Ku ya 20 Mutarama 2017 / Ikigo cya Guangdong cya Microbiology n'Ikigo gishinzwe kurwanya no gukumira indwara mu Ntara ya Guangdong / Ikinyamakuru cya Ethnopharmacology

Inyandiko / Wu Tingyao

Kuva kera bimaze kumenyekana koGanoderma lucidumpolysaccharide irashobora gufasha kuvura diyabete, ariko uko ikora ni ingingo abahanga bifuza kumenya byinshi.

Nko mu mwaka wa 2012, Ikigo cya Guangdong cya Microbiology n'Ikigo gishinzwe kurwanya no gukumira indwara mu Ntara ya Guangdong bafatanije gusohora raporo ivuga ko uburemere bukabije bwa polyisikaride (GLPs) bwakuwe mu mazi ashyushye yaGanoderma lucidumumubiri wera ufite ingaruka nziza ya hypoglycemic kuri diyabete yo mu bwoko bwa 2 (T2D).

Noneho, barushijeho gutandukanya polysaccharide enye muri GLPs, hanyuma bafata F31 ikora cyane (uburemere bwa molekuline igera kuri 15.9 kDa, irimo proteine ​​15.1%) kugirango bakore ubushakashatsi bwimbitse, basanga bidashobora kugenga glucose yamaraso binyuze munzira nyinshi ariko kandi urinde umwijima.

Lingzhipolysaccharide irashobora kugabanya hyperglycemia.

Mu bushakashatsi bw’ibyumweru 6, byagaragaye ko imbeba zo mu bwoko bwa diyabete zo mu bwoko bwa 2 (Ganoderma lucidumitsinda-ryinshi dose) yagaburiwe 50 mg / kgGanoderma lucidumpolysaccharide F31 burimunsi yagabanutse igabanya umuvuduko wamaraso glucose ugereranije nimbeba za diyabete zitavuwe (itsinda rishinzwe kugenzura), kandi hariho itandukaniro rikomeye.

Ibinyuranye, imbeba za diyabete (Ganoderma lucidumitsinda-rito dose) nayo yariyeGanoderma lucidumpolysaccharide F31 buri munsi ariko ku kigero cya 25 mg / kg gusa yagabanutse cyane glucose yamaraso.Ibi birerekana koGanoderma lucidumpolysaccharide igira ingaruka zo kugenzura glucose yamaraso, ariko ingaruka zizagira ingaruka kuri dosiye (Ishusho 1).

Igishushanyo 1 Ingaruka zaGanoderma lucidumku kwiyiriza amaraso glucose mu mbeba za diyabete

[Ibisobanuro] Umuti wa hypoglycemic ukoreshwa muri “Western Medicine Group” ni metformin (Loditon), ifatwa mu kanwa kuri mg / kg 50 buri munsi.Igice cyamaraso glucose mumashusho ni mmol / L.Gabanya amaraso glucose agaciro 0.0555 kugirango ubone mg / dL.Igipimo gisanzwe cyamaraso glucose kigomba kuba munsi ya 5,6 mmol / L (hafi 100 mg / dL), hejuru ya 7 mmol / L (126 mg / dL) ni diyabete.(Byashushanijwe na / Wu Tingyao, isoko yamakuru / J Ethnopharmacol. 2017; 196: 47-57.)

Reishi mushroompolysaccharide igabanya kwangirika kwumwijima guterwa na diyabete.

Irashobora kuboneka kuva ku gishushanyo 1 ko nubwoGanoderma lucidumpolysaccharide F31 irashobora kugenga glucose yamaraso, ingaruka zayo ziri munsi gato yubuvuzi bwiburengerazuba, kandi ntishobora kugarura glucose yamaraso mubisanzwe.Nyamara,Ganoderma lucidumpolysaccharide yatangiye kugira uruhare mukurinda umwijima.

Irashobora kugaragara kuva ku gishushanyo cya 2, mugihe cyubushakashatsi, imiterere na morphologie yumubiri wumwijima wimbeba za diyabete zirinzweGanoderma lucidumpolysaccharide F31 (50 mg / kg) yari imeze nk'iy'imbeba zisanzwe, kandi habaye umuriro muke.Ibinyuranye n'ibyo, umwijima w'imbeba z'imbeba za diyabete zitigeze zivurwa wangiritse ku buryo bugaragara, kandi indwara zo gutwika na nérosose nazo zari zikomeye.

Igishushanyo 2 Ingaruka ya Hepatoprotective yaGanoderma lucidumpolysaccharide ku mbeba za diyabete

[Ibisobanuro] Umwambi wera werekana igikomere cyaka cyangwa nerotic.(Inkomoko / J Ethnopharmacol. 2017; 196: 47-57.)

Indwara ya diyabete yo mu bwoko bwa 2

Ubushakashatsi bwinshi bwashize bwasobanuye uburyo bwaGanoderma lucidumpolysaccharide igenga glucose yamaraso mu rwego rwo "kurinda ingirabuzimafatizo zo mu bwoko bwa pancreatic islet no kongera imisemburo ya insuline."Ubu bushakashatsi bwerekana koGanoderma lucidumpolysaccharide irashobora kandi kunoza hyperglycemia mubundi buryo.

Mbere yo kujya kure, tugomba mbere na mbere kumenya urufunguzo ruto rwo gushiraho diyabete yo mu bwoko bwa 2.Nyuma yuko umuntu ufite imikorere isanzwe ya metabolike amaze kurya, ingirangingo zitwa pancreatic islet selile zizasohora insuline, itera ingirangingo z'imitsi hamwe na selile zibyara amavuta "glucose transport (GLUT4)" hejuru ya selile kugirango "itware" glucose mumaraso mungirangingo.

Kuberako glucose idashobora kwambuka ingirabuzimafatizo, ntishobora kwinjira muri selile idafashijwe na GLUT4.Ipfundo rya diyabete yo mu bwoko bwa 2 ni uko selile zitumva insuline (anti-insuline).Nubwo insuline isohoka kenshi, ntishobora kubyara GLUT4 ihagije hejuru ya selile.

Iki kibazo gishobora kugaragara cyane kubantu bafite umubyibuho ukabije, kubera ko ibinure bihindura imisemburo ya peptide yitwa "resistine", itera insuline mu ngirabuzimafatizo.

Kubera ko glucose ari isoko yingirabuzimafatizo, mugihe selile zabuze glucose, usibye gutuma abantu bashaka kurya byinshi, bizanashishikariza umwijima kubyara glucose.

Hariho uburyo bubiri umwijima utanga glucose: imwe ni ukubora glycogene, ni ukuvuga gukoresha glucose yabitswe mbere mu mwijima;ikindi ni uguhindura glycogene, ni ukuvuga guhindura ibikoresho fatizo bitarimo karubone nka proteyine n'ibinure muri glucose.

Izi ngaruka zombi ku barwayi barwaye diyabete yo mu bwoko bwa 2 zirakomeye kurusha izo mu bantu basanzwe.Iyo igipimo cyo gukoresha glucose na selile zigabanutse mugihe umusaruro wa glucose ukomeje kwiyongera, mubisanzwe biragoye ko glucose yamaraso igabanuka.

Ganoderma lucidumpolysaccharide igabanya urugero rwa glucose ikorwa numwijima kandi igateza imbere ikoreshwa rya glucose na selile.

Ganoderma lucidumpolysaccharide F31 isa nkaho ishoboye gukemura ibibazo byavuzwe haruguru.Nyuma y’igeragezwa ry’inyamaswa, abashakashatsi bakuyemo umwijima wimbeba n’amavuta ya epididimale (nkikimenyetso cyerekana amavuta yumubiri), barasesengura baragereranya, basanga F31 ifite uburyo bukurikira bwibikorwa (Ishusho 3):

1.Kora AMPK protein kinase mu mwijima, gabanya imiterere ya gene yimisemburo myinshi igira uruhare muri glycogenolysis cyangwa gluconeogenezi mu mwijima, kugabanya umusaruro wa glucose, no kugenzura glucose yamaraso ikomoka.

2. Ongera umubare wa GLUT4 kuri adipocytes kandi uhagarike gusohora kwa resin ituruka kuri adipocytes (bigatuma izo mpinduka zombi zegeranye cyane n’imiterere yimbeba zisanzwe), bityo bikongerera imbaraga za adipocytes kuri insuline no kongera ikoreshwa rya glucose.

3. Mugabanye cyane imvugo ya gene yimisemburo yingenzi igira uruhare mukuzuza ibinure muri tipusi ya adipose, bityo bikagabanya igipimo cyibinure muburemere bwumubiri kandi bikagabanya ibintu bifitanye isano no kurwanya insuline.

Birashobora kugaragara koGanoderma lucidumpolysaccharide irashobora kugenga glucose yamaraso ikoresheje byibuze inzira eshatu, kandi izi nzira ntaho zihuriye n "" gutera insuline gusohora ", bitanga amahirwe menshi yo kunoza diyabete. 

Igishushanyo 3 Uburyo bwaGanoderma lucidumpolysaccharide mugutunganya glucose yamaraso

[Ibisobanuro] Epididymis ni umuyoboro umeze nk'igituba kimeze nk'igituba cyoroshye cyane cyegereye hejuru ya testicle, gihuza vas deferens na testicles.Kubera ko ibinure bikikije epididymis bifitanye isano neza n’ibinure byose byumubiri wose (cyane cyane ibinure bya visceral), akenshi biba indorerezi yubushakashatsi.Kubijyanye no kugabanya GP nindi misemburo nyumaGanoderma lucidumpolysaccharide ikora AMPK, igomba kurushaho gusobanurwa, bityo umubano hagati yombi ugaragazwa na "?"ku gishushanyo.(Inkomoko ／ J Ethnopharmacol. 2017; 196: 47-57.）

Ubwoko bumwe bwaGanoderma lucidumpolysaccharide ntabwo byanze bikunze ari byiza.

Ibisubizo byubushakashatsi byavuzwe haruguru biduha kumva neza "uburyoGanoderma lucidumpolysaccharide ni ingirakamaro mu bwoko bwa diyabete yo mu bwoko bwa 2 ”.Iratwibutsa kandi ko mugihe cyambere cyo gukoresha imiti yuburengerazuba cyangwaGanoderma lucidumpolysaccharide, glucose yamaraso ntishobora gusubira mubisanzwe icyarimwe cyangwa ngo ihindagurika hejuru no hepfo mugihe runaka nkuko bigaragara mumashusho 1.

Ntutenguhe muri iki gihe, kuko igihe cyose uryaGanoderma lucidum, ingingo zimbere zarinzwe.

Birakwiye kuvuga ko, nkuko byavuzwe mu ntangiriro yingingo,Ganoderma lucidumpolysaccharide F31 ni nto-molekile polysaccharide "deconstructed" kuva muri GLPs.Ugereranije ingaruka zabo za hypoglycemic mubihe bimwe byubushakashatsi, uzasanga ingaruka za GLPs ari nziza cyane kurenza F31 (Ishusho 4).

Muyandi magambo, ubwoko bumwe bwaGanoderma lucidumpolysaccharide ntabwo aribyiza byanze bikunze, ariko ingaruka rusange yubwoko bwuzuye bwaGanoderma lucidumpolysaccharide nini.Kubera ko GLPs ari polysaccharide yuzuye iboneka muriGanoderma lucidumimbuto zera binyuze mumazi ashyushye, mugihe urya ibicuruzwa birimoGanoderma lucidumimbuto zumubiri zikuramo amazi, ntuzabura GLPs. 

Igicapo 4 Ingaruka zubwoko butandukanye bwaGanoderma lucidumpolysaccharide kurwego rwo kwiyiriza ubusa glucose 

[Ibisobanuro] Nyuma yimbeba zifite diyabete yo mu bwoko bwa 2 (kwiyiriza ubusa glucose yamaraso 12-13 mmol / L) yakiriye inshinge za intraperitoneal ya buri munsiGanoderma lucidumpolysaccharide F31 (50 mg / kg),Ganoderma lucidumpolysaccharide ya GLP (50 mg / kg cyangwa 100 mg / kg) muminsi 7 ikurikiranye, urugero rwamaraso ya glucose rwagereranijwe niz'imbeba zisanzwe niz'imbeba za diyabete zitavuwe.(Byashushanijwe na / Wu Tingyao, isoko yamakuru / Arch Pharm Res. 2012; 35 (10): 1793-801.J Ethnopharmacol. 2017; 196: 47-57.)

Inkomoko

1. Xiao C, n'abandi.Igikorwa cyo kurwanya antiyabete ya Ganoderma lucidum polysaccharides F31 imisemburo ya hepatike glucose igenga imisemburo ya diyabete.J Ethnopharmacol.2017 Mutarama 20; 196: 47-57.

2. Xiao C, n'abandi.Ingaruka za Hypoglycemic ya Ganoderma lucidum polysaccharide mubwoko bwa 2 imbeba za diyabete.Arch Pharm Res.2012 Ukwakira; 35 (10): 1793-801.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao

Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma kuva mu 1999. Ni umwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).

★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi.Works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira n'umwanditsi.★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakurikirana inshingano zemewe n'amategeko.Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.