May 2015/ Jaamacadda Jinan, iwm./ Joornaalka Caalamiga ah ee Oncology

Isku-dubarid / Wu Tingyao

U adkaysiga unugyada kansarka ee dawooyinka kiimikaad ee badan ayaa ka dhigaya daaweynta kansarka mid adag.Mid ka mid ah sababaha ugu muhiimsan ee ay unugyada kansarku u yeeshaan iska caabin dawooyin badan ayaa ah in borotiinka ABCB1 (ATP-binding cassette sub-family B 1) oo ku yaal dusha unuggu ay ka saari doonaan dawooyinka unugyada, taasoo keenta in ku filnaansho daroogo unugyada ay dilaan. unugyada kansarka.

Sida laga soo xigtay cilmi-baaris ay daabacday Jaamacadda Jinan iyo kuwa kale, hal triterpenoid "ganoderenic acid B" oo ka go'anGanoderma lucidumwaxay nidaamin kartaa hidda-wadaha borotiinka iska caabbinta daroogada ABCB1, waxay yaraynaysaa heerka muujinta, isla markaana waxay joojin kartaa dhaqdhaqaaqa ABCB1 ATPase, ka hortagga ABCB1 inay qabato hawsheeda "ka saarida kiimikooyinka ka soo baxa unugga."

Marka la beero ganoderenic acid B iyo khadka unugyada kansarka beerka u adkaysta ee HepG2/ADM, daawada kiimikaad (rhodamine-123) ee markii hore la xannibay waxay geli kartaa unugyada kansarka waxayna ku ururin kartaa qaddar aad u badan.Ganoderenic acid B runtii waxay gacan ka geysan kartaa kordhinta saameynta sunta ah ee doxorubicin, vincristine iyo paclitaxel ee ka dhanka ah daawada u adkeysata HepG2/ADM iyo xitaa hagaajinta saameynta daweynta ee doxorubicin ee ka dhanka ah khadka unugyada kansarka naasaha u adkeysan kara MCF-7/ADR.

Waagii hore, daraasado laga sameeyay Taiwan ayaa lagu xaqiijiyay tijaabooyin unug iyo xayawaan ah oo laga soosaaray ethanolGanoderma waa cudur(laga soosaaray wadarta guud ee triterpenoid) waxay hagaajin kartaa saamaynta daweynta ee dawooyinka kiimikaad ee ka dhanka ah unugyada kansarka sanbabada u adkaysta daroogada (Evid. Based compiement alternat Med. 2012; 2012: 371286).Hadda tijaabada Jaamacadda Jinan waxay si cad u tilmaantay in ganoderenic acid B ee triterpenoid-yada ay tahay walaxda firfircoon ee lagu beddelayo caabbinta daroogada unugyada kansarka.Isku xirka tijaabooyinkan kala duwan ayaa sameeyay shaqadaGanodermalucidumtriterpenoids in ay ka noqdaan caabbinta daroogada unugyada kansarkasii kordhaya cad.

Horumarinta ka-hortagga ka-hortagga borotiinka u adkaysta daawooyinka sida ABCB1 hadda waa hadafka dadaalka firfircoon ee bulshada caafimaadka, laakiin waxay u muuqataa in aysan jirin daawo ku habboon weli (Taiwan Medical Community, 2014, 57: 15-20).Natiijooyinka cilmi-baarista hordhaca ah ayaa tilmaamay awoodda ganoderenic acid B ee aaggan, waxaanan rajeyneynaa tijaabooyin kale oo xayawaan ah si loo bixiyo caddayn xooggan mustaqbalka.

[Isha] Liu DL, iyo al.Ganoderma lucidu oo laga helay ganoderenic acid B waxay beddeshaa iska caabbinta dawooyinka badan ee ABCB1 dhexdhexaadisay ee unugyada HepG2/ADM.Int J Oncol.46 (5): 2029-38.doi: 10.3892/ijo.2015.2925.

DHAMAAD

Ku saabsan qoraaga/Ms. Wu Tingyao
Wu Tingyao ayaa si toos ah uga warbixinayayLingzhi information tan iyo 1999. Iyadu waa qoraagaKu bogsashada Ganoderma(waxaa lagu daabacay Guriga Daabacaada Caafimaadka Dadweynaha Abriil 2017).
 
★ Maqaalkan waxa lagu daabacay ogolaansho gaar ah oo uu leeyahay qoraaga ★ Shaqooyinka kor ku xusan lama soo saari karo, lagana saari karo ama looma isticmaali karo siyaabo kale iyada oo aan oggolaansho laga helin qoraaga ★ ku xad-gudbida hadalka sare, qoraagu waxa uu gudan doonaa waajibaadkiisa sharci ee la xidhiidha ★ Asalka qoraalka maqaalkan waxaa ku qoray Shiinaha Wu Tingyao waxaana Ingiriis u turjumay Alfred Liu.Haddii uu jiro farqi u dhexeeya tarjumaada (Ingiriiska) iyo kan asalka ah (Shiineyska), Shiinaha asalka ah ayaa guulaysan doona.Haddii akhristayaasha ay qabaan wax su'aalo ah, fadlan la xiriir qoraaga asalka ah, Ms. Wu Tingyao.