Mutarama 2020 / Kaminuza ya Peking / Acta Pharmacologica Sinica

Inyandiko / Wu Tingyao

Iri tsinda riyobowe na Porofeseri Baoxue Yang, umuyobozi w’ishami rya farumasi, kaminuza ya Peking, ryasohoye ingingo ebyiri muri Acta Pharmacologica Sinica mu ntangiriro za 2020, zemeza koGanoderma lucidumtriterpène irashobora gutinza iterambere rya fibrosis yimpyiko nindwara yimpyiko ya polycystic, kandi ibyingenzi byingenzi bikora ni acide ganoderic A.

Acide Ganoderic idindiza iterambere rya fibrosis yimpyiko.

Abashakashatsi bahambiriye ureter kuruhande rumwe rwimbeba.Nyuma yiminsi cumi nine, imbeba yakura fibrosis yimpyiko kubera kubuza inkari no gusubira inyuma kwinkari.Muri icyo gihe, amaraso ya urea azote (BUN) na creatinine (Cr) nayo aziyongera, byerekana imikorere mibi yimpyiko.

Ariko, niba acide ganoderic itanzwe kumupanga wa buri munsi wa 50 mg / kg ukoresheje inshinge za intraperitoneal ako kanya nyuma yo guterwa na ureter, urugero rwa fibrosis yimpyiko cyangwa imikorere yimpyiko izagabanuka cyane nyuma yiminsi 14.

Ubundi isesengura ryuburyo bujyanye nibikorwa byerekana ko aside ganoderic ishobora kubuza iterambere rya fibrosis yimpyiko byibura ibintu bibiri:

Ubwa mbere, acide ganoderic irinda impyiko zisanzwe zimpyiko zidahinduka mungirangingo ya mesenchymal isohora ibintu bifitanye isano na fibrosis (iyi nzira yitwa epithelial-to-mesenchymal transition, EMT);icya kabiri, acide ganoderic irashobora kugabanya imvugo ya fibronectine nibindi bintu bifitanye isano na fibrosis.

Nka triterpenoid nyinshi cyaneGanoderma lucidum, Acide ya Ganoderic ifite ubwoko bwinshi.Kugirango hemezwe aside ganoderic igira ingaruka zo kurinda impyiko zavuzwe haruguru, abashakashatsi bateje acide nyamukuru ya ganoderic A, B, na C2 hamwe numurongo wimpyiko zimpyiko za epithelial selile yibice 100 μg / mL.Muri icyo gihe, ibintu byo gukura TGF-β1, ni ntangarugero mu iterambere rya fibrosis, byongewemo kugira ngo bitume selile zisohora poroteyine ziterwa na fibrosis.

Ibisubizo byerekana ko acide ganoderic A igira ingaruka nziza mukubuza gusohora poroteyine ziterwa na fibrosis mu ngirabuzimafatizo, kandi ingaruka zayo zirakomeye kuruta izivanze na aside ya mbere ya ganoderic.Kubwibyo, abashakashatsi bemeza koGanoderma lucidumni isoko ikora yo kugabanya fibrosis.Ni iby'agaciro cyane ko aside ganoderic A idafite ingaruka z'ubumara ku ngirangingo z'impyiko kandi ntizice cyangwa ngo ikomeretsa ingirangingo.

Acide ya Ganoderic idindiza iterambere ryindwara zimpyiko.

Bitandukanye na fibrosis yimpyiko, iterwa ahanini nimpamvu zo hanze nkindwara nibiyobyabwenge, indwara yimpyiko polycystic iterwa na mutation ya gene kuri chromosome.Imitsi ku mpande zombi zimpyiko izagenda iba nini kandi nini cyane kugirango ikande ku ngingo zimpyiko zisanzwe kandi zibangamire imikorere yimpyiko.

Mbere, ikipe ya Baoxue Yang yabigaragajeGanodermalucidumtriterpène irashobora gutinza iterambere ryindwara yimpyiko kandi ikarinda imikorere yimpyiko.ArikoGanodermalucidumtriterpène ikoreshwa mubushakashatsi byibuze harimo acide ganoderic A, B, C2, D, F, G, T, DM na acide ganoderenic A, B, D, na F.

Mu rwego rwo kumenya ibintu by'ingenzi bikora, abashakashatsi basuzumye ubwoko 12 bwa triterpène umwe umwe binyuze mu bushakashatsi bwa vitro basanga nta na kimwe muri byo kigira ingaruka ku mibereho y'uturemangingo tw'impyiko ariko gifite itandukaniro rikomeye mu kubuza gukura kw'imitsi.Muri byo, aside ganoderic A ifite ingaruka nziza.

Byongeye kandi, aside ganoderic A yarezwe muri vitro hamwe nimpyiko zimbeba zo mu nda hamwe ningingo zitera imitsi.Nkigisubizo, acide ganoderic A irashobora kubuza umubare nubunini bwimitsi itagize ingaruka kumikurire yimpyiko.Igipimo cyacyo cyiza cyari 100μg / mL, kimwe na dose ya triterpène yakoreshejwe mubushakashatsi bwabanje.

Ubushakashatsi bw’inyamaswa bwerekanye kandi ko gutera inshinge 50 mg / kg ya acide ganoderic A mu mbeba zavutse zigufi zifite indwara zimpyiko za polycystic buri munsi, nyuma yiminsi ine yo kuvurwa, zishobora kunoza impyiko zitagize ingaruka ku buremere bwumwijima nuburemere bwumubiri.Igabanya kandi ingano numubare wimpyiko zimpyiko, kuburyo agace ko gukwirakwiza imitsi yimpyiko kagabanukaho hafi 40% ugereranije nitsinda rishinzwe kugenzura nta aside ya ganoderic A ikingira.

Kubera ko igipimo cyiza cya acide ganoderic A mubushakashatsi cyari kimwe cya kane cyubushakashatsi bumwe hamweGanodermalucidumtriterpène, herekanwa ko aside ganoderic A mubyukuri aribintu byingenzi bigizeGanodermalucidumtriterpène gutinza iterambere ryindwara zimpyiko.Gukoresha urugero rumwe rwa acide ganoderic A ku mbeba zisanzwe zavutse ntabwo byagize ingaruka ku bunini bwimpyiko zabo, byerekana ko aside ganoderic A ifite umutekano muke.

Kuva fibrosis yimpyiko kugeza kunanirwa kwimpyiko, dushobora kuvuga ko indwara zimpyiko zidakira ziterwa nimpamvu zitandukanye (nka diyabete) byanze bikunze zizagenda munzira yo kutagaruka.

Ku barwayi bafite impyiko za polycystic, umuvuduko wimikorere yimpyiko ushobora kwihuta.Nk’uko imibare ibigaragaza, hafi kimwe cya kabiri cy’abarwayi barwaye impyiko za polycystic bazatera imbere kunanirwa nimpyiko bafite imyaka 60 kandi bisaba dialyse yubuzima.

Tutitaye ku kuba ibintu bitera indwara byabonetse cyangwa byavutse, ntabwo byoroshye "guhindura imikorere y'impyiko"!Ariko, niba igipimo cyo kwangirika kwimpyiko gishobora gutinda kugirango gishobore kuringanizwa nuburebure bwubuzima, birashoboka ko ubuzima bwindwara butagabanuka kandi bukaba bwiza.

Binyuze mu bushakashatsi bw’utugingo n’inyamaswa, itsinda ry’ubushakashatsi bwa Baoxue Yang ryerekanye ko aside Ganoderic A, igize umubare munini waGanoderma lucidumtriterpène, ni ikimenyetso cyerekanaGanoderma lucidumkurinda impyiko.

Ibisubizo byubushakashatsi byerekana ko ubushakashatsi bwa siyanse bwaGanoderma lucidumirakomeye kuburyo ishobora kukubwira ibigize ingaruka zaGanoderma lucidumahanini biva aho kugirango ushushanye gusa pie fantasy kubitekerezo byawe.Nibyo, ntabwo bivuze ko aside ganoderic A yonyine ishobora kurinda impyiko.Mubyukuri, bimwe mubindi bigizeGanoderma lucidumni byiza rwose ku mpyiko.

Kurugero, urundi rupapuro rwashyizwe ahagaragara nitsinda rya Baoxue Yang ku ngingo yo kurinda impyiko rwerekanye koGanoderma lucidumibishishwa bya polysaccharide birashobora kugabanya kwangiza okiside kwangirika kwimpyiko binyuze muri antioxydeant.“Ganoderma lucidumtotal triterpène ”, irimo triterpenoide zitandukanye nka acide ganoderic, acide ganoderenic na ganoderiol, zikorana hamwe kugirango bidindiza iterambere rya fibrosis yimpyiko nindwara yimpyiko ya polycystic, nayo itungura abahanga.

Ikirenzeho, gukenera kurinda impyiko ntibikemurwa no kurinda impyiko wenyine.Ibindi nko kugenzura ubudahangarwa, kunoza uburebure butatu, kuringaniza endocrine, gutuza imitsi no gufasha gusinzira rwose bifasha kurinda impyiko.Izi ngingo ntizishobora gukemurwa rwose na acide ganoderic A yonyine.

Agaciro kaGanoderma lucidumibeshya mubintu bitandukanye bitandukanye nibikorwa bitandukanye, bishobora guhuza hamwe kugirango bitange uburinganire bwiza kumubiri.Muyandi magambo, niba aside ganoderic A ibuze, umurimo wo kurinda impyiko uzabura imbaraga nyinshi zo kurwana nkikipe ibura abakinnyi bakomeye.

Ganoderma lucidumhamwe na acide ganoderic A irakwiriye cyane kubyo dutegereje kubera ingaruka nziza zo kurinda impyiko.

[Inkomoko y'amakuru]

1. Geng XQ, n'abandi.Acide ya Ganoderic ibuza fibrosis yimpyiko binyuze mu guhagarika TGF-β / Smad na MAPK byerekana inzira.Acta Pharmacol Icyaha.2020, 41: 670-677.doi: 10.1038 / s41401-019-0324-7.

2. Meng J, n'abandi.Acide Ganoderic A ni ingirakamaro ya Ganoderma triterpène mu kudindiza iterambere ryimpyiko mu ndwara zimpyiko.Acta Pharmacol Icyaha.2020, 41: 782-790.doi: 10.1038 / s41401-019-0329-2.

3. Su L, n'abandi.Ganoderma triterpenes idindiza iterambere ryimpyiko muguhagarika ibimenyetso bya Ras / MAPK no guteza imbere gutandukanya selile.Impyiko Int.Ukuboza 2017;92 (6): 1404-1418.doi: 10.1016 / j.kint.2017.04.013.

4. Zhong D, n'abandi.Ganoderma lucidum polysaccharide peptide irinda impyiko ischemia reperfusion ibikomere binyuze mukurwanya impagarara za okiside.Sci Rep. 2015 Ugushyingo 25;5: 16910. doi: 10.1038 / srep16910.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao
Wu Tingyao yagiye atanga raporo imbonankuboneGanoderma lucidumamakuru kuva 1999. Niwe mwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).
 
★ Iyi ngingo yasohowe ku ruhushya rwihariye rw’umwanditsi works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mu bundi buryo utabiherewe uburenganzira n’umwanditsi ★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakomeza inshingano zijyanye n’amategeko ★ Umwimerere inyandiko yiyi ngingo yanditswe mu gishinwa na Wu Tingyao ihindurwa mu Cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.