Januware 2020/Peking University/Acta Pharmacologica Sinica

Zolemba / Wu Tingyao

Gulu lotsogozedwa ndi Pulofesa Baoxue Yang, wapampando wa dipatimenti ya zamankhwala ku yunivesite ya Peking, adasindikiza zolemba ziwiri mu Acta Pharmacologica Sinica koyambirira kwa 2020, kutsimikizira kuti.Ganoderma lucidumtriterpenes amatha kuchedwetsa kukula kwa aimpso fibrosis ndi polycystic matenda a impso, ndipo zigawo zake zazikulu zogwira ntchito ndi ganoderic acid A.

Ganoderic acid imachepetsa kukula kwa aimpso fibrosis.

Ofufuzawo anamanga mkodzowo mbali imodzi ya mbewa.Patatha masiku 14, mbewayo imayamba kudwala aimpso fibrosis chifukwa cha kutsekeka kwa mkodzo komanso kubwerera m'mbuyo kwa mkodzo.Nthawi yomweyo, magazi ake a urea nitrogen (BUN) ndi creatinine (Cr) nawonso adzawonjezeka, zomwe zikuwonetsa kuwonongeka kwa aimpso.

Komabe, ngati ganoderic acid imaperekedwa tsiku ndi tsiku mlingo wa 50 mg/kg ndi jakisoni wa intraperitoneal atangomanga mkodzo, kuchuluka kwa aimpso fibrosis kapena kuwonongeka kwa aimpso kumachepetsedwa kwambiri pakadutsa masiku 14.

Kuwunika kwinanso kwamachitidwe ofananirako kukuwonetsa kuti ganoderic acid imatha kuletsa kufalikira kwa aimpso fibrosis kuchokera ku mbali ziwiri:

Choyamba, ma asidi a ganoderic amalepheretsa ma cell a epithelial amphuno kuti asasinthe kukhala maselo a mesenchymal omwe amatulutsa zinthu zokhudzana ndi fibrosis (njira imeneyi imatchedwa epithelial-to-mesenchymal transition, EMT);chachiwiri, ganoderic acids amatha kuchepetsa kufotokoza kwa fibronectin ndi zinthu zina zokhudzana ndi fibrosis.

Monga triterpenoid wochuluka kwambiri waGanoderma lucidum, asidi wa Ganoderic ali ndi mitundu yambiri.Pofuna kutsimikizira kuti ndi ganoderic acid iti yomwe ili ndi chitetezo cha impso zomwe tatchulazi, ofufuzawo adapanga ma ganoderic acid A, B, ndi C2 okhala ndi ma cell a aimpso a epithelial cell pamlingo wa 100 μg/mL.Panthawi imodzimodziyo, kukula kwa TGF-β1, komwe kuli kofunikira kwambiri kuti fibrosis ipite patsogolo, imawonjezedwa kuti ipangitse maselo kutulutsa mapuloteni okhudzana ndi fibrosis.

Zotsatira zikuwonetsa kuti ganoderic acid A imakhala ndi zotsatira zabwino kwambiri poletsa kutulutsidwa kwa mapuloteni okhudzana ndi fibrosis m'maselo, ndipo zotsatira zake zimakhala zamphamvu kwambiri kuposa zosakaniza zoyambirira za ganoderic acid.Choncho, ofufuza amakhulupirira zimenezoGanoderma lucidumndi gwero yogwira kuchepetsa impso fibrosis.Ndikofunikira kwambiri kuti ganoderic acid A alibe mphamvu yowopsa pama cell a aimpso ndipo sangaphe kapena kuvulaza ma cell a aimpso.

Ma asidi a ganoderic amachepetsa kukula kwa matenda a impso a polycystic.

Mosiyana ndi renal fibrosis, yomwe makamaka imayamba chifukwa cha zinthu zakunja monga matenda ndi mankhwala osokoneza bongo, matenda a impso a polycystic amayamba chifukwa cha kusintha kwa jini pa chromosome.Ma vesicles kumbali zonse ziwiri za impso amakula pang'onopang'ono ndikuchulukirachulukira kotero kuti akanikizire minyewa yaimpso ndi kusokoneza ntchito ya impso.

M'mbuyomu, gulu la Baoxue Yang latsimikizira iziGanodermalucidumtriterpenes amatha kuchedwetsa kukula kwa matenda a impso a polycystic ndikuteteza kugwira ntchito kwa impso.Komabe, aGanodermalucidumMa triterpenes omwe amagwiritsidwa ntchito pakuyesako amaphatikiza ma ganoderic acid A, B, C2, D, F, G, T, DM ndi ganoderenic acid A, B, D, ndi F.

Kuti adziwe zomwe zimagwira ntchito, ofufuzawo adafufuza mitundu 12 ya triterpenes imodzi ndi imodzi kudzera mu zoyeserera za in vitro ndipo adapeza kuti palibe yomwe imakhudza kupulumuka kwa maselo a impso koma amasiyana kwambiri pakuletsa kukula kwa vesicle.Pakati pawo, ganoderic acid A imakhala ndi zotsatira zabwino kwambiri.

Kuphatikiza apo, ganoderic acid A idakulitsidwa mu vitro ndi impso za mbewa za embryonic ndi othandizira omwe amapangitsa kupanga ma vesicle.Zotsatira zake, ganoderic acid A imatha kuletsabe kuchuluka ndi kukula kwa ma vesicles popanda kusokoneza kukula kwa impso.Mlingo wake wogwira mtima unali 100μg/mL, mofanana ndi mlingo wa triterpenes wogwiritsidwa ntchito m'mayesero apitalo.

Kuyesa kwanyama kwapezanso kuti jekeseni wocheperako wa 50 mg/kg wa ganoderic acid A mu mbewa zobadwa pang'ono zokhala ndi matenda a impso a polycystic tsiku lililonse, pakatha masiku anayi akulandira chithandizo, zimatha kusintha kutupa kwa impso popanda kukhudza kulemera kwa chiwindi ndi kulemera kwa thupi.Komanso amachepetsa voliyumu ndi chiwerengero cha aimpso vesicles, kotero kuti kugawa dera vesicles aimpso yafupika pafupifupi 40% poyerekeza ndi gulu ulamuliro popanda ganoderic asidi A chitetezo.

Popeza mlingo wogwira mtima wa ganoderic acid A mu kuyesera unali gawo limodzi mwa magawo anayi a kuyesa komweku ndiGanodermalucidumtriterpenes, zikuwonetsedwa kuti ganoderic acid A ndiye gawo lalikulu laGanodermalucidumtriterpenes kuti achedwetse kukula kwa matenda a impso a polycystic.Kugwiritsa ntchito mlingo womwewo wa ganoderic acid A kwa mbewa zachibadwa sikunakhudze kukula kwa impso zawo, kusonyeza kuti ganoderic acid A imakhala ndi chitetezo china.

Kuchokera ku renal fibrosis mpaka kulephera kwaimpso, tinganene kuti matenda aakulu a impso omwe amayamba chifukwa cha zifukwa zosiyanasiyana (monga matenda a shuga) adzapita njira yosabwereranso.

Kwa odwala omwe ali ndi matenda a impso a polycystic, kuchepa kwa ntchito yaimpso kumatha kukhala kofulumira.Malinga ndi ziwerengero, pafupifupi theka la odwala omwe ali ndi matenda a impso a polycystic adzakula mpaka kulephera kwa impso ali ndi zaka 60 ndipo amafunikira dialysis kwa moyo wonse.

Mosasamala kanthu kuti chinthu cha pathogenic chimapezeka kapena chobadwa nacho, sikophweka "kusokoneza ntchito ya impso"!Komabe, ngati kuwonongeka kwa impso kungachedwetsedwe kuti kukhale kofanana ndi kutalika kwa moyo, kungakhale kotheka kupangitsa moyo wa matendawo kukhala wopanda chiyembekezo komanso wowoneka bwino.

Kupyolera mu kuyesa kwa ma cell ndi nyama, gulu lofufuza la Baoxue Yang latsimikizira kuti Ganoderic acid A, yomwe imakhala ndi gawo lalikulu kwambiri la mankhwalawa.Ganoderma lucidumtriterpenes, ndi chigawo cha chizindikiro chaGanoderma lucidumpofuna kuteteza impso.

Zotsatira za kafukufukuyu zikuwonetsa kuti kafukufuku wasayansi waGanoderma lucidumndi olimba kotero kuti akhoza kukuuzani zomwe pophika zotsatira zakeGanoderma lucidummakamaka kuchokera m'malo mongojambulira chitumbuwa chongopeka kuti muganizire.Inde, sizikutanthauza kuti ganoderic acid A yokha ingateteze impso.M'malo mwake, zosakaniza zina zaGanoderma lucidumndithudi opindulitsa kwa impso.

Mwachitsanzo, pepala lina lofalitsidwa ndi gulu la Baoxue Yang pa nkhani yoteteza impso linanena kuti.Ganoderma lucidumKutulutsa kwa polysaccharide kumatha kuchepetsa kuwonongeka kwa okosijeni kwa minofu ya impso kudzera mu antioxidant yake.The “Ganoderma lucidumtotal triterpenes”, yomwe ili ndi ma triterpenoids osiyanasiyana monga ma ganoderic acid, ganoderenic acid ndi ganoderiols, amagwira ntchito limodzi kuti achedwetse kufalikira kwa aimpso fibrosis ndi polycystic impso, zomwe zimadabwitsanso asayansi.

Kuphatikiza apo, kufunika koteteza impso sikuthetsedwa mwa kuteteza impso zokha.Zinthu zina monga kuwongolera chitetezo chamthupi, kuwongolera kukwera katatu, kusanja endocrine, kukhazika mtima pansi ndikuthandizira kugona ndizothandiza kwambiri kuteteza impso.Izi sizingathetsedwe kwathunthu ndi ganoderic acid A yokha.

Kufunika kwaGanoderma lucidumili m'magulu ake osiyanasiyana komanso magwiridwe antchito osiyanasiyana, omwe amatha kulumikizana wina ndi mnzake kuti apangitse bwino thupi.Mwanjira ina, ngati ganoderic acid A ikusowa, ntchito yoteteza impso idzakhala yopanda mphamvu zambiri zolimbana ngati gulu lomwe likusowa osewera akulu.

Ganoderma lucidumyokhala ndi ganoderic acid A ndiyoyenera kwambiri zomwe tikuyembekezera chifukwa imateteza impso.

[Magwero a Data]

1. Geng XQ, ndi al.Ganoderic acid imalepheretsa renal fibrosis popondereza njira zowonetsera za TGF-β/Smad ndi MAPK.Acta Pharmacol Sin.2020, 41: 670-677.doi: 10.1038/s41401-019-0324-7.

2. Meng J, ndi al.Ganoderic acid A ndiye gawo lothandiza la Ganoderma triterpenes pochepetsa kukula kwa impso mu matenda a impso a polycystic.Acta Pharmacol Sin.2020, 41: 782-790.doi: 10.1038/s41401-019-0329-2.

3. Su L, ndi al.Ganoderma triterpenes imachepetsa kukula kwa impso mwa kuchepetsa chizindikiro cha Ras/MAPK ndi kulimbikitsa kusiyana kwa ma cell.Impso Int.2017 Dec;92 (6): 1404-1418.doi: 10.1016/j.kint.2017.04.013.

4. Zhong D, ndi al.Ganoderma lucidum polysaccharide peptide imalepheretsa kuwonongeka kwa aimpso kwa ischemia polimbana ndi kupsinjika kwa okosijeni.Sci Rep. 2015 Nov 25;5: 16910. doi: 10.1038/srep16910.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akunena za zomwe zikuchitikaGanoderma lucidumzambiri kuyambira 1999. Iye ndi mlembi waKuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).
 
★ Nkhaniyi yasindikizidwa ndi chilolezo cha mlembi ★ Ntchito zomwe zili pamwambazi sizingabwerezedwe, kutsanulidwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba ★ Kuphwanya mawu omwe ali pamwambawa, wolemba adzakwaniritsa udindo wake wazamalamulo ★ Zoyambirira Nkhaniyi idalembedwa m'Chitchaina ndi Wu Tingyao ndikumasuliridwa m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.