Umbhalo/Zhi-bin LIN (uprofesa woMnyango Wezakhemisi, Isikole sasePeking University School of Basic Medical Sciences)
★Le ndatshana ikhiqizwa kabusha ku-ganodermanews.com.Ishicilelwe ngemvume yombhali.

Ingabe i-Lingzhi (ebuye ibizwe ngokuthi i-Ganoderma noma i-Reishi mushroom) iyidlala kanjani imiphumela yayo yokulwa namagciwane?Kuyamukelwa ngokuvamile ukuthi i-Lingzhi ivimbela ngokungaqondile amagciwane ukuthi angangeni emzimbeni womuntu futhi ande futhi alimaze emzimbeni ngokuthuthukisa amasosha omzimba.I-Lingzhi inganciphisa nokuvuvukala okubangelwa yigciwane kanye nokulimala kwezitho ezibalulekile ezifana namaphaphu, inhliziyo, isibindi nezinso ngemiphumela yayo yokulwa ne-oxidative kanye ne-free radical scavenging.Ngaphezu kwalokho, kube nemibiko yocwaningo kusukela ngawo-1980 ukuthi i-Lingzhi, ikakhulukazi i-triterpenoids equkethwe kuyo, inomphumela ovimbelayo ezinhlobonhlobo zamagciwane.

UProfesa Zhi-bin LIN ubambe iqhaza ocwaningweni lukaLingzhii-pharmacology iminyaka engu-50 futhi uyingqalabutho ocwaningweni lwe-Lingzhi e-China.(Izithombe/Wu Tingyao)

Isifo seCoronavirus sika-2019 (COVID-19) sisazungeza futhi sisabalale emhlabeni jikelele.Ukuvimbela nokulawula ubhubhane, ukwelapha iziguli kanye nokuqeda ubhubhane kuyizinto ezijwayelekile ezilindelwe kanye nezibopho zawo wonke umphakathi.Emibikweni eyahlukene yabezindaba, kuyangijabulisa ukubona lokho abaningiI-Ganoderma lucidumabakhiqizi banikela ngezinto zokuvikela ubhubhane kanye nemikhiqizo ye-Lingzhi ezindaweni eziwubhubhane nasemaqenjini ezokwelapha e-Hubei.Ngethemba ukuthi i-Lingzhi ingasiza ekuvimbeleni inyumoniya ye-coronavirus entsha futhi ivikele odokotela neziguli.

Isizathu salolu bhubhane yinoveli ye-coronavirus ka-2019 (SARS-CoV-2).Ngaphambi kokuthi kube nemithi nemijovo yokugoma ye-anti-novel coronavirus, indlela yakudala nesebenzayo kwakuwukuhlukanisa iziguli, ukwenza ukwelashwa okunezimpawu nokusekelayo, ukuthuthukisa ukungatheleleki, ukuvimbela amagciwane ukuthi atheleleke futhi alimaze izitho ezibalulekile nezicubu zomzimba futhi ekugcineni sinqobe lesi sifo.Kubantu abathintekayo, ukuqinisa amasosha omzimba kusiza ukumelana nokuhlaselwa ngamagciwane.

Ngaphezu kwalokho, umkhakha wezokwelapha nawo uzama ukuthola izidakamizwa ezingalwa naleli gciwane elisha emithini ekhona yokulwa namagciwane.Kunamahlebezi amaningi kuyi-Internet.Ukuthi ayasebenza noma cha akukaqinisekiswa ngokomtholampilo.

I-Lingzhi ithuthukisa amandla e-anti-virus amasosha omzimba.

I-Lingzhi (I-Ganoderma lucidumfuthiI-Ganoderma sinensis) iyimithi yokwelapha yaseShayina esemthethweni efakwe ku-Pharmacopoeia ye-People's Republic of China (Ingxenye Yokuqala), ngokusho ukuthi i-Lingzhi ingakwazi ukwengeza i-qi, imizwa epholile, ukukhulula ukukhwehlela kanye nesifuba somoya, futhi ingasetshenziselwa ukungahlaliseki, ukuqwasha, ukushaya kwenhliziyo, ukuntula amaphaphu nokukhwehlela nokuhefuzela, isifo sokudla kanye nokuphelelwa umoya, nokuphelelwa ukudla.Kuze kube manje, izinhlobo ezingaphezu kwekhulu zemithi ye-Lingzhi sezigunyaziwe ukuthi zidayiswe ukuze zivikeleke futhi zilashwe.

Ucwaningo lwesimanje lwezokwelapha luye lwafakazela ukuthi i-Lingzhi ingathuthukisa ukusebenza kwamasosha omzimba, imelane nokukhathala, ithuthukise ukulala, imelane ne-oxidation futhi ikhiphe ama-radicals mahhala, futhi ivikele inhliziyo, ubuchopho, amaphaphu, isibindi nezinso.Kuye kwasetshenziswa emtholampilo ekwelapheni noma ekwelapheni i-adjuvant ye-bronchitis engapheli, izifo eziphindaphindiwe zokuphefumula, isifuba somoya nezinye izifo.

I-Lingzhi idlala kanjani imiphumela yayo ye-antiviral?Kuyamukelwa ngokuvamile ukuthi i-Lingzhi ivimbela ngokungaqondile amagciwane ukuthi angangeni emzimbeni womuntu futhi ande futhi alimaze emzimbeni ngokuthuthukisa amasosha omzimba.

Nakuba leli gciwane linolaka kakhulu, lizogcina seliqediwe lapho kubhekene nokuzivikela okuqinile.Lokhu kuxoxwe ngakho esihlokweni esithi “Lingzhi Enhances Immunity” eshicilelwe kumagazini wama-58 we- “GANODERMA” kanye nesihloko esithi “Isisekelo SokuvikelekaI-Ganoderma lucidumUkuvimbela Umkhuhlane - Uma kune-qi eyanele enempilo ngaphakathi, izici ze-pathogenic azikho indlela yokuhlasela umzimba "eshicilelwe kumagazini we-46 we "GANODERMA".

Kafushane, enye iwukuthi i-Lingzhi ingathuthukisa imisebenzi yokuzivikela yomzimba engaqondile njengokukhuthaza ukwanda, ukuhlukaniswa kanye nokusebenza kwamangqamuzana e-dendritic, ukuthuthukisa umsebenzi we-phagocytic wama-macrophages e-mononuclear namangqamuzana abulalayo emvelo, nokuvimbela amagciwane namagciwane ukuthi angangeni kumuntu. umzimba.Okwesibili, i-Lingzhi ingathuthukisa ukusebenza kwe-humoral kanye ne-cell immune njengokugqugquzela ukukhiqizwa kwe-Immunoglobulin M (IgM) ne-Immunoglobulin G (IgG), ikhulise ukwanda kwama-T lymphocyte nama-lymphocyte e-B, futhi ikhuthaze ukukhiqizwa kwe-cytokine interleukin-1 (IL- 1), i-Interleukin-2 (IL-2) ne-interferon gamma (IFN-γ).

Ukungavikeleki kwe-Humoral kanye nokuvikeleka kwamaselula kwakha umugqa wokuzivikela ojulile womzimba ngokumelene negciwane kanye nezifo ezibangelwa amagciwane.Bangakwazi ukukhiya okuhlosiwe ukuze baqhubeke bavikele futhi baqede amagciwane namagciwane ahlasela umzimba.Lapho umsebenzi wokuzivikela komzimba uphansi ngenxa yezizathu ezihlukahlukene, i-Lingzhi ingabuye ithuthukise umsebenzi wokuzivikela komzimba.

Ngaphezu kwalokho, i-Lingzhi inganciphisa nokuvuvukala okubangelwa igciwane kanye nokulimala kwegciwane ezithweni ezibalulekile ezifana namaphaphu, inhliziyo, isibindi, izinso, futhi ivimbele noma inciphise izimpawu ngemiphumela yayo elwa ne-oxidant kanye ne-radical free scavenging.Kumagazini wama-75 we-“GANODERMA”, ingasetshenziselwa ireferensi yokuthi ukubaluleka kwemiphumela elwa ne-oxidant kanye ne-free radical scavengingI-Ganoderma lucidumekuvimbeleni nasekwelapheni izifo kuxoxwa ngazo ngqo esihlokweni esithi "Lingzhi - Ukwelapha Izifo Ezihlukene Ngendlela efanayo".

Kusukela ngeminyaka yawo-1980, kube nemibiko yocwaningo ngemiphumela elwa namagciwane e-Lingzhi.Iningi lalezi zifundo lisebenzisa amamodeli amaseli atheleleke ngegciwane ku-vitro, futhi izifundo ngazinye nazo zasebenzisa izinhlobo zezilwane zokutheleleka ngegciwane ukuze zibheke imiphumela ye-antiviral ye-Lingzhi.

Izindatshana zekholomu ezishicilelwe nguSolwazi Zhibin Lin Ezindabeni 46, 58, kanye ne-75 ze-"GANODERMA"

I-Anti-hepatitis virus

UZhang Zheng et al.(1989) uthole ukuthiI-Ganoderma applanatum,I-Ganoderma atrumfuthiI-Ganoderma capenseinganqanda igciwane le-hepatitis B i-DNA polymerase (HBV-DNA polymerase), yehlise ukuphindaphinda kwe-HBV-DNA futhi ivimbele ukukhiqizwa kwe-hepatitis B surface antigen (HBsAg) ngamaseli e-PLC/PRF/5 (amaseli omdlavuza wesibindi somuntu).

Abacwaningi baphinde babona ukusebenza ngempumelelo kwezidakamizwa zomuthi kumodeli ye-duck hepatitis.Imiphumela yabonisa ukuthi ukuphathwa ngomlomo kweI-Ganoderma applanatum(50 mg/kg) kabili ngosuku izinsuku eziyi-10 ezilandelanayo kunganciphisa imiphumela yegciwane le-duck hepatitis B i-DNA polymerase (DDAP) kanye negciwane le-duck hepatitis B i-DNA (DDNA) yamadada asemancane angenwe igciwane le-duck hepatitis B (DHBV), okuyinto ikhombisa lokhoI-Ganoderma applanatuminomphumela ovimbelayo ku-DHBV emzimbeni [1].

U-Li YQ et al.(2006) kubike ukuthi imigqa yeseli yomdlavuza wesibindi somuntu I-HepG2 idluliselwe nge-HBV-DNA ingaveza i-HBV surface antigen (HbsAg), i-HBV core antigen (HbcAg) kanye ne-HBV virus amaprotheni esakhiwo, futhi ingakhiqiza ngokuzinza izinhlayiya ezivuthiwe ze-hepatitis B.I-Ganoderic acid ekhishwe kuyoG. lucidumisiko medium umthamo-ngokuncike (1-8 μg/mL) ivimbe inkulumo nokukhiqizwa HBsAg (20%) kanye HBcAg (44%), esikisela ukuthi ganoderic acid ivimbele ukuphindaphinda kwe-HBV kumaseli esibindi [2].

I-anti-influenza virus

UZhu Yutong (1998) uthole ukuthi umjovo we-gavage noma we-intraperitoneal weG. applanatumukukhipha (i-decoction yamanzi noma ukumnika okubandayo) kungakhuphula kakhulu izinga lokusinda kanye nesikhathi sokusinda samagundane atheleleke nge-influenza virus FM1 strain, ngaleyo ndlela abe nomphumela ongcono wokuvikela [3].

UMothana RA et al.(2003) ithole ukuthi i-ganodermadiol, i-lucidadiol ne-applanoxidic acid G ekhishwe futhi yahlanzwa ku-G. pfeifferi yaseYurophu ibonise imisebenzi yokulwa namagciwane ngokumelene negciwane lomkhuhlane A kanye ne-herpes simplex virus uhlobo 1 (HSV-1).I-ED50 ye-ganodermadiol yokuvikela amaseli e-MDCK (amaseli e-epithelioid atholakala ezinso ze-canine) ngokumelene nokutheleleka ngegciwane lomkhuhlane A ngu-0.22 mmol/L.I-ED50 (umthamo osebenzayo ongu-50%) ovikela amaseli e-Vero (amaseli ezinso zezinkawu eziluhlaza zase-Afrika) ekuthelelekeni nge-HSV-1 ngu-0.068 mmol/L.I-ED50 ye-ganodermadiol ne-applanoxidic acid G ngokumelene nokutheleleka ngegciwane le-influenza A yayingu-0.22 mmol/L kanye no-0.19 mmol/L, ngokulandelana [4].

Anti-HIV

UKim et al.(1996) uthole ukuthi ingxenye yesisindo samangqamuzana ephansiG. lucidumukukhishwa kwamanzi omzimba okuthela izithelo kanye nengxenye engathathi hlangothi nene-alkali yokukhishwa kwe-methanol kungavimbela ukwanda kwegciwane le-human immunodeficiency virus (HIV) [5].

El-Mekkawy et al.(1998) ibike ukuthi i-triterpenoids ihlukaniswe ne-methanol ekhishweG. lucidumimizimba ethela izithelo inemiphumela ye-cytopathic elwa ne-HIV-1 futhi ibonisa umsebenzi ovimbelayo ku-HIV protease kodwa ayinawo umthelela ovimbelayo emsebenzini we-HIV-1 reverse transcriptase [6].

Min et al.(1998) bathole ukuthi i-ganoderic acid B, lucidumol B, ganodermanondiol, ganodermanontriol kanye ne-ganolucidic acid A ekhishweG. lucidumama-spores anomphumela oqinile wokuvimbela umsebenzi we-HIV-1 protease [7].

Sato N et al.(2009) bathole ukuthi i-lanostane-type triterpenoids entsha ene-oksijini ephezulu kakhulu [i-ganodenic acid GS-2, 20-hydroxylucidenic acid N, 20(21)-dehydrolucidenic acid N kanye ne-ganederol F] ehlukanisiwe ne-fruiting body.I-Ganoderma lucidumabe nomthelela ovimbelayo ku-HIV-1 protease ne-median inhibitory concentration (IC50) njenge-20-40 μm [8].

U-Yu Xiongtao et al.(2012) babike lokhoG. lucidumi-spore water extract inomphumela ovimbelayo ku-Simian Immunodeficiency Virus (SIV) ethelela amaseli e-CEM×174 omugqa weseli ye-T lymphocyte yabantu, futhi i-IC50 yayo ingu-66.62±20.21 mg/L.Umsebenzi wayo oyinhloko ukuvimbela i-SIV kusukela ekukhangisweni kuye nasekungeneni kumaseli esigabeni sokuqala sokutheleleka ngegciwane le-SIV, futhi kunganciphisa izinga lokuvezwa kwe-SIV capsid protein p27 [9].

I-Anti-Herpes Virus

I-Eo SK (1999) ilungise izingcaphuno ezimbili ezincibilikayo emanzini (i-GLhw ne-GLlw) kanye nezingcaphuno eziyisishiyagalombili ze-methanol (GLMe-1-8) ezivela emizimbeni ethela izitheloG. lucidum.Umsebenzi wabo we-antiviral wahlolwa ukuhlolwa kokuvimbela i-cytopathic effect (CPE) kanye nokuhlolwa kokunciphisa ama-plaque.Phakathi kwazo, i-GLhw, i-GLMe-1, i-GLMe-2, i-GLMe-4, ne-GLMe-7 ibonisa imiphumela ecacile yokuvimbela i-herpes simplex virus uhlobo 1 (HSV-1) nohlobo 2 (HSV-2), kanye ne-vesicular stomatitis. virus (VSV) Indiana kanye neNew Jersey strains.Ekuhlolweni kokunciphisa uqwembe, i-GLhw ivimbele ukwakheka koqweqwe lwe-HSV-2 nge-EC50 ka-590 kanye no-580μg/mL kumaseli e-Vero kanye ne-HEp-2, kanye nezinkomba zayo zokukhetha (SI) zazingu-13.32 no-16.26.I-GLMe-4 ayizange ibonise i-cytotoxicity kuze kufike ku-1000 μg/ml, kuyilapho ibonise umsebenzi onamandla wokulwa namagciwane kuhlobo lwe-VSV New Jersey nge-SI engaphezu kuka-5.43 [10].

OH KW et al.(2000) ihlukanise i-polysaccharide ene-acidic eboshwe ngamaprotheni (APBP) kuma-carpophores e-Ganoderma lucidum.I-APBP ibonise umsebenzi onamandla we-antiviral ngokumelene ne-HSV-1 ne-HSV-2 kumaseli e-Vero ku-EC50 yayo ye-300 kanye ne-440μg/mL, ngokulandelanayo.I-APBP yayingenayo i-cytotoxicity kumaseli e-Vero ekuhlanganiseni okungu-1 x 10(4) μg/ml.I-APBP ine-synergistic inhibitory effects ku-HSV-1 ne-HSV-2 uma ihlanganiswa nomuthi wokulwa ne-herpes i-Aciclovir, i-Ara-A noma i-interferonγ (IFN-γ) ngokulandelana [11, 12].

U-Liu Jing et al.(2005) bathole ukuthi i-GLP, i-polysaccharide ehlukanisiwe nayoG. lucidummycelium, ingavimbela ukutheleleka kwamaseli e-Vero nge-HSV-1.I-GLP ivimbe ukutheleleka kwe-HSV-1 ekuqaleni kokutheleleka kodwa ayikwazi ukuvimbela ukuhlanganiswa kwegciwane kanye nama-macromolecule ebhayoloji [13].

Iwatsuki K et al.(2003) bathole ukuthi izinhlobonhlobo zama-triterpenoid akhishwe futhi ahlanzwa kuwoI-Ganoderma lucidumbabe nemiphumela yokuvimbela ekufakweni kwe-antigen ye-Epstein-Barr yokuqala (EBV-EA) kumaseli e-Raji (amaseli e-lymphoma yabantu) [14].

UZheng DS et al.(2017) bathole ukuthi ama-triterpenoid amahlanu akhishwe kuwoG. lucidum,kufaka phakathi i-ganoderic acid A, i-ganoderic acid B, ne-ganoderol B, i-ganodermanontriol ne-ganodermanondiol, kunciphisa kakhulu ukusebenza kwe-nasopharyngeal carcinoma (NPC) amaseli angu-5-8 F akhuliswe ku-vitro, abonisa imiphumela ebalulekile yokuvimbela kokubili i-EBV EA ne-CA kusebenze futhi ivimbele i-telomerase. umsebenzi.Le miphumela inikeze ubufakazi bokusetshenziswa kwalokhuG. lucidumama-triterpenoids ekwelapheni i-NPC [15].

I-Anti-Newcastle Disease Virus

Igciwane lesifo iNewcastle wuhlobo lwegciwane lomkhuhlane wezinyoni, elinokutheleleka okuphezulu kanye nobungozi ezinyonini.Shamaki BU et al.(2014) uthole ukuthiI-Ganoderma lucidumUkukhishwa kwe-methanol, i-n-butanol ne-ethyl acetate kungavimbela umsebenzi we-neuraminidase we-Newcastle disease virus [16].

I-Anti-Dengue Virus

Lim WZ et al.(2019) bathole ukuthi ama-extracts amanzi weG. lucidumngesimo sayo se-antler ivimbe umsebenzi we-DENV2 NS2B-NS3 protease ku-84.6 ± 0.7%, ngaphezu kokujwayelekileG. lucidum[17] .

Bharadwaj S et al.(2019) basebenzise indlela yokuhlola ebonakalayo kanye nokuhlolwa kwe-vitro ukubikezela amandla e-triterpenoids esebenzayo evelaI-Ganoderma lucidumfuthi uthole ukuthi i-ganodermanontriol ikhishweI-Ganoderma lucidumingavimbela igciwane lodenga (DENV) NS2B -NS3 protease umsebenzi [18].

I-Anti-Enterovirus

I-Enterovirus 71 (EV71) iyigciwane eliyinhloko lesifo sesandla, sonyawo nomlomo, esidala izinkinga ezibulalayo zemizwa nesistimu ezinganeni.Kodwa-ke, okwamanje azikho izidakamizwa ezilwa namagciwane ezigunyazwe ngokomtholampilo ezingasetshenziswa ukuvimbela nokwelapha lokhu kutheleleka ngegciwane.

UZhang W et al.(2014) bathole ukuthi laba bobabiliI-Ganoderma lucidumi-triterpenoids (GLTs), okuhlanganisa i-Lanosta-7,9(11), i-24-trien-3-one,15;26-dihydroxy (GLTA) ne-Ganoderic acid Y (GLTB), ibonisa imisebenzi ebalulekile ye-anti-EV71 ngaphandle kwe-cytotoxicity.

Imiphumela yaphakamisa ukuthi i-GLTA ne-GLTB zivimbele ukutheleleka kwe-EV71 ngokusebenzisana nezinhlayiyana zegciwane ukuze kuvinjwe ukusakazwa kwegciwane kumaseli.Ukwengeza, ukusebenzisana phakathi kwe-EV71 virion nezinhlanganisela kwabikezelwa nge-computer ye-molecular docking, ebonisa ukuthi i-GLTA ne-GLTB ingase ibophe iphrotheni ye-capsid yegciwane ephaketheni le-hydrophobic (F site), futhi ngaleyo ndlela ingase ivimbe ukumbozwa kwe-EV71.Ngaphezu kwalokho, babonise ukuthi i-GLTA ne-GLTB zivimbela ngokuphawulekayo ukuphindaphinda kwe-viral RNA (vRNA) yokuphindaphinda kwe-EV71 ngokuvimbela i-EV71 uncoating [19].

Isifinyezo nengxoxo
Imiphumela yocwaningo engenhla ibonisa ukuthi i-Lingzhi, ikakhulukazi i-triterpenoids equkethwe kuyo, inomphumela ovimbelayo ezinhlobonhlobo zamagciwane.Ukuhlaziywa kokuqala kukhombisa ukuthi indlela yayo yokutheleleka ngegciwane ibandakanya ukuvimbela ukukhangisa kanye nokungena kwamagciwane kumaseli, ukuvimbela ukusebenza kwe-antigen yokuqala yegciwane, ukuvimbela umsebenzi wama-enzyme athile adingekayo ekuhlanganiseni kwegciwane kumaseli, ukuvimbela i-viral DNA noma i-RNA ukuphindaphinda ngaphandle i-cytotoxicity futhi inomphumela we-synergistic uma ihlanganiswa nezidakamizwa ezaziwayo ze-antiviral.Le miphumela ihlinzeka ngobufakazi bocwaningo olwengeziwe ngemiphumela ye-antiviral ye-Lingzhi triterpenoids.

Lapho sibuyekeza ukusebenza kahle komtholampilo kwe-Lingzhi ekuvimbeleni nasekwelapheni izifo ezibangelwa amagciwane, sithole ukuthi i-Lingzhi ingakwazi ukuguqula izimpawu zegciwane le-hepatitis B (HBsAg, HBeAg, anti-HBc) zibe zimbi ekuvimbeleni nasekwelapheni i-hepatitis B. Kodwa ngaphandle kwalokho, ukwelashwa kwe-herpes zoster, i-condyloma acuminatum kanye nengculazi ngokuhambisana nemithi elwa namagciwane, asizange sithole ubufakazi bokuthi i-Lingzhi ingavimbela ngokuqondile igciwane ezigulini.Ukusebenza kahle komtholampilo kwe-Lingzhi ezifweni ezibangelwa amagciwane kungase kuhlobane ngokuyinhloko nomthelela wayo wokuzivikela komzimba, imiphumela yayo yokulwa ne-oxidant kanye ne-radical yamahhala kanye nomphumela wayo wokuvikela ekulimaleni kwesitho noma kwezicubu.(Siyabonga kuSolwazi Baoxue Yang ngokulungisa lesi sihloko.)

Izithenjwa

1. UZhang Zheng, et al.Ucwaningo Lokuhlola Lwezinhlobo Ezingu-20 Zesikhunta SaseShayina Ezimelene ne-HBV.Journal yase-Beijing Medical University.1989, 21: 455-458.

2. U-Li YQ, et al.Imisebenzi ye-Anti-hepatitis B ye-ganoderic acid evelaI-Ganoderma lucidum.I-Biotechnol Lett, 2006, 28(11): 837-841.

3. U-Zhu Yutong, et al.Umphumela Wokuvikela we-Extract ofI-Ganoderma applanatum(pers) mbambatha.kumagundane Atheleleke nge-Influenza Virus FM1.Journal of Guangzhou University of Traditional Chinese Medicine.1998, 15(3): 205-207.

4. UMothana RA, et al.I-antiviral lanostanoid triterpenes evela ku-fungusI-Ganoderma pfeifferi.I-Fitoterapia.2003, 74(1-2): 177–180.

5. UKim BK.I-Anti-Human Immunodeficiency Virus Activity ofI-Ganoderma lucidum.1996 International Ganoderma Symposium, Special Lecture, Taipei.

6. El-Mekkawy S, et al.Anti-HIV kanye ne-HIV-protease izinto ezivelaI-Ganoderma lucidum.I-Phytochemistry.1998, 49(6): 1651-1657.

7. Min BS, et al.I-Triterpenes evela ezinhlamvuI-Ganoderma lucidumkanye nomsebenzi wabo wokuvimbela i-HIV-1 protease.I-Chem Pharm Bull (Tokyo).1998, 46(10): 1607-1612.

8. USato N, et al.Anti-human immunodeficiency virus-1 protease umsebenzi we-lanostane-type triterpenoids entsha evelaI-Ganoderma sinense.I-Chem Pharm Bull (Tokyo).2009, 57(10): 1076-1080.

9. U-Yu Xiongtao, nabanye.Ucwaningo Ngemiphumela Yokuvinjelwa kweI-Ganoderma lucidumku-Simian Imunodeficiency Virus in vitro.Ijenali yesiShayina ye-Experimental Traditional Medical Formulae.2012, 18(13): 173-177.

10. Eo SK, et al.Imisebenzi elwa namagciwane yamanzi ahlukahlukene kanye nezinto ezincibilikayo ze-methanol ezihlukanisiwe nazoI-Ganoderma lucidum.J Ethnopharmacol.1999, 68(1-3): 129-136.

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★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguSolwazi Zhi-bin LIN futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.

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