Ndira 2020/Peking University/Acta Pharmacologica Sinica

Chinyorwa/ Wu Tingyao

Chikwata chinotungamirwa naProfessor Baoxue Yang, sachigaro weDhipatimendi rePharmacology, Peking University, yakaburitsa zvinyorwa zviviri muActa Pharmacologica Sinica kutanga kwa2020, zvichisimbisa izvozvo.Ganoderma lucidumtriterpenes inogona kunonoka kufambira mberi kwerenal fibrosis uye chirwere cheitsvo chepolycystic, uye zvikamu zvadzo zvikuru zvinoshanda iganoderic acid A.

Ganoderic acid inononoka kufambira mberi kwerenal fibrosis.

Vatsvakurudzi vakasungira ureter kune rimwe divi regonzo.Kwapera mazuva gumi nemana, mbeva yaizotanga renal fibrosis nekuda kwekuvharirwa kweweti nekudzokera shure kweweti.Panguva imwecheteyo, ropa rayo urea nitrogen (BUN) uye creatinine (Cr) ichawedzerawo, zvichiratidza kukanganisa kwetsvo.

Zvisinei, kana ganoderic acid ikapiwa pachiyero chezuva nezuva che 50 mg/kg nejekiseni re intraperitoneal pakarepo mushure mekubatanidza ureter, chiyero che renal fibrosis kana renal function impairment ichaderedzwa zvakanyanya mushure memazuva gumi nemana.

Kumwe kuongorora kweiyo yakabatana maitiro echiito kunoratidza kuti ganoderic acid inogona kudzivirira kufambira mberi kwerenal fibrosis kubva kune angangoita maviri maficha:

Kutanga, ganoderic acids inodzivirira zvakajairika renal tubular epithelial masero kubva pakushandurwa kuita mesenchymal masero anoburitsa zvinhu zvine chekuita nefibrosis (iyi nzira inonzi epithelial-to-mesenchymal transition, EMT);chechipiri, ganoderic acids inogona kuderedza kutaura kwefibronectin nezvimwe zvinhu zvine chekuita nefibrosis.

Sezvo yakanyanya kuwanda triterpenoid yeGanoderma lucidum, Ganoderic acid ine marudzi akawanda.Kuti uone kuti ndeipi ganoderic acid inoshandisa iyo yataurwa pamusoro pekudzivirira itsvo, vaongorori vakagadzira iyo huru ganoderic acids A, B, uye C2 ine renal tubular epithelial cell mitsara pakusangana kwe100 μg/mL.Panguva imwecheteyo, iyo yekukura chinhu TGF-β1, iyo inonyanya kukosha pakufambira mberi kwefibrosis, inowedzerwa kuita kuti masero abudise mapuroteni ane chekuita nefibrosis.

Zvigumisiro zvinoratidza kuti ganoderic acid A ine simba rakanakisisa mukudzivisa kuvharidzirwa kweprotein-yakabatana nefibrosis mumasero, uye mhedzisiro yayo yakanyanya kusimba kupfuura iyo yekutanga ganoderic acid musanganiswa.Naizvozvo, vatsvakurudzi vanodavira izvozvoGanoderma lucidumndiyo inoshanda sosi yekudzikisa itsvo fibrosis.Zvinonyanya kukosha kuti ganoderic acid A haina chepfu pamasero erenal uye haizourayi kana kukuvadza masero etsvo.

Ganoderic acids inononoka kufambira mberi kwepolycystic itsvo chirwere.

Kusiyana nerenal fibrosis, iyo inonyanya kukonzerwa nezvinhu zvekunze zvakadai sezvirwere nemishonga, chirwere chepolycystic itsvo chinokonzerwa nekuchinja kwemajini pakromosome.Ma vesicles pamativi ese eitsvo anozokura zvishoma nezvishoma uye kuwanda kuitira kudzvanya pane zvakajairika itsvo tishu uye kukanganisa kushanda kweitsvo.

Pakutanga, timu yaBaoxue Yang yakaratidza izvozvoGanodermalucidumtriterpenes inogona kunonoka kufambira mberi kwechirwere chepolycystic itsvo uye kudzivirira kushanda kweitsvo.Zvisinei, theGanodermalucidummatriterpenes anoshandiswa mukuyedza anosanganisira ganoderic acids A, B, C2, D, F, G, T, DM uye ganoderenic acids A, B, D, uye F.

Kuti vaone izvo zvakakosha zvinoshanda, vaongorori vakaongorora mhando gumi nembiri dze triterpenes imwe neimwe kuburikidza ne in vitro kuyedza uye vakaona kuti hapana kana chimwe chazvo chinokanganisa kupona kwemaseru eitsvo asi vane misiyano yakakura mukudzivirira kwekukura kwevesicle.Pakati pavo, ganoderic acid A ine mhedzisiro yakanaka.

Uyezve, ganoderic acid A yakagadzirwa mu vitro neitsvo dze embryo mbeva uye maajenti anokonzera kuumbwa kwevesicle.Nekuda kweizvozvo, ganoderic acid A inogona kuramba ichidzivirira nhamba uye saizi yevhesi pasina kukanganisa kukura kweitsvo.Mushonga wayo unoshanda waiva 100μg/mL, wakafanana nedoro retriterpenes rakashandiswa mukuedza kwekare.

Kuedza kwemhuka kwakawanawo kuti jekiseni rezasi re50 mg/kg yeganoderic acid A mumakonzo akaberekwa kwenguva pfupi ane chirwere chepolycystic itsvo zuva rega rega, mushure memazuva mana ekurapwa, anogona kuvandudza kuzvimba kweitsvo pasina kukanganisa huremu hwechiropa uye uremu hwemuviri.Iyo inoderedzawo vhoriyamu uye nhamba yerenal vesicles, kuitira kuti nzvimbo yekugovera yerenal vesicles inoderedzwa neanenge 40% kana ichienzaniswa neboka rinodzora pasina ganoderic acid A kudzivirira.

Sezvo dhigirii inoshanda yeganoderic acid A mukuyedza yaive chikamu chimwe muzvina chekuyedza kumwe cheteGanodermalucidumtriterpenes, zvinoratidzwa kuti ganoderic acid A ndiyo chikamu chakakosha cheGanodermalucidumtriterpenes kunonoka kufambira mberi kwepolycystic itsvo chirwere.Kushandisa muyero wakafanana weganoderic acid A kumakonzo achangozvarwa hakuna kukanganisa saizi yeitsvo dzavo, zvichiratidza kuti ganoderic acid A ine mwero wakati wekuchengeteka.

Kubva ku renal fibrosis kusvika kune renal kukundikana, zvinogona kutaurwa kuti chirwere chetsvo chisingaperi chinokonzerwa nezvikonzero zvakasiyana-siyana (zvakadai sechirwere cheshuga) zvichaenda nenzira isingadzoki.

Kune varwere vane chirwere chepolycystic itsvo, chiyero chekuderera kwetsvo chinogona kukurumidza.Zvinoenderana nenhamba, inenge hafu yevarwere vane polycystic itsvo chirwere vanozoenderera mberi nekutadza kweitsvo mukati mezera re60 uye inoda dialysis yehupenyu hwese.

Pasinei nokuti iyo pathogenic factor inowanikwa kana kuberekwa, hazvisi nyore "kudzosa basa retsvo"!Zvisinei, kana chiyero chekuora kwetsvo chichigona kuderedzwa kuitira kuti chienzane nehurefu hwehupenyu, zvingave zvichiita kuti hupenyu hwehurwere huve husina tariro uye huwedzere kunaka.

Kuburikidza nekuyedza kwesero uye mhuka, timu yekutsvagisa yeBaoxue Yang yakaratidza kuti Ganoderic acid A, iyo inomiririra chikamu chepamusoro cheGanoderma lucidumtriterpenes, chinhu chechiratidzo cheGanoderma lucidumkuitira kudzivirira itsvo.

Mhedzisiro yetsvagiridzo iyi inoratidza kuti tsvakiridzo yesainzi yeGanoderma lucidumyakasimba zvekuti inogona kukuudza kuti ndeipi ingredient inokonzeresaGanoderma lucidumkunyanya kubva pane kungodhirowa pai yekufungidzira yekufungidzira kwako.Zvechokwadi, hazvirevi kuti chete ganoderic acid A inogona kudzivirira itsvo.Sezvineiwo, zvimwe zvekushandisaGanoderma lucidumzvechokwadi zvinobatsira kune itsvo.

Semuenzaniso, rimwe bepa rakaburitswa nechikwata chaBaoxue Yang pamusoro pekudzivirira itsvo rakaratidza kuti.Ganoderma lucidumpolysaccharide inobvisa inogona kuderedza oxidative kukuvara kune itsvo tishu kuburikidza neiyo antioxidant mhedzisiro.The “Ganoderma lucidumtotal triterpenes”, ine matriterpenoid akasiyana-siyana akadai seanoderic acids, ganoderenic acids uye ganoderiols, anoshanda pamwe chete kunonoka kufambira mberi kwerenal fibrosis uye chirwere cheitsvo chepolycystic, izvo zvinoshamisawo masayendisiti.

Zvakare, kudiwa kwekudzivirira itsvo hakugadziriswe nekudzivirira itsvo chete.Zvimwe zvinhu zvakaita sekudzora kusadzivirirwa, kuvandudza matatu akakwira, kuenzanisa endocrine, kudzikamisa tsinga uye kubatsira kurara zvechokwadi zvinobatsira mukudzivirira itsvo.Aya maitiro haagone kugadziriswa zvizere neganoderic acid A chete.

Kukosha kweGanoderma luciduminorara mumisanganiswa yayo yakasiyana-siyana uye mabasa akasiyana-siyana, ayo anogona kurongeka pamwe chete kuti abudise chiyero chakanakisa chemuviri.Mune mamwe mazwi, kana ganoderic acid A ichishaikwa, basa rekudzivirira itsvo rinoshaya simba rakawanda rekurwisa sechikwata chinoshaya vatambi vakuru.

Ganoderma lucidumine ganoderic acid A inonyanya kukodzera zvatinotarisira nekuda kwekuita kwayo kuri nani kudzivirira itsvo.

[Data Kwakabva]

1. Geng XQ, nevamwe.Ganoderic acid inotadzisa renal fibrosis kuburikidza nekudzvinyirira TGF-β/Smad uye MAPK nzira dzekuratidzira.Acta Pharmacol Sin.2020, 41: 670-677.doi: 10.1038/s41401-019-0324-7.

2. Meng J, nevamwe.Ganoderic acid A ndiyo inoshanda yeGanoderma triterpenes mukudzoreredza renal cyst kukura mu polycystic itsvo chirwere.Acta Pharmacol Sin.2020, 41: 782-790.doi: 10.1038/s41401-019-0329-2.

3. Su L, nevamwe.Ganoderma triterpenes inodzoreredza renal cyst kukura nekudzikisira kusaina kweRas/MAPK uye nekusimudzira kusiyanisa kwesero.Kidney Int.2017 Dec;92(6): 1404-1418.doi: 10.1016/j.kint.2017.04.013.

4. Zhong D, nevamwe.Ganoderma lucidum polysaccharide peptide inodzivirira renal ischemia reperfusion kukuvara kuburikidza nekurwisa oxidative kusagadzikana.Sci Rep. 2015 Nov 25;5: 16910. doi: 10.1038/srep16910.

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Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achitaura nezvekutanga-ruokoGanoderma lucidumruzivo kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).
 
★Chinyorwa ichi chakatsikiswa pasi pemvumo yemunyori chete ★ Mabasa ari pamusoro haagone kutsikiswa, kudonhedzwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori ★ Kutyora chirevo chiri pamusoro, munyori achaita mabasa anoenderana nemutemo ★ Iwo ekutanga. chinyorwa chechinyorwa ichi chakanyorwa neChinese naWu Tingyao uye chakashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.