Mongolo/Zhi-bin LIN (moprofesa oa Lefapha la Pharmacology, Sekolo sa Peking University of Basic Medical Sciences)
★Sengoliloeng sena se hlahisitsoe ho ganodermanews.com.E phatlalalitsoe ka tumello ea mongoli.

Lingzhi (eo hape e bitsoang Ganoderma kapa Reishi mushroom) e bapala litlamorao tsa eona tsa antiviral joang?Ho amoheloa ka kakaretso hore Lingzhi ka tsela e sa tobang e thibela likokoana-hloko hore li se ke tsa hlasela 'mele oa motho le ho ata le ho senya 'meleng ka ho matlafatsa sesole sa' mele.Lingzhi e ka boela ea fokotsa ho ruruha ho bakoang ke kokoana-hloko le tšenyo ea litho tsa bohlokoa tse kang matšoafo, pelo, sebete le liphio ka liphello tsa eona tsa anti-oxidative le mahala.Ho phaella moo, ho bile le litlaleho tsa lipatlisiso ho tloha lilemong tsa bo-1980 hore Lingzhi, haholo-holo triterpenoids e nang le eona, e na le phello e thibelang likokoana-hloko tse fapaneng.

Moprofesa Zhi-bin LIN o kentse letsoho lipatlisisong tsa Lingzhipharmacology bakeng sa halofo ea lekholo mme ke pula-maliboho lipatlisisong tsa Lingzhi Chaena.(Litšoantšo/Wu Tingyao)

Lefu la Coronavirus la 2019 (COVID-19) le ntse le potoloha mme le nametse lefatšeng ka bophara.Ho thibela le ho laola seoa sena, ho phekola bakuli le ho felisa seoa sena ke litebello tse tloaelehileng le boikarabello ba sechaba sohle.Ho tsoa litlalehong tse fapaneng tsa mecha ea litaba, ke thabetse ho bona tse ngata joaloGanoderma lucidumbaetsi ba fana ka lisebelisoa tsa thibelo ea seoa le lihlahisoa tsa Lingzhi libakeng tsa seoa le lihlopha tsa bongaka ho Hubei.Ke ts'epa hore Lingzhi e ka thusa ho thibela "pneumonia" e ncha ea coronavirus le ho sireletsa lingaka le bakuli.

Sesosa sa seoa sena ke "coronavirus" ea 2019 (SARS-CoV-2).Pele ho ne ho e-na le lithethefatsi le liente tsa anti-novel coronavirus, mokhoa oa khale le o sebetsang e ne e le ho behella bakuli ka thoko, ho fana ka kalafo e nang le matšoao le ts'ehetso, ho matlafatsa sesole sa 'mele, ho thibela livaerase hore li se ke tsa tšoaetsa le ho senya litho le litho tsa bohlokoa tsa' mele mme qetellong ba hlole lefu lena.Bakeng sa batho ba hlaselehang habonolo, ho matlafatsa sesole sa 'mele ho thusa ho hanela litlhaselo tsa vaerase.

Ho phaella moo, lefapha la bongaka le boetse le leka ho fumana meriana e ka loantšang kokoana-hloko ena e ncha ho litlhare tse seng li ntse li le teng tsa antiviral.Ho na le menyenyetsi e mengata Inthaneteng.Hore na lia sebetsa kapa che ha li so netefatsoe ke lingaka.

Lingzhi e ntlafatsa matla a antivirus a sesole sa 'mele.

Lingzhi (Ganoderma lucidumleGanoderma sinensis) ke sethethefatsi sa setso sa setso sa Machaena se kenyellelitsoeng Pharmacopoeia ea People's Republic of China (Karolo ea Pele), ho latela hore Lingzhi e ka tlatsetsa qi, methapo e khutsitseng, ho imolla sefuba le asthma, 'me e ka sebelisoa bakeng sa ho hloka botsitso, ho hlobaela, ho otla ha pelo, khaello ea matšoafo le ho khohlela le ho hema, lefu le jeoang ke bolutu le ho haelloa ke moea, le ho lahleheloa ke takatso ea lijo.Ho fihlela joale, mefuta e fetang lekholo ea meriana ea Lingzhi e amohetsoe hore e rekisoe bakeng sa thibelo ea mafu le kalafo.

Liphuputso tsa morao-rao tsa meriana li pakile hore Lingzhi e ka ntlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung, ho hanela mokhathala, ho ntlafatsa boroko, ho hanela oxidation le ho senya li-radicals tsa mahala, le ho sireletsa pelo, boko, matšoafo, sebete le liphio.E 'nile ea sebelisoa ka tleliniking ho phekola kapa ho phekola adjuvant ea bronchitis e sa foleng, tšoaetso ea phefumoloho e tloaelehileng, asthma le mafu a mang.

Lingzhi e bapala litlamorao tsa eona tsa antiviral joang?Ho amoheloa ka kakaretso hore Lingzhi ka tsela e sa tobang e thibela likokoana-hloko hore li se ke tsa hlasela 'mele oa motho le ho ata le ho senya 'meleng ka ho matlafatsa sesole sa' mele.

Le hoja kokoana-hloko e le bohale haholo, e tla qetella e felisitsoe ha e tobane le tšireletso e matla.Sena se tšohliloe sehloohong se reng "Lingzhi e Matlafatsa Tšireletso" e hatisitsoeng khatisong ea 58 ea "GANODERMA" le sehlooho se reng "Motheo oaGanoderma lucidumho Thibela Influenza - Ha ho na le qi e lekaneng ea bophelo bo botle ka hare, lintlha tsa pathogenic ha li na mokhoa oa ho hlasela 'mele" e hatisitsoeng khatisong ea 46 ea "GANODERMA".

Ka kakaretso, e 'ngoe ke hore Lingzhi e ka ntlafatsa ts'ebetso ea' mele ea 'mele ea ho itšireletsa mafung e kang ho khothalletsa ho ata, ho arohana le ho sebetsa ha lisele tsa dendritic, ho ntlafatsa mosebetsi oa phagocytic oa macrophages a mononuclear le lisele tse bolaeang tsa tlhaho, le ho thibela likokoana-hloko le libaktheria hore li se ke tsa hlasela motho. mmele.Ea bobeli, Lingzhi e ka ntlafatsa mesebetsi ea 'mele ea ho itšireletsa mafung le ea lisele tse kang ho khothalletsa tlhahiso ea Immunoglobulin M (IgM) le Immunoglobulin G (IgG), ho eketsa ho ata ha T lymphocyte le B lymphocyte, le ho khothalletsa tlhahiso ea cytokine interleukin-1 (IL- 1), Interleukin-2 (IL-2) le interferon gamma (IFN-γ).

Ho itšireletsa mafung le lisele tsa 'mele ke tšireletso e tebileng ea' mele khahlanong le tšoaetso ea kokoana-hloko le baktheria.Ba ka notlela liphofu tse itseng ho sireletsa le ho felisa livaerase le libaktheria tse hlaselang 'mele.Ha ts'ebetso ea 'mele ea ho itšireletsa mafung e le tlase ka lebaka la mabaka a sa tšoaneng, Lingzhi e ka boela ea ntlafatsa ts'ebetso ea' mele ea ho itšireletsa mafung.

Ho feta moo, Lingzhi e ka boela ea fokotsa ho ruruha ho bakoang ke kokoana-hloko le ts'oaetso ea kokoana-hloko ho litho tsa bohlokoa tse kang matšoafo, pelo, sebete, liphio, le ho thibela kapa ho fokotsa matšoao ka liphello tsa eona tsa anti-oxidant le mahala.Khatisong ea bo75 ea "GANODERMA", e ka sebelisoa ho supa hore bohlokoa ba litlamorao tsa anti-oxidant le free radical scavenging.Ganoderma lucidumka thibelo le kalafo ea mafu a tšohloa ka ho khetheha sehloohong se nang le sehlooho se reng "Lingzhi - Phekola Mafu a sa tšoaneng ka Mokhoa o Tšoanang".

Ho tloha lilemong tsa bo-1980, ho bile le litlaleho tsa lipatlisiso mabapi le litlamorao tsa antiviral tsa Lingzhi.Boholo ba lithuto tsena li sebelisitse mefuta ea lisele tse nang le tšoaetso ea kokoana-hloko ea in vitro, 'me lithuto tsa motho ka mong le tsona li sebelisitse mehlala ea liphoofolo tsa tšoaetso ea kokoana-hloko ho shebella liphello tsa antiviral tsa Lingzhi.

Lingoliloeng tsa kholomo tse hatisitsoeng ke Moprofesa Zhibin Lin Litabeng tsa 46, 58, le 75 tsa "GANODERMA"

Anti-hepatitis kokoana-hloko

Zhang Zheng et al.(1989) o fumane horeGanoderma applanatum,Ganoderma atrumleGanoderma capensee ka thibela kokoana-hloko ea lefu la sebete DNA polymerase (HBV-DNA polymerase), ea fokotsa ho ikatisa ha HBV-DNA le ho thibela secretion ea hepatitis B holim'a antigen (HBsAg) ke lisele tsa PLC/PRF/5 (lisele tsa kankere ea sebete sa motho).

Bafuputsi ba ile ba tsoela pele ho hlokomela katleho e akaretsang ea antiviral ea sethethefatsi mofuteng oa lefu la sebete la letata.Liphetho li bontšitse hore tsamaiso ea molomo eaGanoderma applanatum(50 mg/kg) habeli ka letsatsi bakeng sa matsatsi a 10 a latellanang ka fokotsa liphello tsa letata hepatitis B kokoana-hloko DNA polymerase (DDAP) le letata hepatitis B kokoana-hloko DNA (DDNA) ea matata a manyenyane a tšoaelitsoeng ke letata hepatitis B kokoana-hloko (DHBV), eo e bontša horeGanoderma applanatume na le phello e thibelang DHBV 'meleng [1].

Li YQ et al.(2006) e tlalehile hore kankere ea sebete ea motho HepG2 lisele tsa lisele tse fetisitsoeng ka HBV-DNA li ka hlahisa HBV holim'a antigen (HbsAg), HBV core antigen (HbcAg) le liprotheine tsa sebopeho sa kokoana-hloko ea HBV, 'me e ka hlahisa likaroloana tsa kokoana-hloko ea lefu la sebete la mofuta oa B.Asiti ea Ganoderic e ntšitsoeng hoG. lucidumsetso se itšetlehileng ka lethal dose (1-8 μg/mL) e thibetse polelo le tlhahiso ea HBsAg (20%) le HBcAg (44%), e fana ka maikutlo a hore ganoderic acid e thibela ho ikatisa ha HBV liseleng tsa sebete [2].

Kokoana-hloko ea anti-influenza

Zhu Yutong (1998) o fumane hore ente ea gavage kapa intraperitoneal eaG. applanatumho ntša (li-decoction ea metsi kapa infusion e batang) e ka eketsa haholo lebelo la ho phela le nako ea ho phela ea litoeba tse tšoaelitsoeng ke mafu a feberu ea FM1, kahoo e na le phello e molemo ea tšireletso [3].

Mothana RA et al.(2003) e fumane hore ganodermadiol, lucidadiol le applanoxidic acid G e ntšitsoeng le ho hloekisoa ho tloha Europe G. pfeifferi e bontšitse mesebetsi ea antiviral khahlanong le kokoana-hloko ea ntaramane le herpes simplex kokoana-hloko ea mofuta oa 1 (HSV-1).ED50 ea ganodermadiol ho sireletsa lisele tsa MDCK (lisele tsa epithelioid tse nkiloeng ho liphio tsa canine) khahlanong le tšoaetso ea kokoana-hloko ea ntaramane A ke 0.22 mmol/L.ED50 (50% tekanyo e sebetsang) e sireletsang lisele tsa Vero (lisele tsa liphio tse tala tsa Afrika) khahlano le tšoaetso ea HSV-1 ke 0.068 mmol/L.ED50 ea ganodermadiol le applanoxidic acid G khahlanong le tšoaetso ea kokoana-hloko ea ntaramane A e ne e le 0.22 mmol/L le 0.19 mmol/L, ka ho latellana [4].

Anti-HIV

Kim le al.(1996) o fumane hore karolo e tlase ea boima ba molek'hule eaG. lucidummetsi a 'mele a fruiting le karolo e sa nke lehlakore le ea alkaline ea motsoako oa methanol e ka thibela ho ata ha kokoana-hloko ea immunodeficiency virus (HIV) [5].

El-Mekkawy et al.(1998) e tlaleha hore triterpenoids e arohane le karolo ea methanol eaG. lucidum'mele oa litholoana o na le litlamorao tse khahlanong le HIV-1 cytopathic mme o bonts'a ts'ebetso e thibelang tšoaetso ea HIV empa ha e na phello e thibelang ts'ebetsong ea HIV-1 reverse transcriptase [6].

Min le al.(1998) e fumane hore ganoderic acid B, lucidumol B, ganodermanondiol, ganodermanontriol le ganolucidic acid A e ntšitsoeng hoG. lucidumli-spores li na le phello e matla ea thibelo mosebetsing oa HIV-1 protease [7].

Sato N et al.(2009) e fumane hore triterpenoids e ncha e nang le oksijene e ngata ea mofuta oa lanostane [ganodenic acid GS-2, 20-hydroxylucidenic acid N, 20 (21) -dehydrolucidenic acid N le ganederol F] e arohaneng le 'mele oa litholoana oaGanoderma lucidume na le phello ea inhibitory ho HIV-1 protease le median inhibitory concentration (IC50) e le 20-40 μm [8].

Yu Xiongtao et al.(2012) o tlaleha seoG. lucidumspore water extract e na le phello e thibelang ho Simian Immunodeficiency Virus (SIV) e tšoaetsang lisele tsa CEM×174 tsa mohala oa lisele tsa T lymphocyte tsa motho, 'me IC50 ea eona ke 66.62±20.21 mg/L.Mosebetsi oa eona o ka sehloohong ke ho thibela SIV ho tsoa le ho kena liseleng qalong ea tšoaetso ea kokoana-hloko ea SIV, 'me e ka fokotsa boemo ba polelo ea SIV capsid protein p27 [9].

Anti-Herpes kokoana-hloko

Eo SK (1999) e lokiselitse likhechana tse peli tse qhibilihang ka metsing (GLhw le GLlw) le tse robeli tsa methanol (GLMe-1-8) ho tsoa 'meleng e behang litholoanaG. lucidum.Ts'ebetso ea bona ea antiviral e ile ea hlahlojoa ke tlhahlobo ea inhibition ea cytopathic effect (CPE) le tlhahlobo ea ho fokotsa letlapa.Har'a tsona, GLhw, GLMe-1, GLMe-2, GLMe-4, le GLMe-7 li bonts'a litlamorao tse hlakileng tsa thibelo ho herpes simplex virus mofuta oa 1 (HSV-1) le mofuta oa 2 (HSV-2), hammoho le vesicular stomatitis. kokoana-hloko (VSV) Indiana le New Jersey mefuta.Tekong ea phokotso ea plaque, GLhw e thibelitse ho thehoa ha plaque ea HSV-2 e nang le EC50 ea 590 le 580μg / mL liseleng tsa Vero le HEp-2, 'me li-indices tsa eona tsa khetho (SI) e ne e le 13.32 le 16.26.GLMe-4 ha ea ka ea bontša cytotoxicity ho fihlela ho 1000 μg / ml, ha e ntse e bontša ts'ebetso e matla ea antiviral ho VSV New Jersey e nang le SI e fetang 5.43 [10].

OH KW et al.(2000) e arolelitse protheine e nang le acidic e kopantsoeng le polysaccharide (APBP) ho tloha ho carpophores ea Ganoderma lucidum.APBP e bontšitse tšebetso e matla ea antiviral khahlano le HSV-1 le HSV-2 liseleng tsa Vero ho EC50 ea eona ea 300 le 440μg/mL, ka ho latellana.APBP e ne e se na cytotoxicity liseleng tsa Vero sebakeng sa 1 x 10 (4) μg / ml.APBP e na le litlamorao tsa synergistic inhibitory ho HSV-1 le HSV-2 ha e kopantsoe le moriana oa anti-herpes Aciclovir, Ara-A kapa interferonγ (IFN-γ) ka ho latellana [11, 12].

Liu Jing et al.(2005) e fumane hore GLP, polysaccharide e arohaneng leG. lucidummycelium, e ka thibela tšoaetso ea lisele tsa Vero ka HSV-1.GLP e thibetse ts'oaetso ea HSV-1 methating ea pele ea ts'oaetso empa ha e khone ho thibela motsoako oa vaerase le li-macromolecules tsa biological [13].

Iwatsuki K et al.(2003) o fumane hore mefuta e fapaneng ea li-triterpenoids e ntšitsoe le ho hloekisoa ho eonaGanoderma lucidume na le liphello tse thibelang ho kenngoa ha Epstein-Barr kokoana-hloko ea antigen (EBV-EA) liseleng tsa Raji (lisele tsa lymphoma tsa batho) [14].

Zheng DS et al.(2017) e fumane hore li-triterpenoids tse hlano li ntšitsoe hoG. lucidum,ho kenyelletsa ganoderic acid A, ganoderic acid B, le ganoderol B, ganodermanontriol le ganodermanondiol, e fokotsa haholo ts'ebetso ea nasopharyngeal carcinoma (NPC) 5-8 F lisele tse hlahisitsoeng ka in vitro, li bonts'a litlamorao tse kholo ho EBV EA le CA activation le ho thibela telomerase. mosebetsi.Liphetho tsena li fane ka bopaki ba tšebeliso ea tsenaG. lucidumtriterpenoids kalafo ea NPC [15].

Kokoana-hloko ea Lefu la Newcastle

Kokoana-hloko ea lefu la Newcastle ke mofuta oa kokoana-hloko ea avian influenza, e nang le tšoaetso e phahameng le ho bolaea linonyana.Shamaki BU et al.(2014) o fumane seoGanoderma lucidumli-extracts tsa methanol, n-butanol le ethyl acetate li ka thibela tšebetso ea neuraminidase ea kokoana-hloko ea lefu la Newcastle [16].

Kokoana-hloko ea Anti-Dengue

Lim WZ et al.(2019) e fumane hore likheo tsa metsi tsaG. lucidumka mokhoa oa eona oa li-antler e ile ea thibela mosebetsi oa DENV2 NS2B-NS3 protease ho 84.6 ± 0.7%, e phahameng ho feta e tloaelehileng.G. lucidum[17] .

Bharadwaj S et al.(2019) e sebelisitse mokhoa o hlakileng oa ho hlahloba le liteko tsa in vitro ho bolela esale pele bokhoni ba triterpenoids e sebetsang ho tlohaGanoderma lucidummme a fumana hore ganodermanontriol e ntšitsoe hoGanoderma lucidume ka thibela kokoana-hloko ea dengue (DENV) NS2B -NS3 protease mosebetsi [18].

Anti-Enterovirus

Enterovirus 71 (EV71) ke pathogen e ka sehloohong ea lefu la letsoho, leoto le molomo, le bakang mathata a bolaeang a methapo ea kutlo le ea tsamaiso ho bana.Leha ho le joalo, hajoale ha ho na litlhare tse thibelang kokoana-hloko tse lumelletsoeng ke lingaka tse ka sebelisoang ho thibela le ho alafa tšoaetso ena ea vaerase.

Zhang W et al.(2014) o fumane hore tse peliGanoderma lucidumtriterpenoids (GLTs), ho kenyelletsa Lanosta-7,9 (11), 24-trien-3-one,15; 26-dihydroxy (GLTA) le Ganoderic acid Y (GLTB), e bonts'a mesebetsi ea bohlokoa ea anti-EV71 ntle le cytotoxicity.

Liphetho li khothalelitse hore GLTA le GLTB li thibele tšoaetso ea EV71 ka ho sebelisana le karoloana ea vaerase ho thibela ho ata ha kokoana-hloko liseleng.Ho feta moo, litšebelisano pakeng tsa EV71 virion le metsoako li ile tsa boleloa esale pele ke ho kenngoa ha molek'hule ea k'homphieutha, e bontšang hore GLTA le GLTB li ka tlama ho protheine ea viral capsid pokothong ea hydrophobic (F site), kahoo e ka thibela ho koaheloa ha EV71.Ho feta moo, ba bonts'itse hore GLTA le GLTB li thibela haholo phetisetso ea vaerase ea RNA (vRNA) ea EV71 replication ka ho thibela ho koaloa ha EV71 [19].

Kakaretso le puisano
Liphetho tsa lipatlisiso tse ka holimo li bontša hore Lingzhi, haholo-holo li-triterpenoids tse teng ho eona, li na le phello e thibelang likokoana-hloko tse fapaneng.Tlhahlobo ea pele e bontša hore mokhoa oa eona oa ho thibela kokoana-hloko o kenyelletsa ho thibela ho ata le ho kenella ha likokoana-hloko ka har'a lisele, ho thibela ts'ebetso ea kokoana-hloko ea pele ea antigen, ho thibela ts'ebetso ea li-enzyme tse hlokahalang bakeng sa motsoako oa kokoana-hloko liseleng, ho thibela DNA ea kokoana-hloko kapa ho ikatisa ha RNA ntle le ts'ebetso. cytotoxicity mme e na le phello ea synergistic ha e kopantsoe le lithethefatsi tse tsebahalang tsa antiviral.Liphetho tsena li fana ka bopaki ba lipatlisiso tse ling mabapi le litlamorao tsa antiviral tsa Lingzhi triterpenoids.

Ha re hlahloba katleho e teng ea Lingzhi ea ho thibela le ho phekola mafu a kokoana-hloko, re fumane hore Lingzhi e ka fetola matšoao a kokoana-hloko ea hepatitis B (HBsAg, HBeAg, anti-HBc) ho thibela le ho phekola lefu la sebete la B. Empa ntle le moo, ka phekolo ea herpes zoster, condyloma acuminatum le AIDS hammoho le lithethefatsi tse thibelang likokoana-hloko, ha re e-s'o fumane bopaki ba hore Lingzhi e ka thibela kokoana-hloko ka ho toba ho bakuli.Mesebetsi ea bongaka ea Lingzhi ho mafu a kokoana-hloko e ka 'na ea amana haholo-holo le phello ea eona ea ho itšireletsa mafung, liphello tsa eona tsa anti-oxidant le tsa mahala tsa scavenging le phello ea eona ea tšireletso ho kotsi ea setho kapa lisele.(Ke leboha Moprofesa Baoxue Yang ka ho lokisa sengoloa sena.)

Litšupiso

1. Zhang Zheng, le ba bang.Thuto ea Teko ea Mefuta e 20 ea Li-fungus tsa Sechaena Khahlanong le HBV.Journal ea Univesithi ea Bongaka ea Beijing.1989, 21: 455-458.

2. Li YQ, le ba bang.Anti-hepatitis B mesebetsi ea ganoderic acid ho tlohaGanoderma lucidum.Biotechnol Lett, 2006, 28(11): 837-841.

3. Zhu Yutong, et al.Tshireletso Phello ea Motsoako oaGanoderma applanatum(pers) pat.ka Litoeba tse tšoaelitsoeng ke Influenza Virus FM1. Journal of Guangzhou University of Traditional Chinese Medicine.1998, 15 (3): 205-207.

4. Mothana RA, le ba bang.Antiviral lanostanoid triterpenes ho tsoa ho fungusGanoderma pfeifferi.Fitoterapia.2003, 74 (1-2): 177-180.

5. Kim BK.Anti-Human Immunodeficiency Virus Activity eaGanoderma lucidum.1996 Simposiamo ea Machaba ea Ganoderma, Thuto e Khethehileng, Taipei.

6. El-Mekkawy S, le ba bang.Anti-HIV le anti-HIV-protease lintho tse tsoang hoGanoderma lucidum.Phytochemistry.1998, 49(6): 1651-1657.

7. Min BS, et al.Triterpenes ho tsoa ho li-spores tsaGanoderma lucidumle ts'ebetso ea bona ea thibelo khahlanong le HIV-1 protease.Chem Pharm Bull (Tokyo).1998, 46(10): 1607-1612.

8. Sato N, le ba bang.Anti-human immunodeficiency virus-1 protease activity of new lanostane-type triterpenoids ho tlohaGanoderma sinense.Chem Pharm Bull (Tokyo).2009, 57(10): 1076-1080.

9. Yu Xiongtao, le ba bang.Thuto ka Liphello tsa Thibelo eaGanoderma lucidumho Simian Imunodeficiency Virus in vitro.Chinese Journal of Experimental Traditional Medical Formulae.2012, 18 (13): 173-177.

10. Eo SK, le ba bang.Mesebetsi e thibelang likokoana-hloko ea lintho tse sa tšoaneng tsa metsi le methanol tse qhibilihang ka thōko hoGanoderma lucidum.J Ethnopharmacol.1999, 68(1-3): 129-136.

11. Oh KW, le ba bang.Antiherpetic mesebetsi ea acidic protheine tlamme polysaccharide itšehla thajana hoGanoderma lucidume le mong hape e kopane le acyclovir le vidarabine.J Ethnopharmacol.2000, 72(1-2): 221-227.

12. Kim YS, le ba bang.Antiherpetic mesebetsi ea acidic protheine tlamme polysaccharide itšehla thajana hoGanoderma lucidume le 'ngoe ebile e kopane le li-interferon.J Ethnopharmacol.2000, 72(3): 451-458.

13. Liu Jing, le ba bang.Thibelo ea Tšoaetso ea Herpes Simplex Virus ke GLP e Isolated ho tloha Mycelium eaMofuta oa "Ganoderma Lucidum"..Virologica Sinica.2005, 20(4): 362-365.

14. Iwatsuki K, le ba bang.Lucidenic acids P le Q, methyl lucidenate P, le li-triterpenoids tse ling tse tsoang ho fungus.Ganoderma lucidumle litlamorao tsa bona tse thibelang ts'ebetso ea Epstein-Barrvirus.J Nat Prod.2003, 66(12): 1582-1585.

15. Zheng DS, le ba bang.Triterpenoids ho tlohaGanoderma lucidumthibela ts'ebetso ea li-antigen tsa EBV joalo ka li-telomerase inhibitors.Exp Ther Med.2017, 14 (4): 3273-3278.

16. Shamaki BU, le ba bang.Likaroloana tse qhibilihang tsa methanolic tsa li-mushroom tsa lingzhi orreishimedicinal,Ganoderma lucidum(e phahameng Basidiomycetes) e thibela tšebetso ea neuraminidase ho Newcastle diseasevirus (LaSota).Li-mushroom tsa Int J Med.2014, 16 (6): 579-583.

17. Lim WZ, le ba bang.Khethollo ea metsoako e sebetsang ka har'aGanoderma lucidumvar.Antler extract inhibiting dengue virus serine protease le lithuto tsa eona tsa computational.J Biomol Struct Dyn.2019, 24: 1-16.

18. Bharadwaj S, le ba bang.Ho sibolloa haGanoderma lucidumtriterpenoids e le li-inhibitors tse ka bang teng khahlano le kokoana-hloko ea Dengue NS2B-NS3 protease.Sci Rep. 2019, 9(1): 19059.

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★ Sengoloa sa mantlha sa sengoloa sena se ngotsoe ka Sechaena ke Moprofesa Zhi-bin LIN 'me sa fetoleloa Senyesemaneng ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.

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