Pherekhong 20, 2017 / Setsi sa Guangdong sa Microbiology le Setsi sa Taolo ea Mafu le Thibelo ea Mafu Profinseng ea Guangdong / Journal of Ethnopharmacology

Mongolo/ Wu Tingyao

Ke nako e telele e le 'nete e tsebahalang horeGanoderma lucidumpolysaccharides e ka thusa ho phekola lefu la tsoekere, empa hore na e sebetsa joang ke taba eo bo-ramahlale ba batlang ho tseba haholoanyane ka eona.

Ho tloha ka 2012, Guangdong Institute of Microbiology le Setsi sa Taolo ea Mafu le Thibelo ea Mafu Profinseng ea Guangdong ka kopanelo e ile ea fana ka tlaleho e bolelang hore li-polysaccharides tse boima ba limolek'hule (GLPs) li ntšitsoeng moqomong oa metsi a chesang.Ganoderma lucidum'mele e behang litholoana e na le phello e ntle ea hypoglycemic bakeng sa lefu la tsoekere la mofuta oa 2 (T2D).

Hona joale, ba boetse ba arotse li-polysaccharides tse 'nè ho tloha ho GLPs,' me ba nka F31 e sebetsang haholoanyane (boima ba molek'hule e ka bang 15.9 kDa, e nang le protheine ea 15.1%) bakeng sa boithuto bo tebileng, 'me ba fumane hore e ke ke ea laola tsoekere ea mali feela ka litsela tse ngata empa. hape sireletsa sebete.

LingzhiLi-polysaccharides li ka fokotsa hyperglycemia.

Tekong ea liphoofolo ea libeke tse 6, ho fumanoe hore mofuta oa 2 oa lefu la tsoekere (Ganoderma lucidumsehlopha-high lethal dose) feptjoa ka 50 mg/kgGanoderma lucidumli-polysaccharides F31 letsatsi le leng le le leng li ne li e-na le maemo a tlase a tsoekere ea mali a sa khaotseng ho feta litoeba tse sa phekoloang tsa lefu la tsoekere (sehlopha sa taolo), 'me ho ne ho e-na le liphapang tse kholo.

Ka lehlakoreng le leng, litoeba tsa lefu la tsoekere (Ganoderma lucidumgroup-low dose) eo le eona e jangGanoderma lucidumpolysaccharides F31 letsatsi le letsatsi empa ka tekanyo ea 25 mg/kg feela e bile le phokotseho e sa bonahaleng ea tsoekere ea mali.Sena se bontša horeGanoderma lucidumli-polysaccharides li na le phello ea ho laola tsoekere ea mali, empa phello e tla angoa ke litekanyetso (Setšoantšo sa 1).

Setšoantšo sa 1 Phello eaGanoderma lucidumka ho itima lijo tsa tsoekere maling litoeba tsa lefu la tsoekere

[Tlhaloso] Setlhare sa hypoglycemic se sebelisoang "Sehlopheng sa Meriana ea Bophirimela" ke metformin (Loditon), e nooang ka molomo ho 50 mg / kg letsatsi le letsatsi.Tekanyo ea tsoekere ea mali ke mmol / L.Arola boleng ba tsoekere ea mali ka 0.0555 ho fumana mg/dL.Tekanyo e tloaelehileng ea tsoekere ea mali e lokela ho ba ka tlase ho 5.6 mmol/L (hoo e ka bang 100 mg/dL), ho feta 7 mmol/L (126 mg/dL) ke lefu la tsoekere.(E entsoe ke/Wu Tingyao, mohloli oa data/J Ethnopharmacol. 2017; 196:47-57.)

Reishi li-mushroomli-polysaccharides li fokotsa tšenyo ea sebete e bakoang ke lefu la tsoekere.

E ka fumanoa ho Setšoantšo sa 1 hore leha ho le joaloGanoderma lucidumpolysaccharides F31 e ka laola tsoekere ea mali, phello ea eona e tlase hanyane ho ea meriana ea bophirima, 'me ha e khone ho khutlisetsa tsoekere ea mali maemong a tloaelehileng.Leha ho le joalo,Ganoderma lucidumli-polysaccharides li se li qalile ho phetha karolo ea ho sireletsa sebete.

E ka bonoa ho Setšoantšo sa 2, nakong ea liteko, sebopeho le morphology ea lisele tsa sebete tsa litoeba tsa lefu la tsoekere tse sirelelitsoeng keGanoderma lucidumpolysaccharides F31 (50 mg / kg) e ne e tšoana le ea litoeba tse tloaelehileng, 'me ho ne ho e-na le ho ruruha ho fokolang.Ka lehlakoreng le leng, lisele tsa sebete tsa litoeba tsa lefu la tsoekere tse sa kang tsa fumana phekolo li ne li senyehile haholo, 'me maemo a ho ruruha le necrosis a ne a boetse a tebile haholoanyane.

Setšoantšo sa 2 Phello ea Hepatoprotective eaGanoderma lucidumpolysaccharides ho litoeba tsa lefu la tsoekere

[Tlhaloso] Motsu o mosoeu o supa leqeba le ruruhileng kapa la necrotic.(Mohloli/J Ethnopharmacol. 2017; 196:47-57.)

Pathogenesis ea lefu la tsoekere la mofuta oa 2

Lithuto tse ngata nakong e fetileng li ile tsa hlalosa mochine oaGanoderma lucidumli-polysaccharides tse laolang tsoekere ea mali ho tsoa ponong ea "ho sireletsa lisele tsa pancreatic islet le ho ntlafatsa tlhahiso ea insulin."Phuputso ena e fana ka maikutlo a horeGanoderma lucidumLi-polysaccharides le tsona li ka ntlafatsa hyperglycemia ka litsela tse ling.

Pele re fetela pele, re tlameha ho qala ka ho tseba linotlolo tse 'maloa tsa ho theha lefu la tsoekere la mofuta oa 2.Ka mor'a hore motho ea nang le ts'ebetso e tloaelehileng ea metabolism a je, lisele tsa hae tsa pancreatic islet li tla hlahisa insulin, e susumetsang lisele tsa mesifa le lisele tsa mafura hore li hlahise "glucose transporter (GLUT4)" holim'a sele ho "tsamaisa" tsoekere e maling ho ea liseleng.

Kaha tsoekere ha e khone ho tšela lera la sele ka ho toba, e ke ke ea kena liseleng ntle le thuso ea GLUT4.Sesosa sa lefu la tsoekere la mofuta oa 2 ke hore lisele ha li utloe insulin (insulin resistance).Le ha insulin e hlahisoa khafetsa, e ntse e sitoa ho hlahisa GLUT4 e lekaneng holim'a sele.

Boemo bona bo ka etsahala haholo ho batho ba batenya, hobane mafura a kopanya hormone ea peptide e bitsoang "resistin", e bakang insulin ho hanyetsa lisele tsa mafura.

Kaha glucose ke mohloli oa matla oa sele, ha lisele li ntse li haelloa ke glucose, ntle le ho etsa hore batho ba batle ho ja haholo, e tla boela e khothalletse sebete ho hlahisa tsoekere e eketsehileng.

Ho na le litsela tse peli tsa hore sebete se hlahise tsoekere: e ’ngoe ke ho bola glycogen, ke hore, ho sebelisa tsoekere e neng e bolokiloe pele sebeteng;e ’ngoe ke ea ho nchafatsa glycogen, ke hore, ho fetola thepa e tala eo e seng ea lik’habohaedreite tse kang liprotheine le mafura hore e be tsoekere.

Litlamorao tsena tse peli ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 li matla ho feta tsa batho ba tloaelehileng.Ha sekhahla sa tšebeliso ea tsoekere ke lisele tsa 'mele se fokotseha ha tlhahiso ea tsoekere e ntse e phahama, ka tlhaho ho thata hore tsoekere e theohe.

Ganoderma lucidumli-polysaccharides li fokotsa bongata ba tsoekere e hlahisoang ke sebete le ho ntlafatsa sekhahla sa tšebeliso ea tsoekere ke lisele.

Ganoderma lucidumli-polysaccharides F31 li bonahala li khona ho rarolla mathata a ka holimo.Kamora ho fela ha liteko tsa liphoofolo, bafuputsi ba ile ba ntša sebete sa toeba le mafura a epididymal (e le sesupo sa mafura a 'mele), ba li hlahlobisisa le ho li bapisa, mme ba fumana hore F31 e na le mokhoa o latelang oa ts'ebetso (Setšoantšo sa 3):

1.Activate AMPK protein kinase sebeteng, fokotsa liphatsa tsa lefutso tsa li-enzyme tse 'maloa tse amehang ho glycogenolysis kapa gluconeogenesis sebeteng, ho fokotsa tlhahiso ea tsoekere, le ho laola tsoekere ea mali ho tsoa mohloling.

2. Eketsa palo ea GLUT4 ho li-adipocyte le ho thibela secretion ea resistin ho tloha ho adipocytes (ho etsa hore mefuta ena e 'meli e be haufi haholo le boemo ba litoeba tse tloaelehileng), kahoo ho ntlafatsa kutloisiso ea li-adipocyte ho insulin le ho eketsa tšebeliso ea tsoekere.

3. Ho fokotsa haholo liphatsa tsa lefutso tsa li-enzyme tsa bohlokoa tse amehang ho kopantsoe ha mafura a mafura a mafura, ka hona ho fokotsa karolo ea mafura a boima ba 'mele le ho fokotsa lintlha tse amanang le insulin ho hanyetsa.

Ho ka bonoa horeGanoderma lucidumli-polysaccharides li ka laola tsoekere ea mali ka bonyane litsela tse tharo, 'me litsela tsena ha li amane le "ho hlahisa insulin e susumetsang", ho fana ka menyetla e mengata ea ho ntlafatsa lefu la tsoekere. 

Setšoantšo sa 3 Mokhoa oa hoGanoderma lucidumli-polysaccharides tse laolang tsoekere ea mali

[Tlhaloso] Epididymis ke khoele e tšesaane e kang seminiferous tube e haufi le bokaholimo ba koro, e kopanyang li-vas deferens le li-testicles.Kaha mafura a pota-potileng epididymis a amana hantle le mafura a 'mele oohle (haholo-holo mafura a visceral), hangata e fetoha index ea tlhahlobo ea teko.Mabapi le mokhoa oa ho fokotsa GP le li-enzyme tse ling kamoraGanoderma lucidumpolysaccharides activate AMPK, e hloka ho hlakisoa haholoanyane, kahoo kamano pakeng tsa tse peli e bontšoa ke "?"setšoantšong.(Mohloli) J Ethnopharmacol. 2017; 196:47-57.)

Mofuta o le mong oaGanoderma lucidumpolysaccharides ha e hlile ha e betere.

Liphetho tsa lipatlisiso tse boletsoeng ka holimo li re fa kutloisiso e betere ea "joangGanoderma lucidumli-polysaccharides li molemo ho lefu la tsoekere la mofuta oa 2 ”.E boetse e re hopotsa hore mothating oa pele oa ho sebelisa meriana ea bophirimela kapaGanoderma lucidumpolysaccharides, tsoekere ea mali e kanna ea se khutlele setloaeleng ka nako e le 'ngoe kapa ea fetoha ho ea holimo le tlase ka nako e itseng joalo ka ha ho bonts'itsoe ho Setšoantšo sa 1.

U se ke ua soetseha ka nako ena, hobane ha feela u ntse u jaGanoderma lucidum, litho tsa hao tse ka hare li sirelelitsoe.

Ke habohlokoa ho bolela hore, joalokaha ho boletsoe qalong ea sehlooho sena,Ganoderma lucidumli-polysaccharides F31 ke li-polysaccharides tse nyenyane tsa molek'hule "tse entsoeng" ho tloha ho GLPs.Ha u bapisa liphello tsa bona tsa hypoglycemic tlas'a maemo a tšoanang a liteko, u tla fumana hore phello ea GLPs e molemo haholo ho feta ea F31 (Setšoantšo sa 4).

Ka mantsoe a mang, mofuta o le mong oaGanoderma lucidumpolysaccharides ha se hakaalo hore e betere, empa phello e akaretsang ea mefuta e akaretsang eaGanoderma lucidumli-polysaccharides li feta.Kaha li-GLPs ke li-polysaccharides tse tala tse fumanoang ho tsoaGanoderma lucidum'mele e behang litholoana ka ho ntša metsi a chesang, ha feela u ja lihlahisoa tse nang leGanoderma lucidum'mele oa litholoana o ntša metsi, u ke ke ua fetoa ke GLPs. 

Setšoantšo sa 4 Phello ea mefuta e fapaneng eaGanoderma lucidumli-polysaccharides tse amang maemo a tsoekere ea mali 

[Tlhaloso] Kamora hore litoeba tse nang le lefu la tsoekere la mofuta oa 2 (boleng ba tsoekere ea mali bo potlakileng ho 12-13 mmol / L) li fumane ente ea letsatsi le letsatsi ea intraperitoneal.Ganoderma lucidumpolysaccharides F31 (50 mg/kg),Ganoderma lucidumcrude polysaccharides GLPs (50 mg/kg kapa 100 mg/kg) ka matsatsi a 7 a latellanang, maemo a bona a tsoekere ea mali a ile a bapisoa le a litoeba tse tloaelehileng le tsa litoeba tse sa phekoloang tsa lefu la tsoekere.(E entsoe ke/Wu Tingyao, mohloli oa data/Arch Pharm Res. 2012; 35(10):1793-801.J Ethnopharmacol. 2017; 196:47-57.)

Mehloli

1. Xiao C, le ba bang.Ts'ebetso ea antidiabetic ea Ganoderma lucidum polysaccharides F31 e laolang li-enzyme tse laolang tsoekere ea sebete ho litoeba tsa lefu la tsoekere.J Ethnopharmacol.2017 Jan 20;196:47-57.

2. Xiao C, le ba bang.Litlamorao tsa Hypoglycemic tsa Ganoderma lucidum polysaccharides mofuteng oa 2 oa litoeba tsa lefu la tsoekere.Arch Pharm Res.2012 Oct;35(10):1793-801.

QETA

Mabapi le mongoli/ Mme Wu Tingyao

Wu Tingyao esale a tlaleha ka litaba tsa Ganoderma tsa pele ho tloha 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).

★ Sengoliloeng sena se hatisitsoe tlas'a tumello e khethehileng ea mongoli.★ Libuka tse ka holimo li ke ke tsa hlahisoa, tsa qotsoa kapa tsa sebelisoa ka litsela tse ling ntle le tumello ea mongoli.★ Bakeng sa tlōlo ea polelo e ka holimo, mongoli o tla phehella boikarabelo bo nepahetseng ba molao.★ Sengoloa sa mantlha sa sengoloa sena se ngotsoe ka Sechaena ke Wu Tingyao mme se fetoleloa ho Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.