Chivabvu 2015/ Jinan University, etc./ International Journal of Oncology

Compilation / Wu Tingyao

Kupokana kwemasero egomarara kune akawanda chemotherapeutic mishonga kunoita kuti kurapwa kwegomarara kuome.Chimwe chezvikonzero zvakakosha nei maseru egomarara achikura kurwisa-mishonga yakawanda ndechekuti protein ABCB1 (ATP-inosunga kaseti sub-mhuri B nhengo 1) iri pasero inoburitsa mishonga kunze kwesero, zvichikonzera kusakwana kwemishonga mumasero kuuraya. kenza masero.

Zvinoenderana netsvagiridzo yakabudiswa neJinan University nevamwe, imwe triterpenoid "ganoderenic acid B" yakaparadzaniswaGanoderma luciduminogona kudzora jini reprotein rekurwisa zvinodhaka ABCB1, kuderedza danho rekutaura, uye panguva imwechete inhibisa basa reABCB1 ATPase, kudzivirira ABCB1 kuita basa rayo re "kudzinga chemotherapeutics kunze kwesero."

Nekurima ganoderenic acid B uye inodzivirira kenza yechiropa cell line HepG2/ADM pamwe chete, mushonga wechemotherapeutic (rhodamine-123) wakambovharwa unogona kupinda mumaseru egomarara uye kuunganidza mari yakawanda ipapo.Ganoderenic acid B inogona zvechokwadi kubatsira kuwedzera muchetura we doxorubicin, vincristine uye paclitaxel kurwisa HepG2/ADM isingaurayiwi nemishonga uye kunyange kunatsiridza kurapa kwedoxorubicin kurwisa kenza yemazamu isingauraye mutsara MCF-7/ADR.

Munguva yakapfuura, zvidzidzo muTaiwan zvakasimbisa kuburikidza nesero uye mhuka kuyedza kuti iyo ethanol inotorwaGanoderma tsugae(triterpenoid total extract) inogona kuvandudza maitiro ekurapa kwemishonga yechemotherapeutic inopesana nemishonga inopesana nekenza yemapapu masero (Evid. Based compiement alternat Med. 2012; 2012: 371286).Ikozvino kuyedza kweJinan University kwakaratidza pachena kuti ganoderenic acid B iri mu triterpenoids ndiyo inoshandiswa kudzoreredza kuramba zvinodhaka kwemasero egomarara.Kubatana kwezviedzo zvakasiyana izvi zvakaita basa reGanodermalucidumtriterpenoids mukudzoreredza kuramba kwemishonga kwemasero egomararazvichiwedzera pachena.

Kuvandudzwa kwemainhibitors kurwisa mapuroteni asingaurayiwi nemishonga akadai seABCB1 parizvino ndicho chinangwa chekushanda nesimba kwenharaunda yezvokurapa, asi zvinoita sekunge hapasati pave nemushonga wakanaka (Taiwan Medical Community, 2014, 57: 15-20).Mhedzisiro yekutanga yekutsvagisa yakaratidza kugona kweganoderenic acid B munzvimbo ino, uye isu tinotarisira kuenderera mberi nekuedza kwemhuka kuti ipe humbowo hwakasimba mune ramangwana.

[Mabviro] Liu DL, et al.Ganoderma lucidu yakatorwa ganoderenic acid B inodzosera ABCB1-mediated multidrug resistance muHepG2/ADM masero.Int J Oncol.46(5):2029-38.doi: 10.3892/ijo.2015.2925.

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Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achitaura nezvekutanga-ruokoLingzhi ruzivo kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).
 
★Chinyorwa ichi chakatsikiswa pasi pemvumo yemunyori chete ★ Mabasa ari pamusoro haagone kutsikiswa, kudonhedzwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori ★ Kutyora chirevo chiri pamusoro, munyori achaita mabasa anoenderana nemutemo ★ Iwo ekutanga. chinyorwa chechinyorwa ichi chakanyorwa neChinese naWu Tingyao uye chakashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.