May 2015/Jinan University, njll./ International Journal of Oncology

Ukuhlanganiswa / Wu Tingyao

Ukumelana namaseli omdlavuza emithini eminingi ye-chemotherapeutic kwenza ukwelashwa komdlavuza kube nzima.Esinye sezizathu ezibalulekile ezenza amangqamuzana omdlavuza athuthuke ukumelana nezidakamizwa ukuthi iphrotheni i-ABCB1 (i-ATP-binding cassette sub-family B member 1) endaweni yeseli izokhipha izidakamizwa engqamuzaneni, okubangele ukugcwala kwezidakamizwa okunganele emangqamuzaneni ukubulala. amangqamuzana omdlavuza.

Ngokocwaningo olushicilelwe yiJinan University nabanye, i-triterpenoid eyodwa “ganoderenic acid B” ehlukanisiwe nayo.I-Ganoderma lucidumingalawula isakhi sofuzo seprotheni yokumelana nomuthi i-ABCB1, yehlise izinga layo lokukhuluma, futhi ngesikhathi esifanayo ivimbe umsebenzi we-ABCB1 ATPase, ivimbele i-ABCB1 ekwenzeni umsebenzi wayo "wokuxosha i-chemotherapeutics ngaphandle kweseli."

Ngokuhlakulela i-ganoderenic acid B kanye nomugqa weseli womdlavuza wesibindi ongazweli emthini i-HepG2/ADM ndawonye, ​​umuthi we-chemotherapeutic (i-rhodamine-123) owawuvinjelwe ekuqaleni ungangena kumaseli omdlavuza futhi uqongelele inani elikhulu lapho.I-Ganoderenic acid B ingasiza ngempela ukukhulisa umphumela onobuthi we-doxorubicin, i-vincristine ne-paclitaxel ngokumelene ne-HepG2/ADM engazweli emthini futhi ithuthukise umphumela wokwelapha we-doxorubicin kumaseli womdlavuza webele ongazweli emuthini i-MCF-7/ADR.

Esikhathini esidlule, izifundo eTaiwan ziye zaqinisekisa ngokuhlolwa kwamaseli nezilwane ukuthi i-ethanol ekhishwe ngayoI-Ganoderma tsugae(i-triterpenoid total extract) ingathuthukisa umphumela wokwelapha wezidakamizwa ze-chemotherapeutic ngokumelene namangqamuzana omdlavuza wamaphaphu angamelana nezidakamizwa (Evid. Based compiement alternat Med. 2012; 2012: 371286).Manje ucwaningo lwaseJinan University luveze ngokusobala ukuthi i-ganoderenic acid B kuma-triterpenoids iyisithako esisebenzayo sokuhlehlisa ukumelana nezidakamizwa kumaseli omdlavuza.Ukuxhumana kwalokhu kuhlolwa okuhlukene kwenze umsebenzi weI-Ganodermalucidumama-triterpenoids ekubuyiseleni ukumelana nezidakamizwa kumaseli omdlavuzangokwandayo sobala.

Ukuthuthukiswa kwama-inhibitors ngokumelene namaprotheni amelana nezidakamizwa njenge-ABCB1 okwamanje kuwumgomo wemizamo esebenzayo yomphakathi wezokwelapha, kodwa kubonakala sengathi awukho umuthi ongcono okwamanje (Taiwan Medical Community, 2014, 57: 15-20).Imiphumela yocwaningo lokuqala iveze amandla e-ganoderenic acid B kule ndawo, futhi sibheke phambili ekuqhubekiseni ucwaningo lwezilwane ukuze sinikeze ubufakazi obunamandla esikhathini esizayo.

[Umthombo] Liu DL, et al.I-Ganoderma lucidu etholakala ku-ganoderenic acid B ibuyisela emuva i-ABCB1-mediated multidrug resistance kumaseli e-HepG2/ADM.Int J Oncol.46(5):2029-38.doi: 10.3892/ijo.2015.2925.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao
U-Wu Tingyao ubelokhu ebika mathuphaLingzhi ulwazi kusukela 1999. Ungumbhali weUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).
 
★ Lesi sihloko sishicilelwe ngaphansi kwegunya elikhethekile lombhali ★ Le misebenzi engenhla ayikwazi ukuphinda ikhiqizwe, icashunwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali ★ Ukwephulwa kwesitatimende esingenhla, umbhali uzoqhuba izibopho zayo zomthetho ezihlobene ★ Eyokuqala umbhalo walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.