Text/Zhi-bin LIN (tus xibfwb ntawm Department of Pharmacology, Peking University School of Basic Medical Sciences)
★ Kab lus no yog luam tawm los ntawm ganodermanews.com.Nws yog luam tawm nrog tus kws sau ntawv tso cai.

Lingzhi (tseem hu ua Ganoderma lossis Reishi nceb) ua rau nws cov tshuaj tiv thaiv kab mob li cas?Nws feem ntau lees txais tias Lingzhi indirectly inhibits kab mob los ntawm invading tib neeg lub cev thiab proliferating thiab puas nyob rau hauv lub cev los ntawm boosting lub cev.Lingzhi tseem tuaj yeem txo qhov mob tshwm sim los ntawm tus kab mob thiab kev puas tsuaj rau lub cev tseem ceeb xws li ntsws, plawv, siab thiab raum los ntawm nws cov tshuaj tiv thaiv oxidative thiab dawb radical scavenging.Tsis tas li ntawd, muaj cov ntaub ntawv tshawb fawb txij li xyoo 1980s tias Lingzhi, tshwj xeeb tshaj yog cov triterpenoids muaj nyob hauv nws, muaj kev cuam tshuam rau ntau yam kab mob.

Xib fwb Zhi-bin LIN tau koom nrog kev tshawb fawb ntawm Lingzhipharmacology rau ib nrab xyoo pua thiab yog ib tug pioneer hauv kev tshawb fawb ntawm Lingzhi hauv Suav teb.(Kev yees duab / Wu Tingyao)

Tus kab mob Coronavirus 2019 (COVID-19) tseem kis tau thiab kis thoob ntiaj teb.Tiv thaiv thiab tswj kev sib kis, kho cov neeg mob thiab xaus kev sib kis yog qhov kev cia siab thiab lub luag haujlwm ntawm tag nrho lub zej zog.Los ntawm ntau yam xov xwm tshaj tawm, Kuv zoo siab pom tias muaj ntauGanoderma lucidumcov tuam txhab pub dawb cov khoom siv tiv thaiv kab mob sib kis thiab cov khoom lag luam Lingzhi rau thaj chaw kis mob thiab pab pawg kho mob rau Hubei.Kuv vam tias Lingzhi tuaj yeem pab tiv thaiv tus kab mob coronavirus tshiab thiab tiv thaiv cov kws kho mob thiab cov neeg mob.

Tus neeg ua txhaum ntawm tus kabmob kis no yog tus kabmob tshiab 2019 (SARS-CoV-2).Ua ntej muaj cov tshuaj tiv thaiv kab mob tshiab thiab tshuaj tiv thaiv kab mob, txoj hauv kev tseem ceeb tshaj plaws thiab zoo tshaj plaws yog cais cov neeg mob, ua cov tsos mob thiab txhawb nqa kev kho mob, txhim kho kev tiv thaiv kab mob, tiv thaiv kab mob los ntawm kev kis kab mob thiab ua rau lub cev tseem ceeb thiab cov ntaub so ntswg ntawm lub cev thiab thaum kawg kov yeej tus kab mob.Rau cov neeg raug tsim txom, kev txhawb nqa lub cev tiv thaiv kab mob pab tiv thaiv kab mob.

Tsis tas li ntawd, kev kho mob tseem tab tom sim nrhiav cov tshuaj uas tuaj yeem tua tus kab mob tshiab no los ntawm cov tshuaj tiv thaiv kab mob uas twb muaj lawm.Muaj ntau cov lus xaiv hauv Internet.Txawm hais tias lawv ua tau zoo lossis tseem tsis tau raug kuaj xyuas.

Lingzhi txhim kho lub peev xwm tiv thaiv kab mob ntawm lub cev tiv thaiv kab mob.

Lingzhi (Ganoderma lucidumthiabGanoderma sinensis) yog ib qho kev cai lij choj suav tshuaj suav tshuaj suav nrog hauv Pharmacopoeia ntawm Cov Neeg Tuam Txhab Tuam Txhab Tuam Txhab Tuam Tshoj (Pib Ib), raws li cov Lingzhi tuaj yeem ntxiv qi, cov hlab ntsha siab, txo qhov hnoos thiab mob hawb pob, thiab tuaj yeem siv rau kev so, insomnia, palpitation, mob ntsws tsis muaj peev xwm thiab hnoos thiab panting, kab mob noj thiab ua tsis taus pa luv, thiab tsis qab los noj mov.Txog tam sim no, ntau tshaj li ib puas hom tshuaj Lingzhi tau pom zoo los ua lag luam rau kev tiv thaiv kab mob thiab kev kho mob.

Cov kev tshawb fawb tshuaj niaj hnub no tau ua pov thawj tias Lingzhi tuaj yeem txhim kho kev tiv thaiv kab mob, tiv thaiv kev qaug zog, txhim kho kev pw tsaug zog, tiv thaiv oxidation thiab tshem tawm cov dawb radicals, thiab tiv thaiv lub plawv, hlwb, ntsws, siab thiab lub raum.Nws tau raug siv nyob rau hauv kev kho mob los yog kev kho mob adjuvant ntawm mob ntsws bronchitis, recurrent respiratory tract infections, hawb pob thiab lwm yam kab mob.

Lingzhi ua si nws cov tshuaj tiv thaiv kab mob li cas?Nws feem ntau lees txais tias Lingzhi indirectly inhibits kab mob los ntawm invading tib neeg lub cev thiab proliferating thiab puas nyob rau hauv lub cev los ntawm boosting lub cev.

Txawm hais tias tus kab mob no hnyav heev, nws yuav raug tshem tawm thaum kawg ntawm kev tiv thaiv muaj zog.Qhov no tau tham hauv tsab xov xwm "Lingzhi Txhim Kho Kev Tiv Thaiv" luam tawm nyob rau hauv 58th qhov teeb meem ntawm "GANODERMA" thiab tsab xov xwm "Lub hauv paus rauGanoderma lucidumTiv Thaiv Kab Mob khaub thuas - Thaum muaj kev noj qab nyob zoo qi hauv, cov kab mob pathogenic tsis muaj txoj hauv kev los cuam tshuam lub cev" luam tawm hauv 46th qhov teeb meem ntawm "GANODERMA".

Hauv cov ntsiab lus, ib qho yog tias Lingzhi tuaj yeem txhim kho lub cev tsis muaj zog tiv thaiv kab mob xws li txhawb kev loj hlob, kev sib txawv thiab kev ua haujlwm ntawm cov hlwb dendritic, txhim kho phagocytic kev ua haujlwm ntawm mononuclear macrophages thiab ntuj tua kab mob, thiab tiv thaiv kab mob thiab kab mob los ntawm kev ua phem rau tib neeg. lub cev.Qhov thib ob, Lingzhi tuaj yeem txhim kho kev lom zem thiab kev tiv thaiv kab mob hauv lub cev xws li txhawb kev tsim cov Immunoglobulin M (IgM) thiab Immunoglobulin G (IgG), ua rau kev loj hlob ntawm T lymphocytes thiab B lymphocytes, thiab txhawb kev tsim cov cytokine interleukin-1 (IL- 1), Interleukin-2 (IL-2) thiab interferon gamma (IFN-γ).

Kev tiv thaiv kab mob humoral thiab cellular tiv thaiv yog lub cev tiv thaiv kab mob sib sib zog nqus tiv thaiv kab mob thiab kab mob.Lawv tuaj yeem kaw lub hom phiaj tshwj xeeb los tiv thaiv thiab tshem tawm cov kab mob thiab cov kab mob uas nkag mus rau hauv lub cev.Thaum lub cev tsis muaj zog vim muaj ntau yam laj thawj, Lingzhi tuaj yeem txhim kho kev tiv thaiv kab mob.

Tsis tas li ntawd, Lingzhi tseem tuaj yeem txo qhov mob tshwm sim los ntawm tus kab mob thiab cov kab mob ua rau lub cev tseem ceeb xws li ntsws, plawv, siab, raum, thiab tiv thaiv lossis txo cov tsos mob los ntawm nws cov tshuaj tiv thaiv oxidant thiab dawb radical scavenging.Hauv 75th qhov teeb meem ntawm "GANODERMA", nws tuaj yeem siv rau kev siv hais tias qhov tseem ceeb ntawm kev tiv thaiv oxidant thiab dawb radical scavenging los ntawmGanoderma lucidumHauv kev tiv thaiv thiab kho cov kab mob tshwj xeeb tau tham hauv tsab xov xwm hu ua "Lingzhi - Kho Cov Kab Mob Sib Txawv nrog Tib Txoj Kev".

Txij li thaum xyoo 1980s, muaj kev tshawb fawb qhia txog cov tshuaj tiv thaiv kab mob ntawm Lingzhi.Feem ntau ntawm cov kev tshawb fawb no tau siv cov qauv ntawm cov kab mob kis kab mob hauv vitro, thiab cov kev tshawb fawb ntawm ib tus neeg kuj tau siv cov qauv tsiaj ntawm tus kab mob los saib xyuas cov tshuaj tiv thaiv kab mob ntawm Lingzhi.

Cov kab lus tshaj tawm los ntawm Xib Fwb Zhibin Lin hauv Is Taws Nem 46, 58, thiab 75 ntawm "GANODERMA"

Tshuaj tiv thaiv kab mob siab

Zhang Zheng et al.(1989) pom tiasGanoderma applanatum,Ganoderma atrumthiabGanoderma capensetuaj yeem tiv thaiv kab mob siab B DNA polymerase (HBV-DNA polymerase), txo HBV-DNA replication thiab inhibit qhov tso tawm ntawm kab mob siab B nto antigen (HBsAg) los ntawm PLC / PRF / 5 hlwb ( tib neeg lub siab mob qog noj ntshav).

Cov kws tshawb fawb ntxiv tau soj ntsuam tag nrho cov tshuaj tiv thaiv kab mob ntawm cov tshuaj ntawm tus qauv duck kab mob siab.Cov txiaj ntsig tau pom tias qhov ncauj tswj hwm ntawmGanoderma applanatum(50 mg/kg) ob zaug hauv ib hnub rau 10 hnub sib law liag tuaj yeem txo qhov cuam tshuam ntawm duck hepatitis B virus DNA polymerase (DDNAP) thiab duck hepatitis B virus DNA (DDNA) ntawm cov ducks hluas uas kis tus kab mob siab B (DHBV), uas qhia tiasGanoderma applanatummuaj cov nyhuv inhibitory ntawm DHBV hauv lub cev [1].

Li YQ et al.(2006) tau tshaj tawm tias tib neeg daim siab mob qog noj ntshav HepG2 cov kab cell kis nrog HBV-DNA tuaj yeem nthuav qhia HBV nto antigen (HbsAg), HBV core antigen (HbcAg) thiab HBV cov kab mob cov kab mob, thiab tuaj yeem tsim cov kab mob siab B loj hlob tuaj.Ganoderic acid muab rho tawm los ntawmG. lucidumkab lis kev cai nruab nrab koob tshuaj-raws li (1-8 μg / mL) inhibited kev qhia thiab tsim ntawm HBsAg (20%) thiab HBcAg (44%), qhia tias ganoderic acid inhibited replication ntawm HBV hauv daim siab hlwb [2].

Anti-influenza virus

Zhu Yutong (1998) pom tias gavage lossis intraperitoneal txhaj ntawmG. applanatumextract (dej decoction los yog txias infusion) tuaj yeem ua rau kom muaj sia nyob thiab lub sijhawm muaj sia nyob ntawm cov nas uas kis tus kab mob khaub thuas FM1 hom, yog li muaj kev tiv thaiv zoo dua [3].

Mothana RA et al.(2003) pom tias ganodermadiol, lucidadiol thiab applanoxidic acid G tau muab rho tawm thiab ua kom huv los ntawm European G. pfeifferi tau pom cov tshuaj tiv thaiv kab mob tiv thaiv kab mob khaub thuas A thiab herpes simplex virus type 1 (HSV-1).ED50 ntawm ganodermadiol los tiv thaiv MDCK hlwb (epithelioid hlwb muab tau los ntawm lub raum canine) tiv thaiv kab mob khaub thuas A yog 0.22 mmol / L.ED50 (50% koob tshuaj zoo) uas tiv thaiv Vero hlwb (African ntsuab liab raum hlwb) tiv thaiv kab mob HSV-1 yog 0.068 mmol / L.ED50 ntawm ganodermadiol thiab applanoxidic acid G tiv thaiv kab mob khaub thuas A yog 0.22 mmol / L thiab 0.19 mmol / L, raws li [4].

Anti-HIV

Kim et al.(1996) pom tias qhov hnyav molecular ib feem ntawmG. lucidumfruiting lub cev dej extract thiab nruab nrab thiab alkaline ib feem ntawm methanol extract yuav inhibit qhov kev loj hlob ntawm tib neeg immunodeficiency virus (HIV) [5].

El-Mekkawy et al.(1998) qhia tias triterpenoids cais los ntawm methanol extract ntawmG. lucidumCov txiv hmab txiv ntoo lub cev muaj cov tshuaj tiv thaiv kab mob HIV-1 cytopathic thiab qhia txog kev ua haujlwm inhibitory ntawm HIV protease tab sis tsis muaj kev cuam tshuam rau kev ua haujlwm ntawm HIV-1 thim rov qab transcriptase [6].

Min et al.(1998) pom tias ganoderic acid B, lucidumol B, ganodermanondiol, ganodermanontriol thiab ganolucidic acid A muab rho tawm los ntawmG. lucidumspores muaj zog inhibitory nyhuv ntawm HIV-1 protease kev ua [7].

Sato N et al.(2009) pom tias cov pa oxygenated lanostane tshiab-hom triterpenoids [ganodenic acid GS-2, 20-hydroxylucidenic acid N, 20(21)-dehydrolucidenic acid N thiab ganederol F] cais tawm ntawm lub cev ntawm txiv hmab txiv ntoo.Ganoderma lucidummuaj cov nyhuv inhibitory ntawm HIV-1 protease nrog qhov nruab nrab inhibitory concentration (IC50) li 20-40 μm [8].

Yu Xiongtao et al.(2012) qhia tiasG. lucidumspore dej extract muaj cov nyhuv inhibitory ntawm Simian Immunodeficiency Virus (SIV) uas kis CEM × 174 hlwb ntawm tib neeg T lymphocyte cell kab, thiab nws IC50 yog 66.62 ± 20.21 mg / L.Nws lub luag haujlwm tseem ceeb yog inhibit SIV los ntawm adsorbing rau thiab nkag mus rau hauv cov hlwb thaum ntxov ntawm SIV tus kab mob kis, thiab nws tuaj yeem txo qhov kev qhia ntawm SIV capsid protein p27 [9].

Anti-Herpes Virus

Eo SK (1999) npaj ob cov dej-soluble extracts (GLhw thiab GLlw) thiab yim methanol rho tawm (GLMe-1-8) los ntawm lub cev fruiting ntawmG. lucidum.Lawv cov tshuaj tiv thaiv kab mob tau raug tshuaj xyuas los ntawm cytopathic effect (CPE) inhibition test thiab kuaj cov quav hniav.Ntawm lawv, GLhw, GLMe-1, GLMe-2, GLMe-4, thiab GLMe-7 qhia pom tseeb inhibition cuam tshuam rau tus kab mob herpes simplex virus type 1 (HSV-1) thiab type 2 (HSV-2), as well as vesicular stomatitis. Tus kab mob (VSV) Indiana thiab New Jersey hom.Hauv kev ntsuam xyuas txo cov quav hniav, GLhw inhibited plaque tsim ntawm HSV-2 nrog EC50 ntawm 590 thiab 580μg / mL hauv Vero thiab HEp-2 hlwb, thiab nws cov qhab nia xaiv (SI) yog 13.32 thiab 16.26.GLMe-4 tsis muaj cytotoxicity txog li 1000 μg / ml, thaum nws nthuav tawm cov tshuaj tiv thaiv muaj zog ntawm VSV New Jersey hom nrog SI ntau dua 5.43 [10].

OH KW et al.(2000) cais cov acidic protein bound polysaccharide (APBP) los ntawm carpophores ntawm Ganoderma lucidum.APBP tau pom muaj zog tiv thaiv kab mob tiv thaiv HSV-1 thiab HSV-2 hauv Vero hlwb ntawm nws EC50 ntawm 300 thiab 440μg / mL, feem.APBP tsis muaj cytotoxicity ntawm Vero hlwb ntawm qhov concentration ntawm 1 x 10 (4) μg / ml.APBP muaj synergistic inhibitory teebmeem ntawm HSV-1 thiab HSV-2 thaum ua ke nrog cov tshuaj tiv thaiv herpes Aciclovir, Ara-A lossis interferonγ (IFN-γ) feem [11, 12].

Liu Jing et al.(2005) pom tias GLP, polysaccharide cais los ntawmG. lucidummycelium, tuaj yeem tiv thaiv kab mob ntawm Vero hlwb los ntawm HSV-1.GLP tau thaiv cov kab mob HSV-1 thaum ntxov ntawm tus kab mob tab sis tsis tuaj yeem cuam tshuam kev sib txuas ntawm tus kab mob thiab cov kab mob lom macromolecules [13].

Iwatsuki K et al.(2003) pom tias ntau yam triterpenoids muab rho tawm thiab ua kom huv los ntawmGanoderma lucidummuaj inhibitory cuam tshuam rau induction ntawm Epstein-Barr tus kab mob thaum ntxov antigen (EBV-EA) nyob rau hauv Raji hlwb (tib neeg lymphoma hlwb) [14].

Zheng DS et al.(2017) pom tias tsib triterpenoids muab rho tawm los ntawmG. lucidum,suav nrog ganoderic acid A, ganoderic acid B, thiab ganoderol B, ganodermanontriol thiab ganodermanondiol, txo qhov kev muaj peev xwm ntawm nasopharyngeal carcinoma (NPC) 5-8 F hlwb kab lis kev cai hauv vitro, qhia qhov cuam tshuam tseem ceeb ntawm EBV EA thiab CA ua kom muaj zog thiab inhibit telomerase. kev ua si.Cov txiaj ntsig no tau muab pov thawj rau kev siv cov noG. lucidumtriterpenoids hauv kev kho mob ntawm NPC [15].

Anti-Newcastle Kab Mob Virus

Tus kab mob Newcastle yog ib hom kab mob khaub thuas avian, uas muaj kev kis kab mob siab thiab ua kom tuag ntawm cov noog.Shamaki BU et al.(2014) pom tiasGanoderma lucidumextracts ntawm methanol, n-butanol thiab ethyl acetate tuaj yeem inhibit neuraminidase kev ua ntawm tus kab mob Newcastle [16].

Anti-Dengue Virus

Lim WZ et al.(2019) pom tias cov dej rho tawm ntawmG. lucidumNyob rau hauv nws daim ntawv antler inhibited DENV2 NS2B-NS3 protease kev ua ntawm 84.6 ± 0.7%, siab dua li qub.G. lucidum[17].

Bharadwaj S et al.(2019) ua haujlwm ib qho kev tshuaj ntsuam xyuas virtual thiab hauv vitro kuaj los kwv yees lub peev xwm ntawm kev ua haujlwm triterpenoids los ntawmGanoderma lucidumthiab pom tias ganodermanontriol muab rho tawm los ntawmGanoderma lucidumtuaj yeem tiv thaiv tus kab mob dengue (DENV) NS2B -NS3 protease kev ua haujlwm [18].

Anti-Enterovirus

Enterovirus 71 (EV71) yog tus kab mob tseem ceeb ntawm tes, ko taw thiab qhov ncauj kab mob, ua rau tuag taus ntawm lub paj hlwb thiab cov teeb meem hauv cov menyuam yaus.Txawm li cas los xij, tam sim no tsis muaj cov tshuaj tiv thaiv kab mob pom zoo uas tuaj yeem siv los tiv thaiv thiab kho tus kab mob no.

Zhang W et al.(2014) pom tias obGanoderma lucidumtriterpenoids (GLTs), suav nrog Lanosta-7,9(11), 24-trien-3-one, 15; 26-dihydroxy (GLTA) thiab Ganoderic acid Y (GLTB), tso saib cov haujlwm tseem ceeb ntawm EV71 yam tsis muaj cytotoxicity.

Cov txiaj ntsig tau qhia tias GLTA thiab GLTB tiv thaiv EV71 tus kab mob los ntawm kev cuam tshuam nrog cov kab mob sib kis los thaiv cov adsorption ntawm tus kab mob mus rau lub hlwb.Tsis tas li ntawd, kev sib cuam tshuam ntawm EV71 virion thiab cov tebchaw tau kwv yees los ntawm lub khoos phis tawj molecular docking, uas qhia tau tias GLTA thiab GLTB tuaj yeem khi rau cov kab mob capsid protein ntawm lub hnab ntim dej hydrophobic (F site), thiab yog li tuaj yeem thaiv tsis tau ntawm EV71.Ntxiv mus, lawv tau pom tias GLTA thiab GLTB cuam tshuam qhov kev rov ua dua ntawm tus kab mob RNA (vRNA) ntawm EV71 replication los ntawm kev thaiv EV71 uncoating [19].

Summary thiab kev sib tham
Cov kev tshawb fawb saum toj no qhia tau hais tias Lingzhi, tshwj xeeb tshaj yog cov triterpenoids muaj nyob rau hauv nws, muaj ib tug inhibitory nyhuv ntawm ntau yam kab mob.Kev soj ntsuam ua ntej qhia tau hais tias nws cov tshuaj tiv thaiv kab mob tiv thaiv kab mob cuam tshuam nrog inhibiting adsorption thiab nkag mus ntawm cov kab mob mus rau hauv cov hlwb, inhibiting kev ua kom tus kab mob thaum ntxov antigen, inhibiting cov kev ua ntawm qee cov enzymes xav tau rau tus kab mob synthesis hauv hlwb, thaiv cov kab mob DNA lossis RNA replication yam tsis muaj. cytotoxicity thiab muaj cov nyhuv synergistic thaum ua ke nrog cov tshuaj tiv thaiv kab mob paub.Cov txiaj ntsig no muab pov thawj rau kev tshawb fawb ntxiv ntawm cov tshuaj tiv thaiv kab mob ntawm Lingzhi triterpenoids.

Kev tshuaj xyuas cov kev kho mob uas twb muaj lawm ntawm Lingzhi hauv kev tiv thaiv thiab kho cov kab mob kis, peb pom tias Lingzhi tuaj yeem hloov cov kab mob siab B (HBsAg, HBeAg, anti-HBc) tsis zoo rau kev tiv thaiv thiab kho kab mob siab B. Tab sis lwm yam tshaj li ntawd, hauv kev kho mob herpes zoster, condyloma acuminatum thiab AIDS nyob rau hauv ua ke nrog cov tshuaj tiv thaiv kab mob, peb tsis tau pom muaj pov thawj tias Lingzhi tuaj yeem cuam tshuam tus kab mob hauv cov neeg mob.Kev kho mob ntawm Lingzhi ntawm cov kab mob kis tau feem ntau cuam tshuam nrog nws cov nyhuv immunomodulatory, nws cov tshuaj tiv thaiv oxidant thiab dawb radical scavenging cuam tshuam thiab nws cov kev tiv thaiv ntawm lub cev lossis cov ntaub so ntswg raug mob.(Ua tsaug rau Xib Fwb Baoxue Yang rau kev kho cov kab lus no.)

Cov ntaub ntawv

1. Zhang Xu, et al.Kev Tshawb Fawb Txog Kev Tshawb Fawb ntawm 20 Hom Suav Fungi Tawm Tsam HBV.Journal of Beijing Medical University.1989, 21: 455-458.

2. Li YQ, et al.Anti-hepatitis B kev ua ub no ntawm ganoderic acid los ntawmGanoderma lucidum.Biotechnol Lett, 2006, 28(11): 837-841.

3. Zhu Yutong, thiab al.Protective nyhuv ntawm Extract ntawmGanoderma applanatum(pers) pab.ntawm nas kis kab mob khaub thuas FM1.Journal of Guangzhou University of Traditional Chinese Medicine.1998, 15(3): 205-207.

4. Mothana RA, et al.Antiviral lanostanoid triterpenes los ntawm fungusGanoderma pfeifferi.Fitoterapia.2003, 74(1-2): 177–180.

5. Kim IB.Anti-human Immunodeficiency Virus Activity ofGanoderma lucidum.1996 International Ganoderma Symposium, Kev Qhia Tshwj Xeeb, Taipei.

6. El-Mekkawy S, et al.Anti-HIV thiab anti-HIV-protease tshuaj los ntawmGanoderma lucidum.Phytochemistry.1998, 49(6): 1651-1657.

7. Min BS, et al.Triterpenes los ntawm spores ntawmGanoderma lucidumthiab lawv cov haujlwm inhibitory tiv thaiv HIV-1 protease.Chem Pharm Bull (Tokyo).1998, 46(10): 1607-1612.

8. Sato N, et al.Anti-human immunodeficiency virus-1 protease act of new lanostane-type triterpenoids los ntawmGanoderma sinense.Chem Pharm Bull (Tokyo).2009, 57(10): 1076-1080.

9. Yu Xiongtao, et al.Kawm txog Cov teebmeem ntawm Inhibition ntawmGanoderma lucidumntawm Simian Imunodeficiency Virus hauv vitro.Suav Journal of Experimental Traditional Medical Formulae.2012, 18(13): 173-177.

10. Eo SK, et al.Antiviral kev ua ub no ntawm ntau yam dej thiab methanol soluble tshuaj cais los ntawmGanoderma lucidum.J Ethnopharmacol.1999, 68(1-3): 129-136.

11. Oh KW, et al.Antiherpetic kev ua ub no ntawm acidic protein khi polysaccharide cais los ntawmGanoderma lucidumib leeg thiab ua ke nrog acyclovir thiab vidarabine.J Ethnopharmacol.2000, 72(1-2): 221-227.

12. Kim YS, et al.Antiherpetic kev ua ub no ntawm acidic protein khi polysaccharide cais los ntawmGanoderma lucidumib leeg thiab ua ke nrog interferons.J Ethnopharmacol.2000, 72(3): 451-458.

13. Liu J., et al.Inhibition of Herpes Simplex Virus Infection los ntawm GLP cais los ntawm Mycelium ntawmGanoderma Lucidum.Virologica Sinica.2005, 20(4): 362-365.

14. Iwatsuki K, et al.Lucidenic acids P thiab Q, methyl lucidenate P, thiab lwm yam triterpenoids los ntawm fungusGanoderma lucidumthiab lawv cov teebmeem inhibitory ntawm Epstein-Barrvirus ua kom.J Nat Prod.2003, 66(12): 1582-1585.

15. Zheng DS, et al.Triterpenoids los ntawmGanoderma luciduminhibit qhov ua kom ntawm EBV antigens li telomerase inhibitors.Exp Ther Med.2017, 14(4): 3273-3278.

16. Shamaki BU, et al.Methanolic soluble feem ntawm lingzhi orreishimedicinal nceb,Ganoderma lucidum(siab dua Basidiomycetes) extract inhibit neuraminidase kev ua haujlwm hauv Newcastle tus kab mob (LaSota).Int J Med Mushrooms.2014, 16(6): 579-583.

17. Lim WS, et al.Kev txheeb xyuas cov active compounds nyob rau hauvGanoderma lucidumvar.antler extract inhibiting dengue virus serine protease thiab nws cov kev tshawb fawb suav.J Biomol Struct Dyn.2019, 24:1-16.

18. Bharadwaj S, et al.Discovery ntawmGanoderma lucidumtriterpenoids uas muaj peev xwm inhibitors tiv thaiv tus kab mob Dengue NS2B-NS3 protease.Sci Rep. 2019, 9(1): 19059.

19. Zhang W, et al.Antiviral teebmeem ntawm obGanoderma lucidumtriterpenoids tiv thaiv tus kab mob enterovirus 71.Biochem Biophys Res Commun.2014, 449(3): 307-312.

★ Cov ntawv qub ntawm tsab xov xwm no tau sau ua lus Suav los ntawm xibfwb Zhi-bin LIN thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.

Dhau ntawm Millennia Health Culture
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