets;
I-4.Umxholo wayo ophezulu we-zinc unenzuzo ekukhuthazeni ukuphuhliswa kwengqondo, ukugcina i-acuity ebonakalayo kunye nokukhuthaza ukuphulukiswa kwesilonda;
I-5.Ukudibanisa umxholo ophezulu we-vitamin E kunye ne-selenium yenza ukuba ibe nemiphumo yokuchasana nokuguga, ukuphuculwa kwememori kunye nokuphucula ukuvakalelwa.Ngexesha elifanayo, i-immunomodulator egqwesileyo.
6.Njengonyango lwaseTshayina, i-Grifola frondosa ilingana nePolyporus umbellatus.Iyakwazi ukunyanga i-dysuria, i-edema, unyawo lomdlali, i-cirrhosis, i-ascites kunye nesifo seswekile.
I-7.Inayo nefuthe lokuthintela uxinzelelo lwegazi kunye nokukhuluphala.
8.Umthamo ophezulu weselenium weGrifola frondosa unokuthintela umhlaza.

Uvavanyo lwezilwanyana kunye novavanyo lweklinikhi lubonisa ukuba i-Maitake D-fraction yenza iziphumo ezichasene nomhlaza ngale miba ilandelayo:
I-1.Inokusebenzisa iiseli ze-immune ezifana ne-phagocytes, iiseli ezibulalayo zendalo kunye neeseli ze-cytotoxic T, kwaye zenze ukukhutshwa kwee-cytokines ezifana ne-leukin, i-interferon-γ, kunye ne-tumor necrosis factor-α.
2.Inokwenza i-apoptosis yeeseli zomhlaza.
I-3.Idibaniswe neziyobisi ze-chemotherapy zendabuko (ezifana ne-mitomycin kunye ne-Carmustine), azigcini nje ukwandisa ukusebenza kweyeza kodwa zinciphisa iziphumo ezinobuthi kunye nemiphumo emibi ngexesha le-chemotherapy.
I-4.Impembelelo ye-Synergistic kunye neziyobisi ze-immunotherapy (interferon-α2b).
5. Iyakwazi ukukhulula intlungu yezigulane ezinomhlaza ophezulu, ukwandisa ukutya kunye nokuphucula umgangatho wobomi bezigulane.