Gicurasi 2015 / Kaminuza ya Jinan, nibindi / Ikinyamakuru mpuzamahanga cya Oncology

Icyegeranyo / Wu Tingyao

Kurwanya kanseri ya kanseri kumiti myinshi ya chimiotherapeutique bituma kuvura kanseri bigorana.Imwe mu mpamvu zingenzi zituma ingirabuzimafatizo za kanseri zitera imiti myinshi ni uko poroteyine ABCB1 (ATP-binding cassette sub-family B umunyamuryango wa 1) hejuru y’akagari izirukana ibiyobyabwenge mu kagari, bigatuma ibiyobyabwenge bidahagije mu ngirabuzimafatizo byica selile kanseri.

Nk’uko ubushakashatsi bwashyizwe ahagaragara na kaminuza ya Jinan hamwe n’abandi bubivuga, triterpenoid imwe “aside ganoderenic B” yitaruyeGanoderma lucidumirashobora kugenga gene ya proteine ​​irwanya ibiyobyabwenge ABCB1, kugabanya urwego rwimvugo, kandi icyarimwe ikabuza ibikorwa bya ABCB1 ATPase, ikabuza ABCB1 gukora imirimo yayo yo "kwirukana imiti ivura imiti mu kagari."

Muguhinga aside ganoderenic B hamwe numurongo wa kanseri yumwijima irwanya imiti HepG2 / ADM hamwe, imiti ya chimiotherapeutique (rhodamine-123) yari yarahagaritswe mbere irashobora kwinjira mungirangingo ya kanseri kandi ikarundanya umubare utari muto.Acide Ganoderenic B irashobora rwose gufasha kongera ingaruka zuburozi bwa doxorubicin, vincristine na paclitaxel kurwanya imiti HepG2 / ADM irwanya ibiyobyabwenge ndetse ikanatezimbere uburyo bwo kuvura doxorubicine irwanya ibiyobyabwenge kanseri y'ibere MCF-7 / ADR.

Mu bihe byashize, ubushakashatsi bwakorewe muri Tayiwani bwemeje binyuze mu bushakashatsi bwakozwe mu ngirabuzimafatizo no ku nyamaswa ko Ethanol ikuramoGanoderma tsugae.Ubu ubushakashatsi bwakozwe na kaminuza ya Jinan bwerekanye neza ko aside ganoderenic B muri triterpenoide ari cyo kintu cyiza cyo kurwanya ibiyobyabwenge bya kanseri.Ihuza ryibi bigeragezo bitandukanye ryakoze imikorere yaGanodermalucidumtriterpenoide muguhindura imiti irwanya kanserikwiyongera biragaragara.

Iterambere rya inhibitor zirwanya poroteyine zidashobora kurwanya ibiyobyabwenge nka ABCB1 kuri ubu ni yo ntego y’ibikorwa by’ubuvuzi, ariko bigaragara ko nta muti mwiza uhari (Umuryango w’ubuvuzi wa Tayiwani, 2014, 57: 15-20).Ibisubizo byubushakashatsi bwibanze byerekanye ubushobozi bwa acide ganoderenic B muri kano karere, kandi turategereje ubundi bushakashatsi bw’inyamaswa kugira ngo butange ibimenyetso bifatika mu gihe kizaza.

[Inkomoko] Liu DL, n'abandi.Ganoderma lucidu ikomoka kuri acide ganoderenic B ihindura ABCB1 yunganirwa na multidrug irwanya selile HepG2 / ADM.Int J Oncol.46 (5): 2029-38.doi: 10.3892 / ijo.2015.2925.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao
Wu Tingyao yagiye atanga raporo imbonankuboneLingzhi makuru kuva 1999. Niwe mwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).
 
★ Iyi ngingo yasohowe ku ruhushya rwihariye rw’umwanditsi works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mu bundi buryo utabiherewe uburenganzira n’umwanditsi ★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakomeza inshingano zijyanye n’amategeko ★ Umwimerere inyandiko yiyi ngingo yanditswe mu gishinwa na Wu Tingyao ihindurwa mu Cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.