Ianuali 2020/Ke Kulanui o Peking/Acta Pharmacologica Sinica

Text/ Wu Tingyao

ʻO ka hui i alakaʻi ʻia e Professor Baoxue Yang, ka luna o ke Keʻena ʻOihana Pharmacology, Ke Kulanui ʻo Peking, i paʻi i ʻelua mau ʻatikala ma Acta Pharmacologica Sinica i ka hoʻomaka ʻana o 2020, e hōʻoia ana i kēlā.ʻO Ganoderma lucidumHiki i nā triterpenes ke hoʻolōʻihi i ka piʻi ʻana o ka renal fibrosis a me ka maʻi maʻi maʻi polycystic, a ʻo kā lākou mea hana nui he ganoderic acid A.

Hoʻopaneʻe ka Ganoderic acid i ka holomua o ka fibrosis renal.

Ua nakinaki nā mea noiʻi i ka ureter ma kekahi ʻaoʻao o ka ʻiole.He ʻumikumamāhā mau lā ma hope mai, e ulu ana ka ʻiole i ka fibrosis renal ma muli o ke keʻakeʻa ʻana o ka mimi a me ke kahe ʻana o ka mimi.I ka manawa like, e hoʻonui pū ʻia kona koko urea nitrogen (BUN) a me ka creatinine (Cr), e hōʻike ana i ka hana renal impaired.

Eia nō naʻe, inā hāʻawi ʻia ka waikawa ganoderic i kēlā me kēia lā o 50 mg/kg e ka intraperitoneal injection ma hope koke o ka ligation o ka ureter, e hoʻemi nui ʻia ke degere o ka fibrosis renal a i ʻole ka hana ʻino ʻana ma hope o 14 mau lā.

ʻO ka nānā hou ʻana o ka hana pili e hōʻike ana e hiki i ka ganoderic acid ke pale i ka piʻi ʻana o ka fibrosis renal mai ʻelua mau ʻāpana:

ʻO ka mea mua,ʻo nā waikawa ganoderic e pale i nā pūnaewele epithelial tubular renal maʻamau mai ka hoʻololiʻana i nā pūnaewele mesenchymal e hūnā i nā mea pili i ka fibrosis (ua kapaʻia kēia kaʻina hana epithelial-to-mesenchymal transition, EMT);ʻO ka lua, hiki i nā waikawa ganoderic ke hōʻemi i ka hōʻike ʻana o ka fibronectin a me nā mea pili i ka fibrosis.

E like me ka triterpenoid nui loa oʻO Ganoderma lucidum, He nui nā ʻano ʻano Ganoderic acid.I mea e hōʻoia ai i ka waika ganoderic e hoʻokō ai i ka hopena o ka pale ʻana i ka puʻupaʻa i ʻōlelo ʻia ma luna, ua hoʻomohala nā mea noiʻi i nā waikawa ganoderic nui A, B, a me C2 me nā laina cell epithelial tubular renal kanaka ma kahi ʻano o 100 μg / mL.I ka manawa like, hoʻohui ʻia ka mea ulu TGF-β1, he mea nui ia no ka holomua o ka fibrosis, e hoʻoulu i nā cell e hūnā i nā protein pili i ka fibrosis.

Hōʻike nā hopena i ka hopena maikaʻi loa o ka waikawa ganoderic A i ka pale ʻana i ka huna ʻana o nā protein pili i ka fibrosis i loko o nā cell, a ʻoi aku ka ikaika o kona hopena ma mua o ka hui ʻana o ka waikawa ganoderic kumu.No laila, manaʻo ka poʻe noiʻiʻO Ganoderma lucidumʻO ia ke kumu ikaika o ka hōʻemi ʻana i ka fibrosis kidney.He mea waiwai nui ka waika ganoderic A ʻaʻohe hopena ʻawaʻawa ma nā pūnaewele renal a ʻaʻole ia e pepehi a hōʻeha paha i nā ʻāpana renal.

Hoʻopaneʻe ka Ganoderic acid i ka piʻi ʻana o ka maʻi puʻupaʻa polycystic.

ʻAʻole like me ka fibrosis renal, ka mea i kumu nui ʻia e nā kumu o waho e like me nā maʻi a me nā lāʻau lapaʻau, ʻo ka maʻi maʻi maʻi polycystic ma muli o ka mutation gene ma ka chromosome.ʻO nā vesicle ma nā ʻaoʻao ʻelua o ka puʻupaʻa e liʻiliʻi a nui a nui aʻe i mea e paʻi ai i nā ʻiʻo maʻamau o ka puʻupaʻa a hoʻopilikia i ka hana ʻāʻī.

Ma mua, ua hōʻoia ka hui o Baoxue YangGanodermalucidumHiki i nā triterpenes ke hoʻopaneʻe i ka piʻi ʻana o ka maʻi maʻi maʻi polycystic a pale i ka hana ʻāʻī.Eia naʻe, ʻo kaGanodermalucidumʻO nā triterpenes i hoʻohana ʻia i ka hoʻokolohua ma ka liʻiliʻi loa me nā waikawa ganoderic A, B, C2, D, F, G, T, DM a me nā waikawa ganoderenic A, B, D, a me F.

I mea e ʻike ai i nā mea hana koʻikoʻi, ua nānā ka poʻe noiʻi i nā ʻano triterpenes he 12 i kēlā me kēia ma o nā hoʻokolohua in vitro a ʻike ʻia ʻaʻohe o lākou e hoʻopilikia i ke ola ʻana o nā cell kidney akā he ʻokoʻa ko lākou i ka pale ʻana i ka ulu ʻana o ka vesicle.I waena o lākou, ʻo ka ganoderic acid A ka hopena maikaʻi loa.

Eia kekahi, ua hoʻoulu ʻia ka ganoderic acid A in vitro me nā puʻupaʻa o nā ʻiole embryonic a me nā mea hana e hoʻoulu ai i ka hoʻokumu ʻana o nā vesicle.ʻO ka hopena, hiki i ka ganoderic acid A ke kāohi i ka helu a me ka nui o nā vesicle me ka ʻole e pili i ka ulu ʻana o nā puʻupaʻa.ʻO 100μg / mL kona hopena kūpono, e like me ka nui o nā triterpenes i hoʻohana ʻia i nā hoʻokolohua mua.

Ua ʻike pū ʻia nā hoʻokolohua holoholona e hiki ke hoʻomaikaʻi i ka pehu ʻana o ka puʻupaʻa me ka ʻole o ke kaumaha o ke akepaʻa a me ke kaumaha o ke kino.Hoʻemi pū ia i ka nui a me ka helu o nā vesicle renal, no laila e hoʻemi ʻia ka mahele o nā vesicle renal ma kahi o 40% i hoʻohālikelike ʻia me ka pūʻulu hoʻomalu me ka pale ʻole ganoderic acid A.

No ka mea, ʻo ka nui o ka waika ganoderic A i loko o ka hoʻokolohua he hoʻokahi hapahā o ka hoʻokolohua like meGanodermalucidumtriterpenes, ua hōʻike ʻia ʻo ka ganoderic acid A ʻo ia ka mea nui oGanodermalucidumtriterpenes e hoʻopaneʻe i ka piʻi ʻana o ka maʻi puʻupaʻa polycystic.ʻO ka hoʻohana ʻana i ka nui like o ka waika ganoderic A i nā ʻiole maʻamau i hānau hou ʻaʻole i pili i ka nui o kā lākou mau puʻupaʻa, e hōʻike ana he ʻano palekana ko ka waikawa ganoderic A.

Mai ka fibrosis renal a hiki i ka hiki ʻole o ka renal, hiki ke ʻōlelo ʻia ʻo ka maʻi kīkī mau i hoʻokumu ʻia e nā kumu like ʻole (e like me ka maʻi maʻi diabetes) e hele mau ana ma ke ala ʻaʻole hoʻi.

No nā poʻe maʻi me ka maʻi puʻupaʻa polycystic, ʻoi aku ka wikiwiki o ka emi ʻana o ka hana renal.Wahi a nā helu helu, ma kahi o ka hapalua o nā poʻe maʻi me ka maʻi maʻi maʻi polycystic e holomua i ka hōʻino ʻole ʻana ma kahi o 60 mau makahiki a koi ʻia ka dialysis ola lōʻihi.

Ma muli o ka loaʻa ʻana o ka mea pathogenic a i ʻole congenital, ʻaʻole maʻalahi ke "hoʻohuli i ka hana ʻāʻī"!Eia nō naʻe, inā hiki ke hoʻolōʻihi ʻia ka nui o ka hōʻino ʻana o nā puʻupaʻa i hiki ke kaulike ʻia me ka lōʻihi o ke ola, hiki paha ke hoʻemi ʻia ke ola maʻi i ka pessimistic a ʻoi aku ka nani.

Ma o nā hoʻokolohua cell a me nā holoholona, ​​​​ua hōʻike ka hui noiʻi o Baoxue Yang i ka Ganoderic acid A, ʻo ia ka helu kiʻekiʻe o kaʻO Ganoderma lucidumtriterpenes, he mea kuhikuhi oʻO Ganoderma lucidumno ka hoomalu ana i ke kinikini.

Hōʻike kēia hopena noiʻi i ka noiʻi ʻepekema oʻO Ganoderma lucidumpaʻa loa e hiki iā ia ke haʻi iā ʻoe i ka mea hoʻohui i nā hopena oʻO Ganoderma lucidumhele mai ka nui ma kahi o ke kahakiʻi wale ʻana i kahi pai noʻonoʻo no kou noʻonoʻo.ʻO kaʻoiaʻiʻo, ʻaʻole ia e ʻōlelo ʻo ka ganoderic acid A wale nō e hiki ke pale i ke kīpē.ʻOiaʻiʻo, kekahi mau mea ʻē aʻe oʻO Ganoderma lucidumhe mea pono i na puupaa.

No ka laʻana, ʻo kekahi pepa i paʻi ʻia e ka hui ʻo Baoxue Yang e pili ana i ke kumuhana o ka pale ʻana i ke kīpē i kuhikuhi i kēlāʻO Ganoderma lucidumHiki i ka polysaccharide extract ke hōʻemi i ka pōʻino oxidative i ka ʻiʻo ʻāʻī ma o kāna hopena antioxidant.ʻO ka "ʻO Ganoderma lucidumtotal triterpenes", i loko o nā triterpenoids like ʻole e like me ganoderic acids, ganoderenic acids a me ganoderiols, e hana pū ana e hoʻopaneʻe i ka holomua o ka renal fibrosis a me ka maʻi maʻi polycystic kidney, kahi mea e kahaha ai nā ʻepekema.

ʻO ka mea ʻē aʻe, ʻaʻole i hoʻoholo ʻia ka pono no ka pale ʻana i ka puʻupaʻa ma ka pale ʻana i ke kīkī wale nō.ʻO nā mea ʻē aʻe e like me ka hoʻoponopono ʻana i ka palekana, ka hoʻomaikaʻi ʻana i nā kiʻekiʻe ʻekolu, ke kaulike ʻana i ka endocrine, ka hoʻomaha ʻana i nā aʻalolo a me ke kōkua ʻana i ka hiamoe he mea kōkua maoli ia no ka pale ʻana i nā puʻupaʻa.ʻAʻole hiki ke hoʻopau piha ʻia kēia mau mea me ka ganoderic acid A wale nō.

Ka makamae oʻO Ganoderma lucidumaia i loko o kāna mau mea ʻokoʻa a me nā hana versatile, hiki ke hoʻohui pū kekahi i kekahi e hana i ke kaulike maikaʻi loa no ke kino.I nā huaʻōlelo ʻē aʻe, inā nele ka ganoderic acid A, ʻaʻole nui ka ikaika o ka pale ʻana i ka puʻupaʻa e like me kahi hui i nele i nā mea pāʻani nui.

ʻO Ganoderma lucidumme ka ganoderic acid A ʻoi aku ka maikaʻi o kā mākou mau manaʻo no ka maikaʻi o kāna hopena pale-kiʻi.

[Kumu ʻikepili]

1. Geng XQ, et al.ʻO ka waikawa Ganoderic ka mea e pale ai i ka fibrosis renal ma ke kāohi ʻana i nā ala hōʻailona TGF-β/Smad a me MAPK.Acta Pharmacol Sin.2020, 41: 670-677.doi: 10.1038/s41401-019-0324-7.

2. Meng J, et al.ʻO Ganoderic acid A ka mea hana pono o Ganoderma triterpenes i ka hoʻopaneʻe ʻana i ka hoʻomohala ʻana o ka renal cyst i ka maʻi maʻi maʻi polycystic.Acta Pharmacol Sin.2020, 41: 782-790.doi: 10.1038/s41401-019-0329-2.

3. Su L, et al.Hoʻopaneʻe ʻo Ganoderma triterpenes i ka hoʻomohala ʻana o ka renal cyst ma ka hoʻohaʻahaʻa ʻana i ka hōʻailona Ras/MAPK a me ka hoʻolaha ʻana i ka ʻokoʻa cell.Kidney Int.2017 Dek;92(6): 1404-1418.doi: 10.1016/j.kint.2017.04.013.

4. Zhong D, et al.Mālama ʻo Ganoderma lucidum polysaccharide peptide i ka hōʻeha renal ischemia reperfusion ma o ka pale ʻana i ke kaumaha oxidative.Sci Rep. 2015 Nov 25;5: 16910. doi: 10.1038/srep16910.

HOPE

No ka mea kākau/ Ms. Wu Tingyao
Ua hōʻike ʻo Wu Tingyao ma ka lima muaʻO Ganoderma lucidumʻike mai ka makahiki 1999. ʻO ia ke kumu oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).
 
★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau ★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻoki ʻia a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻana o ka mea kākau ★ ʻAʻole i ʻae ʻia ka ʻōlelo ma luna, e hahai ka mea kākau i kāna mau kuleana pili i ke kānāwai ★ ʻO ke kumu kumu. Ua kākau ʻia nā kikokikona o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.