Janairu 2020/Jami'ar Peking/Acta Pharmacologica Sinica

Rubutu/ Wu Tingyao

Tawagar karkashin jagorancin Farfesa Baoxue Yang, shugaban Sashen Kimiyyar Magunguna na Jami'ar Peking, ya buga labarai guda biyu a cikin Acta Pharmacologica Sinica a farkon 2020, yana mai tabbatar da cewa.Ganoderma lucidumtriterpenes na iya jinkirta ci gaban fibrosis na koda da cututtukan koda na polycystic, kuma manyan abubuwan aikin su shine ganoderic acid A.

Ganoderic acid yana jinkirta ci gaban fibrosis na koda.

Masu binciken sun daure fitsarin a gefe daya na linzamin kwamfuta.Bayan kwana goma sha hudu, linzamin kwamfuta zai fara tasowa na renal fibrosis saboda toshewar fitsari da komawar fitsari.A lokaci guda kuma, sinadarin urea nitrogen (BUN) da creatinine (Cr) suma zasu karu, wanda ke nuna gazawar aikin koda.

Duk da haka, idan an ba da ganoderic acid a kashi na yau da kullum na 50 mg / kg ta hanyar allurar intraperitoneal nan da nan bayan da aka haɗa da ureter, ƙimar fibrosis na koda ko rashin aikin koda zai ragu sosai bayan kwanaki 14.

Ƙarin nazarin tsarin aikin da ke da alaƙa ya nuna cewa ganoderic acid zai iya hana ci gaban fibrosis na koda daga akalla abubuwa biyu:

Na farko, ganoderic acid ya hana al'ada tubular renal tubular epithelial sel daga canzawa zuwa sel mesenchymal wanda ke ɓoye abubuwan da ke da alaƙa da fibrosis (wannan tsari ana kiransa canjin epithelial-to-mesenchymal, EMT);na biyu, ganoderic acid na iya rage maganganun fibronectin da sauran abubuwan da suka shafi fibrosis.

Kamar yadda mafi yawan triterpenoid naGanoderma lucidum, Ganoderic acid yana da iri-iri.Don tabbatar da abin da ganoderic acid ke aiwatar da tasirin kariya na koda da aka ambata a sama, masu bincike sun haɓaka babban ganoderic acid A, B, da C2 tare da layin kwayar halitta na renal tubular epithelial cell a wani taro na 100 μg/mL.A lokaci guda kuma, TGF-β1 mai girma, wanda yake da mahimmanci don ci gaban fibrosis, an ƙara shi don haifar da sel don ɓoye sunadaran da ke da alaka da fibrosis.

Sakamakon ya nuna cewa ganoderic acid A yana da mafi kyawun tasiri wajen hana ɓoyewar sunadaran da ke da alaka da fibrosis a cikin sel, kuma tasirinsa ya fi karfi fiye da na asali na ganoderic acid cakuda.Saboda haka, masu bincike sun yi imanin cewaGanoderma lucidumshine tushen aiki na rage fibrosis na koda.Yana da mahimmanci musamman cewa ganoderic acid A ba shi da wani tasiri mai guba akan ƙwayoyin koda kuma ba zai kashe ko cutar da ƙwayoyin koda ba.

Ganoderic acid yana jinkirta ci gaban cututtukan koda na polycystic.

Ba kamar fibrosis na renal ba, wanda galibi ke haifar da abubuwan waje kamar cututtuka da magunguna, cutar koda ta polycystic tana faruwa ne ta hanyar maye gurbin kwayoyin halitta akan chromosome.Vesicles a bangarorin biyu na koda sannu a hankali za su yi girma kuma suna da yawa don danna kan kyallen koda na yau da kullun kuma suna lalata aikin koda.

A baya can, tawagar Baoxue Yang ta tabbatar da hakanGanodermalucidumtriterpenes na iya jinkirta ci gaban cututtukan koda na polycystic da kare aikin koda.Duk da haka, daGanodermalucidumtriterpenes da aka yi amfani da su a cikin gwajin aƙalla sun haɗa da ganoderic acid A, B, C2, D, F, G, T, DM da ganoderenic acid A, B, D, da F.

Don gano mahimman abubuwan da ke aiki, masu binciken sun bincika nau'ikan triterpenes guda 12 daya bayan daya ta hanyar gwaje-gwajen in vitro kuma sun gano cewa babu ɗayansu da ke shafar rayuwar ƙwayoyin koda amma suna da bambance-bambance masu mahimmanci a cikin hana haɓakar vesicle.Daga cikin su, ganoderic acid A yana da sakamako mafi kyau.

Bugu da ƙari, ganoderic acid A an haɓaka shi a cikin vitro tare da kodan berayen amfrayo da kuma abubuwan da ke haifar da samuwar vesicle.A sakamakon haka, ganoderic acid A zai iya hana lamba da girman vesicles ba tare da rinjayar ci gaban kodan ba.Matsayinsa mai tasiri shine 100μg/mL, daidai da adadin triterpenes da aka yi amfani da su a gwaje-gwajen da suka gabata.

Gwajin dabbobi kuma sun gano cewa allurar da aka yi ta hanyar subcutaneous na 50 mg/kg na ganoderic acid A cikin ƴaƴan ƙudan zuma masu ciwon koda na polycystic a kowace rana, bayan kwanaki huɗu na jiyya, na iya inganta kumburin koda ba tare da shafar nauyin hanta da nauyin jiki ba.Har ila yau, yana rage ƙarar da adadin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar kuma yana rage yawan ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta, ta yadda za a rage yawan rarraba kwayoyin cutar ta hanyar 40% idan aka kwatanta da ƙungiyar kulawa ba tare da ganoderic acid A kariya ba.

Tun da ingantaccen kashi na ganoderic acid A a cikin gwajin ya kasance kashi ɗaya cikin huɗu na gwaji ɗaya tare daGanodermalucidumtriterpenes, an nuna cewa ganoderic acid A hakika shine babban bangarenGanodermalucidumtriterpenes don jinkirta ci gaban cututtukan koda na polycystic.Yin amfani da kashi iri ɗaya na ganoderic acid A ga ƙullun da aka haifa na yau da kullum bai shafi girman kodan su ba, yana nuna cewa ganoderic acid A yana da matakan tsaro.

Tun daga fibrosis na koda zuwa gazawar koda, ana iya cewa cutar koda da ta haifar da dalilai daban-daban (kamar ciwon sukari) ba makawa za ta hau hanyar rashin dawowa.

Ga marasa lafiya da ciwon koda polycystic, yawan raguwar aikin koda na iya zama da sauri.Bisa kididdigar da aka yi, kusan rabin majinyata da ke fama da cutar koda na polycystic za su ci gaba zuwa gazawar koda a kusan shekaru 60 kuma suna buƙatar dialysis na tsawon rayuwa.

Ko da kuwa ko an samo kwayoyin cutar ko kuma na haihuwa, ba shi da sauƙi don "juya aikin koda"!Duk da haka, idan za a iya rage yawan lalacewar koda ta yadda za a iya daidaitawa da tsawon rayuwa, yana iya yiwuwa a sa rayuwar marasa lafiya ta zama rashin tausayi da kuma yanayin yanayi.

Ta hanyar gwaje-gwajen tantanin halitta da dabbobi, ƙungiyar bincike ta Baoxue Yang ta tabbatar da cewa Ganoderic acid A, wanda ke da mafi girman kaso naGanoderma lucidumtriterpenes, shine mai nuna alama bangarenGanoderma lucidumdomin kare koda.

Wannan sakamakon binciken ya nuna cewa binciken kimiyya naGanoderma lucidumyana da ƙarfi sosai wanda zai iya gaya muku wane sashi ne sakamakonGanoderma lucidumyafi zo daga maimakon kawai zana fantasy kek don tunanin ku.Tabbas, ba wai kawai ganoderic acid A zai iya kare koda ba.A gaskiya ma, wasu sauran sinadaran naGanoderma lucidumtabbas suna da amfani ga koda.

Misali, wata takarda da tawagar Baoxue Yang ta buga kan batun kare koda ta yi nuni da cewa.Ganoderma lucidumCire polysaccharide na iya rage lalacewar oxidative ga ƙwayar koda ta hanyar tasirin antioxidant.The"Ganoderma lucidumtotal triterpenes”, wanda ya ƙunshi nau'ikan triterpenoid irin su ganoderic acid, ganoderenic acid da ganoderiols, suna aiki tare don jinkirta ci gaban fibrosis na koda da cututtukan koda na polycystic, wanda kuma ya ba masana kimiyya mamaki.

Menene ƙari, buƙatun kare koda ba a warware ta ta hanyar kare koda kawai.Sauran abubuwa kamar daidaita garkuwar jiki, inganta manyan matakai guda uku, daidaita tsarin endocrin, kwantar da hankulan jijiyoyi da taimakawa barci tabbas suna taimakawa wajen kare koda.Ba za a iya warware waɗannan abubuwan gaba ɗaya ta ganoderic acid A kadai ba.

Da daraja naGanoderma lucidumya ta'allaka ne a cikin nau'o'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'in nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i nau'i) daban-daban, wanda zai iya daidaitawa da juna don samar da mafi kyawun ma'auni ga jiki.A wasu kalmomi, idan ganoderic acid A ya rasa, aikin kare lafiyar koda zai rasa ƙarfin gwagwarmaya kamar ƙungiyar da ba ta da manyan 'yan wasa.

Ganoderma lucidumtare da ganoderic acid A ya fi dacewa da tsammaninmu saboda mafi kyawun tasirin kare koda.

[Tsarin Bayanai]

1. Geng XQ, et al.Ganoderic acid yana hana fibrosis na renal ta hanyar murkushe hanyoyin siginar TGF-β/Smad da MAPK.Acta Pharmacol Sin.2020, 41: 670-677.doi: 10.1038/s41401-019-0324-7.

2. Meng J, da dai sauransu.Ganoderic acid A shine ingantaccen sashi na Ganoderma triterpenes a cikin jinkirta ci gaban cyst na koda a cikin cututtukan koda na polycystic.Acta Pharmacol Sin.2020, 41: 782-790.doi: 10.1038/s41401-019-0329-2.

3. Su L, et al.Ganoderma triterpenes retard renal cyst ci gaban ta hanyar rage daidaita siginar Ras/MAPK da haɓaka bambancin tantanin halitta.Koda Int.2017 Dec;92 (6): 1404-1418.doi: 10.1016/j.kint.2017.04.013.

4. Zhong D, da dai sauransu.Ganoderma lucidum polysaccharide peptide yana hana raunin ischemia reperfusion na koda ta hanyar magance damuwa na iskar oxygen.Sci Rep. 2015 Nuwamba 25;5: 16910. doi: 10.1038/srep16910.

KARSHE

Game da marubucin / Ms. Wu Tingyao
Wu Tingyao ya kasance yana bayar da rahoto da farkoGanoderma lucidumbayanai tun 1999. Ita ce marubucinWaraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).
 
★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubuci ★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cirewa ko amfani da su ta wasu hanyoyi ba tare da izini daga marubucin ba. Wu Tingyao ne ya rubuta wannan labarin da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.