Ndira 20, 2017 / Guangdong Institute of Microbiology uye Center for Disease Control and Prevention yeGuangdong Province / Journal yeEthnopharmacology

Chinyorwa/ Wu Tingyao

Chave chave chiri chokwadi chakazivikanwa kutiGanoderma lucidumpolysaccharides inogona kubatsira kurapa chirwere cheshuga, asi kuti inoshanda sei inyaya iyo masayendisiti anoda kuziva zvakawanda nezvayo.

Kubva muna 2012, Guangdong Institute of Microbiology uye Center for Disease Control and Prevention yeGuangdong Province vakabatana vakaburitsa gwaro rinotaura kuti yakakwira molecular weight polysaccharides (GLPs) yakatorwa kubva mumvura inopisaGanoderma lucidumMitumbi inobereka michero ine yakanaka hypoglycemic mhedzisiro yerudzi rwechipiri chirwere cheshuga (T2D).

Ikozvino, vakawedzerazve kutsaura mapolysaccharides mana kubva kuGLPs, uye vakatora iyo inoshanda zvakanyanya F31 (molecular huremu hunosvika 15.9 kDa, ine 15.1% protein) yekudzidza zvakadzama, uye vakawana kuti haingogone kudzora shuga yeropa kuburikidza nenzira dzakawanda asi. chengetedzawo chiropa.

Lingzhipolysaccharides inogona kuderedza hyperglycemia.

Mukuedza kwemhuka kwemavhiki matanhatu, zvakaonekwa kuti mhando 2 chirwere cheshuga mbeva (Ganoderma lucidumboka-yakakwirira dose) inodyiswa ne50 mg/kgGanoderma lucidumpolysaccharides F31 zuva rega rega raigara richidzika kutsanya kweglucose yeropa pane isina kurapwa mbeva dzeshuga (boka rekutonga), uye pakanga paine misiyano yakakura.

Kusiyana neizvi, mbeva dzine chirwere cheshuga (Ganoderma lucidumgroup-low dose) vakadyawoGanoderma lucidumpolysaccharides F31 zuva nezuva asi pachiyero che 25 mg / kg chete yakanga ine kuderera kusinganyatsooneki muropa reglucose.Izvi zvinoratidza kutiGanoderma lucidumpolysaccharides ine mhedzisiro yekudzora shuga yeropa, asi iyo mhedzisiro ichakanganiswa nedosi (Mufananidzo 1).

Mufananidzo 1 Mhedzisiro yeGanoderma lucidumpakutsanya mazinga eglucose weropa mumakonzo ane chirwere cheshuga

[Tsanangudzo] Mushonga we hypoglycemic unoshandiswa mu "Western Medicine Group" ndeye metformin (Loditon), inotorwa nemuromo pa50 mg/kg zuva nezuva.Chiyero cheglucose yeropa mumufananidzo ndeye mmol / L.Kamura kukosha kweglucose yeropa ne0.0555 kuti uwane iyo mg/dL.Chiyero chekutsanya cheglucose muropa chinofanira kunge chiri pasi pe5.6 mmol/L (inenge 100 mg/dL), inopfuura 7 mmol/L (126 mg/dL) chirwere cheshuga.(Yakatorwa na/Wu Tingyao, kunobva data/J Ethnopharmacol. 2017; 196:47-57.)

Reishi mushroompolysaccharides inoderedza kukuvara kwechiropa kunokonzerwa nechirwere cheshuga.

Inogona kuwanikwa kubva kuMufananidzo 1 kuti kunyangweGanoderma lucidumpolysaccharides F31 inogona kudzora shuga yeropa, mhedzisiro yayo yakaderera zvishoma kune yemishonga yekumadokero, uye haigone kudzorera glucose yeropa kune yakajairika.Zvakadaro,Ganoderma lucidumma polysaccharides atanga kuita basa rekuchengetedza chiropa.

Inogona kuoneka kubva kuMufananidzo 2, panguva yekuyedza, chimiro uye morphology yechiropa chembeva dzeshuga dzinodzivirirwa na.Ganoderma lucidumpolysaccharides F31 (50 mg/kg) yakanga yakafanana neyemakonzo akajairwa, uye pakanga paine kuzvimba kushoma.Kusiyana neizvi, matishu echiropa emakonzo ane chirwere cheshuga asina kugamuchira chero kurapwa akakuvadzwa zvakanyanya, uye mamiriro ekuzvimba uye necrosis aivewo akanyanya.

Mufananidzo 2 Hepatoprotective effect yeGanoderma lucidumpolysaccharides pamakonzo ane chirwere cheshuga

[Tsanangudzo] Museve muchena unonongedzera kune yakazvimba kana necrotic ronda.(Kwakabva/J Ethnopharmacol. 2017; 196:47-57.)

Pathogenesis yerudzi rwechipiri chirwere cheshuga

Zvidzidzo zvakawanda munguva yakapfuura zvakatsanangura nzira yeGanoderma lucidumpolysaccharides inodzora shuga yeropa kubva pakuona kwe "kuchengetedza pancreatic islet masero uye kuwedzera insulin secretion."Chidzidzo ichi chinoratidza kutiGanoderma lucidumpolysaccharides inogonawo kuvandudza hyperglycemia nedzimwe nzira.

Tisati taenda mberi, tinofanira kutanga taziva makiyi mashoma ekuumbwa kwechirwere cheshuga cherudzi rwechipiri.Mushure mekunge munhu ane metabolic function adya, ake pancreatic islet masero anoburitsa insulin, iyo inokurudzira tsandanyama masero uye mafuta masero kuti abudise "glucose transporter (GLUT4)" pane sero pamusoro "kutakura" glucose muropa mumasero.

Nokuti glucose haigoni kuyambuka sero membrane zvakananga, haigoni kupinda mumasero pasina rubatsiro rweGLUT4.Iyo yakakosha yerudzi rwechipiri chirwere cheshuga ndechekuti masero haanzwisisi insulin (insulin resistance).Kunyangwe kana insulin yakavanzwa kazhinji, haigone kuburitsa yakakwana GLUT4 pachitokisi.

Mamiriro ezvinhu aya anowanzoitika muvanhu vakafuta, nekuti mafuta anogadzira peptide hormone inonzi "resistin", iyo inokonzera insulin kuramba mumasero emafuta.

Sezvo glucose iri simba resero, apo masero anga asina glucose, kunze kwekuita kuti vanhu vade kudya zvakanyanya, zvinokurudzirawo chiropa kuburitsa glucose yakawanda.

Kune nzira mbiri dzekuti chiropa chibudise glucose: imwe ndeyekuora glycogen, ndiko kuti, kushandisa glucose yakatanga kuchengetwa muchiropa;imwe yacho ndeyekugadzirisazve glycogen, ndiko kuti, kushandura zvinhu zvisiri zve-carbohydrates zvakadai seprotein nemafuta kuita glucose.

Izvi zviviri zvinokonzeresa muvarwere vane Type 2 chirwere cheshuga zvine simba kupfuura izvo zviri muvanhuwo zvavo.Kana chiyero chekushandiswa kweglucose nemasero ematishu chikadzikira nepo huwandu hwekugadzirwa kweglucose huchiramba huchikwira, zvakangooma kuti shuga yeropa idonhe.

Ganoderma lucidumpolysaccharides inoderedza huwandu hweglucose inogadzirwa nechiropa uye inovandudza kushandiswa kweglucose nemasero.

Ganoderma lucidumpolysaccharides F31 inoita kunge inokwanisa kugadzirisa matambudziko ari pamusoro.Mushure mekupera kwekuedza kwemhuka, vatsvakurudzi vakatora chiropa chembeva uye epididymal mafuta (sechiratidzo chemafuta emuviri), vakaongorora uye vakaenzanisa, uye vakawana kuti F31 ine nzira inotevera yekuita (Mufananidzo 3):

1.Activate AMPK protein kinase muropa, kuderedza gene expression ye enzymes dzakawanda dzinobatanidzwa mu glycogenolysis kana gluconeogenesis muchiropa, kuderedza kugadzirwa kweglucose, uye kudzora shuga yeropa kubva kunobva.

2. Kuwedzera nhamba yeGLUT4 pane adipocytes uye inhibit secretion ye resistin kubva kune adipocytes (ichiita izvi zviviri zvakasiyana zvakanyanya pedyo nemamiriro ezvinhu emakonzo), nokudaro nekuvandudza kunzwisisika kweadipocytes kune insulini uye kuwedzera kushandiswa kweglucose.

3. Zvinonyanya kuderedza kuratidzwa kwejeni rema enzymes anokosha anobatanidzwa mukugadzirwa kwemafuta mune adipose tissue, nokudaro kuderedza chikamu chemafuta muhuremu hwemuviri uye kuderedza zvinhu zvine chokuita ne insulin kudzivisa.

Zvinogona kuonekwa kutiGanoderma lucidumpolysaccharides inogona kugadzirisa shuga yeropa kuburikidza nenzira dzinenge nhatu, uye nzira idzi hadzina chokuita ne "kukurudzira insulin secretion", zvichipa mikana yakawanda yekuvandudzwa kwechirwere cheshuga. 

Mufananidzo 3 Nzira yeGanoderma lucidumpolysaccharides mukudzora shuga yeropa

[Tsanangudzo] Epididymis ichubhu yakaita seminaferous chubhu yakatetepa iri padyo nepamusoro pechende, ichibatanidza vas deferens nemachende.Sezvo mafuta akapoteredza epididymis akanyatsobatanidzwa nemafuta ose emuviri wose (kunyanya visceral mafuta), inowanzova iyo yekucherechedza indekisi yekuedza.Kana iri nzira yekudzikisa GP uye mamwe ma enzymes mushureGanoderma lucidumpolysaccharides activate AMPK, inoda kujekeswa zvakare, saka hukama pakati pezviviri izvi zvinoratidzwa ne "?"mumufananidzo.(Kwakabva／J Ethnopharmacol. 2017; 196:47-57.)

Rudzi rumwe rweGanoderma lucidumpolysaccharides haisi nani.

Mhedzisiro yataurwa pamusoro apa inotipa kunzwisisa kuri nani kwe "seiGanoderma lucidumpolysaccharides inobatsira kune Type 2 chirwere cheshuga ”.Inotiyeuchidza zvakare kuti padanho rekutanga rekushandisa mushonga wekumadokero kanaGanoderma lucidumpolysaccharides, shuga yeropa inogona kusadzokera kune yakajairwa kamwechete kana kushanduka ichikwira nekudzika kwenguva yakati rebei sezvakaratidzwa mumufananidzo 1.

Usaora mwoyo panguva ino, nokuti chero bedzi iwe uchidyaGanoderma lucidum, nhengo dzako dzomukati dzakachengetedzwa.

Zvakakodzera kutaura kuti, sezvataurwa pakutanga kwechinyorwa,Ganoderma lucidumpolysaccharides F31 idiki-morekuru polysaccharides "deconstructed" kubva kuGLPs.Kuenzanisa mhedzisiro yavo yehypoglycemic pasi pemamiriro akafanana ekuedza, uchaona kuti mhedzisiro yeGLPs iri nani zvakanyanya pane yeF31 (Mufananidzo 4).

Mune mamwe mazwi, mhando imwe chete yeGanoderma lucidumpolysaccharides haisati iri nani, asi iyo yakazara mhedzisiro yemhando dzakakwana dzeGanoderma lucidumpolysaccharides yakakura.Sezvo GLPs ari crude polysaccharides inowanikwa kubvaGanoderma lucidummichero miviri kuburikidza nekuchera mvura inopisa, chero bedzi iwe uchidya zvigadzirwa zvineGanoderma lucidummichero miviri yemvura inobvisa, iwe haungapotsa GLPs. 

Mufananidzo 4 Mhedzisiro yemhando dzakasiyana dzeGanoderma lucidumpolysaccharides pakutsanya mazinga eglucose weropa 

[Tsanangudzo] Mushure membeva dzine chirwere cheshuga chechipiri (kutsanya kweglucose yeropa kukosha 12-13 mmol/L) yakagamuchira zuva nezuva intraperitoneal jekiseni reGanoderma lucidumpolysaccharides F31 (50 mg/kg),Ganoderma lucidumcrude polysaccharides GLPs (50 mg/kg kana 100 mg/kg) kwemazuva manomwe akatevedzana, mazinga eglucose eropa akaenzaniswa neaya emakonzo akajairwa uye aya emakonzo asina kurapwa ane chirwere cheshuga.(Yakatorwa na/Wu Tingyao, kunobva data/Arch Pharm Res. 2012; 35(10):1793-801.J Ethnopharmacol. 2017; 196:47-57.)

Sources

1. Xiao C, nevamwe.Antidiabetic chiitiko cheGanoderma lucidum polysaccharides F31 pasi-yakagadziriswa hepatic glucose regulatory enzymes mumakonzo ane chirwere cheshuga.J Ethnopharmacol.2017 Jan 20;196:47-57.

2. Xiao C, nevamwe.Hypoglycemic mhedzisiro yeGanoderma lucidum polysaccharides murudzi rwe2 chirwere cheshuga mbeva.Arch Pharm Res.2012 Oct;35(10):1793-801.

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Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.