Text/Zhi-bin LIN (polofesa o ke Keʻena ʻOihana Lapaʻau, Ke Kula Nui o Peking University of Basic Medical Sciences)
★Ua paʻi hou ʻia kēia ʻatikala mai ganodermanews.com.Ua paʻi ʻia me ka ʻae a ka mea kākau.

Pehea e pāʻani ai ʻo Lingzhi (i kapa ʻia ʻo Ganoderma a i ʻole Reishi mushroom) i kona hopena antiviral?Ua ʻae ʻia ʻo Lingzhi ke kāohi ʻole i nā maʻi mai ka hoʻouka ʻana i ke kino o ke kanaka a me ka hoʻonui ʻana a me ka hōʻino ʻana i ke kino ma ka hoʻoikaika ʻana i ka ʻōnaehana pale.Hiki i ka Lingzhi ke hoʻemi i ka mumū i hoʻokumu ʻia e ka maʻi maʻi a me ka hōʻino ʻana i nā kino koʻikoʻi e like me ka māmā, ka puʻuwai, ka ate a me ka puʻupaʻa ma o kāna mau hopena anti-oxidative a me nā radical free scavenging.Eia kekahi, aia nā hōʻike noiʻi mai ka makahiki 1980 mai Lingzhi, ʻoi aku ka triterpenoids i loko o ia mea, he hopena pale i nā ʻano maʻi like ʻole.

Ua komo ʻo Professor Zhi-bin LIN i ka noiʻi o Lingzhilāʻau lapaʻau no ka hapalua haneli a he paionia i ka noiʻi o Lingzhi ma Kina.(Photography/Wu Tingyao)

Ke hoʻomau nei ka maʻi Coronavirus 2019 (COVID-19) a ua laha a puni ka honua.ʻO ka paleʻana a me ka hoʻomaluʻana i ka maʻi maʻi, ka mālamaʻana i nā maʻi a me ka hoʻopauʻana i ka maʻi maʻi nā manaʻo a me nā kuleana maʻamau o ka hui holoʻokoʻa.Mai nā hōʻike media like ʻole, hauʻoli wau i ka ʻike ʻana i kēlā nuiʻO Ganoderma lucidumHāʻawi nā mea hana i nā lako pale pale a me nā huahana Lingzhi i nā wahi maʻi maʻi a me nā hui lapaʻau iā Hubei.Manaʻo wau e hiki iā Lingzhi ke kōkua i ka pale ʻana i ka maʻi maʻi coronavirus novel a pale i nā kauka a me nā maʻi.

ʻO ka culprit o kēia maʻi maʻi ʻo ka 2019 novel coronavirus (SARS-CoV-2).Ma mua o ka loaʻa ʻana o nā lāʻau lapaʻau anti-novel coronavirus a me nā lāʻau lapaʻau, ʻo ke ala mua a maikaʻi hoʻi ka hoʻokaʻawale ʻana i nā maʻi maʻi, hana i ka maʻi hōʻailona a me ke kākoʻo ʻana, hoʻonui i ka pale ʻana, pale i nā maʻi mai ka maʻi a me ka hōʻino ʻana i nā kino koʻikoʻi a me nā ʻiʻo o ke kino a lanakila i ka maʻi.No nā poʻe maʻi maʻi, ʻo ka hoʻoikaika ʻana i ka ʻōnaehana pale e kōkua i ka pale ʻana i ka hoʻouka ʻana.

Eia kekahi, ke hoʻāʻo nei ka ʻoihana lapaʻau e ʻimi i nā lāʻau e hiki ke hakakā i kēia maʻi hou mai nā lāʻau antiviral e kū nei.Nui nā lono ma ka Pūnaewele.Inā maikaʻi lākou a i ʻole ʻaʻole i hōʻoia ʻia.

Hoʻonui ʻo Lingzhi i ka hiki anti-virus o ka ʻōnaehana pale.

Lingzhi (ʻO Ganoderma lucidumaʻO Ganoderma sinensis) he statutory kuʻuna Chinese lāʻau lapaʻau i komo i loko o ka Pharmacopoeia o ka People's Republic of China (Part One), e like me ka Lingzhi hiki ke hoʻonui i ka qi, mālie aʻalolo, hoʻokuʻu i ka maʻi a me ka hānō, a hiki ke hoʻohana no ka restlessness, insomnia, palpitation, ʻo ka maʻi māmā a me ka ʻuʻu a me ka ʻūhā, ka maʻi ʻai a me ka hanu pōkole, a me ka pau ʻana o ka ʻai.I kēia manawa, ʻoi aku ma mua o hoʻokahi haneli mau ʻano lāʻau Lingzhi i ʻae ʻia e kūʻai ʻia no ka pale ʻana a me ka mālama ʻana.

Ua hōʻike ʻia nā haʻawina lāʻau lapaʻau hou e hiki ai iā Lingzhi ke hoʻoikaika i ka hana immune, pale i ka luhi, hoʻomaikaʻi i ka hiamoe, pale aku i ka oxidation a scavenge free radicals, a pale i ka naʻau, ka lolo, ka māmā, ka ate a me ka puʻupaʻa.Ua hoʻohana ʻia i ka lāʻau lapaʻau a i ʻole ka adjuvant lapaʻau o ka bronchitis maʻi, nā maʻi o ka ʻōpū hanu, ka hānō a me nā maʻi ʻē aʻe.

Pehea e pāʻani ai ʻo Lingzhi i kāna hopena antiviral?Ua ʻae ʻia ʻo Lingzhi ke kāohi ʻole i nā maʻi mai ka hoʻouka ʻana i ke kino o ke kanaka a me ka hoʻonui ʻana a me ka hōʻino ʻana i ke kino ma ka hoʻoikaika ʻana i ka ʻōnaehana pale.

ʻOiai ʻo ka maʻi maʻi ʻino loa, e hoʻopau ʻia i ke alo o ka pale kino ikaika.Ua kūkākūkā ʻia kēia ma ka ʻatikala "Lingzhi Enhances Immunity" i paʻi ʻia ma ka pukana 58th o "GANODERMA" a me ka ʻatikala "The Basis forʻO Ganoderma lucidume pale i ka maʻi maʻi maʻi - Inā lawa ka qi olakino i loko, ʻaʻohe ala e komo ai nā kumu pathogenic i ke kino" i paʻi ʻia ma ka pukana 46th o "GANODERMA".

I ka hōʻuluʻulu manaʻo, ʻo ka Lingzhi hiki ke hoʻoikaika i nā hana kūlohelohe ʻole o ke kino e like me ka hoʻolaha ʻana i ka proliferation, ka ʻokoʻa a me ka hana o nā cell dendritic, hoʻonui i ka hana phagocytic o mononuclear macrophages a me nā mea pepehi maoli, a me ka pale ʻana i nā maʻi a me nā maʻi mai ka hoʻouka ʻana i ke kanaka. kino.ʻO ka lua, hiki iā Lingzhi ke hoʻonui i ka hana humoral a me ka cellular immune e like me ka hoʻoikaika ʻana i ka hana ʻana o Immunoglobulin M (IgM) a me Immunoglobulin G (IgG), e hoʻonui ana i ka hoʻonui ʻana o T lymphocytes a me B lymphocytes, a me ka paipai ʻana i ka hana ʻana o ka cytokine interleukin-1 (IL-). 1), Interleukin-2 (IL-2) a me interferon gamma (IFN-γ).

ʻO ka palekana humoral a me ka palekana pūnaewele ka laina pale hohonu o ke kino e kū'ē i nā maʻi maʻi a me nā maʻi bacteria.Hiki iā lākou ke hoʻopaʻa i nā pahuhopu kikoʻī e pale hou a hoʻopau i nā maʻi a me nā maʻi bacteria e hoʻouka ana i ke kino.Ke haʻahaʻa ka hana immune ma muli o nā kumu like ʻole, hiki iā Lingzhi ke hoʻomaikaʻi i ka hana immune.

Eia hou, hiki i ka Lingzhi ke hoʻemi i ka mumū i hoʻokumu ʻia e ka maʻi maʻi a me ka pōʻino viral i nā kino koʻikoʻi e like me ka māmā, ka puʻuwai, ka ate, ka puʻupaʻa, a pale a hōʻemi paha i nā hōʻailona ma o kāna mau mea anti-oxidant a me nā hopena scavenging radical manuahi.Ma ka pukana 75th o "GANODERMA", hiki ke hoʻohana ʻia no ka ʻike ʻana i ke koʻikoʻi o nā hopena anti-oxidant a me nā radical free scavenging.ʻO Ganoderma lucidumi ka pale ʻana a me ka mālama ʻana i nā maʻi i kūkākūkā nui ʻia ma ka ʻatikala i kapa ʻia ʻo "Lingzhi - Ka mālama ʻana i nā maʻi like ʻole me ke ʻano like".

Mai ka 1980s, aia nā hōʻike noiʻi e pili ana i nā hopena antiviral o Lingzhi.Ua hoʻohana ka hapa nui o kēia mau haʻawina i nā hiʻohiʻona kelepona i hoʻopili ʻia i ka maʻi maʻi in vitro, a ua hoʻohana pū nā haʻawina hoʻokahi i nā hiʻohiʻona holoholona o ka maʻi virus e nānā i nā hopena antiviral o Lingzhi.

ʻO nā ʻatikala kolamu i paʻi ʻia e Professor Zhibin Lin ma nā Helu 46, 58, a me 75 o "GANODERMA"

ʻAi-hepatitis virus

Zhang Zheng et al.(1989) loaʻa kēlāʻO Ganoderma applanatum,ʻO Ganoderma atrumaʻO Ganoderma capensehiki ke pale i ka ma'i hepatitis B DNA polymerase (HBV-DNA polymerase), e hoemi i ka HBV-DNA replication a keakea i ka huna ana o ka ma'i hepatitis B surface antigen (HBsAg) e PLC/PRF/5 mau keena (ke ma'i ma'i o ke ake kanaka).

Ua nānā hou ka poʻe noiʻi i ka hopena antiviral holoʻokoʻa o ka lāʻau lapaʻau ma ke ʻano hepatitis duck.Ua hōʻike nā hopena i ka hoʻoponopono waha oʻO Ganoderma applanatum(50 mg/kg) ʻelua i ka lā no nā lā he 10 mau lā hiki ke hōʻemi i nā hopena o ka maʻi hepa B duck DNA polymerase (DDNAP) a me ka maʻi hepatitis B DNA (DDNA) o nā pēpē ʻōpio i loaʻa i ka maʻi hepa B (DHBV), ka mea. hōʻike i kēlāʻO Ganoderma applanatumLoaʻa ka hopena pale i ka DHBV i ke kino [1].

Li YQ et al.(2006) hōʻike i ke kanaka ake maʻi 'aʻai maʻi 'aʻai HepG2 laina transfected me HBV-DNA hiki ke hoike HBV surface antigen (HbsAg), HBV kumu antigen (HbcAg) a me HBV mea hoʻomaʻi structural proteins, a hiki stably hana oʻo hepatitis B viral particles.ʻAka Ganoderic i unuhi ʻia maiG. lucidumʻO ka moʻomeheu medium dose-dependently (1-8 μg / mL) i kāohi i ka hōʻike a me ka hana ʻana o HBsAg (20%) a me HBcAg (44%), e hōʻike ana i ka waikawa ganoderic i kāohi i ka replication o HBV i loko o nā pūnaʻi ate [2].

ʻAi-influenza virus

Ua ʻike ʻo Zhu Yutong (1998) i kēlā gavage a i ʻole intraperitoneal injection oG. applanatumhiki ke hoʻonui i ka nui o ke ola a me ka manawa ola o nā ʻiole i loaʻa i ka maʻi maʻi influenza FM1 strain, pēlā e loaʻa ai ka hopena pale maikaʻi loa [3].

Mothana RA et al.(2003) ua ʻike ʻo ganodermadiol, lucidadiol a me applanoxidic acid G i unuhi ʻia a hoʻomaʻemaʻe ʻia mai ka European G. pfeifferi i hōʻike i nā hana antiviral e kūʻē i ka maʻi influenza A a me ka herpes simplex virus type 1 (HSV-1).He 0.22 mmol/L ka ED50 o ka ganodermadiol no ka pale ʻana i nā pūnaewele MDCK.He 0.068 mmol/L ka ED50 (50% ka hopena maikaʻi) e pale ana i nā pūnaewele ʻo Vero (ʻo ka maʻi maʻi HSV-1).ʻO ka ED50 o ka ganodermadiol a me ka applanoxidic acid G e kūʻē i ka maʻi maʻi influenza A he 0.22 mmol/L a me 0.19 mmol/L, i kēlā me kēia [4].

Anti-HIV

ʻO Kim et al.(1996) i loaʻa i ka haʻahaʻa molekala kaumaha hapa oG. lucidumʻO ka ʻili wai kino hua a me ka ʻāpana kūʻokoʻa a me ka alkaline o ka methanol extract hiki ke kāohi i ka hoʻonui ʻana o ka maʻi immunodeficiency kanaka (HIV) [5].

ʻO El-Mekkawy et al.(1998) hōʻike i ka triterpenoids kaawale mai ka methanol extract oG. lucidumLoaʻa i nā kino hua hua nā hopena cytopathic anti-HIV-1 a hōʻike i ka hana inhibitory ma ka protease HIV akā ʻaʻohe hopena pale i ka hana o HIV-1 reverse transcriptase [6].

Min et al.(1998) ua loaʻa i ka ganoderic acid B, lucidumol B, ganodermanondiol, ganodermanontriol a me ganolucidic acid A i unuhi ʻia mai.G. lucidumLoaʻa i nā spores kahi hopena pale ikaika i ka hana protease HIV-1 [7].

Sato N et al.(2009) ua ʻike ʻia nā triterpenoids hou loa o ka lanostane-type hou oxygenated [ʻakika ganodenic GS-2, 20-hydroxylucidenic acid N, 20(21)-dehydrolucidenic acid N a me ganederol F] i hoʻokaʻawale ʻia mai ke kino hua oʻO Ganoderma lucidumloaʻa i kahi hopena pale i ka protease HIV-1 me ka median inhibitory concentration (IC50) e like me 20-40 μm [8].

ʻO Yu Xiongtao et al.(2012) hōʻike i kēlāG. lucidumspore wai extract i ka hopena inhibitory ma Simian Immunodeficiency Virus (SIV) i infects CEM × 174 mau keena o ke kanaka T lymphocyte laina laina, a me kona IC50 mea 66.62±20.21 mg/L.ʻO kāna hana nui ka pale ʻana i ka SIV mai ka adsorbing a i ke komo ʻana i loko o nā cell i ka wā mua o ka maʻi maʻi SIV, a hiki iā ia ke hōʻemi i ka pae hōʻike o ka SIV capsid protein p27 [9].

Anti-Herpes Virus

Ua hoʻomākaukau ʻo Eo SK (1999) i ʻelua mea hoʻoheheʻe wai-soluble (GLhw a me GLlw) a me ʻewalu methanol extracts (GLMe-1-8) mai nā kino hua oG. lucidum.Ua loiloi ʻia kā lākou hana antiviral e ka cytopathic effect (CPE) inhibition test and the plaque reduction test.Ma waena o lākou, ʻo GLhw, GLMe-1, GLMe-2, GLMe-4, a me GLMe-7 e hōʻike ana i nā hopena inhibition maopopo i ka herpes simplex virus type 1 (HSV-1) a me ke ʻano 2 (HSV-2), a me ka stomatitis vesicular. virus (VSV) Indiana a me New Jersey.Ma ka ho'āʻo hoʻohaʻahaʻa plaque, ua kāohi ʻo GLhw i ka hoʻokumu ʻana o ka plaque o HSV-2 me EC50 o 590 a me 580μg / mL ma Vero a me HEp-2 pūnaewele, a ʻo kāna mau koho koho (SI) he 13.32 a me 16.26.ʻAʻole i hōʻike ʻo GLMe-4 i ka cytotoxicity a hiki i 1000 μg / ml, ʻoiai ua hōʻike ʻo ia i ka hana antiviral potent ma ka VSV New Jersey strain me kahi SI o ka 5.43 [10].

OH KW et al.(2000) i hoʻokaʻawale i kahi protein acidic bound polysaccharide (APBP) mai nā carpophores o Ganoderma lucidum.Ua hōʻike ʻo APBP i ka hana antiviral ikaika e kūʻē iā HSV-1 a me HSV-2 i nā pūnae Vero ma kāna EC50 o 300 a me 440μg / mL, kēlā me kēia.ʻAʻole he cytotoxicity o APBP ma nā pūnaewele Vero ma kahi o 1 x 10 (4) μg / ml.Loaʻa i ka APBP nā hopena inhibitory synergistic ma HSV-1 a me HSV-2 ke hui pū me ka lāʻau anti-herpes Aciclovir, Ara-A a i ʻole interferonγ (IFN-γ) i kēlā me kēia [11, 12].

Liu Jing et al.(2005) ʻike ʻo GLP, kahi polysaccharide i hoʻokaʻawale ʻia maiG. lucidummycelium, hiki ke pale i ka ma'i o Vero cell e HSV-1.Ua kāohi ka GLP i ka maʻi HSV-1 i ka wā mua o ka maʻi akā ʻaʻole hiki ke kāohi i ka synthesis o ka maʻi a me nā macromolecules biological [13].

Iwatsuki K et al.(2003) ʻike i nā ʻano triterpenoids i unuhi ʻia a hoʻomaʻemaʻe ʻia maiʻO Ganoderma lucidumloaʻa nā hopena pale i ka hoʻokomo ʻana o ka maʻi Epstein-Barr antigen mua (EBV-EA) i loko o nā pūnaewele Raji (nā lymphoma cell kanaka) [14].

ʻO Zheng DS et al.(2017) loaʻa i ʻelima triterpenoids i unuhi ʻia maiG. lucidum,me ka ganoderic acid A, ganoderic acid B, a me ganoderol B, ganodermanontriol a me ganodermanondiol, e ho'ēmi loa i ka hiki o ka nasopharyngeal carcinoma (NPC) 5-8 F pūnaewele i hoʻouluʻia i loko o ka vitro, e hōʻike i nā hopena pale nui ma ka EBV EA a me ka ho'āʻana o CA a kāohi i ka telomerase hana.Hāʻawi kēia mau hopena i nā hōʻike no ka hoʻohana ʻana i kēia mau meaG. lucidumtriterpenoids i ka mālama ʻana i ka NPC [15].

ʻO ka maʻi maʻi anti-Newcastle

ʻO ka maʻi maʻi Newcastle he ʻano maʻi maʻi avian influenza, he kiʻekiʻe ka maʻi a me ka make i waena o nā manu.Shamaki BU et al.(2014) loaʻa kēlāʻO Ganoderma lucidumHiki i nā unuhi o ka methanol, n-butanol a me ka ethyl acetate ke kāohi i ka hana neuraminidase o ka maʻi maʻi Newcastle [16].

Virus Anti-Dengue

Lim WZ et al.(2019) ua ʻike ʻia nā ʻāpana wai oG. lucidumi kona ʻano antler i kāohi i ka hana protease DENV2 NS2B-NS3 ma 84.6 ± 0.7%, ʻoi aku ka kiʻekiʻe ma mua o ka mea maʻamau.G. lucidum[17] .

Bharadwaj S et al.(2019) i hoʻohana i kahi ala hoʻomaʻamaʻa virtual a me nā hoʻokolohua in vitro e wānana i ka hiki o nā triterpenoids hana maiʻO Ganoderma luciduma loaʻa i ka ganodermanontriol i unuhi ʻia maiʻO Ganoderma lucidumhiki ke pale i ka ma'i dengue (DENV) NS2B -NS3 hana protease [18].

Anti-Enterovirus

ʻO Enterovirus 71 (EV71) ka maʻi maʻi nui o ka maʻi lima, ka wāwae a me ka waha, e hoʻopiʻi ai i nā pilikia neurological a me nā ʻōnaehana i nā keiki.Eia nō naʻe, ʻaʻohe lāʻau antiviral i ʻae ʻia i kēia manawa e hiki ke hoʻohana e pale a mālama i kēia maʻi maʻi.

ʻO Zhang W et al.(2014) ua ʻike nā mea ʻeluaʻO Ganoderma lucidumtriterpenoids (GLTs), me Lanosta-7,9(11),24-trien-3-one,15;26-dihydroxy (GLTA) a me Ganoderic acid Y (GLTB), hōʻike i nā hana anti-EV71 nui me ka cytotoxicity.

Ua hōʻike ʻia nā hopena e pale aku ʻo GLTA a me GLTB i ka maʻi EV71 ma o ka launa pū ʻana me ka ʻāpana viral e pale i ka adsorption o ka maʻi i nā cell.Eia kekahi, ua wānana ʻia nā pilina ma waena o ka virion EV71 a me nā pūhui e ka docking molecular computer, kahi i hōʻike ʻia e hiki ke hoʻopaʻa ʻia ʻo GLTA a me GLTB i ka protein capsid viral ma kahi ʻeke hydrophobic (F site), a no laila hiki ke pale i ka wehe ʻana o EV71.Eia kekahi, ua hōʻike lākou i ka GLTA a me ka GLTB i kaohi nui i ka replication o ka viral RNA (vRNA) o ka replication EV71 ma o ka pale ʻana i ka EV71 uncoating [19].

Ka hōʻuluʻulu a me ke kūkākūkā
Hōʻike nā hopena noiʻi ma luna aʻe he hopena pale ʻo Lingzhi, ʻoi aku ka triterpenoids i loko o ia mea, i nā ʻano maʻi like ʻole.Hōʻike ka hōʻike mua ʻana i kāna ʻano maʻi anti-viral e pili ana i ka pale ʻana i ka adsorption a me ke komo ʻana o nā maʻi i loko o nā cell, kaohi ʻana i ka hoʻōla ʻana o ka antigen mua, ke kāohi ʻana i ka hana o kekahi mau enzyme e pono ai no ka synthesis virus i loko o nā cell, ke kāohi ʻana i ka DNA viral a i ʻole RNA replication me ka ʻole. cytotoxicity a loaʻa ka hopena synergistic ke hui pū me nā lāʻau antiviral i ʻike ʻia.Hāʻawi kēia mau hopena i nā hōʻike no ka noiʻi hou ʻana i nā hopena antiviral o Lingzhi triterpenoids.

I ka nānā ʻana i nā pono lapaʻau o Lingzhi i kēia manawa i ka pale ʻana a me ka mālama ʻana i nā maʻi viral, ua ʻike mākou ua hiki iā Lingzhi ke hoʻololi i nā hōʻailona maʻi hepatitis B (HBsAg, HBeAg, anti-HBc) i mea ʻino i ka pale ʻana a me ka mālama ʻana i ka maʻi hepatitis B. ʻO ka mālama ʻana i ka herpes zoster, condyloma acuminatum a me AIDS i hui pū ʻia me nā lāʻau antiviral, ʻaʻole mākou i ʻike i nā hōʻike e hiki ai iā Lingzhi ke kāohi pololei i ka maʻi maʻi.ʻO ka hopena lapaʻau o Lingzhi i nā maʻi maʻi maʻi e pili nui i kona hopena immunomodulatory, kona anti-oxidant a me nā hopena scavenging radical manuahi a me kona hopena pale i ka ʻeha a i ʻole ka ʻiʻo.(Mahalo iā Professor Baoxue Yang no ka hoʻoponopono ʻana i kēia ʻatikala.)

Nā kuhikuhi

1. Zhang Zheng, et al.ʻO ka hoʻokolohua hoʻokolohua o 20 ʻano o nā ʻano haʻuki Kina e kūʻē i ka HBV. Journal of Beijing Medical University.1989, 21: 455-458.

2. Li YQ, et al.Nā hana anti-hepatitis B o ka waika ganoderic maiʻO Ganoderma lucidum.Biotechnol Lett, 2006, 28 (11): 837-841.

3. Zhu Yutong, et al.Ka hopena pale o ka Extract oʻO Ganoderma applanatum(pers) pat.on Mice Influenza Virus FM1.Journal of Guangzhou University of Traditional Chinese Medicine.1998, 15(3): 205-207.

4. Mothana RA, et al.ʻO nā antiviral lanostanoid triterpenes mai ka haʻikiʻO Ganoderma pfeifferi.Fitoterapia.2003, 74(1-2): 177–180.

5. Kim BK.Anti-human Immunodeficiency Virus Activity oʻO Ganoderma lucidum.1996 International Ganoderma Symposium, Haʻi Kūikawā, Taipei.

6. El-Mekkawy S, et al.Nā mea anti-HIV a me ka anti-HIV-protease maiʻO Ganoderma lucidum.Phytochemistry.1998, 49(6): 1651-1657.

7. Min BS, et al.Triterpenes mai nā spores oʻO Ganoderma luciduma me kā lākou hana pale e kū'ē i ka protease HIV-1.ʻO Chem Pharm Bull (Tokyo).1998, 46(10): 1607-1612.

8. Sato N, et al.Anti-human immunodeficiency virus-1 protease hana o ka lanostane-type triterpenoids hou maiGanoderma sinense.ʻO Chem Pharm Bull (Tokyo).2009, 57(10): 1076-1080.

9. Yu Xiongtao, et al.Haʻawina e pili ana i nā hopena o ke kāohi ʻana oʻO Ganoderma lucidumma ka Simian Imunodeficiency Virus in vitro.ʻO ka puke moʻolelo Pākē o ka Formula Lapaʻau Kuʻuna Kūʻai.2012, 18 (13): 173-177.

10. Eo SK, et al.Nā hana antiviral o nā wai like ʻole a me nā mea hiki ke hoʻoheheʻe ʻia methanol i hoʻokaʻawale ʻia maiʻO Ganoderma lucidum.J Ethnopharmacol.1999, 68(1-3): 129-136.

11. Oh KW, et al.Nā hana antiherpetic o ka polysaccharide i hoʻopaʻa ʻia i ka protein acidic i hoʻokaʻawale ʻia maiʻO Ganoderma lucidumHoʻokahi a hui pū me ka acyclovir a me ka vidarabine.J Ethnopharmacol.2000, 72(1-2): 221-227.

12. Kim YS, et al.Nā hana antiherpetic o ka polysaccharide i hoʻopaʻa ʻia i ka protein acidic i hoʻokaʻawale ʻia maiʻO Ganoderma lucidumwale a hui pū me nā interferon.J Ethnopharmacol.2000, 72(3): 451-458.

13. Liu Jing, et al.Kāohi i ka maʻi maʻi Herpes Simplex e kahi GLP i hoʻokaʻawale ʻia mai ka Mycelium oGanoderma Lucidum.Virologica Sinica.2005, 20(4): 362-365.

14. Iwatsuki K, et al.ʻO nā ʻakika Lucidenic P a me Q, methyl lucidenate P, a me nā triterpenoids ʻē aʻe mai ka haʻi.ʻO Ganoderma luciduma me kā lākou mau hopena pale i ka hoʻoulu ʻana o Epstein-Barrvirus.J Nat Prod.2003, 66(12): 1582-1585.

15. Zheng DS, et al.Triterpenoids maiʻO Ganoderma lucidumpale i ka ho'āla ʻana o nā antigens EBV ma ke ʻano he telomerase inhibitors.Exp Ther Med.2017, 14 (4): 3273-3278.

16. Shamaki BU, et al.Methanolic soluble hakina o lingzhi orreishimedicinal mushroom,ʻO Ganoderma lucidum(ʻoi aku ka Basidiomycetes kiʻekiʻe) kāʻili i ka hana neuraminidase ma Newcastle maʻi maʻi (LaSota).Int J Med Halo.2014, 16(6): 579-583.

17. Lim WZ, et al.ʻO ka ʻike ʻana o nā mea hoʻohui i lokoʻO Ganoderma lucidumvar.antler extract e pale ana i ka dengue virus serine protease a me kāna mau haʻawina helu.J Biomol Struct Dyn.2019, 24: 1-16.

18. Bharadwaj S, et al.ʻIke ʻia oʻO Ganoderma lucidumtriterpenoids ma ke ʻano he mea hiki ke pale aku i ka maʻi Dengue NS2B-NS3 protease.Sci Rep. 2019, 9(1): 19059.

19. Zhang W, et al.Nā hopena antiviral o ʻeluaʻO Ganoderma lucidumtriterpenoids e kū'ē i ka maʻi enterovirus 71.Biochem Biophys Res Commun.2014, 449 (3): 307-312.

★ Ua kākau ʻia ka kikokikona mua o kēia ʻatikala ma ka ʻōlelo Pākē e Polofesa Zhi-bin LIN a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.

E hoʻomau i ka Moʻomeheu Ola Millennia
Hāʻawi i ka Ola no nā mea a pau