Mei 2015/ Jinan University, etc./ International Journal of Oncology

Huihui / Wu Tingyao

ʻO ke kūʻē ʻana o nā pūnaewele maʻi maʻi i nā lāʻau chemotherapeutic he paʻakikī ka mālama ʻana i ka maʻi kanesa.ʻO kekahi o nā kumu koʻikoʻi e ulu ai nā maʻi maʻi maʻi i ka pale ʻana i nā lāʻau he nui, ʻo ia ka protein ABCB1 (ATP-binding cassette sub-family B member 1) ma ka ʻili o ka cell e kipaku aku i nā lāʻau mai loko aku o ka cell, no ka lawa ʻole ʻana o ka lāʻau lapaʻau i loko o nā cell e pepehi. maʻi maʻi ʻaʻai.

Wahi a ka noiʻi i paʻi ʻia e Jinan University a me nā mea ʻē aʻe, hoʻokahi triterpenoid "ganoderenic acid B" i hoʻokaʻawale ʻia maiʻO Ganoderma lucidumHiki iā ia ke hoʻoponopono i ka gene o ka protein resistance drug ABCB1, e hoʻemi i kona pae hōʻike, a ma ka manawa like e keʻakeʻa i ka hana o ABCB1 ATPase, e pale ana iā ABCB1 mai ka hana ʻana i kāna hana o ka "kipaku ʻana i nā chemotherapeutics i waho o ke kelepona."

Ma ka hoʻoulu ʻana i ka waikawa ganoderenic B a me ka lāʻau maʻi maʻi ʻaʻai kūpaʻa ʻole i ka lāʻau HepG2/ADM i hui pū ʻia, hiki i ka lāʻau chemotherapeutic (rhodamine-123) i hoʻopaʻa mua ʻia ke komo i loko o nā keʻena maʻi maʻi a hōʻiliʻili i kahi nui ma laila.Hiki i ka Ganoderenic acid B ke kōkua i ka hoʻonui ʻana i ka hopena ʻona o ka doxorubicin, vincristine a me ka paclitaxel e kūʻē i ka HepG2/ADM kūʻē i ka lāʻau lapaʻau a hiki i ka hoʻomaikaʻi ʻana i ka hopena therapeutic o doxorubicin e kūʻē i ka lāʻau lapaʻau pale umauma maʻi maʻi maʻi laina MCF-7/ADR.

I ka wā ma mua, ua hoʻopaʻa ʻia nā haʻawina ma Taiwan ma o nā hoʻokolohua cell a me nā holoholona i ʻike ʻia e ka ethanol extract oʻO Ganoderma tsugae(triterpenoid total extract) hiki ke hoʻomaikaʻi i ka hopena therapeutic o nā lāʻau chemotherapeutic e kūʻē i ka lāʻau lapaʻau-kū'ē i ka maʻi maʻi maʻi maʻi maʻi (Evid. Based compiement alternat Med. 2012; 2012:371286).I kēia manawa ua hōʻike maopopo ʻia ka hoʻokolohua o ke Kulanui ʻo Jinan ʻo ka ganoderenic acid B i loko o nā triterpenoids ka mea hana e hoʻohuli ai i ke kūʻē ʻana i ka lāʻau lapaʻau o nā maʻi kanesa.ʻO ka pilina o kēia mau hoʻokolohua like ʻole i hana i ka hana oGanodermalucidumtriterpenoids i ka hoʻohuli ʻana i ka lāʻau kūʻē o nā maʻi maʻimahuahua ana maopopo.

ʻO ka hoʻomohala ʻana i nā mea pale e kūʻē i nā protein kūʻē i ka lāʻau lapaʻau e like me ABCB1 i kēia manawa ka pahuhopu o nā hoʻoikaika ikaika o ke kaiāulu olakino, akā me he mea lā ʻaʻohe lāʻau kūpono i kēia manawa (Taiwan Medical Community, 2014, 57: 15-20).Ua hōʻike ʻia nā hopena noiʻi mua i ka hiki o ka ganoderenic acid B ma kēia wahi, a ke kakali nei mākou i nā hoʻokolohua holoholona hou e hāʻawi i nā hōʻike ikaika i ka wā e hiki mai ana.

[Source] Liu DL, et al.ʻO Ganoderma lucidu i loaʻa i ka ganoderenic acid B e hoʻohuli i ka ABCB1-mediated multidrug resistance i loko o nā pūnaewele HepG2/ADM.Int J Oncol.46(5):2029-38.doi: 10.3892/ijo.2015.2925.

HOPE

No ka mea kākau/ Ms. Wu Tingyao
Ua hōʻike ʻo Wu Tingyao ma ka lima muaLingzhi ʻike mai ka makahiki 1999. ʻO ia ke kumu oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).
 
★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau ★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻoki ʻia a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻana o ka mea kākau ★ ʻAʻole i ʻae ʻia ka ʻōlelo ma luna, e hahai ka mea kākau i kāna mau kuleana pili i ke kānāwai ★ ʻO ke kumu kumu. Ua kākau ʻia nā kikokikona o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.