He kanaka maoli ʻo Grifola frondosa (i kapa ʻia ʻo Maitake) i nā wahi mauna o ka ʻākau o Iapana.He ʻano mea ʻai-lāʻau lāʻau me ka ʻono maikaʻi a me nā hopena lāʻau lapaʻau.Ua manaʻo nui ʻia ʻo ia he hoʻomaikaʻi i ka ʻohana aliʻi Iapana mai ka wā kahiko.ʻAʻole i mahi maikaʻi ʻia kēia ʻaha a hiki i ka waena o 1980s.Mai ia manawa, ua hana nā kānaka ʻepekema nui ma Iapana i kahi noiʻi nui e pili ana i ka halo Maitake ma ke kemika, ka biochemistry a me ka lāʻau lapaʻau, e hōʻoia ana he halo waiwai ʻo Maitake no ka lāʻau lapaʻau a me ka meaʻai.Maikaʻi loa ʻo Maitake D-fraction, ka mea hoʻoikaika ikaika loa i unuhi ʻia mai loko mai o Maitake mushroom, he hopena anti-cancer ikaika.

ʻO nā haʻawina piha e pili ana i nā hopena pharmacological o Grifola frondosa ma Iapana, Kanada, Italia a me United Kingdom i nā makahiki i hala iho nei ua hōʻike ʻo Grifola frondosa i nā hopena o ka anti-cancer, hoʻoikaika kino, anti-hypertension, hoʻohaʻahaʻa i ke kō koko, hoʻohaʻahaʻa i nā lipids koko a nā maʻi anti-hepatitis.

I ka hōʻuluʻulu ʻana, loaʻa iā Grifola frondosa nā hana mālama olakino:
1. No ka mea he waiwai ia i ka hao, ke keleawe a me ka huaora C, hiki iā ia ke pale i ka anemia, scurvy, vitiligo, arteriosclerosis a me ka thrombosis cerebral;
2. He kiʻekiʻe ka selenium a me ka chromium maʻiʻo, hiki ke pale i ke ake a me ka pancreas, pale i ka cirrhosis ate a me ka maʻi diabetes;ʻO kāna mau mea selenium kiʻekiʻe ka hana o ka pale ʻana i ka maʻi Keshan, Kashin-Beck maʻi a me kekahi mau maʻi puʻuwai;
3. Loaʻa iā ia ka calcium a me ka vitamina D. ʻO ka hui pū ʻana o nā mea ʻelua hiki ke pale a mālama pono i nā rickets;
4. ʻO kāna mau mea zinc kiʻekiʻe he mea pono e hoʻoikaika i ka ulu ʻana o ka lolo, mālama i ka ʻike acuity a paipai i ka ho'ōla ʻana i ka ʻeha;
5. ʻO ka hui pū ʻana o kahi maʻiʻo kiʻekiʻe o ka vitamina E a me ka selenium hiki iā ia ke loaʻa nā hopena o ka anti-aging, hoʻomaikaʻi hoʻomanaʻo a me ka hoʻonui ʻana i ka naʻau.I ka manawa like, he immunomodulator maikaʻi loa.
6. Ma ke ʻano he lāʻau lapaʻau kuʻuna Kina, ua like ʻo Grifola frondosa me Polyporus umbellatus.Hiki iā ia ke ho'ōla i ka dysuria, edema, ka wāwae o ka 'âlapa, cirrhosis, ascites a me ka ma'i ma'i.
7. It no hoi ka hopena o ka inhibiting hypertension a me ka momona.
8. ʻO ka mea kiʻekiʻe o ka selenium o Grifola frondosa hiki ke pale i ka maʻi kanesa.

Hōʻike nā hoʻokolohua holoholona a me nā hoʻokolohua lapaʻau e hoʻohana ana ʻo Maitake D-fraction i nā hopena anti-cancer ma o kēia mau ʻaoʻao:
1. Hiki iā ia ke ho'āla i nā pūnaewele immune e like me nā phagocytes, nā pūnaewele pepehi maoli a me nā pūnaewele T cytotoxic, a hoʻoulu i ka huna o nā cytokines e like me ka leukin, interferon-γ, a me ka tumor necrosis factor-α.
2. Hiki iā ia ke hoʻoulu i ka apoptosis o nā maʻi kanesa.
3.Hoʻohuiʻia me nā lāʻau lapaʻau maʻamau (e like me ka mitomycin a me Carmustine),ʻaʻole ia e hoʻonui wale i ka pono o ka lāʻau akā e ho'ēmi i nā meaʻawaʻawa a me nā hopena i ka wā o ka chemotherapy.
4.Synergistic hopena me immunotherapy lāʻau (interferon-α2b).
5. Hiki iā ia ke hoʻomaha i ka ʻeha o nā maʻi maʻi maʻi maʻi, hoʻonui i ka ʻai a hoʻomaikaʻi i ka maikaʻi o ke ola o nā maʻi.