Jenụwarị 20, 2017 / Ụlọ ọrụ Guangdong nke Microbiology na Center maka Nchịkwa na Mgbochi Ọrịa nke Guangdong Province / Journal of Ethnopharmacology

Ederede/ Wu Tingyao

Ọ dịla anya a ghọtara naGanoderma lucidumpolysaccharides nwere ike inye aka na-agwọ ọrịa shuga, mana ka o si arụ ọrụ bụ isiokwu nke ndị ọkà mmụta sayensị chọrọ ịmatakwu banyere ya.

N'ihe dị ka afọ 2012, Guangdong Institute of Microbiology and Centre for Disease Control and Prevention nke Guangdong Province jikọtara ọnụ nyere akụkọ na-ekwupụta na polysaccharides dị arọ nke molecular arọ (GLPs) ewepụtara na mmiri ọkụ.Ganoderma lucidumAhụ ndị na-amị mkpụrụ nwere mmetụta hypoglycemic dị mma maka ụdị ọrịa shuga 2 (T2D).

Ugbu a, ha ekewapụla polysaccharides anọ na GLPs, wee were F31 na-arụsi ọrụ ike (ihe dị ka 15.9 kDa, nke nwere protein 15.1) maka nyocha miri emi, wee chọpụta na ọ bụghị naanị na ọ nwere ike ịhazi glucose ọbara site n'ọtụtụ ụzọ mana. na-echebekwa imeju.

Lingzhipolysaccharides nwere ike belata hyperglycemia.

N'ime nnwale anụmanụ dị izu 6, ahụrụ ya ụdị oke oke nwere ọrịa shuga 2 (Ganoderma lucidumotu oke dose) rie ya na 50 mg / kgGanoderma lucidumpolysaccharides F31 kwa ụbọchị na-agbadata ọkwa glucose ọbara na-ebu ọnụ karịa ụmụ oke ndị ọrịa mamịrị anaghị agwọta (otu njikwa), yana enwere nnukwu ọdịiche.

N'ụzọ dị iche, ụmụ oke na-arịa ọrịa shuga (Ganoderma lucidumotu obere dose) nke ririkwaGanoderma lucidumpolysaccharides F31 kwa ụbọchị mana na dose nke naanị 25 mg/kg nwere mbelata nke ukwuu n'ọbara glucose ọbara.Nke a na-egosi naGanoderma lucidumpolysaccharides nwere mmetụta nke ịhazi glucose ọbara, mana usoro onunu ogwu ga-emetụta nsonaazụ ya (Fig 1).

Ọgụgụ 1 Mmetụta nkeGanoderma lucidumna ọkwa glucose ọbara na-ebu ọnụ na ụmụ oke ndị nwere ọrịa shuga

Ọgwụ hypoglycemic eji na "Western Medicine Group" bụ metformin (Loditon), nke a na-ewere ọnụ na 50 mg / kg kwa ụbọchị.Ngalaba glucose ọbara dị na foto a bụ mmol/L.Kewaa uru glucose ọbara site na 0.0555 iji nweta mg/dL.Ọkwa glucose ọbara na-ebu ọnụ kwesịrị ịdị n'okpuru 5.6 mmol / L (ihe dị ka 100 mg / dL), karịa 7 mmol / L (126 mg / dL) bụ ọrịa shuga.(Nke sitere na/Wu Tingyao, isi iyi data/J Ethnopharmacol. 2017; 196:47-57.)

Reishi eropolysaccharides na-ebelata mmebi imeju nke ọrịa shuga na-akpata.

Enwere ike ịchọta ya site na eserese 1 na ọ bụ ezie naGanoderma lucidumpolysaccharides F31 nwere ike ịhazi glucose ọbara, mmetụta ya dị ntakịrị ala karịa nke ọgwụ ndị ọdịda anyanwụ, ọ nweghịkwa ike iweghachi glucose ọbara na nkịtị.Ka o sina dị,Ganoderma lucidumpolysaccharides amalitela ịrụ ọrụ n'ichekwa imeju.

Enwere ike ịhụ ya site na eserese 2, n'oge nnwale ahụ, usoro na morphology nke anụ ahụ imeju nke ụmụ oke ọrịa shuga na-echekwa ya.Ganoderma lucidumpolysaccharides F31 (50 mg/kg) yiri nke ụmụ oke nkịtị, ma enwere obere mbufụt.N'ụzọ dị iche, anụ ahụ imeju nke ụmụ oke ọrịa shuga nke na-enwetaghị ọgwụgwọ ọ bụla mebiri emebi nke ukwuu, ọnọdụ mbufụt na necrosis dịkwa njọ karị.

Ọgụgụ 2 Hepatoprotective mmetụta nkeGanoderma lucidumpolysaccharides na ụmụ oke na-arịa ọrịa shuga

[Nkọwa] Àkụ́ na-acha ọcha na-ezo aka na ọnya na-ere ọkụ ma ọ bụ necrotic.(Isi mmalite/J Ethnopharmacol. 2017; 196:47-57.)

pathogenesis nke ụdị ọrịa shuga 2

Ọtụtụ ọmụmụ n'oge gara aga kọwara usoro nkeGanoderma lucidumpolysaccharides na-achịkwa glucose ọbara site n'echiche nke "ichekwa mkpụrụ ndụ islet pancreatic na ịkwalite mmepụta insulin."Ọmụmụ ihe a na-egosi naGanoderma lucidumpolysaccharides nwekwara ike melite hyperglycemia n'ụzọ ndị ọzọ.

Tupu anyị aga n'ihu, anyị ga-ebu ụzọ mara igodo ole na ole na-emepụta ụdị ọrịa shuga 2.Mgbe onye nwere ọrụ metabolic nkịtị risịrị nri, mkpụrụ ndụ islet ya nke pancreatic ga-ezobe insulin, nke na-akpali mkpụrụ ndụ akwara na sel abụba imepụta “onye na-ebugharị glucose (GLUT4)” n'elu sel ka ọ “bufee” glucose dị n'ọbara n'ime sel.

N'ihi na glucose enweghị ike ịgafe akpụkpọ ahụ ozugbo, ọ nweghị ike ịbanye na sel na-enweghị enyemaka nke GLUT4.Ihe dị mkpa nke ụdị ọrịa shuga 2 bụ na mkpụrụ ndụ anaghị anabata insulin (nguzogide insulin).Ọbụlagodi na a na-ezobe insulin ugboro ugboro, ọ ka nwere ike imepụta GLUT4 zuru oke n'elu sel.

Ọnọdụ a yikarịrị ka ọ ga-eme na ndị buru ibu, n'ihi na abụba na-emepụta hormone peptide nke a na-akpọ "resistin", nke na-ebute nkwụsị insulin na sel abụba.

Ebe ọ bụ na glucose bụ isi iyi ike nke mkpụrụ ndụ, mgbe mkpụrụ ndụ enweghị glucose, na mgbakwunye na ime ka ndị mmadụ chọkwuo iri nri, ọ ga-agbakwa ume imeju iwepụtakwu glucose.

Enwere ụzọ abụọ maka imeju si emepụta glucose: otu bụ ire ere glycogen, ya bụ, iji glucose e debere n'imeju na mbụ;nke ọzọ bụ ime ka glycogen dịghachi, ya bụ, ịgbanwe ihe ndị na-abụghị carbohydrate dị ka protein na abụba ka ọ bụrụ glucose.

Mmetụta abụọ a na ndị ọrịa nwere ụdị ọrịa shuga 2 dị ike karịa nke ndị mmadụ nkịtị.Mgbe ọnụọgụ glucose site na mkpụrụ ndụ anụ ahụ na-ebelata ka ọnụọgụ nke mmepụta glucose na-aga n'ihu na-arị elu, ọ na-esiri glucose ọbara ike ịdaba.

Ganoderma lucidumpolysaccharides na-ebelata oke glucose nke imeju na-emepụta ma na-emeziwanye ọnụọgụ glucose site na mkpụrụ ndụ.

Ganoderma lucidumpolysaccharides F31 yiri ka ọ ga-edozi nsogbu ndị dị n'elu.Mgbe njedebe nke nnwale anụmanụ gasịrị, ndị nchọpụta ahụ wepụrụ imeju òké na abụba epididymal (dị ka ihe na-egosi abụba anụ ahụ), nyochaa ma jiri ya tụnyere ha, wee chọpụta na F31 nwere usoro ọrụ ndị a (Nyocha 3):

1.Ativate AMPK protein kinase na imeju, belata okwu mkpụrụ ndụ ihe nketa nke ọtụtụ enzymes na-etinye aka na glycogenolysis ma ọ bụ gluconeogenesis na imeju, belata mmepụta glucose, na ịchịkwa glucose ọbara site na isi iyi.

2. Mụbaa ọnụ ọgụgụ GLUT4 na adipocytes ma gbochie nzuzo nke resistin site na adipocytes (na-eme ka mgbanwe abụọ a dị nso na ọnọdụ ụmụ oke nkịtị), si otú ahụ na-eme ka mmetụta nke adipocytes na insulin dịkwuo elu ma na-amụba ojiji nke glucose.

3. Na-ebelata nke ọma okwu mkpụrụ ndụ ihe nketa nke isi enzymes na-etinye aka na njikọ abụba na anụ ahụ adipose, si otú ahụ na-ebelata oke abụba n'ime ahụ ma na-ebelata ihe ndị metụtara nkwụsị insulin.

Enwere ike ịhụ nke ahụGanoderma lucidumpolysaccharides nwere ike ịhazi glucose ọbara site na ụzọ atọ ma ọ dịkarịa ala, ụzọ ndị a enweghị ihe jikọrọ ya na "ịmepụta insulin na-akpali akpali", na-enye ohere karịa maka mmụba nke ọrịa shuga. 

Ọgụgụ 3 Usoro nkeGanoderma lucidumpolysaccharides na-achịkwa glucose ọbara

[Nkọwa] The epididymis bụ eriri igwe dị ka mkpara seminiferous tube nke dị nso n'elu testicle, na-ejikọta vas deferens na testicles.Ebe ọ bụ na abụba dị n'akụkụ epididymis na-ejikọta nke ọma na abụba zuru oke nke ahụ dum (karịsịa abụba visceral), ọ na-abụkarị ihe nleba anya nke nnwale ahụ.Maka otu esi ebelata GP na enzymes ndị ọzọ mgbeGanoderma lucidumpolysaccharides na-arụ ọrụ AMPK, ọ dị mkpa ka akọwakwuo ya, ya mere mmekọrịta dị n'etiti abụọ ahụ na-egosi "?"na ọnụ ọgụgụ.(Isi mmalite: J Ethnopharmacol. 2017; 196:47-57.)

The otu ụdịGanoderma lucidumpolysaccharides adịchaghị mma.

Nsonaazụ nyocha a kpọtụrụ aha n'elu na-enye anyị nghọta nke ọma banyere “otuGanoderma lucidumpolysaccharides bara uru maka ụdị ọrịa shuga 2.Ọ na-echetara anyị na na mbụ ogbo nke iji Western ọgwụ ma ọ bụGanoderma lucidumpolysaccharides, glucose ọbara nwere ike ọ gaghị alaghachi na nkịtị otu oge ma ọ bụ ọbụna na-efegharị elu na ala ruo oge dị ka egosiri na foto 1.

Emela ka ihe wutere gị n'oge a, n'ihi na ọ bụrụhaala na ị na-eri nriGanoderma lucidum, e chebewo akụkụ ahụ gị.

Ọ bara uru ịkọwa na, dị ka e kwuru na mmalite nke isiokwu ahụ,Ganoderma lucidumpolysaccharides F31 bụ obere molekul polysaccharides “mepụtara” site na GLP.N'ịtụle mmetụta hypoglycemic ha n'okpuru otu ọnọdụ nnwale, ị ga-achọpụta na mmetụta GLPs dị mma karịa nke F31 (Nyocha 4).

N'ikwu ya n'ụzọ ọzọ, otu ụdịGanoderma lucidumpolysaccharides bụchaghị mma, ma n'ozuzu mmetụta nke keukwu iche iche nkeGanoderma lucidumpolysaccharides ka ukwuu.Ebe ọ bụ na GLP bụ polysaccharides crude enwetara naGanoderma lucidumahụ na-amị mkpụrụ site na mmịpụta mmiri ọkụ, ọ bụrụhaala na ị na-eri ngwaahịa nwereGanoderma lucidumMwepụta mmiri na-amị mkpụrụ, ị gaghị echefu GLPs. 

Ọgụgụ 4 Mmetụta nke ụdị dị iche icheGanoderma lucidumpolysaccharides na-ebu ọnụ na ọkwa glucose ọbara 

[Nkọwa] Mgbe ụmụ oke nwere ụdị ọrịa shuga 2 (ọnụahịa glucose ọbara na-ebu ọnụ 12-13 mmol / L) na-enweta ọgwụ intraperitoneal kwa ụbọchị.Ganoderma lucidumpolysaccharides F31 (50 mg / kg),Ganoderma lucidumcrude polysaccharides GLPs (50 mg/kg ma ọ bụ 100 mg/kg) maka ụbọchị asaa n'usoro, a na-atụnyere ọkwa glucose ọbara ha na nke ụmụ oke nkịtị yana nke ụmụ oke na-arịa ọrịa shuga na-agwọghị ya.(Nke sitere na/Wu Tingyao, isi iyi data/Arch Pharm Res. 2012; 35(10):1793-801.J Ethnopharmacol. 2017; 196:47-57.)

Isi mmalite

1. Xiao C, et al.Ọrụ antidiabetic nke Ganoderma lucidum polysaccharides F31 na-achịkwa enzymes imeju imeju na-achịkwa n'ime ụmụ oke ndị nwere ọrịa shuga.J Ethnopharmacol.2017 Jan 20;196:47-57 .

2. Xiao C, et al.Mmetụta hypoglycemic nke Ganoderma lucidum polysaccharides na ụdị 2 oke oke nwere ọrịa shuga.Arch Pharm Res.2012 Ọkt; 35 (10): 1793-801 .

N'ikpeazụ

Banyere onye odee/ Oriakụ Wu Tingyao

Wu Tingyao na-akọ akụkọ gbasara Ganoderma nke mbụ kemgbe 1999. Ọ bụ ya bụ onye dere akwụkwọ akụkọ.Ọgwụgwọ na Ganoderma(nke e bipụtara na The People's Medical Publishing House na Eprel 2017).

★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede.★ Enweghị ike imepụtagharị ọrụ ndị a dị n'elu, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke onye edemede.★ Maka mmebi nke nkwupụta a dị n'elu, onye edemede ga-agbaso ọrụ iwu dị mkpa.★ Wu Tingyao dere ederede izizi nke akụkọ a n'asụsụ Chinese wee sụgharịa ya n'asụsụ Bekee site n'aka Alfred Liu.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ bụ Oriakụ Wu Tingyao.