Ndira 10, 2017 /Tongji University, Shanghai Institute yeMateria Medica, Chinese Academy yeScience, nezvimwewo / Stem Cell Reports

Chinyorwa/Wu Tingyao

“Kanganwa kuti ndiwe ani uye kuti ndini ani” zvinogona kunzi ndicho chiratidzo chechirwere cheAlzheimer.Chikonzero chekukanganwa, kana kusakwanisa kuyeuka zviitiko zvenguva pfupi yapfuura, ndechekuti masero etsinga anotarisira mabasa enjere anofa zvishoma nezvishoma nekufamba kwemakore, izvo zvinoita kuti munhu mukurukuziva levelramba uchidzikira.

Vakatarisana nechirwere cheAlzheimer chiri kuramba chichiwanda, masayendisiti ari kushanda nesimba kuti adzidze marapirwo anobvira.Vamwe vanhu vanotarisa kune muparadzi anokonzera nerve cell death, achiedza kuderedza kugadzirwa kwe beta-amyloid protein;vamwe vakazvipira kusimudzira masero etsinga, vachitarisira kutsiva nzvimbo yokukuvadzwa kwesero retsinga, zvichida iri pfungwa yoku“igadzira kana isipo.”

Muhuropi hwemammalian hwakura, pane zvechokwadi nzvimbo mbiri dzinoramba dzichigadzira masero matsva etsinga, imwe yacho iri muhippocampal gyrus.Aya masero etsinga anozviwedzera anonzi "neural progenitor cells".Iwo maseru achangozvarwa kubva kwavari anozowedzerwa kune ekutanga neural maseketi kubatsira kudzidza hunyanzvi hutsva uye kugadzira ndangariro nyowani.

Nekudaro, zvinogona kucherechedzwa muvanhu kana mbeva kuti chirwere cheAlzheimer chinogona kukanganisa kupararira kweneural precursor masero.Mazuvano, humbowo huzhinji hunoratidza kuti kukurudzira kuwanda kwemasero emutsinga kunogona kuderedza kuderera kwekuziva kunokonzerwa nechirwere cheAlzheimer uye inogona kuve nzira inogoneka yekurapa chirwere cheAlzheimer.

Muna Ndira 2017, chidzidzo chakabatanidzwa chakabudiswa mu "Stem Cell Reports" neTongji University, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, nezvimwewo, yakaratidza kuti polysaccharides kana mvura inotorwa kubva.Ganoderma lucidum (Reishi mushroom, Lingzhi) inogona kuderedza kukanganiswa kwekuziva kunokonzerwa nechirwere cheAlzheimer, kuderedza kuiswa kweamyloid-β (Aβ) muuropi, uye kukurudzira kuvandudzwa kwemasero e-neural precursor mu hippocampal gyrus.Iyo yekupedzisira nzira yekuita ingangove yakabatana nekushandiswa kweiyo receptor inonzi FGFR1 pane neural precursor masero nekuda kwekutonga kwe.Ganoderma lucidum.

mbeva dzeAlzheimer dzinodyaGanoderma lucidumrangarira zviri nani.

Mhuka dzakaedza muchidzidzo ichi dzakashandisa 5 kusvika 6-mwedzi-yekuzvarwa APP/PS1 transgenic mice-kureva, kushandiswa kweiyo gene transgenic tekinoroji kuendesa mutant gene remunhu APP uye PS1 (iyo inogona kukonzera nhaka yekutanga-kutanga-kutanga kwechirwere cheAlzheimer) kupinda. mbeva dzichangozvarwa kuti dzinyatsoratidza majini.Izvi zvichaita kuti huropi hwemakonzo hutange kubudisa amyloid-β (Aβ) kubva paudiki (mushure memwedzi miviri yezera), uye kana vakura kusvika kumwedzi ye5-6 yezera, zvishoma nezvishoma vanotanga kuoma mukuzivikanwa kwenzvimbo nekuyeuka. .

Mune mamwe mazwi, mbeva dzakashandiswa mukuyedza dzatove nezviratidzo zvekutanga zvechirwere cheAlzheimer.Vatsvagiri vakadyisa mbeva dzeAlzheimer neGLP (pure polysaccharides yakaparadzaniswa kubvaGanoderma lucidumSpore powder ine molecular weight ye 15 kD) pachiyero chezuva nezuva che 30 mg / kg (kureva, 30 mg pa kilogram yehuremu hwemuviri pazuva) kwemazuva makumi mapfumbamwe akatevedzana.

Zvadaro, vatsvakurudzi vakapedza mamwe mazuva gumi nemaviri vachiyedza kugona kwemakonzo muMorris water maze (MWM) uye vakaaenzanisa neaya emakonzo ane chirwere cheAlzheimer anga asina kurapwa uye neaya emakonzo akajairwa.

Mbeva dzine chisikwa chekuvenga mvura.Pavanoiswa mumvura, vanoedza kutsvaga nzvimbo yakaoma yekuzorora.Iyo "Morris Water Maze Test" inoshandisa hunhu hwavo kumisikidza chikuva chekuzorora panzvimbo yakatarwa mune hombe denderedzwa dziva.Sezvo chikuva chakavigwa pasi pemvura, mbeva dzinofanirwa kuiwana chete nekudzidza nekurangarira.Nekuda kweizvozvo, vaongorori vaigona kutonga kuti mbeva dzave kuita dumber here kana kuti dzakangwara panguva iyo mbeva dzakawana chikuva, chinhambwe chadzakashambira uye nzira yadzakatora.

Zvakaonekwa kuti pakanga pasina musiyano wakakosha mukushambira kwemakonzo muboka rega rega.Asi tichienzanisa nemakonzo akajairwa, mbeva dzeAlzheimer dzakanga dzisina kurapwa dzaifanira kupedza nguva yakawanda uye kushambira madaro marefu kuti vawane chikuva munzira isina kurongeka sekunge pane rombo rakanaka, zvichiratidza kuti ndangariro yavo yenzvimbo yakanga yakanganiswa zvakanyanya.

Mukupesana, mbeva dzeAlzheimer dzakadyiswa neReishi mushroompolysaccharides kanaGanoderma lucidummvura yemvura yakawana chikuva nekukurumidza, uye vasati vawana chikuva, vainyanya kudzungaira munzvimbo (quadrant) paive nepuratifomu, sekunge vaiziva nzvimbo inenge yepuratifomu, zvichiratidza kuti kukuvadzwa kwehuropi hwavo hakuna kunyanya.【Mufananidzo 1, Mufananidzo 2】

Mukuwedzera, vatsvakurudzi vakacherechedzawo mune imwe kuedza kuti kune nhunzi dzemichero dzinobudisa huwandu hwakawanda hweamyloid-β (Aβ) muhuropi hwavo (zvakare kuburikidza nemaitiro ekufambisa mazita ekutanga maitiro ekuedza),Ganoderma lucidummvura inobviswa haingonatsiridza kucherechedzwa kwenzvimbo uye kugona kurangarira kwenhunzi dzemichero asiwo kuwedzera hupenyu hwenhunzi dzemichero.

Vatsvakurudzi vakashandisa zvakareGanoderma lucidummvura inotorwa (300mg/kg pazuva) mune yambotaurwa yemhuka yekuyedza uye yakaona kuti inogona zvakare kudzoreredza kukanganiswa kwekuziva kwenzvimbo kunokonzerwa nechirwere cheAlzheimer sezvambotaurwa.Ganoderma lucidumpolysaccharides (GLP).

Shandisa "Morris Water Maze Test" kuongorora kugona kwekurangarira kwembeva

[Mufananidzo 1] Nzira dzekushambira dzembeva muboka rega rega.Bhuruu ndiro dziva, chena inzvimbo yepuratifomu, uye tsvuku ndiyo nzira yekushambira.

[Mufananidzo 2] Ivhareji yenguva inodiwa kune rimwe nerimwe boka remakonzo kuwana nzvimbo yekuzorora pazuva rechinomwe rebvunzo dzeMorris water maze.

(Kwakabva/Stem Cell Reports. 2017 Jan 10;8(1):84-94.)

Lingzhiinokurudzira kuwanda kwemasero e-neural precursor mu hippocampal gyrus.

Mushure memazuva gumi nemaviri bvunzo yemvura, vaongorori vakaongorora huropi hwembeva vakawana kutiGanoderma lucidumpolysaccharides uyeGanoderma lucidumzvinyorwa zvemvura zvose zvinokurudzira kuvandudzwa kwemasero etsinga mu hippocampal gyrus uye kuderedza amyloid-β deposition.

Zvakazosimbiswa zvakare kuti masero etsinga achangozvarwa muhippocampus gyrus anonyanya kuve neural precursor masero.UyeGanoderma luciduminoshanda kune chirwere cheAlzheimer mbeva.Kudyisa mbeva diki dzakura neGanoderma lucidumpolysaccharides (GLP) pachiyero chezuva nezuva che 30 mg/kg kwemazuva gumi nemana inogonawo kukurudzira kuwanda kwemasero emutsinga anotangira muchiuno chehippocampal.

In vitro kuyedza zvakare yakasimbisa kuti kune neural precursor masero akaparadzaniswa kubva kune hippocampal gyrus yemakonzo akajairwa akura kana mbeva dzeAlzheimer kana masero emuneural precursor anobva kumasero emunhu.Ganoderma lucidumpolysaccharides inogona kunyatso kusimudzira masero aya ekutanga kuti awedzere, uye masero achangobva kugadzirwa anochengetedza maitiro ekutanga e-neural precursor masero, ndiko kuti, anogona kuita kuwedzera uye kuzvivandudza.

Kumwe kuongorora kwakaratidza izvozvoGanoderma lucidumpolysaccharides (GLP) inogona kukurudzira neurogenesis kunyanya nekuti inogona kusimbisa receptor inonzi "FGFR1" (kwete EGFR receptor) pane neural precursor masero, zvichiita kuti zvive nyore kukurudzirwa kwe "nerve growth factor bFGF", iyo inotumira mamwe mashoko e "sero." kuwanda” kumasero etsinga dzetsinga, uyezve mamwe masero matsva etsinga anoberekwa.

Sezvo masero etsinga achangozvarwa achigona kuenderera mberi nekujoinha masero etsinga aripo kuti ashande mushure mekunge atamira kunzvimbo yehuropi inoida, izvi zvinofanirwa kurerutsira huwandu hwekukanganisika kwekuziva kunokonzerwa nekufa kwetsinga muchirwere cheAlzheimer.

Basa rakasiyana-siyana reGanoderma luciduminononoka kukurumidza kukanganwa.

Mhedzisiro dzetsvagurudzo dziri pamusoro dzinoita kuti tione kudzivirira kweGanoderma lucidumpamasero etsinga.Pamusoro peiyo inopesana nekuputika, anti-oxidant, anti-apoptotic, anti-β-amyloid deposition uye mamwe maitiro anozivikanwa munguva yakapfuura,Ganodermaluciduminogonawo kukurudzira neurogenesis.Kune mbeva dzeAlzheimer dzine hurema hwakafanana uye dziri muzviratidzo zvakafanana, ndosaka kuomarara kwechiratidzo chechirwere kwakasiyana zvakanyanya pakati peavo vanodya.Ganoderma lucidumnevasingadyiGanoderma lucidum.

Ganoderma luciduminogona kusakwanisa kudzoreredza zvachose basa rekurangarira muvarwere veAlzheimer, asi nzira dzayo dzakasiyana dzekuita dzinogona kunonoka kuderera kwechirwere cheAlzheimer.Chero bedzi murwere achizviyeuka iye nevamwe kwoupenyu hwake hwose, hosha yeAlzheimer ingasava yakaipisisa.

[Kwakabva] Huang S, et al.Polysaccharides kubva kuGanoderma lucidum Kurudzira Basa reKuziva uye Neural Progenitor Proliferation muMouse Model yeAlzheimer's Disease.Stem Cell Reports.2017 Jan 10;8(1):84-94.doi: 10.1016/j.stemcr.2016.12.007.

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Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.