Januwari 2020/Peking University/Acta Pharmacologica Sinica

Umbhalo/ Wu Tingyao

Ithimba eliholwa nguSolwazi Baoxue Yang, usihlalo woMnyango Wezemithi, i-Peking University, lishicilele izindatshana ezimbili ku-Acta Pharmacologica Sinica ekuqaleni kuka-2020, eqinisekisa lokho.I-Ganoderma lucidumama-triterpenes angabambezela ukuqhubeka kwe-renal fibrosis nesifo sezinso se-polycystic, futhi izingxenye zawo eziyinhloko ezisebenzayo i-ganoderic acid A.

I-Ganoderic acid ibambezela ukuqhubeka kwe-renal fibrosis.

Abacwaningi babophe i-ureter ohlangothini olulodwa lwegundane.Ezinsukwini eziyishumi nane kamuva, igundane lalizoba ne-renal fibrosis ngenxa yokuphazamiseka kokuchama nokubuyela emuva komchamo.Ngesikhathi esifanayo, igazi layo le-urea nitrogen (BUN) ne-creatinine (Cr) nayo izokwanda, okubonisa ukungasebenzi kahle kwezinso.

Kodwa-ke, uma i-ganoderic acid inikezwa ngethamo lansuku zonke lama-50 mg/kg ngomjovo we-intraperitoneal ngokushesha ngemva kokuxhunywa kwe-ureter, izinga le-renal fibrosis noma ukukhubazeka kokusebenza kwezinso kuzoncipha kakhulu ngemva kwezinsuku ezingu-14.

Ukuhlaziywa okwengeziwe kwendlela yokusebenza ehlobene kukhombisa ukuthi i-ganoderic acid ingavimbela ukuqhubeka kwe-renal fibrosis okungenani ezicini ezimbili:

Okokuqala, ama-acids e-ganoderic avimbela amangqamuzana e-renal tubular epithelial avamile ukuthi angaguquki abe amaseli e-mesenchymal akhipha izinto ezihlobene ne-fibrosis (le nqubo ibizwa ngokuthi i-epithelial-to-mesenchymal transition, EMT);okwesibili, i-ganoderic acids inganciphisa ukubonakaliswa kwe-fibronectin nezinye izinto ezihlobene ne-fibrosis.

Njenge-triterpenoid egcwele kakhuluI-Ganoderma lucidum, i-Ganoderic acid inezinhlobo eziningi.Ukuze kuqinisekiswe ukuthi iyiphi i-ganoderic acid enomphumela oshiwo ngenhla wokuvikela izinso, abacwaningi bahlakulela i-ganoderic acid eyinhloko A, B, kanye ne-C2 ngemigqa yamaseli e-renal tubular epithelial cell ekuhlanganiseni kwe-100 μg/mL.Ngesikhathi esifanayo, isici sokukhula i-TGF-β1, esibaluleke kakhulu ekuqhubekeleni phambili kwe-fibrosis, yengezwa ukuze kusetshenziswe amaseli ukuthi akhiphe amaprotheni ahlobene ne-fibrosis.

Imiphumela ibonisa ukuthi i-ganoderic acid A inomphumela omuhle kakhulu ekuvimbeleni ukukhishwa kwamaprotheni ahlobene ne-fibrosis emangqamuzaneni, futhi umphumela wayo unamandla nakakhulu kunalowo wengxube yokuqala ye-ganoderic acid.Ngakho-ke, abacwaningi bayakukholelwa lokhoI-Ganoderma lucidumiwumthombo osebenzayo wokunciphisa i-fibrosis yezinso.Kubaluleke kakhulu ukuthi i-ganoderic acid A ayinawo umthelela onobuthi kumaseli ezinso futhi ngeke ibulale noma ilimaze amaseli ezinso.

I-Ganoderic acids ibambezela ukuqhubeka kwesifo sezinso se-polycystic.

Ngokungafani ne-renal fibrosis, ebangelwa kakhulu izici zangaphandle njengezifo nezidakamizwa, isifo sezinso se-polycystic sibangelwa ukuguqulwa kofuzo ku-chromosome.Ama-vesicle ezinhlangothini zombili zezinso kancane kancane azokhula futhi abe maningi ukuze acindezele izicubu ezivamile zezinso futhi aphazamise ukusebenza kwezinso.

Phambilini, iqembu lika-Baoxue Yang likufakazele lokhoI-Ganodermalucidumama-triterpenes angabambezela ukuqhubeka kwesifo sezinso ze-polycystic futhi avikele ukusebenza kwezinso.Nokho, iI-Ganodermalucidumama-triterpenes asetshenziswe ocwaningweni okungenani afaka ama-ganoderic acid A, B, C2, D, F, G, T, DM kanye nama-ganoderenic acid A, B, D, no-F.

Ukuze bathole izithako ezisebenzayo ezibalulekile, abacwaningi bahlole izinhlobo eziyi-12 zama-triterpenes ngamunye ngamunye ngokusebenzisa izivivinyo ze-in vitro futhi bathola ukuthi azikho kuzo ezithinta ukusinda kwamangqamuzana ezinso kodwa anomehluko omkhulu ekuvinjweni kokukhula kwe-vesicle.Phakathi kwabo, i-ganoderic acid A inomphumela omuhle kakhulu.

Ngaphezu kwalokho, i-ganoderic acid A yakhuliswa ku-vitro ngezinso zamagundane e-embryonic kanye nama-ejenti adala ukwakheka kwe-vesicle.Ngenxa yalokho, i-ganoderic acid A isengakwazi ukuvimbela inombolo nobukhulu bama-vesicles ngaphandle kokuphazamisa ukukhula kwezinso.Umthamo wayo osebenzayo wawungu-100μg/mL, ofanayo nomthamo we-triterpenes osetshenziswe ekuhloleni kwangaphambilini.

Ukuhlolwa kwezilwane kuphinde kwathola ukuthi umjovo ongaphansi kwesikhumba we-50 mg/kg we-ganoderic acid A kumagundane azalwa isikhashana anesifo sezinso se-polycystic nsuku zonke, ngemva kwezinsuku ezine zokwelashwa, ungathuthukisa ukuvuvukala kwezinso ngaphandle kokuphazamisa isisindo sesibindi nesisindo somzimba.Futhi kunciphisa umthamo kanye nenani lama-vesicles ezinso, ukuze indawo yokusabalalisa yama-vesicles ezinso yehliswe cishe ngama-40% uma kuqhathaniswa neqembu lokulawula ngaphandle kokuvikelwa kwe-ganoderic acid A.

Njengoba umthamo osebenzayo we-ganoderic acid A ekuhlolweni wawuyingxenye eyodwa kwezine yokuhlolwa okufanayoGi-anodermalucidumtriterpenes, kuboniswa ukuthi i-ganoderic acid A iyisici esibalulekileGi-anodermalucidumama-triterpenes ukuze abambezele ukuqhubeka kwesifo sezinso se-polycystic.Ukusebenzisa umthamo ofanayo we-ganoderic acid A kumagundane avamile asanda kuzalwa akuzange kuthinte usayizi wezinso zawo, okubonisa ukuthi i-ganoderic acid A inezinga elithile lokuphepha.

Kusukela ku-renal fibrosis kuya ekuhlulekeni kwezinso, kungashiwo ukuthi isifo sezinso esingalapheki esibangelwa izimbangela ezihlukahlukene (ezifana nesifo sikashukela) nakanjani sizohamba endleleni engabuyi.

Ezigulini ezinesifo sezinso ze-polycystic, izinga lokwehla komsebenzi wezinso lingase libe ngokushesha.Ngokwezibalo, cishe uhhafu weziguli ezinesifo sezinso ze-polycystic zizoqhubekela phambili ekuhlulekeni kwezinso lapho sezineminyaka engama-60 futhi zidinga i-dialysis impilo yonke.

Kungakhathaliseki ukuthi i-pathogenic factor itholakala noma izalwa, akulula "ukuguqula umsebenzi wezinso"!Kodwa-ke, uma izinga lokuwohloka kwezinso lingancishiswa ukuze lilingane nobude bempilo, kungase kwenzeke ukwenza ukuphila okugulayo kungabi nathemba futhi kubukeke kakhudlwana.

Ngokuhlola amangqamuzana nezilwane, ithimba labacwaningi lika-Baoxue Yang likufakazele ukuthi i-Ganoderic acid A, eyenza ingxenye enkulu kakhulu ye-I-Ganoderma lucidumtriterpenes, iyingxenye yenkomba yeI-Ganoderma lucidumukuvikela izinso.

Lo mphumela wocwaningo ugqamisa ukuthi ucwaningo lwesayensi lweI-Ganoderma lucidumiqinile kangangokuthi ingakutshela ukuthi iyiphi isithako imiphumela yayoI-Ganoderma lucidumikakhulukazi zivela esikhundleni nje ukudweba fantasy pie ngomcabango wakho.Yiqiniso, akusho ukuthi i-ganoderic acid A kuphela engavikela izinso.Eqinisweni, ezinye izithako ze-I-Ganoderma lucidumziwusizo ngempela ezinso.

Isibonelo nje, elinye iphepha elishicilelwe ithimba likaBaoxue Yang ngesihloko sokuvikela izinso liveze ukuthiI-Ganoderma lucidumUkukhishwa kwe-polysaccharide kunganciphisa ukulimala kwe-oxidative ezicutshini zezinso ngomphumela wayo we-antioxidant.I-“I-Ganoderma lucidumi-total triterpenes”, equkethe ama-triterpenoid ahlukahlukene njengama-ganoderic acid, ama-ganoderenic acid nama-ganoderiol, asebenza ndawonye ukuze abambezele ukuqhubeka kwe-renal fibrosis nesifo sezinso se-polycystic, nakho okumangazayo ososayensi.

Ngaphezu kwalokho, isidingo sokuvikela izinso asixazululeki ngokuvikela izinso kuphela.Ezinye izinto ezinjengokulawula ukungatheleleki, ukuthuthukisa amazinga amathathu aphezulu, ukulinganisa i-endocrine, ukuthulisa imizwa nokusiza ukulala ngokuqinisekile kuyasiza ekuvikeleni izinso.Lezi zici azikwazi ukuxazululwa ngokuphelele nge-ganoderic acid A iyodwa.

Ubugugu beI-Ganoderma lucidumilele ezithakweni zayo ezihlukene kanye nemisebenzi ehlukahlukene, engakwazi ukusebenzisana ukuze ikhiqize ibhalansi engcono kakhulu yomzimba.Ngamanye amazwi, uma i-ganoderic acid A ishoda, umsebenzi wokuvikela izinso uzontula amandla amaningi okulwa njengeqembu elintula abadlali abakhulu.

I-Ganoderma lucidumene-ganoderic acid A ikufanelekela kakhulu lokho esikulindele ngenxa yomphumela wayo ongcono wokuvikela izinso.

[Umthombo Wedatha]

1. Geng XQ, et al.I-Ganoderic acid ivimbela i-renal fibrosis ngokucindezela izindlela zokusayina ze-TGF-β/Smad kanye ne-MAPK.I-Acta Pharmacol Sin.2020, 41: 670-677.doi: 10.1038/s41401-019-0324-7.

2. UMeng J, et al.I-Ganoderic acid A iyisithako esisebenzayo se-Ganoderma triterpenes ekuvimbeleni ukuthuthukiswa kwe-cyst yezinso kwisifo sezinso se-polycystic.I-Acta Pharmacol Sin.2020, 41: 782-790.doi: 10.1038/s41401-019-0329-2.

3. USu L, et al.I-Ganoderma triterpenes ibuyisela emuva ukuthuthukiswa kwesimila sezinso ngokunciphisa ukusayinda kwe-Ras/MAPK nokukhuthaza ukuhlukaniswa kwamaseli.Izinso Int.2017 Dec;92(6): 1404-1418.doi: 10.1016/j.kint.2017.04.013.

4. UZhong D, nabanye.I-Ganoderma lucidum polysaccharide peptide ivimbela ukulimala kwe-renal ischemia reperfusion ngokuphikisana nengcindezi ye-oxidative.Sci Rep. 2015 Nov 25;5: 16910. doi: 10.1038/srep16910.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao
U-Wu Tingyao ubelokhu ebika mathuphaI-Ganoderma lucidumulwazi kusukela ngo-1999. Ungumbhali weUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).
 
★ Lesi sihloko sishicilelwe ngaphansi kwegunya elikhethekile lombhali ★ Le misebenzi engenhla ayikwazi ukuphinda ikhiqizwe, icashunwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali ★ Ukwephulwa kwesitatimende esingenhla, umbhali uzoqhuba izibopho zayo zomthetho ezihlobene ★ Eyokuqala umbhalo walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.