Inyandiko / Zhi-bin LIN (umwarimu w’ishami rya farumasi, ishuri rya kaminuza ya Peking yubumenyi bwibanze bwubuvuzi)
★ Iyi ngingo yakuwe kuri ganodermanews.com.Byatangajwe nuburenganzira bwumwanditsi.

Nigute Lingzhi (nanone yitwa Ganoderma cyangwa ibihumyo bya Reishi) ikina ingaruka za virusi?Muri rusange biremewe ko Lingzhi ibuza mu buryo butaziguye virusi kwinjira mu mubiri w'umuntu no kwiyongera no kwangiza umubiri mu kongera ubudahangarwa bw'umubiri.Lingzhi irashobora kandi kugabanya uburibwe buterwa na virusi ndetse no kwangirika kwingingo zingirakamaro nkibihaha, umutima, umwijima nimpyiko binyuze mu kurwanya anti-okiside kandi ku buntu bikabije.Byongeye kandi, hari raporo z’ubushakashatsi kuva mu myaka ya za 1980 zerekana ko Lingzhi, cyane cyane triterpenoide irimo, igira ingaruka mbi kuri virusi zitandukanye.

Porofeseri Zhi-bin LIN yagize uruhare mu bushakashatsi bwa Lingzhifarumasi mu binyejana byikinyejana kandi ni intangiriro mubushakashatsi bwa Lingzhi mubushinwa.(Ifoto / Wu Tingyao)

Indwara ya Coronavirus 2019 (COVID-19) iracyakwirakwira kandi ikwira isi yose.Kwirinda no kurwanya icyorezo, kuvura abarwayi no kurangiza icyorezo nibyo bitezwe hamwe ninshingano rusange byumuryango wose.Kuva mubitangazamakuru bitandukanye, nshimishijwe no kubona benshiGanoderma lucidumabayikora batanga ibikoresho byo gukumira icyorezo hamwe nibicuruzwa bya Lingzhi mubice by’ibyorezo hamwe nitsinda ryubuvuzi kuri Hubei.Nizere ko Lingzhi ashobora gufasha kwirinda igitabo cyitwa coronavirus pneumonia no kurinda abaganga n'abarwayi.

Nyirabayazana w'iki cyorezo ni igitabo cyitwa coronavirus ya 2019 (SARS-CoV-2).Mbere yuko habaho imiti n’inkingo birwanya udushya, inzira yambere kandi nziza yari iyo guha akato abarwayi, gukora imiti y’ibimenyetso kandi ifasha, kongera ubudahangarwa, kwirinda virusi kwanduza no kwangiza ingingo n’ingingo z’umubiri hanyuma amaherezo ikanesha indwara.Kubantu bakunze kwibasirwa, kongera ubudahangarwa bw'umubiri bifasha kurwanya virusi.

Byongeye kandi, ubuvuzi bugerageza kandi gushaka imiti ishobora kurwanya iyi virusi nshya ivuye mu miti iriho virusi.Hano haribihuha byinshi kuri enterineti.Niba bifite akamaro cyangwa bitarakorwa neza mubuvuzi.

Lingzhi yongerera ubushobozi anti-virusi sisitemu yumubiri.

Lingzhi (Ganoderma lucidumnaGanoderma sinensis. kubura ibihaha no gukorora no kwipanga, indwara itwara no guhumeka neza, no kubura ubushake bwo kurya.Kugeza ubu, ubwoko burenga ijana bw'imiti ya Lingzhi bwemejwe ko bugurishwa ku rwego rwo kwirinda no kuvura indwara.

Ubushakashatsi bugezweho bwa farumasi bwerekanye ko Lingzhi ishobora kongera imikorere yumubiri, kurwanya umunaniro, kunoza ibitotsi, kurwanya okiside na scavenge radicals yubusa, no kurinda umutima, ubwonko, ibihaha, umwijima nimpyiko.Yakoreshejwe mubuvuzi mu kuvura cyangwa kuvura indwara ya bronhite idakira, indwara zifata imyanya y'ubuhumekero, asima n'izindi ndwara.

Nigute Lingzhi akina ingaruka zayo za virusi?Muri rusange biremewe ko Lingzhi ibuza mu buryo butaziguye virusi kwinjira mu mubiri w'umuntu no kwiyongera no kwangiza umubiri mu kongera ubudahangarwa bw'umubiri.

Nubwo virusi ikaze cyane, amaherezo izakurwaho imbere yubudahangarwa bukomeye.Ibi byaganiriweho mu kiganiro “Lingzhi Yongera Ubudahangarwa” cyasohotse mu nomero ya 58 ya “GANODERMA” n'ingingo “Ishingiro ryaGanoderma lucidumKurinda Ibicurane - Iyo hari qi ihagije imbere, ibintu bitera indwara nta buryo bwo gutera umubiri "byasohotse mu nomero ya 46 ya" GANODERMA ".

Muri make, kimwe nuko Lingzhi ishobora kongera imikorere yumubiri idasanzwe yumubiri nko guteza imbere ikwirakwizwa, itandukaniro nimikorere ya selile dendritic, kongera ibikorwa bya fagocyitike ya macrophage monone n selile selile, no kwirinda virusi na bagiteri kwibasira umuntu umubiri.Icya kabiri, Lingzhi irashobora kongera imikorere yubudahangarwa bwimikorere ningirabuzimafatizo nko guteza imbere umusaruro wa Immunoglobulin M (IgM) na Immunoglobulin G (IgG), kongera ubwiyongere bwa lymphocytes T na lymphocytes B, no guteza imbere umusaruro wa cytokine interleukin-1 (IL- 1), Interleukin-2 (IL-2) na interma ya gamma (IFN-γ).

Ubudahangarwa bw'urwenya hamwe n'ubudahangarwa bw'akagari bigize umurongo wimbitse wo kwirinda umubiri na virusi.Barashobora gufunga intego zihariye kugirango barinde kandi bakureho virusi na bagiteri zinjira mumubiri.Iyo imikorere yubudahangarwa iba mike kubera impamvu zitandukanye, Lingzhi irashobora kandi kunoza imikorere yumubiri.

Byongeye kandi, Lingzhi irashobora kandi kugabanya uburibwe buterwa na virusi ndetse no kwangirika kwa virusi ku ngingo zingenzi nk'ibihaha, umutima, umwijima, impyiko, kandi ikumira cyangwa igabanya ibimenyetso binyuze mu kurwanya anti-okiside ndetse n'ingaruka zayo zo kwikuramo ubusa.Mu nomero ya 75 ya "GANODERMA", irashobora gukoreshwa kugirango yerekane ko akamaro ko kurwanya anti-okiside hamwe nubusa bwa radical scavenging ingaruka zaGanoderma lucidummu gukumira no kuvura indwara byaganiriweho cyane cyane mu kiganiro cyiswe “Lingzhi - Kuvura Indwara Zinyuranye Uburyo bumwe”.

Kuva mu myaka ya za 1980, hari raporo z’ubushakashatsi ku ngaruka za virusi ya Lingzhi.Inyinshi muri ubwo bushakashatsi zakoresheje ingirabuzimafatizo zanduye virusi muri vitro, kandi ubushakashatsi bwakozwe ku giti cyabo bwakoresheje kandi inyamaswa z’ubwandu bwa virusi kugira ngo harebwe ingaruka za virusi ya Lingzhi.

Ingingo z'inkingi zasohowe na Porofeseri Zhibin Lin mu nomero ya 46, 58, na 75 za “GANODERMA”

Virusi irwanya hepatite

Zhang Zheng n'abandi.(1989) yasanze ibyoGanoderma applanatum,Ganoderma atrumnaGanoderma capenseIrashobora guhagarika virusi ya hepatite B ADN polymerase (HBV-ADN polymerase), kugabanya kwigana HBV-ADN no kubuza gusohora antigen (HBsAg) na selile PLC / PRF / 5 (selile kanseri yumwijima yumuntu).

Abashakashatsi bakomeje kureba imikorere rusange ya virusi ya virusi ku cyorezo cya hepatite.Ibisubizo byerekanaga ko ubuyobozi bwo mu kanwa bwaGanoderma applanatum. byerekana koGanoderma applanatumigira ingaruka mbi kuri DHBV mumubiri [1].

Li YQ n'abandi..Acide ya Ganoderic yakuwe muriG. lucidumumuco uciriritse ikabije (1-8 μg / mL) yabujije imvugo n'umusaruro wa HBsAg (20%) na HBcAg (44%), byerekana ko aside ganoderic yabujije kwigana HBV mu ngirabuzimafatizo z'umwijima [2].

Virusi yo kurwanya ibicurane

Zhu Yutong (1998) yasanze inshinge ya gavage cyangwa intraperitonealG. applanatumibiyikuramo (gutobora amazi cyangwa gushiramo ubukonje) birashobora kongera cyane ubuzima bwo kubaho nigihe cyo kubaho kwimbeba zanduye virusi ya grippe FM1, bityo bikagira ingaruka nziza zo kurinda [3].

Mothana RA n'abandi..ED50 ya ganodermadiol kugirango irinde selile MDCK (selile epithelioid ikomoka ku mpyiko ya kine) kwirinda virusi ya grippe A ni 0.22 mmol / L.ED50 (50% ikora neza) irinda selile Vero (ingirabuzimafatizo zimpyiko nyafurika) kwirinda kwandura HSV-1 ni 0.068 mmol / L.ED50 ya ganodermadiol na aside yitwa Applanoxidic G irwanya virusi ya grippe A yari 0.22 mmol / L na 0.19 mmol / L, [4].

Kurwanya VIH

Kim n'abandi.(1996) yasanze uburemere buke bwa molekuline igice cyaG. lucidumkwera amazi yumubiri hamwe nigice kitagira aho kibogamiye na alkaline cyumusemburo wa methanol birashobora kubuza ikwirakwizwa rya virusi itera SIDA (5).

El-Mekkawy n'abandi.(1998) yatangaje ko triterpenoide yitandukanije na methanol yaG. lucidumimibiri yera imbuto igira ingaruka zo kurwanya virusi itera SIDA-1 kandi ikerekana ibikorwa byo guhagarika protease ya sida ariko nta ngaruka zibuza gukora ibikorwa bya virusi itera SIDA-1 [6].

Min n'abandi..G. lucidumspore igira ingaruka zikomeye zo guhagarika ibikorwa bya virusi ya VIH-1 [7].

Sato N n'abandi..Ganoderma lucidumbigira ingaruka mbi kuri protease ya virusi ya VIH-1 hamwe na median inhibitory concentration (IC50) nka 20-40 mm [8].

Yu Xiongtao n'abandi.(2012) yatangaje koG. lucidumAmazi ya spore afite ingaruka zo kubuza virusi ya Simian Immunodeficiency (SIV) yanduza CEM × 174 ingirabuzimafatizo z'umuntu T lymphocyte T, naho IC50 yayo ni 66.62 ± 20.21 mg / L.Igikorwa cyacyo nyamukuru ni ukubuza SIV kwinjirira no kwinjira mu ngirabuzimafatizo hakiri kare kwandura virusi ya SIV, kandi irashobora kugabanya urugero rwa imvugo ya SIV capsid protein p27 [9].

Virusi irwanya Herpes

Eo SK (1999) yateguye ibivamo amazi abiri (GLhw na GLlw) hamwe na metani umunani (GLMe-1-8) biva mumibiri yimbuto zaG. lucidum.Ibikorwa byabo bya virusi byasuzumwe ningaruka za cytopathic (CPE) ikizamini cyo kubuza no kugabanya icyapa.Muri byo, GLhw, GLMe-1, GLMe-2, GLMe-4, na GLMe-7 bagaragaza ingaruka zigaragara zo kubuza virusi ya herpes simplex virusi yo mu bwoko bwa 1 (HSV-1) n'ubwoko bwa 2 (HSV-2), ndetse na stomatite ya viticular. virusi (VSV) Indiana na New Jersey.Mu kugabanya icyapa, GLhw yabujije gukora plaque ya HSV-2 hamwe na EC50 ya 590 na 580μg / mL muri selile Vero na HEp-2, kandi ibimenyetso byatoranijwe (SI) byari 13.32 na 16.26.GLMe-4 ntiyerekanye cytotoxicitike igera kuri 1000 μg / ml, mu gihe yerekanaga ibikorwa bikomeye byo kurwanya virusi ku bwoko bwa VSV New Jersey hamwe na SI irenga 5.43 [10].

OH KW n'abandi..APBP yerekanye ibikorwa bikomeye bya virusi irwanya HSV-1 na HSV-2 muri selile Vero kuri EC50 ya 300 na 440μg / mL.APBP nta cytotoxicité yari ifite kuri selile Vero yibanze kuri 1 x 10 (4) μg / ml.APBP ifite ingaruka zo guhagarika HSV-1 na HSV-2 iyo ihujwe nubuvuzi burwanya herpes Aciclovir, Ara-A cyangwa interferonγ (IFN-γ) buri kimwe [11, 12].

Liu Jing n'abandi.(2005) yasanze GLP, polysaccharide yitaruyeG. lucidummycelium, irashobora kubuza kwanduza selile Vero na HSV-1.GLP yahagaritse kwandura HSV-1 hakiri kare kwandura ariko ntishobora kubuza synthesis ya virusi na macromolecules biologiya [13].

Iwatsuki K n'abandi.(2003) yasanze triterpenoide itandukanye yakuwe kandi isukurwaGanoderma lucidumbigira ingaruka mbi zo kwinjiza virusi ya Epstein-Barr antigen kare (EBV-EA) mu tugari twa Raji (selile lymphoma muntu) [14].

Zheng DS n'abandi.(2017) yasanze triterpenoide eshanu yakuwe muriG. lucidum,harimo aside ganoderic A, acide ganoderic B, na ganoderol B, ganodermanontriol na ganodermanondiol, bigabanya cyane ubuzima bwa kanseri ya nasofaryngeal (NPC) 5-8 F ingirabuzimafatizo muri vitro, byerekana ingaruka zikomeye zibuza gukora EBV EA na CA no kubuza telomerase ibikorwa.Ibisubizo byatanze ibimenyetso byerekana ishyirwa mu bikorwa ryabyoG. lucidumtriterpenoide mu kuvura NPC [15].

Virusi Kurwanya Indwara ya Newcastle

Virusi yindwara ya Newcastle ni ubwoko bwa virusi yibicurane by’ibiguruka, bifite ubwandu bukabije kandi bwica mu nyoni.Shamaki BU n'abandi.(2014) yasanze ibyoGanoderma lucidumIbikomoka kuri methanol, n-butanol na Ethyl acetate bishobora guhagarika ibikorwa bya neuraminidase ya virusi y’indwara ya Newcastle [16].

Virusi yo Kurwanya Dengue

Lim WZ n'abandi.(2019) yasanze ibivamo amazi yaG. lucidummuburyo bwa antler yabujije ibikorwa bya protease DENV2 NS2B-NS3 kuri 84,6 ± 0.7%, birenze ibisanzweG. lucidum[17].

Bharadwaj S n'abandi.(2019) yakoresheje uburyo bwo gusuzuma busanzwe no mubizamini bya vitro kugirango hamenyekane ubushobozi bwa triterpenoide ikoraGanoderma lucidumugasanga ganodermanontriol yakuwe muriGanoderma lucidumIrashobora guhagarika virusi ya dengue (DENV) NS2B -NS3 ibikorwa bya protease [18].

Kurwanya Enterovirus

Enterovirus 71 (EV71) nindwara nyamukuru itera indwara zamaboko, ibirenge numunwa, bitera ibibazo byica imitsi ndetse na sisitemu byica abana.Ariko, kuri ubu nta miti yemewe na virusi yemewe ishobora gukoreshwa mu gukumira no kuvura iyi virusi.

Zhang W n'abandi.(2014) yasanze bombiGanoderma lucidumtriterpenoide (GLTs), harimo Lanosta-7,9 (11), 24-trien-3-imwe, 15; 26-dihydroxy (GLTA) na aside Ganoderic Y (GLTB), igaragaza ibikorwa bikomeye byo kurwanya EV71 nta cytotoxicity.

Ibisubizo byavugaga ko GLTA na GLTB birinda kwandura EV71 binyuze mu gukorana na virusi kugirango babuze kwanduza virusi ingirabuzimafatizo.Byongeye kandi, imikoranire hagati ya virusi ya EV71 hamwe n’ibintu byahanuwe na mudasobwa ya molekile ya mudasobwa, byagaragazaga ko GLTA na GLTB zishobora guhuza poroteyine ya virusi ya capsid ya virusi ku mufuka wa hydrophobique (F site), bityo bikaba bishobora guhagarika gufunga EV71.Byongeye kandi, berekanye ko GLTA na GLTB bibuza cyane kwigana virusi ya RNA (vRNA) yo kwigana EV71 binyuze mu guhagarika EV71 idapfundikira [19].

Incamake n'ibiganiro
Ibisubizo byubushakashatsi byavuzwe haruguru byerekana ko Lingzhi, cyane cyane triterpenoide irimo, igira ingaruka mbi kuri virusi zitandukanye.Isesengura ryibanze ryerekana ko uburyo bwayo bwo kurwanya virusi burimo kwanduza adsorption no kwinjira kwa virusi mu ngirabuzimafatizo, kubuza gukora virusi ya antigen hakiri kare, kubuza ibikorwa bya enzymes zimwe na zimwe zisabwa kugira ngo virusi ikorwe mu ngirabuzimafatizo, guhagarika ADN ya virusi cyangwa RNA itabigana nta cytotoxicity kandi ifite ingaruka zo guhuza iyo ihujwe nibiyobyabwenge bizwi na virusi.Ibisubizo biratanga gihamya yubushakashatsi bwimbitse ku ngaruka za virusi ya Lingzhi triterpenoids.

Twihweje ingaruka zisanzwe z’amavuriro ya Lingzhi mu gukumira no kuvura indwara ziterwa na virusi, twasanze Lingzhi ishobora guhindura ibimenyetso bya virusi ya hepatite B (HBsAg, HBeAg, anti-HBc) ikabi mu gukumira no kuvura indwara ya hepatite B. Ariko usibye ibyo, muri kuvura herpes zoster, condyloma acuminatum na sida hamwe n’imiti igabanya ubukana bwa virusi, ntitwabonye ibimenyetso byerekana ko Lingzhi ashobora guhagarika virusi mu barwayi mu buryo butaziguye.Ingaruka z’amavuriro ya Lingzhi ku ndwara ziterwa na virusi zishobora kuba zifitanye isano ahanini n’ingaruka zayo zo gukingira indwara, anti-okiside ndetse n’ingaruka zo kwisanzura ku buntu ndetse n'ingaruka zayo zo gukomeretsa ibikomere cyangwa ingingo.(Ndashimira Porofeseri Baoxue Yang kuba yarakosoye iyi ngingo.)

Reba

1. Zhang Zheng, n'abandi.Ubushakashatsi Bwakozwe bwubwoko 20 bwibihumyo byubushinwa Kurwanya HBV. Ikinyamakuru cya kaminuza yubuvuzi ya Beijing.1989, 21: 455-458.

2. Li YQ, n'abandi.Ibikorwa byo kurwanya hepatite B ya acide ganoderic kuvaGanoderma lucidum.Ibinyabuzima bya Biotechnol, 2006, 28 (11): 837-841.

3. Zhu Yutong, n'abandi. Ingaruka zo Kurinda GukuramoGanoderma applanatum(pers) pat.ku mbeba zanduye virusi ya grippe FM1.Ikinyamakuru cya kaminuza ya Guangzhou yubuvuzi gakondo bwabashinwa.1998, 15 (3): 205-207.

4. Mothana RA, n'abandi.Antiviral lanostanoid triterpène kuva muri fungusGanoderma pfeifferi.Fitoterapiya.2003, 74 (1-2): 177–180.

5. Kim BK.Kurwanya virusi ya immunodeficiency ya virusi yaGanoderma lucidum.1996 Symposium mpuzamahanga ya Ganoderma, Inyigisho idasanzwe, Taipei.

6. El-Mekkawy S, n'abandi.Kurwanya virusi itera sida no kurwanya virusi itera SIDA bivaGanoderma lucidum.Phytochemie.1998, 49 (6): 1651-1657.

7. Min BS, n'abandi.Triterpène kuva kuri spores yaGanoderma lucidumn'ibikorwa byabo byo kubuza kurwanya virusi ya VIH-1.Chem Pharm Bull (Tokiyo).1998, 46 (10): 1607-1612.

8. Sato N, n'abandi.Kurwanya immunodeficiency virusi-1 ibikorwa bya protease byubwoko bushya bwa lanostane-triterpenoids kuvaGanoderma sinense.Chem Pharm Bull (Tokiyo).2009, 57 (10): 1076-1080.

9. Yu Xiongtao, n'abandi.Kwiga ku ngaruka zo KubuzaGanoderma lucidumkuri virusi ya Simian Imunodeficiency muri vitro.Ikinyamakuru cyo mu Bushinwa cy’ubuvuzi bwa gakondo Ubuvuzi bwa 2012, 18 (13): 173-177.

10. Eo SK, n'abandi.Ibikorwa bya virusi byamazi atandukanye hamwe na methanol soluble ibintu bitandukanijwe naGanoderma lucidum.J Ethnopharmacol.1999, 68 (1-3): 129-136.

11. Oh KW, n'abandi.Ibikorwa bya antherpetike ya proteine ​​acide ihuza polysaccharide yitaruyeGanoderma lucidumwenyine kandi mukomatanya na acyclovir na vidarabine.J Ethnopharmacol.2000, 72 (1-2): 221-227.

12. Kim YS, n'abandi.Ibikorwa bya antherpetike ya proteine ​​acide ihuza polysaccharide yitaruyeGanoderma lucidumwenyine kandi muguhuza hamwe na interferons.J Ethnopharmacol.2000, 72 (3): 451-458.

13. Liu Jing, n'abandi.Kubuza Herpes Simplex Virus Yanduye na GLP Yitaruye Mycelium yaGanoderma Lucidum.Virologica Sinica.2005, 20 (4): 362-365.

14. Iwatsuki K, n'abandi.Acide ya Lucidenic P na Q, methyl lucidenate P, nizindi triterpenoide ziva muri fungusGanoderma lucidumn'ingaruka zabo zibuza gukora Epstein-Barrvirus.J Nat Prod.2003, 66 (12): 1582-1585.

15. Zheng DS, n'abandi.Triterpenoids kuvaGanoderma lucidumkubuza gukora antigene ya EBV nka telomerase inhibitor.Kwagura Med.2017, 14 (4): 3273-3278.

16. Shamaki BU, n'abandi.Ibice bya methanolike bishonga bya lingzhi orreishimedicinal ibihumyo,Ganoderma lucidum(Basidiomycetes yo hejuru) ikuramo ibuza ibikorwa bya neuraminidase muri virusi ya Newcastle (LaSota).Int J Ibihumyo.2014, 16 (6): 579-583.

17. Lim WZ, n'abandi.Kumenyekanisha ibintu bifatika muriGanoderma lucidumvar.antler ikuramo ibuza virusi ya dengue serine protease nubushakashatsi bwayo bwo kubara.J Biomol Yubaka Dyn.2019, 24: 1-16.

18. Bharadwaj S, n'abandi.Ubuvumbuzi bwaGanoderma lucidumtriterpenoide nkibishobora gukumira virusi ya Dengue NS2B-NS3 protease.Sci Rep. 2019, 9 (1): 19059.

19. Zhang W, n'abandi.Ingaruka za virusi ebyiriGanoderma lucidumtriterpenoide irwanya enterovirus 71.Biochem Biophys Res Commun.2014, 449 (3): 307-312.

Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Porofeseri Zhi-bin LIN uhindurwa mu Cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.

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