May 2015/ Jinan University, etc./ International Journal of Oncology

Kuphatikiza / Wu Tingyao

Kukana kwa maselo a khansa ku mankhwala ambiri a chemotherapeutic kumapangitsa kuchiza khansa kukhala kovuta.Chimodzi mwazifukwa zazikulu zomwe ma cell a khansa amayamba kukana kugwiritsa ntchito mankhwala ambiri ndikuti puloteni ya ABCB1 (ATP-binding cassette sub-family B membala 1) pa cell imatulutsa mankhwala m'selo, ndikupangitsa kusakwanira kwa mankhwala m'maselo kupha. maselo a khansa.

Malinga ndi kafukufuku wofalitsidwa ndi Jinan University ndi ena, limodzi triterpenoid "ganoderenic asidi B" olekanitsidwa ndiGanoderma lucidumimatha kuwongolera jini ya puloteni yolimbana ndi mankhwala ABCB1, kuchepetsa kuchuluka kwa mawu ake, ndipo nthawi yomweyo kuletsa ntchito ya ABCB1 ATPase, kulepheretsa ABCB1 kugwira ntchito yake "yotulutsa chemotherapeutics m'selo."

Pokulitsa ganoderenic acid B ndi hepG2 / ADM yosamva mankhwala a khansa ya chiwindi, mankhwala a chemotherapeutic (rhodamine-123) omwe poyamba anali otsekedwa amatha kulowa m'maselo a khansa ndikudziunjikira ndalama zambiri kumeneko.Ganoderenic acid B ingathandizedi kuonjezera mphamvu ya poizoni ya doxorubicin, vincristine ndi paclitaxel motsutsana ndi HepG2/ADM yosamva mankhwala komanso ngakhale kusintha mankhwala a doxorubicin motsutsana ndi maselo a khansa ya m'mawere ya MCF-7/ADR.

M'mbuyomu, maphunziro ku Taiwan atsimikizira kudzera mu kuyesa kwa selo ndi nyama kuti Mowa TingafinyeGanoderma tsugae(triterpenoid total extract) ikhoza kupititsa patsogolo chithandizo cha mankhwala a chemotherapeutic motsutsana ndi maselo a khansa ya m'mapapo osamva mankhwala (Evid. Based compiement alternat Med. 2012; 2012: 371286).Tsopano kuyesera kwa Jinan University kunanena momveka bwino kuti ganoderenic asidi B mu triterpenoids ndi yogwira pophika kuti asinthe kukana mankhwala a khansa maselo.Kugwirizana kwa mayesero osiyanasiyanawa kwapanga ntchito yaGanodermalucidumtriterpenoids pobwezeretsa kukana kwamankhwala kwa ma cell a khansamochulukira zoonekeratu.

Kukula kwa zoletsa motsutsana ndi mapuloteni osamva mankhwala monga ABCB1 pakali pano ndi cholinga cha kuyesetsa mwakhama kwa gulu lachipatala, koma zikuwoneka kuti palibe mankhwala abwino (Taiwan Medical Community, 2014, 57: 15-20).Zotsatira za kafukufuku woyambirira zawonetsa kuthekera kwa ganoderenic acid B m'derali, ndipo tikuyembekeza kupitilira kuyesa kwa nyama kuti tipereke umboni wamphamvu m'tsogolomu.

[Source] Liu DL, et al.Ganoderma lucidu yochokera ku ganoderenic acid B imatembenuza ABCB1-mediated multidrug resistance mu maselo a HepG2/ADM.Ine J Oncol.46(5):2029-38.doi: 10.3892/ijo.2015.2925.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akunena za zomwe zikuchitikaLingzhine zambiri kuyambira 1999. Iye ndi mlembi waKuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).
 
★ Nkhaniyi yasindikizidwa ndi chilolezo cha mlembi ★ Ntchito zomwe zili pamwambazi sizingabwerezedwe, kutsanulidwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba ★ Kuphwanya mawu omwe ali pamwambawa, wolemba adzakwaniritsa udindo wake wazamalamulo ★ Zoyambirira Nkhaniyi idalembedwa m'Chitchaina ndi Wu Tingyao ndikumasuliridwa m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.