Janaayo 20, 2017 / Machadka Guangdong ee Microbiology iyo Xarunta Xakamaynta iyo Kahortagga Cudurrada ee Gobolka Guangdong / Joornaalka Ethnopharmacology

Qoraal/ Wu Tingyao

Waxay ahayd in muddo dheer xaqiiqo la aqoonsan yahayGanoderma lucidumpolysaccharides waxay kaa caawin kartaa daaweynta sonkorowga, laakiin sida uu u shaqeeyo waa mawduuc ay saynisyahannadu rabaan inay wax badan ka ogaadaan.

Horaantii 2012, Machadka Guangdong ee Microbiology iyo Xarunta Xakamaynta iyo Kahortagga Cudurrada ee Gobolka Guangdong ayaa si wada jir ah u soo saartay warbixin sheegaysa in polysaccharides-ka culeyska kelliga ah (GLPs) laga soosaaray biyaha kululGanoderma lucidumJidhka miraha waxay leeyihiin saameyn wanaagsan oo hypoglycemic ah nooca 2 ee sonkorowga (T2D).

Hadda, waxay sii fogeeyeen afar polysaccharides oo ka yimid GLPs, waxayna qaateen F31 aad u firfircoon (miisaanka molecular ee ku saabsan 15.9 kDa, oo ka kooban 15.1% borotiinka) daraasad qotodheer, waxayna ogaadeen inaysan kaliya xakamayn karin gulukooska dhiigga iyada oo loo marayo waddooyin badan laakiin sidoo kale ilaali beerka.

Lingzhipolysaccharides waxay yareyn kartaa hyperglycemia.

Tijaabo xayawaan ah oo 6-usbuuc ah, ayaa lagu ogaaday nooca 2 ee jiirka macaanka (Ganoderma lucidumqiyaasta sare ee kooxda) oo lagu quudiyo 50 mg / kgGanoderma lucidumpolysaccharides F31 maalin kasta waxay si joogto ah uga hoosaysay heerarka gulukooska dhiigga ee soonka marka loo eego jiirarka aan la daweynin ee sonkorowga (kooxda xakamaynta), waxaana jiray farqi weyn.

Taas bedelkeeda, jiirarka macaanka qaba (Ganoderma lucidumqiyaasta koox-hooseeya) oo waliba cunayGanoderma lucidumpolysaccharides F31 maalin kasta laakiin qiyaasta kaliya ee 25 mg/kg ayaa hoos u dhac yar oo cad ku lahaa gulukooska dhiigga.Tani waxay muujinaysaa inGanoderma lucidumpolysaccharides waxay leeyihiin saamaynta habaynta gulukooska dhiigga, laakiin saamaynta waxa saamayn doonta qiyaasta (Jaantuska 1).

Jaantuska 1 SaamayntaGanoderma lucidumheerarka gulukoosta dhiigga ee soonka ee jiirarka macaanka

[Sharaxaad] Daawada hypoglycemic ee loo isticmaalo "Kooxda Daawada Galbeedka" waa metformin (Loditon), kaas oo afka laga qaato 50 mg/kg maalin kasta.Unugga gulukoosta dhiigga ee shaxanka waa mmol/L.U qaybi qiimaha gulukoosta dhiigga 0.0555 si aad u hesho mg/dL.Heerka gulukooska dhiigga ee soonka ee caadiga ah waa inuu ka hooseeyaa 5.6 mmol/L (qiyaastii 100 mg/dL), in ka badan 7 mmol/L (126 mg/dL) waa sonkorow.(Waxaa sawiray/Wu Tingyao, isha xogta/J Ethnopharmacol. 2017; 196:47-57.)

likaha Reishipolysaccharides waxay yareeyaan dhaawaca beerka ee uu keeno sonkorowga.

Waxaa laga heli karaa sawirka 1 in kastooGanoderma lucidumpolysaccharides F31 waxay nidaamin kartaa gulukoosta dhiigga, saamaynteeduna wax yar bay ka liidataa ta daawada reer galbeedka, mana soo celin karto gulukoosta dhiigga sidii caadiga ahayd.Si kastaba ha ahaatee,Ganoderma lucidumpolysaccharides waxay bilaabeen inay door ka ciyaaraan ilaalinta beerka.

Waxaa laga arki karaa Jaantuska 2, inta lagu jiro tijaabada, qaabka iyo qaab-dhismeedka unugyada beerka ee jiirarka sonkorowgaGanoderma lucidumpolysaccharides F31 (50 mg/kg) waxay la mid ahaayeen jiirarka caadiga ah, waxaana jiray barar yar.Taas bedelkeeda, unugyada beerka ee jiirarka macaanka ee aan helin wax daaweyn ah ayaa si weyn u dhaawacmay, xaaladaha caabuqa iyo necrosis ayaa sidoo kale aad u daran.

Jaantuska 2 Saamaynta Hepatoprotective eeGanoderma lucidumpolysaccharides ee jiirarka macaanka

[Sharaxaad] Falaadha cad waxay tilmaamaysaa nabar bararsan ama necrotic ah.(Isha/J Ethnopharmacol. 2017; 196:47-57.)

Cudurka macaanka nooca 2aad

Daraasado badan oo hore ayaa sharaxay habkaGanoderma lucidumpolysaccharides oo nidaamisa gulukoosta dhiigga marka loo eego aragtida "ilaalinta unugyada islet-ka ee ganaca iyo kor u qaadista dheecaanka insulin."Daraasadani waxay soo jeedinaysaa inGanoderma lucidumpolysaccharides waxay sidoo kale wanaajin kartaa hyperglycemia siyaabo kale.

Kahor intaanan sii gudbin, waa in aan marka hore ogaano dhowr fure u ah samaynta nooca 2aad ee sonkorowga.Ka dib marka qofka qaba shaqada dheef-shiid kiimikaadka caadiga ah uu cuno, unugyadiisa islet-ka ee ganaca ayaa soo saari doona insulin, taas oo kicisa unugyada murqaha iyo unugyada baruurta si ay u soo saaraan "gulukoosta qaada (GLUT4)" oogada unugyada si ay "u qaadaan" gulukooska dhiigga ku jira unugyada.

Sababtoo ah gulukoos si toos ah uma gudbi karto xuubka unugyada, ma geli karto unugyada la'aanteed kaalmada GLUT4.Nuxurka nooca 2-aad ee sonkorowga ayaa ah in unugyadu aanay dareen u lahayn insulinta ( caabbinta insulinta).Xataa haddii insuliinka si joogto ah loo soo daayo, weli ma soo saari karto GLUT4 ku filan oogada unugyada.

Xaaladdan waxay u badan tahay inay ku dhacdo dadka cayilan, sababtoo ah dufanku waxay soo saartaa hormoonka peptide ee loo yaqaan "resistin", kaas oo keena caabbinta insulin ee unugyada baruurta.

Maadaama gulukoosku ay tahay isha tamarta ee unugyadu, marka unugyadu ay ka maqnaayeen gulukoos, marka laga reebo in dadku ay rabaan inay cunto badan cunaan, waxay sidoo kale dhiirigelin doontaa beerka inuu soo saaro gulukoos badan.

Waxaa jira laba siyaabood oo beerku u soo saaro gulukoos: mid waa inuu burburiyo glycogen, taas oo ah, inuu isticmaalo gulukooska asal ahaan ku kaydsan beerka;Midda kale waa in dib loo soo nooleeyo glycogen, taas oo ah, in loo beddelo alaabta ceeriin ee aan karbohaydraytka ahayn sida borotiinka iyo dufanka oo loo beddelo glucose.

Labadan saameyn ee bukaanada qaba nooca 2 ee sonkorowga ayaa ka xoog badan kuwa dadka caadiga ah.Marka heerka isticmaalka gulukooska ee unugyada unuggu uu hoos u dhaco inta xaddiga wax soo saarka gulukoosku uu sii socdo inuu kordho, dabiici ahaan way adag tahay in gulukoosta dhiiggu hoos u dhacdo.

Ganoderma lucidumpolysaccharides waxay yareeyaan xaddiga gulukooska ee beerku soo saaro waxayna wanaajisaa heerka isticmaalka gulukooska unugyadu.

Ganoderma lucidumpolysaccharides F31 waxay u muuqataa inay awood u leedahay inay xalliso dhibaatooyinka kor ku xusan.Ka dib markii ay dhammaatay tijaabada xayawaanka, cilmi-baarayaashu waxay soo saareen beerka jiirka iyo dufanka epididymal (sida tusaha dufanka jidhka), waxay falanqeeyeen oo ay barbar dhigeen, waxayna ogaadeen in F31 ay leedahay habka soo socda ee ficilka (Jaantus 3):

1. Dhaqdhaqaaqa AMPK borotiinka kinase ee beerka, yaraynta muujinta hidda-wadaha ee dhowr enzymes oo ku lug leh glycogenolysis ama gluconeogenesis ee beerka, yaraynta soosaarka gulukooska, iyo xakamaynta gulukooska dhiigga ee isha.

2. Kordhi tirada GLUT4 on adipocytes iyo in la xakameeyo dheecaanka resistin ka adipocytes (samaynta labadan doorsoome aad ugu dhow xaaladda jiirarka caadiga ah), taas oo hagaajinaysa dareenka adipocytes ee insulin iyo kordhinta isticmaalka gulukooska.

3. Si weyn u yareeya muujinta hidda-wadaha enzymes-yada muhiimka ah ee ku lug leh isku-dhafka dufanka ee unugyada adipose, taas oo yaraynaysa saamiga dufanka ee miisaanka jidhka iyo yaraynta arrimaha la xidhiidha caabbinta insulin.

Taas waa la arki karaaGanoderma lucidumpolysaccharides waxay nidaamin kartaa gulukoosta dhiigga iyada oo loo marayo ugu yaraan saddex dariiqo, dariiqyadani wax shaqo ah kuma laha "kicinta dheecaanka insulinta", taasoo siinaya fursado badan oo lagu hagaajinayo sonkorowga. 

Jaantuska 3 HabkaGanoderma lucidumpolysaccharides nidaaminta gulukooska dhiigga

[Sharaxaad] epididymis waa tuubo dhuuban oo dhuuban oo u eeg xaga sare ee xiniinyaha, isku xira vas deferens iyo xiniinyaha.Maaddaama dufanka ku wareegsan epididymis uu si togan ugu xidhan yahay wadarta dufanka jidhka oo dhan (gaar ahaan dufanka visceral), waxay inta badan noqotaa tusaha fiirsiga ee tijaabada.Sida loo yareeyo GP-ga iyo enzymes kale ka dibGanoderma lucidumpolysaccharides waxay kicisaa AMPK, waxay u baahan tahay in la sii caddeeyo, markaa xiriirka ka dhexeeya labada waxaa lagu muujiyay "?"shaxanka.(Isha J Ethnopharmacol. 2017; 196:47-57.)

Nooca kali ahGanoderma lucidumpolysaccharides maahan mid ka fiican.

Natiijooyinka cilmi-baarista ee kor ku xusan waxay na siinayaan faham wanaagsan oo ku saabsan "sidaGanoderma lucidumpolysaccharides waxay faa'iido u leeyihiin nooca 2aad ee sonkorowga".Waxa kale oo ay ina xasuusinaysaa in marxaladda bilowga ah ee isticmaalka daawada reer galbeedka amaGanoderma lucidumpolysaccharides, gulukoosta dhiigu halmar kuma soo noqon karto caadi ama xataa kor iyo hoos ayay u rogmataa muddo wakhti ah sida ku cad sawirka 1.

Ha niyad jabin wakhtigan, sababtoo ah inta aad wax cunaysoGanoderma lucidum, xubnahaaga gudaha waa la ilaaliyay.

Waxaa xusid mudan, sida ku xusan bilowga maqaalka.Ganoderma lucidumpolysaccharides F31 waa polysaccharides-yar-yar oo laga sameeyay GLP-yada.Marka la barbardhigo saameyntooda hypoglycemic ee hoos timaada isla xaaladaha tijaabada, waxaad ogaan doontaa in saameynta GLPs ay aad uga fiican tahay tan F31 (Jaantuska 4).

Si kale haddii loo dhigo, nooca kali ahGanoderma lucidumpolysaccharides ma aha daruuri ka wanaagsan, laakiin saamaynta guud ee noocyada dhamaystiran eeGanoderma lucidumpolysaccharides ayaa ka weyn.Maadaama GLPs ay yihiin polysaccharides cayriin oo laga helayGanoderma lucidummidho-dhalatada iyada oo la soo saarayo biyaha kulul, ilaa iyo inta aad cunto alaabta ay ku jiraanGanoderma lucidumMiraha miraha laga soosaaray biyaha, kama maqnaan doontid GLPs. 

Jaantuska 4 Saamaynta noocyada kala duwan eeGanoderma lucidumpolysaccharides ee heerarka gulukooska dhiigga ee soonka 

[Sharaxaad] Ka dib jiirarka qaba nooca 2 ee sonkorowga (soonka qiimaha gulukoosta dhiigga 12-13 mmol/L) ayaa la helay duritaan maalinle ah intraperitonealGanoderma lucidumpolysaccharides F31 (50 mg/kg),Ganoderma lucidumGLPs cayriin polysaccharides (50 mg/kg ama 100 mg/kg) 7 maalmood oo isku xigta, heerarka gulukooska dhiigooda ayaa la barbar dhigay kuwa jiirarka caadiga ah iyo kuwa jiirka macaanka ee aan la daweyn.(Waxaa sawiray/Wu Tingyao, isha xogta/Arch Pharm Res. 2012; 35(10):1793-801.J Ethnopharmacol. 2017; 196:47-57.)

Ilaha

1. Xiao C, iyo al.Dhaqdhaqaaqa antidiabetic ee Ganoderma lucidum polysaccharides F31 hoos u habaysan enzymes gulukoosta beerka ee jiirka macaanka.J Ethnopharmacol.2017 Jan 20;196:47-57.

2. Xiao C, iyo al.Saamaynta hypoglycemic ee Ganoderma lucidum polysaccharides ee nooca 2 jiirka macaanka.Arch Pharm Res.2012 Oct;35(10):1793-801.

DHAMAAD

Ku saabsan qoraaga/Ms. Wu Tingyao

Wu Tingyao waxa ay ka warbixinaysay macluumaadka Ganoderma ee gacanta koowaad tan iyo 1999. Iyadu waa qoraagaKu bogsashada Ganoderma(waxaa lagu daabacay Guriga Daabacaada Caafimaadka Dadweynaha Abriil 2017).

★ Maqaalkan waxa lagu daabacay oggolaansho gaar ah oo qoraaga.★ Shaqooyinka kor ku xusan lama soo saari karo, lama soo saari karo, ama siyaabo kale looma isticmaali karo iyada oo aan oggolaansho laga helin qoraaga.Jebinta bayaankan sare, qoraagu wuxuu raaci doonaa mas'uuliyadaha sharciga ah ee khuseeya.★ Qoraalka asalka ah ee maqaalkan waxaa ku qoray Shiinaha Wu Tingyao, waxaana u turjumay Ingiriisi Alfred Liu.Haddii uu jiro farqi u dhexeeya tarjumaada (Ingiriiska) iyo kan asalka ah (Shiineyska), Shiinaha asalka ah ayaa guulaysan doona.Haddii akhristayaasha ay qabaan wax su'aalo ah, fadlan la xiriir qoraaga asalka ah, Ms. Wu Tingyao.